BR112015004580A2 - processo para a preparação de um composto, composto, e, composição - Google Patents
processo para a preparação de um composto, composto, e, composiçãoInfo
- Publication number
- BR112015004580A2 BR112015004580A2 BR112015004580A BR112015004580A BR112015004580A2 BR 112015004580 A2 BR112015004580 A2 BR 112015004580A2 BR 112015004580 A BR112015004580 A BR 112015004580A BR 112015004580 A BR112015004580 A BR 112015004580A BR 112015004580 A2 BR112015004580 A2 BR 112015004580A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- preparation
- composition
- ioforminol
- bis
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- BFVVDRUCXCIALU-UHFFFAOYSA-N 5-[[3-[3,5-bis(2,3-dihydroxypropylcarbamoyl)-n-formyl-2,4,6-triiodoanilino]-2-hydroxypropyl]-formylamino]-1-n,3-n-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound OCC(O)CNC(=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(N(CC(O)CN(C=O)C=2C(=C(C(=O)NCC(O)CO)C(I)=C(C(=O)NCC(O)CO)C=2I)I)C=O)=C1I BFVVDRUCXCIALU-UHFFFAOYSA-N 0.000 abstract 2
- 229950004332 ioforminol Drugs 0.000 abstract 2
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20121103 | 2012-09-27 | ||
| PCT/US2013/060092 WO2014052092A1 (en) | 2012-09-27 | 2013-09-17 | Preparation of ioforminol, an x-ray contrast agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015004580A2 true BR112015004580A2 (pt) | 2017-07-04 |
Family
ID=49237721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015004580A BR112015004580A2 (pt) | 2012-09-27 | 2013-09-17 | processo para a preparação de um composto, composto, e, composição |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9827334B2 (enExample) |
| EP (1) | EP2900631B1 (enExample) |
| JP (1) | JP6325547B2 (enExample) |
| KR (1) | KR20150061634A (enExample) |
| AU (1) | AU2013323982B2 (enExample) |
| BR (1) | BR112015004580A2 (enExample) |
| CA (1) | CA2881853A1 (enExample) |
| ES (1) | ES2702275T3 (enExample) |
| IN (1) | IN2015DN01186A (enExample) |
| MX (1) | MX365249B (enExample) |
| RU (1) | RU2642436C2 (enExample) |
| WO (1) | WO2014052092A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX354604B (es) * | 2012-09-27 | 2018-03-07 | Ge Healthcare As | Preparacion de un compuesto intermediario de ioforminol. |
| JP6325547B2 (ja) | 2012-09-27 | 2018-05-16 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | Ｘ線造影剤イオホルミノールの調製 |
| KR102787110B1 (ko) * | 2015-12-23 | 2025-03-26 | 로드아일랜드하스피틀 | 열 촉진제 조성물 및 사용 방법 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5698739A (en) * | 1989-07-05 | 1997-12-16 | Schering Aktiengesellschaft | Carboxamide non-ionic contrast media |
| IL94718A (en) | 1989-07-05 | 1994-10-21 | Schering Ag | Non-ionic carboxamide contrast agent and method of preparation |
| NO20043305D0 (no) | 2004-08-09 | 2004-08-09 | Amersham Health As | Preparation of lodixanol |
| US20080267884A1 (en) | 2005-11-10 | 2008-10-30 | Oskar Axelsson | Contrast Agents and Diagnostic Compositions Based on Iodine-Containing Cyanuric Acid Derivatives |
| RU2469021C2 (ru) * | 2007-07-12 | 2012-12-10 | ДжиИ Хелткер АС | Контрастные агенты |
| KR101585751B1 (ko) | 2010-07-12 | 2016-01-14 | 지이 헬스케어 에이에스 | 저농도의 조영제 및/또는 저방사선량의 x-선 영상화 |
| CN102816085B (zh) | 2012-08-20 | 2013-08-14 | 浙江司太立制药股份有限公司 | 碘海醇杂质的制备方法 |
| JP6325547B2 (ja) | 2012-09-27 | 2018-05-16 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | Ｘ線造影剤イオホルミノールの調製 |
-
2013
- 2013-09-17 JP JP2015534550A patent/JP6325547B2/ja active Active
- 2013-09-17 KR KR1020157007423A patent/KR20150061634A/ko not_active Ceased
- 2013-09-17 CA CA2881853A patent/CA2881853A1/en not_active Abandoned
- 2013-09-17 WO PCT/US2013/060092 patent/WO2014052092A1/en not_active Ceased
- 2013-09-17 ES ES13766870T patent/ES2702275T3/es active Active
- 2013-09-17 RU RU2015107017A patent/RU2642436C2/ru not_active IP Right Cessation
- 2013-09-17 US US14/430,148 patent/US9827334B2/en not_active Expired - Fee Related
- 2013-09-17 BR BR112015004580A patent/BR112015004580A2/pt not_active IP Right Cessation
- 2013-09-17 EP EP13766870.3A patent/EP2900631B1/en not_active Not-in-force
- 2013-09-17 MX MX2015003913A patent/MX365249B/es active IP Right Grant
- 2013-09-17 AU AU2013323982A patent/AU2013323982B2/en not_active Ceased
-
2015
- 2015-02-13 IN IN1186DEN2015 patent/IN2015DN01186A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20150265727A1 (en) | 2015-09-24 |
| JP6325547B2 (ja) | 2018-05-16 |
| RU2642436C2 (ru) | 2018-01-25 |
| CA2881853A1 (en) | 2014-04-03 |
| CN104661995A (zh) | 2015-05-27 |
| IN2015DN01186A (enExample) | 2015-06-26 |
| KR20150061634A (ko) | 2015-06-04 |
| AU2013323982B2 (en) | 2017-11-23 |
| MX2015003913A (es) | 2015-08-05 |
| RU2015107017A (ru) | 2016-11-20 |
| MX365249B (es) | 2019-05-28 |
| EP2900631A1 (en) | 2015-08-05 |
| ES2702275T3 (es) | 2019-02-28 |
| EP2900631B1 (en) | 2018-11-14 |
| AU2013323982A1 (en) | 2015-03-05 |
| US9827334B2 (en) | 2017-11-28 |
| WO2014052092A1 (en) | 2014-04-03 |
| JP2015530415A (ja) | 2015-10-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2640 DE 10-08-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |