BR112015016231A8 - método para identificar um sujeito em risco de ou tendo um distúrbio mediado por pkal, método para avaliar um tratamento de um distúrbio mediado por pkal em um sujeito, método para tratar uma doença mediada por pkal, composição farmacêutica para uso no tratamento de uma doença mediada por pkal de um sujeito e método para determinar um valor de cininogênio clivado, cininogênio intacto ou ambos, em uma amostra - Google Patents
método para identificar um sujeito em risco de ou tendo um distúrbio mediado por pkal, método para avaliar um tratamento de um distúrbio mediado por pkal em um sujeito, método para tratar uma doença mediada por pkal, composição farmacêutica para uso no tratamento de uma doença mediada por pkal de um sujeito e método para determinar um valor de cininogênio clivado, cininogênio intacto ou ambos, em uma amostra Download PDFInfo
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- BR112015016231A8 BR112015016231A8 BR112015016231A BR112015016231A BR112015016231A8 BR 112015016231 A8 BR112015016231 A8 BR 112015016231A8 BR 112015016231 A BR112015016231 A BR 112015016231A BR 112015016231 A BR112015016231 A BR 112015016231A BR 112015016231 A8 BR112015016231 A8 BR 112015016231A8
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- pkal
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- kininogen
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- 230000001404 mediated effect Effects 0.000 title abstract 12
- 238000000034 method Methods 0.000 title abstract 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 11
- 108010077861 Kininogens Proteins 0.000 title abstract 7
- 102000010631 Kininogens Human genes 0.000 title abstract 7
- 201000010099 disease Diseases 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 208000028185 Angioedema Diseases 0.000 abstract 1
- 101800004538 Bradykinin Proteins 0.000 abstract 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 abstract 1
- 102100035792 Kininogen-1 Human genes 0.000 abstract 1
- 102000003827 Plasma Kallikrein Human genes 0.000 abstract 1
- 108090000113 Plasma Kallikrein Proteins 0.000 abstract 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000011156 evaluation Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
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- G—PHYSICS
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
- G01N33/5735—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes co-enzymes or co-factors, e.g. NAD, ATP
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- A61K38/00—Medicinal preparations containing peptides
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Abstract
método para identificar um sujeito em risco de ou tendo um distúrbio mediado por pkal, método para determinar se um distúrbio é suscetível ao tratamento com um inibidor de pkal, método para avaliar um tratamento de um distúrbio mediado por pkal em um sujeito, método para tratar uma doença mediada por pkal, composição farmacêutica para uso no tratamento de uma doença mediada por pkal de um sujeito e método para determinar um valor de cininogênio clivado, cininogênio intacto ou ambos, em uma amostra a presente divulgação provê métodos para avaliar um sujeito, por exemplo, um sujeito em risco de ou sofrendo de um distúrbio mediado por pkal ou mediado por bradicinina, com base nos valores (por exemplo, porcentagens) de cininogênio intacto e/ou clivado em uma amostra do sujeito. métodos providos admitem análise de pacientes com angioedema mediada por calicreína plasmática (kma) ou outras doenças mediadas por pkal úteis na avaliação e tratamento. tais métodos podem envolver o uso de um agente de detecção que liga preferencialmente cininogênio clivado ou cininogênio intacto.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361754607P | 2013-01-20 | 2013-01-20 | |
| US61/754,607 | 2013-01-20 | ||
| PCT/US2014/012107 WO2014113712A1 (en) | 2013-01-20 | 2014-01-17 | Evaluation and treatment of bradykinin-mediated disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112015016231A2 BR112015016231A2 (pt) | 2017-07-11 |
| BR112015016231A8 true BR112015016231A8 (pt) | 2019-10-29 |
| BR112015016231B1 BR112015016231B1 (pt) | 2024-04-24 |
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