BR112015003516A2 - compostos e métodos para inibição de antiporte mediado por nhe no tratamento de transtornos associados à retenção de fluido ou sobrecarga de sal e transtornos do trato gastrintestinal - Google Patents
compostos e métodos para inibição de antiporte mediado por nhe no tratamento de transtornos associados à retenção de fluido ou sobrecarga de sal e transtornos do trato gastrintestinalInfo
- Publication number
- BR112015003516A2 BR112015003516A2 BR112015003516A BR112015003516A BR112015003516A2 BR 112015003516 A2 BR112015003516 A2 BR 112015003516A2 BR 112015003516 A BR112015003516 A BR 112015003516A BR 112015003516 A BR112015003516 A BR 112015003516A BR 112015003516 A2 BR112015003516 A2 BR 112015003516A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- disorders
- compounds
- gastrointestinal tract
- fluid retention
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 5
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 210000001035 gastrointestinal tract Anatomy 0.000 title abstract 4
- 150000003839 salts Chemical class 0.000 title abstract 3
- 206010016807 Fluid retention Diseases 0.000 title abstract 2
- 230000002337 anti-port Effects 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title abstract 2
- 230000001404 mediated effect Effects 0.000 title abstract 2
- 208000035475 disorder Diseases 0.000 abstract 5
- 206010019280 Heart failures Diseases 0.000 abstract 2
- 208000020832 chronic kidney disease Diseases 0.000 abstract 2
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 206010057573 Chronic hepatic failure Diseases 0.000 abstract 1
- 208000010334 End Stage Liver Disease Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 229940126033 PPAR agonist Drugs 0.000 abstract 1
- 101150014691 PPARA gene Proteins 0.000 abstract 1
- 208000011444 chronic liver failure Diseases 0.000 abstract 1
- 208000028208 end stage renal disease Diseases 0.000 abstract 1
- 201000000523 end stage renal failure Diseases 0.000 abstract 1
- 239000002307 peroxisome proliferator activated receptor agonist Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Inorganic Chemistry (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
resumo patente de invenção: "compostos e métodos para inibição de antiporte mediado por nhe no tratamento de transtornos associados à retenção de fluido ou sobrecarga de sal e transtornos do trato gastrintestinal". a presente descrição é dirigida a compostos e métodos para o tratamento de transtornos associados à retenção de fluidos ou sobrecarga de sal, tais como insuficiência cardíaca (em particular, insuficiência cardíaca congestiva), doença renal crônica, doença renal em estágio terminal, doença hepática e retenção de fluidos induzida por agente agonista de receptor ativado por proliferador de peroxissomo (ppar) gama. a presente descrição é também dirigida a compostos e métodos para o tratamento de hipertensão. a presente descrição é também dirigida a compostos e métodos para o tratamento de transtornos do trato gastrintestinal, incluindo tratamento ou redução de dor associada a transtornos do trato gastrintestinal.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261691637P | 2012-08-21 | 2012-08-21 | |
PCT/GB2013/052193 WO2014029984A1 (en) | 2012-08-21 | 2013-08-20 | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015003516A2 true BR112015003516A2 (pt) | 2017-07-04 |
Family
ID=49036603
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015003516A BR112015003516A2 (pt) | 2012-08-21 | 2013-08-20 | compostos e métodos para inibição de antiporte mediado por nhe no tratamento de transtornos associados à retenção de fluido ou sobrecarga de sal e transtornos do trato gastrintestinal |
Country Status (13)
Country | Link |
---|---|
US (2) | US20150299131A1 (pt) |
EP (1) | EP2887963B1 (pt) |
JP (2) | JP6726964B2 (pt) |
KR (1) | KR102138391B1 (pt) |
CN (1) | CN104837503B (pt) |
AU (2) | AU2013304813B2 (pt) |
BR (1) | BR112015003516A2 (pt) |
CA (1) | CA2880432C (pt) |
ES (1) | ES2644309T3 (pt) |
HK (1) | HK1211838A1 (pt) |
MX (1) | MX363056B (pt) |
RU (1) | RU2684097C2 (pt) |
WO (1) | WO2014029984A1 (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5827328B2 (ja) | 2010-07-07 | 2015-12-02 | アーデリクス,インコーポレーテッド | リン酸輸送を阻害する化合物及び方法 |
WO2012006473A1 (en) | 2010-07-07 | 2012-01-12 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
EP2590656B1 (en) | 2010-07-07 | 2017-11-15 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
EP2590965B1 (en) | 2010-07-07 | 2016-04-20 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
AU2013304813B2 (en) | 2012-08-21 | 2016-08-04 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
JP6377132B2 (ja) * | 2013-04-12 | 2018-08-22 | アーデリクス,インコーポレーテッド | Nhe3結合化合物およびリン酸輸送の阻害方法 |
CN106536502B (zh) * | 2014-07-25 | 2019-03-05 | 大正制药株式会社 | 被杂芳基取代的苯基四氢异喹啉化合物 |
US10531837B1 (en) * | 2015-09-25 | 2020-01-14 | Cerner Innovation, Inc. | Predicting chronic kidney disease progression |
WO2017172816A1 (en) * | 2016-03-29 | 2017-10-05 | Colonaryconcepts Llc | Formulations for treating constipation |
KR102353040B1 (ko) * | 2016-04-25 | 2022-01-18 | 젤레시스 엘엘씨 | 변비 치료 방법 |
BR112019013963A2 (pt) * | 2017-01-09 | 2020-04-28 | Ardelyx Inc | inibidores de antiporte mediado por nhe |
UA126283C2 (uk) | 2017-01-09 | 2022-09-14 | Арделікс, Інк. | Сполуки, придатні для лікування розладів шлунково-кишкового тракту |
EP3661945B1 (en) | 2017-08-04 | 2024-04-03 | Ardelyx, Inc. | Glycyrrhetinic acid derivatives for treating hyperkalemia |
GB2565823A (en) * | 2017-08-24 | 2019-02-27 | Xiros Ltd | Psyllium based moisture absorbent material |
CN107782829A (zh) * | 2017-11-01 | 2018-03-09 | 上海莱士血液制品股份有限公司 | 一种利用离子色谱法检测生物制品中三羟甲基氨基甲烷(Tris)的方法 |
CN109813897A (zh) * | 2017-11-18 | 2019-05-28 | 镇江亿特生物科技发展有限公司 | 盐酸可乐定快速时间分辨荧光免疫层析定量检测试纸条 |
JP7164114B2 (ja) * | 2018-01-19 | 2022-11-01 | 学校法人 名古屋電気学園 | バナジウム錯体及びそれを用いた窒素固定方法 |
CA3129233A1 (en) | 2019-02-07 | 2020-08-13 | Ardelyx, Inc. | Glycyrrhetinic acid derivatives for use in treating hyperkalemia |
CN115427031A (zh) * | 2020-04-24 | 2022-12-02 | 香港大学 | 光响应纳米载体的受控药物释放系统、其制备和使用方法 |
AU2021401102B2 (en) * | 2020-12-18 | 2024-03-07 | Jiangxi Jemincare Group Co., Ltd | Benzoheterocycle substituted tetrahydroisoquinoline compound |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19941764A1 (de) * | 1999-09-02 | 2001-03-15 | Aventis Pharma Gmbh | Substituierte Acylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika sowie sie enthaltende Medikamente |
CO5271699A1 (es) * | 2000-01-24 | 2003-04-30 | Pfizer Prod Inc | Procedimiento para el tratamiento de cardiomiopatia utilizando inhibidores de la glucogeno fosforilasa |
AU2002356689B2 (en) * | 2001-12-05 | 2008-05-15 | Sanofi-Aventis Deutschland Gmbh | Substituted 4-phenyltetrahydroisoquinolines, method for the production thereof, the use thereof as medicaments, in addition to a medicament containing same |
BRPI0923861B8 (pt) * | 2008-12-31 | 2021-05-25 | Ardelyx Inc | compostos e composições farmacêuticas para inibir o antiporte nhe-mediado no tratamento de distúrbios associados com a retenção de fluido ou com a sobrecarga de sal e distúrbios do trato gastrointestinal |
AU2013304813B2 (en) | 2012-08-21 | 2016-08-04 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
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2013
- 2013-08-20 AU AU2013304813A patent/AU2013304813B2/en active Active
- 2013-08-20 ES ES13753340.2T patent/ES2644309T3/es active Active
- 2013-08-20 CA CA2880432A patent/CA2880432C/en active Active
- 2013-08-20 US US14/421,454 patent/US20150299131A1/en not_active Abandoned
- 2013-08-20 WO PCT/GB2013/052193 patent/WO2014029984A1/en active Application Filing
- 2013-08-20 JP JP2015527966A patent/JP6726964B2/ja active Active
- 2013-08-20 CN CN201380054632.XA patent/CN104837503B/zh active Active
- 2013-08-20 RU RU2015107018A patent/RU2684097C2/ru active
- 2013-08-20 MX MX2015002284A patent/MX363056B/es unknown
- 2013-08-20 KR KR1020157006560A patent/KR102138391B1/ko active IP Right Grant
- 2013-08-20 EP EP13753340.2A patent/EP2887963B1/en active Active
- 2013-08-20 BR BR112015003516A patent/BR112015003516A2/pt not_active Application Discontinuation
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2015
- 2015-12-24 HK HK15112686.7A patent/HK1211838A1/xx unknown
-
2016
- 2016-08-24 AU AU2016219612A patent/AU2016219612A1/en not_active Abandoned
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2018
- 2018-06-13 US US16/007,622 patent/US10385024B2/en active Active
-
2019
- 2019-08-22 JP JP2019151700A patent/JP2019218376A/ja active Pending
Also Published As
Publication number | Publication date |
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CN104837503A (zh) | 2015-08-12 |
ES2644309T3 (es) | 2017-11-28 |
US20150299131A1 (en) | 2015-10-22 |
CA2880432C (en) | 2023-03-14 |
EP2887963A1 (en) | 2015-07-01 |
US20190062279A1 (en) | 2019-02-28 |
JP2019218376A (ja) | 2019-12-26 |
JP6726964B2 (ja) | 2020-07-22 |
US10385024B2 (en) | 2019-08-20 |
HK1211838A1 (en) | 2016-06-03 |
AU2013304813B2 (en) | 2016-08-04 |
JP2015526459A (ja) | 2015-09-10 |
RU2684097C2 (ru) | 2019-04-04 |
RU2015107018A (ru) | 2016-10-20 |
KR20150073162A (ko) | 2015-06-30 |
AU2016219612A1 (en) | 2016-09-15 |
AU2013304813A1 (en) | 2015-02-05 |
CA2880432A1 (en) | 2014-02-27 |
CN104837503B (zh) | 2018-11-09 |
WO2014029984A1 (en) | 2014-02-27 |
MX363056B (es) | 2019-03-06 |
EP2887963B1 (en) | 2017-07-19 |
KR102138391B1 (ko) | 2020-07-27 |
MX2015002284A (es) | 2016-02-09 |
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