RU2642436C2 - Получение иоформинола - рентгеноконтрастного агента - Google Patents
Получение иоформинола - рентгеноконтрастного агента Download PDFInfo
- Publication number
- RU2642436C2 RU2642436C2 RU2015107017A RU2015107017A RU2642436C2 RU 2642436 C2 RU2642436 C2 RU 2642436C2 RU 2015107017 A RU2015107017 A RU 2015107017A RU 2015107017 A RU2015107017 A RU 2015107017A RU 2642436 C2 RU2642436 C2 RU 2642436C2
- Authority
- RU
- Russia
- Prior art keywords
- compound
- bis
- ioforminol
- obtaining
- agent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20121103 | 2012-09-27 | ||
| NO20121103 | 2012-09-27 | ||
| PCT/US2013/060092 WO2014052092A1 (en) | 2012-09-27 | 2013-09-17 | Preparation of ioforminol, an x-ray contrast agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015107017A RU2015107017A (ru) | 2016-11-20 |
| RU2642436C2 true RU2642436C2 (ru) | 2018-01-25 |
Family
ID=49237721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015107017A RU2642436C2 (ru) | 2012-09-27 | 2013-09-17 | Получение иоформинола - рентгеноконтрастного агента |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9827334B2 (enExample) |
| EP (1) | EP2900631B1 (enExample) |
| JP (1) | JP6325547B2 (enExample) |
| KR (1) | KR20150061634A (enExample) |
| AU (1) | AU2013323982B2 (enExample) |
| BR (1) | BR112015004580A2 (enExample) |
| CA (1) | CA2881853A1 (enExample) |
| ES (1) | ES2702275T3 (enExample) |
| IN (1) | IN2015DN01186A (enExample) |
| MX (1) | MX365249B (enExample) |
| RU (1) | RU2642436C2 (enExample) |
| WO (1) | WO2014052092A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150061635A (ko) * | 2012-09-27 | 2015-06-04 | 지이 헬스케어 에이에스 | 아이오포르미놀의 중간체 화합물의 제조법 |
| AU2013323982B2 (en) | 2012-09-27 | 2017-11-23 | Ge Healthcare As | Preparation of Ioforminol, an X-ray contrast agent |
| CN108430362A (zh) * | 2015-12-23 | 2018-08-21 | 罗得岛州医院 | 热促进剂组合物及其使用方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009008734A2 (en) * | 2007-07-12 | 2009-01-15 | Ge Healthcare As | Contrast agents |
| RU2385316C2 (ru) * | 2004-08-09 | 2010-03-27 | Джи-И Хелткер АС | Получение иодиксанола |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL94718A (en) | 1989-07-05 | 1994-10-21 | Schering Ag | Carboxamide non-ionic contrast media and method for the preparation thereof |
| US5698739A (en) * | 1989-07-05 | 1997-12-16 | Schering Aktiengesellschaft | Carboxamide non-ionic contrast media |
| WO2007055580A1 (en) * | 2005-11-10 | 2007-05-18 | Ge Healthcare As | Contrast agents and diagnostic compositions based on iodine-containing cyanuric acid derivatives |
| NZ605674A (en) | 2010-07-12 | 2014-11-28 | Ge Healthcare As | X-ray imaging at low contrast agent concentrations and/or low dose radiation |
| CN102816085B (zh) * | 2012-08-20 | 2013-08-14 | 浙江司太立制药股份有限公司 | 碘海醇杂质的制备方法 |
| AU2013323982B2 (en) | 2012-09-27 | 2017-11-23 | Ge Healthcare As | Preparation of Ioforminol, an X-ray contrast agent |
-
2013
- 2013-09-17 AU AU2013323982A patent/AU2013323982B2/en not_active Ceased
- 2013-09-17 ES ES13766870T patent/ES2702275T3/es active Active
- 2013-09-17 WO PCT/US2013/060092 patent/WO2014052092A1/en not_active Ceased
- 2013-09-17 US US14/430,148 patent/US9827334B2/en not_active Expired - Fee Related
- 2013-09-17 BR BR112015004580A patent/BR112015004580A2/pt not_active IP Right Cessation
- 2013-09-17 RU RU2015107017A patent/RU2642436C2/ru not_active IP Right Cessation
- 2013-09-17 CA CA2881853A patent/CA2881853A1/en not_active Abandoned
- 2013-09-17 MX MX2015003913A patent/MX365249B/es active IP Right Grant
- 2013-09-17 KR KR1020157007423A patent/KR20150061634A/ko not_active Ceased
- 2013-09-17 EP EP13766870.3A patent/EP2900631B1/en not_active Not-in-force
- 2013-09-17 JP JP2015534550A patent/JP6325547B2/ja active Active
-
2015
- 2015-02-13 IN IN1186DEN2015 patent/IN2015DN01186A/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2385316C2 (ru) * | 2004-08-09 | 2010-03-27 | Джи-И Хелткер АС | Получение иодиксанола |
| WO2009008734A2 (en) * | 2007-07-12 | 2009-01-15 | Ge Healthcare As | Contrast agents |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2900631B1 (en) | 2018-11-14 |
| JP6325547B2 (ja) | 2018-05-16 |
| WO2014052092A1 (en) | 2014-04-03 |
| US9827334B2 (en) | 2017-11-28 |
| AU2013323982B2 (en) | 2017-11-23 |
| CA2881853A1 (en) | 2014-04-03 |
| JP2015530415A (ja) | 2015-10-15 |
| ES2702275T3 (es) | 2019-02-28 |
| CN104661995A (zh) | 2015-05-27 |
| US20150265727A1 (en) | 2015-09-24 |
| MX365249B (es) | 2019-05-28 |
| MX2015003913A (es) | 2015-08-05 |
| BR112015004580A2 (pt) | 2017-07-04 |
| KR20150061634A (ko) | 2015-06-04 |
| EP2900631A1 (en) | 2015-08-05 |
| RU2015107017A (ru) | 2016-11-20 |
| IN2015DN01186A (enExample) | 2015-06-26 |
| AU2013323982A1 (en) | 2015-03-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20200918 |