CA2881853A1 - Preparation of ioforminol, an x-ray contrast agent - Google Patents

Preparation of ioforminol, an x-ray contrast agent Download PDF

Info

Publication number
CA2881853A1
CA2881853A1 CA2881853A CA2881853A CA2881853A1 CA 2881853 A1 CA2881853 A1 CA 2881853A1 CA 2881853 A CA2881853 A CA 2881853A CA 2881853 A CA2881853 A CA 2881853A CA 2881853 A1 CA2881853 A1 CA 2881853A1
Authority
CA
Canada
Prior art keywords
compound
bis
preparation
water
loforminol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2881853A
Other languages
English (en)
French (fr)
Inventor
Mikkel Jacob Thaning
Andreas Olsson
Christian Glogard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
GE Healthcare AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare AS filed Critical GE Healthcare AS
Publication of CA2881853A1 publication Critical patent/CA2881853A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2881853A 2012-09-27 2013-09-17 Preparation of ioforminol, an x-ray contrast agent Abandoned CA2881853A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20121103 2012-09-27
NO20121103 2012-09-27
PCT/US2013/060092 WO2014052092A1 (en) 2012-09-27 2013-09-17 Preparation of ioforminol, an x-ray contrast agent

Publications (1)

Publication Number Publication Date
CA2881853A1 true CA2881853A1 (en) 2014-04-03

Family

ID=49237721

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2881853A Abandoned CA2881853A1 (en) 2012-09-27 2013-09-17 Preparation of ioforminol, an x-ray contrast agent

Country Status (12)

Country Link
US (1) US9827334B2 (enExample)
EP (1) EP2900631B1 (enExample)
JP (1) JP6325547B2 (enExample)
KR (1) KR20150061634A (enExample)
AU (1) AU2013323982B2 (enExample)
BR (1) BR112015004580A2 (enExample)
CA (1) CA2881853A1 (enExample)
ES (1) ES2702275T3 (enExample)
IN (1) IN2015DN01186A (enExample)
MX (1) MX365249B (enExample)
RU (1) RU2642436C2 (enExample)
WO (1) WO2014052092A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6325547B2 (ja) 2012-09-27 2018-05-16 ジーイー・ヘルスケア・アクスイェ・セルスカプ Ｘ線造影剤イオホルミノールの調製
EP2900632B1 (en) * 2012-09-27 2019-10-30 Ge Healthcare As Preparation of an intermediate compound of ioforminol
CA3009649A1 (en) * 2015-12-23 2017-06-29 Brown University Thermal accelerant compositions and methods of use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698739A (en) 1989-07-05 1997-12-16 Schering Aktiengesellschaft Carboxamide non-ionic contrast media
IL94718A (en) 1989-07-05 1994-10-21 Schering Ag Non-ionic carboxamide contrast agent and method of preparation
NO20043305D0 (no) 2004-08-09 2004-08-09 Amersham Health As Preparation of lodixanol
US20080267884A1 (en) 2005-11-10 2008-10-30 Oskar Axelsson Contrast Agents and Diagnostic Compositions Based on Iodine-Containing Cyanuric Acid Derivatives
KR20100033405A (ko) 2007-07-12 2010-03-29 지이 헬스케어 에이에스 조영제
MX2013000476A (es) * 2010-07-12 2013-02-11 Ge Healthcare As Generacion de imagenes de rayos x en bajas concentraciones de agente y/o dosis de radiacion.
CN102816085B (zh) * 2012-08-20 2013-08-14 浙江司太立制药股份有限公司 碘海醇杂质的制备方法
JP6325547B2 (ja) 2012-09-27 2018-05-16 ジーイー・ヘルスケア・アクスイェ・セルスカプ Ｘ線造影剤イオホルミノールの調製

Also Published As

Publication number Publication date
AU2013323982B2 (en) 2017-11-23
EP2900631A1 (en) 2015-08-05
MX2015003913A (es) 2015-08-05
JP6325547B2 (ja) 2018-05-16
EP2900631B1 (en) 2018-11-14
RU2015107017A (ru) 2016-11-20
CN104661995A (zh) 2015-05-27
US9827334B2 (en) 2017-11-28
US20150265727A1 (en) 2015-09-24
IN2015DN01186A (enExample) 2015-06-26
JP2015530415A (ja) 2015-10-15
AU2013323982A1 (en) 2015-03-05
BR112015004580A2 (pt) 2017-07-04
RU2642436C2 (ru) 2018-01-25
ES2702275T3 (es) 2019-02-28
WO2014052092A1 (en) 2014-04-03
KR20150061634A (ko) 2015-06-04
MX365249B (es) 2019-05-28

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20210303