BR112015021885A8 - 1,4-butanodiol bioderivado, seus processos e sistemas para purificação e produção de 1,4-butanodiol, plástico biobaseado, fibra elástica, poliuretano, poliéster, poli-4-hidróxi butirato ou seu copolímero, poli (tetra metileno éter) glicol ecopolímero de poliuretano – poliureia - Google Patents

1,4-butanodiol bioderivado, seus processos e sistemas para purificação e produção de 1,4-butanodiol, plástico biobaseado, fibra elástica, poliuretano, poliéster, poli-4-hidróxi butirato ou seu copolímero, poli (tetra metileno éter) glicol ecopolímero de poliuretano – poliureia Download PDF

Info

Publication number
BR112015021885A8
BR112015021885A8 BR112015021885A BR112015021885A BR112015021885A8 BR 112015021885 A8 BR112015021885 A8 BR 112015021885A8 BR 112015021885 A BR112015021885 A BR 112015021885A BR 112015021885 A BR112015021885 A BR 112015021885A BR 112015021885 A8 BR112015021885 A8 BR 112015021885A8
Authority
BR
Brazil
Prior art keywords
butanediol
polyurethane
poly
systems
ecopolymer
Prior art date
Application number
BR112015021885A
Other languages
English (en)
Other versions
BR112015021885A2 (pt
BR112015021885B1 (pt
Inventor
M Sonico Ishmael
Japs Michael
Janardhan Garikipati Svb
Original Assignee
Genomatica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genomatica Inc filed Critical Genomatica Inc
Publication of BR112015021885A2 publication Critical patent/BR112015021885A2/pt
Publication of BR112015021885A8 publication Critical patent/BR112015021885A8/pt
Publication of BR112015021885B1 publication Critical patent/BR112015021885B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
    • C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
    • C07C29/80—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by distillation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/22—Evaporating by bringing a thin layer of the liquid into contact with a heated surface
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/001—Processes specially adapted for distillation or rectification of fermented solutions
    • B01D3/002—Processes specially adapted for distillation or rectification of fermented solutions by continuous methods
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/14—Fractional distillation or use of a fractionation or rectification column
    • B01D3/143—Fractional distillation or use of a fractionation or rectification column by two or more of a fractionation, separation or rectification step
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/14—Fractional distillation or use of a fractionation or rectification column
    • B01D3/143—Fractional distillation or use of a fractionation or rectification column by two or more of a fractionation, separation or rectification step
    • B01D3/145—One step being separation by permeation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
    • C07C29/88—Separation; Purification; Use of additives, e.g. for stabilisation by treatment giving rise to a chemical modification of at least one compound
    • C07C29/90—Separation; Purification; Use of additives, e.g. for stabilisation by treatment giving rise to a chemical modification of at least one compound using hydrogen only
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/18—Polyhydroxylic acyclic alcohols
    • C07C31/20—Dihydroxylic alcohols
    • C07C31/207—1,4-Butanediol; 1,3-Butanediol; 1,2-Butanediol; 2,3-Butanediol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

"processo e sistemas para obtenção de 1,4-butanodiol a partir de caldos de fermentação". a presente invenção refere-se a um processo de purificação de 1,4-butanodiol (1,4-bdo) a partir de um caldo de fermentação, incluindo separação de materiais sólidos, sais e água, e submeter o material resultante a um sistema de destilação de duas, três ou quatro colunas, que pode incluir um evaporador de filme limpo para produzir um produto 1,4-butanodiol purificado.
BR112015021885-7A 2013-03-15 2014-03-14 Processo para purificação de 1,4-butanodiol (1,4-bdo) BR112015021885B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361801107P 2013-03-15 2013-03-15
US61/801,107 2013-03-15
US201361829625P 2013-05-31 2013-05-31
US61/829,625 2013-05-31
US201461928966P 2014-01-17 2014-01-17
US61/928,966 2014-01-17
PCT/US2014/027593 WO2014152665A1 (en) 2013-03-15 2014-03-14 Process and systems for obtaining 1,4-butanediol from fermentation broths

Publications (3)

Publication Number Publication Date
BR112015021885A2 BR112015021885A2 (pt) 2017-07-18
BR112015021885A8 true BR112015021885A8 (pt) 2019-09-03
BR112015021885B1 BR112015021885B1 (pt) 2021-08-17

Family

ID=51581277

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015021885-7A BR112015021885B1 (pt) 2013-03-15 2014-03-14 Processo para purificação de 1,4-butanodiol (1,4-bdo)

Country Status (8)

Country Link
US (2) US9873652B2 (pt)
EP (2) EP3964493B1 (pt)
CN (3) CN108358755B (pt)
AU (2) AU2014239256B2 (pt)
BR (1) BR112015021885B1 (pt)
CA (1) CA2900536A1 (pt)
MY (1) MY181137A (pt)
WO (1) WO2014152665A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104685058B (zh) 2012-06-04 2020-07-07 基因组股份公司 制造4-羟基丁酸酯、1，4-丁二醇和相关化合物的微生物和方法
EP3964493B1 (en) * 2013-03-15 2024-03-27 Genomatica, Inc. Process and systems for obtaining 1,4-butanediol from fermentation broths
WO2015167043A1 (ko) * 2014-04-30 2015-11-05 삼성전자 주식회사 증가된 알파-케토글루타레이트 데카르복실라제 활성을 갖는 미생물 및 이를 이용한 1,4-부탄디올 생산방법
EP3050970B1 (en) 2015-01-28 2019-09-18 Metabolic Explorer Modified microorganism for optimized production of 1,4-butanediol
CN108276465B (zh) * 2017-03-14 2020-01-07 桂林莱茵生物科技股份有限公司 一种以亚临界水解吸附技术分离纯化罗汉果甜苷ⅴ的方法
CA3053053C (en) 2017-03-20 2020-04-14 Lanzatech, Inc. A process and system for product recovery and cell recycle
CN110831680B (zh) * 2017-03-31 2023-04-07 基因组股份公司 用于从发酵液获得1，3-丁二醇的过程和系统
JP7219383B2 (ja) * 2017-11-27 2023-02-08 ノバモント・ソシエタ・ペル・アチオニ 再生可能資源由来の１，４－ブタンジオールの製造方法及びそれから得られるポリエステル
MX2021003364A (es) * 2018-09-21 2021-08-16 Versalis Spa Proceso para la purificacion de bio-1,3-butanodiol a partir de un caldo de fermentacion.
BR112021015449A2 (pt) 2019-02-08 2021-10-05 Lanzatech, Inc. Métodos para recuperar produto a partir de um caldo de fermentação e para recuperar produto a partir de uma corrente enriquecida com produto
EP3956006A4 (en) 2019-04-17 2023-08-16 Bard Access Systems, Inc. STRONG CATHETER FIXATION DEVICE INCLUDING EXTENDED ANCHOR PAD AND RELEASE LINER TIGHTENING ACCESSORIES
CN111593000B (zh) * 2020-05-18 2022-07-22 西北农林科技大学 一株降解塑料地膜的克雷伯氏菌及其应用
IT202000013243A1 (it) 2020-06-04 2021-12-04 Novamont Spa Processo per la purificazione di una miscela di dioli
RU2751695C1 (ru) * 2020-07-15 2021-07-15 Федеральное государственное бюджетное образовательное учреждение высшего образования "Уфимский государственный нефтяной технический университет" Устройство для ректификации
CN112439216A (zh) * 2020-12-14 2021-03-05 河南久圣化工有限公司 一种从己二酸废液中回收二元羧酸的三级蒸发系统
IT202100006419A1 (it) * 2021-03-17 2022-09-17 Novamont Spa Recupero di dioli da una miscela
IT202100030572A1 (it) 2021-12-02 2023-06-02 Novamont Spa 1,3-butandiolo purificato da una miscela di dioli

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3976430A (en) 1974-08-05 1976-08-24 Hooker Chemicals & Plastics Corporation Forced circulation cooling crystallizer
US4032458A (en) * 1975-08-08 1977-06-28 Petro-Tex Chemical Corporation Production of 1,4-butanediol
US4032583A (en) * 1975-08-08 1977-06-28 Petro-Tex Chemical Corporation Purification of 1,4-butanediol
US4383895A (en) * 1980-08-21 1983-05-17 E. I. Du Pont De Nemours And Company Purification of 1,4-butanediol
JPS62285779A (ja) 1986-06-04 1987-12-11 Chiyoda Chem Eng & Constr Co Ltd １，４−ブタンジオ−ル産生バチルス属細菌及びそれを用いる１，４−ブタンジオ−ルの製造方法
US5162214A (en) 1991-04-05 1992-11-10 General Atomics International Services Corporation Cma production utilizing acetate ion exchange from fermentation broth
DE4205471A1 (de) * 1992-02-22 1993-08-26 Basf Ag Verfahren zur abtrennung von 1,4-butandiol aus hydriergemischen
DE4220759A1 (de) 1992-06-24 1994-01-05 Inst Genbiologische Forschung DNA-Sequenzen für Oligosaccharid-Transporter, Plasmide, Bakterien und Pflanzen enthaltend einen Transporter sowie Verfahren zur Herstellung und Transformation von Hefestämmen zur Identifikation des Transporteers
US5766439A (en) 1996-10-10 1998-06-16 A. E. Staley Manufacturing Co. Production and recovery of organic acids
SG65043A1 (en) * 1997-01-23 1999-05-25 Mitsubishi Chem Corp Process for purifying crude 1,4-butanediol
US5981810A (en) * 1997-06-16 1999-11-09 Mitsubishi Chemical Corporation Process for preparing 1,4-butanediol
US5986133A (en) 1997-06-30 1999-11-16 The Texas A&M University System Recovery of fermentation salts from dilute aqueous solutions
US6228579B1 (en) 1997-11-14 2001-05-08 San Diego State University Foundation Method for identifying microbial proliferation genes
US6361983B1 (en) 1999-09-30 2002-03-26 E. I. Du Pont De Nemours And Company Process for the isolation of 1,3-propanediol from fermentation broth
DE10021703A1 (de) 2000-05-04 2001-11-08 Basf Ag Verfahren zur destillativen Trennung von Tetrahydrofuran, gamma-Butyrolacton und/oder 1,4-Butandiol enthaltenden Gemischen
US6515187B1 (en) 2001-10-03 2003-02-04 Atofina Chemicals, Inc. Process for recovering acrolein or propionaldehyde from dilute aqueous streams
CN1217001C (zh) 2002-01-04 2005-08-31 清华大学 一种生产d－(－)－3－羟基丁酸的方法
BR0307010A (pt) 2002-01-18 2006-04-11 Cargill Inc alanina 2,3-aminomutase
US7856317B2 (en) 2002-06-14 2010-12-21 Genomatica, Inc. Systems and methods for constructing genomic-based phenotypic models
EP1625224B1 (en) 2003-05-06 2010-07-28 E.I. Du Pont De Nemours And Company Purification of biologically-produced 1,3-propanediol
US7708865B2 (en) 2003-09-19 2010-05-04 Texas A&M University System Vapor-compression evaporation system and method
US7601858B2 (en) 2004-08-17 2009-10-13 Gs Cleantech Corporation Method of processing ethanol byproducts and related subsystems
US7947485B2 (en) 2005-06-03 2011-05-24 Hewlett-Packard Development Company, L.P. Method and apparatus for molecular analysis using nanoelectronic circuits
DE102005042541A1 (de) 2005-09-07 2007-03-08 Basf Ag Fermentative Herstellung nichtflüchtiger mikrobieller Stoffwechselprodukte in fester Form
AU2006287257A1 (en) 2005-09-09 2007-03-15 Genomatica, Inc. Methods and organisms for the growth-coupled production of succinate
JP2010518174A (ja) * 2007-02-15 2010-05-27 ビーエーエスエフ ソシエタス・ヨーロピア 極めて純粋な１，４−ブタンジオールの製造方法
AU2008229076B2 (en) 2007-03-16 2014-05-15 Genomatica, Inc. Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors
US20090023182A1 (en) 2007-07-18 2009-01-22 Schilling Christophe H Complementary metabolizing organisms and methods of making same
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
KR101042242B1 (ko) 2007-09-07 2011-06-17 한국과학기술원 1,4-부탄디올 생성능을 가지는 변이체 및 이를 이용한1,4-부탄디올의 제조방법
DE102007048277A1 (de) 2007-10-08 2009-04-09 Agraferm Technologies Ag Verfahren und Vorrichtung zur mikrobiellen Herstellung eines bestimmten Produktes und Methan
EP2245137B1 (en) 2008-01-22 2017-08-16 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
JP2011519561A (ja) 2008-05-01 2011-07-14 ジェノマティカ， インコーポレイテッド メタクリル酸の産生のための微生物
WO2010006076A2 (en) 2008-07-08 2010-01-14 Opx Biotechnologies Inc. Methods, compositions and systems for biosynthetic bio production of 1,4-butanediol
JP4712882B2 (ja) 2008-07-11 2011-06-29 株式会社神戸製鋼所 耐水素脆化特性および加工性に優れた高強度冷延鋼板
EP3514242A3 (en) 2008-09-10 2019-08-28 Genomatica, Inc. Microrganisms for the production of 1,4-butanediol
CA2738452C (en) * 2008-10-03 2016-06-21 Metabolic Explorer Method for purifying an alcohol from a fermentation broth using a falling film, a wiped film, a thin film or a short path evaporator
US20110014669A1 (en) 2009-01-23 2011-01-20 Microbia, Inc. Production of 1,4 Butanediol in a Microorganism
CN106119113A (zh) 2009-04-30 2016-11-16 基因组股份公司 用于生产 1,3‑丁二醇的生物
US20100305519A1 (en) 2009-06-02 2010-12-02 Becton, Dickinson And Company Cannula having an overlapping cannula feature and notch feature
VN29801A1 (pt) 2009-06-04 2012-05-25
CN102459138A (zh) * 2009-06-04 2012-05-16 基因组股份公司 分离发酵液成分的方法
US7893305B2 (en) * 2009-06-10 2011-02-22 Global Bio-Chem Technology Group Company Limited Separation of diols from a mixture comprising diols and polyols
KR20120068021A (ko) 2009-09-09 2012-06-26 게노마티카 인코포레이티드 아이소프로판올과 1차 알콜, 다이올 및 산과의 공동 생산을 위한 미생물 및 방법
CN102762735B (zh) 2009-10-13 2016-08-03 基因组股份公司 生产1,4-丁二醇、4-羟基丁醛、4-羟基丁酰-coa、腐胺和相关化合物的微生物及其相关方法
WO2011066076A1 (en) 2009-11-25 2011-06-03 Genomatica, Inc. Microorganisms and methods for the coproduction of 1,4-butanediol and gamma-butyrolactone
RU2012128843A (ru) 2009-12-10 2014-01-20 Дженоматика, Инк. Способы и организмы для превращения синтез-газа или других газообразных источников углерода и метанола в 1,3-бутандиол
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US8637286B2 (en) 2010-02-23 2014-01-28 Genomatica, Inc. Methods for increasing product yields
WO2011137192A1 (en) 2010-04-27 2011-11-03 The Regents Of The University Of California Production of 1,4-butanediol by recombinant microorganisms
CN102161615B (zh) * 2011-02-22 2013-06-19 重庆大学 一种回收1,4-丁二醇的工艺
EP2686290B1 (en) * 2011-03-14 2017-09-27 Archer-Daniels-Midland Company Improved methods for producing bioderived propylene glycol
US9024082B2 (en) * 2011-04-26 2015-05-05 Celanese International Corporation Using a dilute acid stream as an extractive agent
US9464030B2 (en) * 2011-05-18 2016-10-11 Bioamber Inc. Processes for producing butanediol (BDO), diaminobutane (DAB), succinic dinitrile (SDN) and succinamide (DAM)
WO2012177619A2 (en) 2011-06-22 2012-12-27 Genomatica, Inc. Microorganisms for producing 1,3-butanediol and methods related thereto
WO2013005747A1 (ja) 2011-07-04 2013-01-10 三菱化学株式会社 １，４－ブタンジオール含有組成物
KR101970369B1 (ko) 2011-07-04 2019-04-18 미쯔비시 케미컬 주식회사 테트라하이드로푸란의 제조 방법
CN103635469B (zh) 2011-07-04 2015-05-06 三菱化学株式会社 四氢呋喃的制造方法
WO2013005748A1 (ja) 2011-07-04 2013-01-10 三菱化学株式会社 １，４－ブタンジオールの製造方法
WO2013008686A1 (ja) 2011-07-08 2013-01-17 三菱化学株式会社 １，４－ブタンジオール含有組成物
WO2013012047A1 (ja) 2011-07-20 2013-01-24 三菱化学株式会社 炭素原子数４の不飽和化合物を原料とする水素化物の製造方法
JP5970998B2 (ja) 2011-07-20 2016-08-17 三菱化学株式会社 １，４−ブタンジオールの製造方法
JP5790246B2 (ja) 2011-07-26 2015-10-07 三菱化学株式会社 ポリエステルの製造方法
US8575405B2 (en) * 2011-08-03 2013-11-05 Celanese International Corporation Reducing acetals during ethanol separation process
BR112014005352A2 (pt) 2011-09-08 2017-03-28 Genomatica Inc organismos eucarióticos e métodos para aumentar a disponibilidade de acetil-coa citosólico e para produzir 1,3-butanodiol
GB201115617D0 (en) * 2011-09-09 2011-10-26 Davy Process Techn Ltd Proacess
EP2857377B1 (en) * 2012-06-05 2019-05-08 Mitsubishi Chemical Corporation Production method for 1, 4-butanediol
EP3964493B1 (en) * 2013-03-15 2024-03-27 Genomatica, Inc. Process and systems for obtaining 1,4-butanediol from fermentation broths
US20140275465A1 (en) * 2013-03-15 2014-09-18 Genomatica, Inc. Process and systems for obtaining 1,4-butanediol from fermentation broths

Also Published As

Publication number Publication date
AU2019200878A1 (en) 2019-02-28
EP2970068B1 (en) 2021-07-28
EP3964493C0 (en) 2024-03-27
MY181137A (en) 2020-12-18
CA2900536A1 (en) 2014-09-25
BR112015021885A2 (pt) 2017-07-18
CN105209414A (zh) 2015-12-30
EP2970068A4 (en) 2016-12-21
EP2970068A1 (en) 2016-01-20
AU2014239256A1 (en) 2015-08-20
AU2014239256B2 (en) 2018-11-08
EP3964493B1 (en) 2024-03-27
CN108358755B (zh) 2021-08-10
CN105209414B (zh) 2018-04-17
CN113248347A (zh) 2021-08-13
US9873652B2 (en) 2018-01-23
CN113248347B (zh) 2024-05-10
CN108358755A (zh) 2018-08-03
EP3964493A1 (en) 2022-03-09
US20160031778A1 (en) 2016-02-04
WO2014152665A1 (en) 2014-09-25
BR112015021885B1 (pt) 2021-08-17
US20180237367A1 (en) 2018-08-23

Similar Documents

Publication Publication Date Title
BR112015021885A8 (pt) 1,4-butanodiol bioderivado, seus processos e sistemas para purificação e produção de 1,4-butanodiol, plástico biobaseado, fibra elástica, poliuretano, poliéster, poli-4-hidróxi butirato ou seu copolímero, poli (tetra metileno éter) glicol ecopolímero de poliuretano – poliureia
BR112016016705A8 (pt) Processo para a purificação de oligossacarídeos neutros de leite humano (hmo), oligossacarídeo de leite humano (hmo) neutro, e uso de um hmo
UY37878A (es) Formación de ésteres de ácido tereftálico
BR112018008460A2 (pt) sais de valbenazina e seus polimorfos
BR112012012947A2 (pt) forma cristalina e amorfa de hemitartarato genz 112638 como inibidor de glicosilceramida sintase
BR112014012358A2 (pt) 2-oxo-1,3-dioxolano-4-carboxamidas, sua preparação e uso
BR112013020476A2 (pt) método para produzir um líquido de açúcar
BR112015028599A2 (pt) carbodiimidas com grupos ureia e/ou uretano terminais; método para a produção das carbodiimidas; composição; método para a produção das composições; e uso das carbodiimidas
BR112012019406A2 (pt) processo para purificacao de um produto de etanol bruto
BR112013011149A2 (pt) adutos poliacetal, métodos de fabricação e seus usos.
BR112013025630A2 (pt) derivados de piridopirazina e seu uso
BR112013027033A2 (pt) separação da água a partir do etanol em bruto
BRPI0819976A2 (pt) composto mimético de ácido para a inibição de isoprenil-s-cisteinil metiltransferase, composição compreedendo os mesmos, bem como uso dos ditos compostos.
BR112019003371A2 (pt) método para produzir glicóis de uma alimentação de anidroaçúcar.
TH164057A (th) กระบวนการและระบบสำหรับเตรียม 1,4-บิวเทนไดออลจากน้ำหมัก
BR112019008821A8 (pt) derivados de piridazina como moduladores de rorc
Huangfu et al. Establishment and optimization ofα2-macroglobulin activity detection assay
BR112016026814A8 (pt) 2,2,2-trifluoroetil-tiadiazinas, intermediário, seu uso e seu processo de preparação, e composição farmacêutica
DENG Purification and identification of chemical constituents of Pedicularis longiflora Rudolph. var. tubiformis (Klotz). Tsoong
XU et al. Effects of sevoflurane pretreatment on lung metastasis of mouse Lewis lung cancer cells
Shi et al. The role of peer education for rehabilitative patients with schizophrenia
Wang et al. Application of wearable systems in upper extremity rehabilitation: Research and practice
Zheng Clinical observation on ribavirin atonization inhalation in the treatment of young child pneumonia
Hui et al. Efifcacy of thalidomide combined with VAD in treatment of Elderly multiple myeloma and its adverse reactions
DI Effect of two traction ways compression on hemostasis with three-way two-capsule

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/03/2014, OBSERVADAS AS CONDICOES LEGAIS.