BR112015001020B1 - Vacinas de influenza suína atenuada e métodos de produção e utilização das mesmas - Google Patents

Vacinas de influenza suína atenuada e métodos de produção e utilização das mesmas Download PDF

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Publication number
BR112015001020B1
BR112015001020B1 BR112015001020-2A BR112015001020A BR112015001020B1 BR 112015001020 B1 BR112015001020 B1 BR 112015001020B1 BR 112015001020 A BR112015001020 A BR 112015001020A BR 112015001020 B1 BR112015001020 B1 BR 112015001020B1
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BR
Brazil
Prior art keywords
swine
attenuated
strain
virulent
influenza
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BR112015001020-2A
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English (en)
Portuguese (pt)
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BR112015001020A2 (https=
Inventor
Benjamin M. Hause
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Merial, Inc.
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Publication date
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Publication of BR112015001020A2 publication Critical patent/BR112015001020A2/pt
Publication of BR112015001020B1 publication Critical patent/BR112015001020B1/pt

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/145Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/0241Mollicutes, e.g. Mycoplasma, Erysipelothrix
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/21Retroviridae, e.g. equine infectious anemia virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04Inactivation or attenuation; Producing viral sub-units
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5252Virus inactivated (killed)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552Veterinary vaccine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16121Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16161Methods of inactivation or attenuation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
BR112015001020-2A 2012-07-17 2013-07-11 Vacinas de influenza suína atenuada e métodos de produção e utilização das mesmas BR112015001020B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261672398P 2012-07-17 2012-07-17
US61/672,398 2012-07-17
PCT/US2013/050000 WO2014014726A1 (en) 2012-07-17 2013-07-11 Attenuated swine influenza vaccines and methods of making and use thereof

Publications (2)

Publication Number Publication Date
BR112015001020A2 BR112015001020A2 (https=) 2017-08-15
BR112015001020B1 true BR112015001020B1 (pt) 2022-04-19

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BR112015001020-2A BR112015001020B1 (pt) 2012-07-17 2013-07-11 Vacinas de influenza suína atenuada e métodos de produção e utilização das mesmas

Country Status (19)

Country Link
US (2) US9216211B2 (https=)
EP (1) EP2874656B1 (https=)
JP (1) JP6467672B2 (https=)
KR (1) KR102027758B1 (https=)
CN (1) CN104582725B (https=)
AU (2) AU2013290597B2 (https=)
BR (1) BR112015001020B1 (https=)
CA (1) CA2879228C (https=)
DK (1) DK2874656T3 (https=)
EA (1) EA033027B1 (https=)
ES (1) ES2662022T3 (https=)
HU (1) HUE036110T2 (https=)
MX (1) MX365880B (https=)
MY (1) MY166879A (https=)
NZ (2) NZ712713A (https=)
PH (1) PH12015500095A1 (https=)
PL (1) PL2874656T3 (https=)
PT (1) PT2874656T (https=)
WO (1) WO2014014726A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2874656T3 (pl) * 2012-07-17 2018-04-30 Merial, Inc. Atenuowane szczepionki przeciw grypie świń oraz ich sposoby wytwarzania i zastosowanie
JP6839714B2 (ja) * 2015-12-28 2021-03-10 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド M Hyo多重ワクチン及びその使用
EA201991319A1 (ru) * 2016-11-30 2019-11-29 Вакцины аттенуированного свиного гриппа и способы их изготовления и применения
CN106939355A (zh) * 2017-03-01 2017-07-11 苏州系统医学研究所 一种流感病毒弱毒活疫苗毒株的筛选和鉴定方法
CN107064499B (zh) * 2017-03-15 2019-06-18 青岛蔚蓝生物制品有限公司 禽流感病毒np蛋白抗原表位多肽及其胶体金试纸盒
JP2021508696A (ja) 2017-12-22 2021-03-11 コーダ−ジェニックス・インコーポレイテッドCoda−Genix, Inc. がん処置のためのコドン対脱最適化領域を有する組換え型ウイルス及びその使用法
CN112040977A (zh) 2018-03-08 2020-12-04 科达金尼克斯有限公司 减毒黄病毒

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708871A (en) 1983-03-08 1987-11-24 Commonwealth Serum Laboratories Commission Antigenically active amino acid sequences
US5585250A (en) 1993-08-20 1996-12-17 The United States Of America As Represented By The Department Of Health & Human Services Dampening of an immunodominant epitope of an antigen for use in plant, animal and human compositions and immunotherapies
ES2241042T3 (es) 1996-10-11 2005-10-16 The Regents Of The University Of California Conjugados de polinucleotido inmunoestimulador/ molecula inmunomoduladora.
US5980912A (en) 1997-03-25 1999-11-09 Zonagen, Inc. Chitosan induced immunopotentiation
KR20060026854A (ko) 2003-05-28 2006-03-24 위스콘신 얼럼나이 리서어치 화운데이션 PolⅡ 프로모터 및 리보자임을 갖는 재조합 인플루엔자벡터
US7871626B2 (en) * 2005-08-04 2011-01-18 St. Jude Children's Research Hospital Modified influenza virus for monitoring and improving vaccine efficiency
CA2690196A1 (en) * 2007-06-18 2008-12-24 Medimmune, Llc Influenza b viruses having alterations in the hemaglutinin polypeptide
CA2716340A1 (en) 2008-02-21 2009-08-27 Biological Mimetics, Inc. Immunogenic influenza composition
CN102985107A (zh) 2010-01-24 2013-03-20 生物模仿公司 免疫性流感成分
PL2874656T3 (pl) * 2012-07-17 2018-04-30 Merial, Inc. Atenuowane szczepionki przeciw grypie świń oraz ich sposoby wytwarzania i zastosowanie

Also Published As

Publication number Publication date
CA2879228A1 (en) 2014-01-23
HK1209325A1 (en) 2016-04-01
PT2874656T (pt) 2018-03-09
EA201500140A1 (ru) 2016-02-29
KR20150036685A (ko) 2015-04-07
HUE036110T2 (hu) 2018-06-28
ES2662022T3 (es) 2018-04-05
US9216211B2 (en) 2015-12-22
US9623105B2 (en) 2017-04-18
CA2879228C (en) 2021-07-13
BR112015001020A2 (https=) 2017-08-15
WO2014014726A1 (en) 2014-01-23
MX365880B (es) 2019-06-18
AU2016202693A1 (en) 2016-05-19
AU2016202693B2 (en) 2017-11-16
NZ712713A (en) 2017-05-26
US20160120973A1 (en) 2016-05-05
DK2874656T3 (en) 2018-01-15
EA033027B1 (ru) 2019-08-30
AU2013290597B2 (en) 2016-02-04
PH12015500095B1 (en) 2015-03-02
JP2015524266A (ja) 2015-08-24
EP2874656A1 (en) 2015-05-27
KR102027758B1 (ko) 2019-10-02
NZ704188A (en) 2016-04-29
PL2874656T3 (pl) 2018-04-30
CN104582725B (zh) 2017-06-23
CN104582725A (zh) 2015-04-29
JP6467672B2 (ja) 2019-02-13
PH12015500095A1 (en) 2015-03-02
US20140023681A1 (en) 2014-01-23
MY166879A (en) 2018-07-24
AU2013290597A1 (en) 2015-02-19
EP2874656B1 (en) 2017-12-06
MX2015000713A (es) 2015-10-12

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B25A Requested transfer of rights approved

Owner name: MERIAL, INC (US)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI.

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 11/07/2013, OBSERVADAS AS CONDICOES LEGAIS.

B25A Requested transfer of rights approved

Owner name: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC. (US)