BR112015017492A2 - análogo de insulina, ácido nucleico, vetor de expressão, célula hospedeira, método para diminuir o açúcar do sangue de um paciente, método para a preparação de análogos de insulina deficientes em resíduos b1-b3 e polipeptídio - Google Patents

análogo de insulina, ácido nucleico, vetor de expressão, célula hospedeira, método para diminuir o açúcar do sangue de um paciente, método para a preparação de análogos de insulina deficientes em resíduos b1-b3 e polipeptídio

Info

Publication number
BR112015017492A2
BR112015017492A2 BR112015017492A BR112015017492A BR112015017492A2 BR 112015017492 A2 BR112015017492 A2 BR 112015017492A2 BR 112015017492 A BR112015017492 A BR 112015017492A BR 112015017492 A BR112015017492 A BR 112015017492A BR 112015017492 A2 BR112015017492 A2 BR 112015017492A2
Authority
BR
Brazil
Prior art keywords
polypeptide
lowering
residue
patient
preparing
Prior art date
Application number
BR112015017492A
Other languages
English (en)
Inventor
Weiss Michael
Original Assignee
Univ Case Western Reserve
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Case Western Reserve filed Critical Univ Case Western Reserve
Publication of BR112015017492A2 publication Critical patent/BR112015017492A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BR112015017492A 2013-01-22 2014-01-22 análogo de insulina, ácido nucleico, vetor de expressão, célula hospedeira, método para diminuir o açúcar do sangue de um paciente, método para a preparação de análogos de insulina deficientes em resíduos b1-b3 e polipeptídio BR112015017492A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361755020P 2013-01-22 2013-01-22
PCT/US2014/012615 WO2014116753A1 (en) 2013-01-22 2014-01-22 N-terminal truncated insulin analogues

Publications (1)

Publication Number Publication Date
BR112015017492A2 true BR112015017492A2 (pt) 2017-07-11

Family

ID=51228007

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015017492A BR112015017492A2 (pt) 2013-01-22 2014-01-22 análogo de insulina, ácido nucleico, vetor de expressão, célula hospedeira, método para diminuir o açúcar do sangue de um paciente, método para a preparação de análogos de insulina deficientes em resíduos b1-b3 e polipeptídio

Country Status (9)

Country Link
US (1) US9725493B2 (pt)
EP (1) EP2948166B1 (pt)
JP (1) JP2016506927A (pt)
KR (1) KR20150110677A (pt)
CN (1) CN105142660A (pt)
BR (1) BR112015017492A2 (pt)
CA (1) CA2937532A1 (pt)
MX (1) MX2015009399A (pt)
WO (1) WO2014116753A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106102763A (zh) 2014-01-13 2016-11-09 塞尔玛琳糖尿病有限责任公司 速效胰岛素制剂和药物递送系统
US10822386B2 (en) * 2014-12-24 2020-11-03 Case Western Reserve University Insulin analogues with enhanced stability and reduced mitogenicity
WO2017210242A1 (en) * 2016-06-02 2017-12-07 Indiana University Research And Technology Corporation Insulin-nuclear hormone conjugates
CN110198722A (zh) * 2016-11-21 2019-09-03 卡斯西部储备大学 稳定性增强的快速作用的胰岛素类似物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6531448B1 (en) * 1997-12-23 2003-03-11 Eli Lilly And Company Insoluble compositions for controlling blood glucose
SE521356C2 (sv) * 1999-04-27 2003-10-28 Getinge Sterilization Aktiebol Fördelningsmedel för luftflöde
AU5453300A (en) * 1999-06-29 2001-01-31 Eli Lilly And Company Insulin crystals for pulmonary administration
JP5780958B2 (ja) * 2008-07-31 2015-09-16 ケイス、ウエスタン、リザーブ、ユニバーシティ ハロゲン安定化インスリン
SG173112A1 (en) * 2009-01-28 2011-08-29 Smartcells Inc Conjugate based systems for controlled drug delivery
WO2013010048A2 (en) * 2011-07-13 2013-01-17 Case Western Reserve University Non-standard insulin analogues

Also Published As

Publication number Publication date
KR20150110677A (ko) 2015-10-02
JP2016506927A (ja) 2016-03-07
MX2015009399A (es) 2016-04-13
EP2948166A4 (en) 2016-10-12
WO2014116753A1 (en) 2014-07-31
EP2948166B1 (en) 2020-12-09
EP2948166A1 (en) 2015-12-02
CN105142660A (zh) 2015-12-09
CA2937532A1 (en) 2014-07-31
US20150353621A1 (en) 2015-12-10
US9725493B2 (en) 2017-08-08

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Legal Events

Date Code Title Description
B08F Application fees: dismissal - article 86 of industrial property law
B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)