BR112015014869A2 - derivados de pirazolo-pirimidina terapeuticamente ativos - Google Patents

derivados de pirazolo-pirimidina terapeuticamente ativos

Info

Publication number
BR112015014869A2
BR112015014869A2 BR112015014869A BR112015014869A BR112015014869A2 BR 112015014869 A2 BR112015014869 A2 BR 112015014869A2 BR 112015014869 A BR112015014869 A BR 112015014869A BR 112015014869 A BR112015014869 A BR 112015014869A BR 112015014869 A2 BR112015014869 A2 BR 112015014869A2
Authority
BR
Brazil
Prior art keywords
pyrimidine derivatives
therapeutically active
pyrazolo pyrimidine
pyrazolo
active pyrazolo
Prior art date
Application number
BR112015014869A
Other languages
English (en)
Inventor
Ramrao Ghawalkar Anant
Vanderhoydonck Bart
James Ford Daniel
Tracey Horsley Helen
Thomas Reuberson James
Huang Qiuya
Jeremy Franklin Richard
Original Assignee
Katholieke Univ Leuven K U Leuven R&D
Ucb Biopharma Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49886937&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112015014869(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB1223021.5A external-priority patent/GB201223021D0/en
Priority claimed from GBGB1301935.1A external-priority patent/GB201301935D0/en
Application filed by Katholieke Univ Leuven K U Leuven R&D, Ucb Biopharma Sprl filed Critical Katholieke Univ Leuven K U Leuven R&D
Publication of BR112015014869A2 publication Critical patent/BR112015014869A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

1/1 resumo “derivados de pirazolo-pirimidina terapeuticamente ativos” a presente invenção refere-se a uma série de derivados de pirazolo[3,4d] pirimidina que são substituídos na posição 4 por uma porção diaza monocíclica, em ponte bicíclica ou espirocíclica, que é benéfica no tratamento e/ou prevenção de várias enfermidades humanas, incluindo distúrbios inflamatórios, autoimunes e oncológicos; doenças virais e malária; e rejeição de transplante de célula e órgão.
BR112015014869A 2012-12-20 2013-12-20 derivados de pirazolo-pirimidina terapeuticamente ativos BR112015014869A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1223021.5A GB201223021D0 (en) 2012-12-20 2012-12-20 Therapeutic agents
GBGB1301935.1A GB201301935D0 (en) 2013-02-04 2013-02-04 Therapeutic agents
PCT/EP2013/077846 WO2014096423A1 (en) 2012-12-20 2013-12-20 Therapeutically active pyrazolo-pyrimidine derivatives

Publications (1)

Publication Number Publication Date
BR112015014869A2 true BR112015014869A2 (pt) 2017-07-11

Family

ID=49886937

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015014869A BR112015014869A2 (pt) 2012-12-20 2013-12-20 derivados de pirazolo-pirimidina terapeuticamente ativos

Country Status (33)

Country Link
US (1) US9714248B2 (pt)
EP (1) EP2935269B1 (pt)
JP (1) JP6298830B2 (pt)
KR (1) KR102215490B1 (pt)
CN (1) CN105008360B (pt)
AP (1) AP2015008552A0 (pt)
AU (1) AU2013366480B2 (pt)
BR (1) BR112015014869A2 (pt)
CA (1) CA2893704C (pt)
CL (1) CL2015001752A1 (pt)
CR (1) CR20150379A (pt)
CY (1) CY1120415T1 (pt)
DK (1) DK2935269T3 (pt)
EA (1) EA027752B1 (pt)
ES (1) ES2676515T3 (pt)
HK (1) HK1215705A1 (pt)
HR (1) HRP20181008T1 (pt)
HU (1) HUE038310T2 (pt)
IL (1) IL239163B (pt)
LT (1) LT2935269T (pt)
MX (1) MX2015007774A (pt)
MY (1) MY189182A (pt)
NZ (1) NZ709360A (pt)
PE (1) PE20151767A1 (pt)
PH (1) PH12015501222B1 (pt)
PL (1) PL2935269T3 (pt)
PT (1) PT2935269T (pt)
SA (1) SA515360627B1 (pt)
SG (2) SG11201504291SA (pt)
SI (1) SI2935269T1 (pt)
TN (1) TN2015000285A1 (pt)
TR (1) TR201809140T4 (pt)
WO (1) WO2014096423A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201410815D0 (en) 2014-06-17 2014-07-30 Ucb Biopharma Sprl And Katholieke Universiteit Leuven Therapeutic agents
GB201517263D0 (en) 2015-09-30 2015-11-11 Ucb Biopharma Sprl And Katholieke Universiteit Leuven Therapeutic agents
GB201517264D0 (en) * 2015-09-30 2015-11-11 Ucb Biopharma Sprl And Katholieke Universiteit Leuven Therapeutic agents
GB201521767D0 (en) * 2015-12-10 2016-01-27 Ucb Biopharma Sprl And Katholieke Universiteit Leuven K U Leuven R&D Therapeutic agents
IL269390B (en) 2017-03-20 2022-08-01 Broad Inst Inc Preparations and methods for the treatment of parasitic diseases
CN109721531B (zh) * 2017-10-27 2022-07-29 中国科学院合肥物质科学研究院 一种新型的脂质体激酶抑制剂
EP3740489A1 (en) 2018-01-17 2020-11-25 GlaxoSmithKline Intellectual Property Development Limited Pi4kiiibeta inhibitors
BR112021002515A2 (pt) 2018-08-21 2021-07-27 Kyorin Pharmaceutical Co., Ltd. derivado de anel heteroaromático bicíclico
WO2021252505A1 (en) * 2020-06-08 2021-12-16 University Of Vermont And State Agricultural College Arylacetamide analogs of piperazine-[1,2,4]triazolo[4,3-b]pyridazines
CN116444485B (zh) * 2023-03-30 2024-01-23 广西中医药大学 吡啶基取代不对称脲的非金属催化、免柱层析合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1110649B (de) * 1957-11-22 1961-07-13 Ciba Geigy Verfahren zur Herstellung von 1-Isopropyl-pyrazolo[3, 4-d]pyrimidinen
ATE496035T1 (de) * 1998-03-31 2011-02-15 Kyowa Hakko Kirin Co Ltd Stickstoffenthaltende heterocyclische verbindungen
US6815444B2 (en) * 2002-05-24 2004-11-09 National Health Research Institutes Anti-enterovirus compounds
CA2535265C (en) * 2003-08-22 2014-01-28 Dendreon Corporation Compositions and methods for the treatment of disease associated with trp-p8 expression
EP1750727A2 (en) * 2004-04-23 2007-02-14 Exelixis, Inc. Kinase modulators and methods of use
US20080081817A1 (en) * 2004-07-23 2008-04-03 Tanabe Seiyaku Co., Ltd. Nitrogenous Fused Bicyclic Compound
WO2006071819A1 (en) * 2004-12-28 2006-07-06 Exelixis, Inc. [1h-pyrazolo[3, 4-d]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (p70s6k, atk1 and atk2) for the treatment of immunological, inflammatory and proliferative diseases
CN101981037B (zh) * 2008-01-30 2013-09-04 吉宁特有限公司 吡唑并嘧啶pi3k抑制剂化合物及使用方法
ES2543216T3 (es) * 2009-03-13 2015-08-17 Katholieke Universiteit Leuven, K.U. Leuven R&D Moduladores de tiazolopirimidina como agentes inmunosupresores
WO2010118367A2 (en) * 2009-04-10 2010-10-14 Progenics Pharmaceuticals, Inc. Antiviral pyrimidines

Also Published As

Publication number Publication date
KR102215490B1 (ko) 2021-02-15
LT2935269T (lt) 2018-07-10
SI2935269T1 (sl) 2018-09-28
NZ709360A (en) 2020-01-31
AP2015008552A0 (en) 2015-06-30
SG11201504291SA (en) 2015-07-30
EA027752B1 (ru) 2017-08-31
PH12015501222A1 (en) 2015-08-17
PE20151767A1 (es) 2015-12-11
EP2935269A1 (en) 2015-10-28
EP2935269B1 (en) 2018-04-11
CL2015001752A1 (es) 2016-06-03
CA2893704C (en) 2020-12-15
JP6298830B2 (ja) 2018-03-20
CY1120415T1 (el) 2019-07-10
SA515360627B1 (ar) 2018-05-31
SG10201703094UA (en) 2017-06-29
IL239163B (en) 2018-06-28
EA201500654A1 (ru) 2015-12-30
PL2935269T3 (pl) 2018-09-28
US20160194329A1 (en) 2016-07-07
AU2013366480B2 (en) 2017-06-22
CR20150379A (es) 2015-10-08
CA2893704A1 (en) 2014-06-26
IL239163A0 (en) 2015-07-30
MX2015007774A (es) 2015-09-04
TR201809140T4 (tr) 2018-07-23
PH12015501222B1 (en) 2015-08-17
AU2013366480A1 (en) 2015-07-09
CN105008360A (zh) 2015-10-28
PT2935269T (pt) 2018-07-16
TN2015000285A1 (en) 2016-10-03
DK2935269T3 (en) 2018-07-16
MY189182A (en) 2022-01-31
ES2676515T3 (es) 2018-07-20
HK1215705A1 (zh) 2016-09-09
HRP20181008T1 (hr) 2018-08-24
KR20150111348A (ko) 2015-10-05
US9714248B2 (en) 2017-07-25
JP2016503049A (ja) 2016-02-01
CN105008360B (zh) 2017-09-19
WO2014096423A1 (en) 2014-06-26
HUE038310T2 (hu) 2018-10-29

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements