CN104582725B - 减毒的猪流感疫苗及其制备和使用方法 - Google Patents

减毒的猪流感疫苗及其制备和使用方法 Download PDF

Info

Publication number
CN104582725B
CN104582725B CN201380043383.4A CN201380043383A CN104582725B CN 104582725 B CN104582725 B CN 104582725B CN 201380043383 A CN201380043383 A CN 201380043383A CN 104582725 B CN104582725 B CN 104582725B
Authority
CN
China
Prior art keywords
strain
influenza
virus
attenuated
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201380043383.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN104582725A (zh
Inventor
B·M·豪斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Animal Health USA Inc
Original Assignee
Merial Ltd
Merial Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Ltd, Merial Inc filed Critical Merial Ltd
Publication of CN104582725A publication Critical patent/CN104582725A/zh
Application granted granted Critical
Publication of CN104582725B publication Critical patent/CN104582725B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0241—Mollicutes, e.g. Mycoplasma, Erysipelothrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16161—Methods of inactivation or attenuation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
CN201380043383.4A 2012-07-17 2013-07-11 减毒的猪流感疫苗及其制备和使用方法 Active CN104582725B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261672398P 2012-07-17 2012-07-17
US61/672,398 2012-07-17
PCT/US2013/050000 WO2014014726A1 (en) 2012-07-17 2013-07-11 Attenuated swine influenza vaccines and methods of making and use thereof

Publications (2)

Publication Number Publication Date
CN104582725A CN104582725A (zh) 2015-04-29
CN104582725B true CN104582725B (zh) 2017-06-23

Family

ID=48874529

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380043383.4A Active CN104582725B (zh) 2012-07-17 2013-07-11 减毒的猪流感疫苗及其制备和使用方法

Country Status (19)

Country Link
US (2) US9216211B2 (https=)
EP (1) EP2874656B1 (https=)
JP (1) JP6467672B2 (https=)
KR (1) KR102027758B1 (https=)
CN (1) CN104582725B (https=)
AU (2) AU2013290597B2 (https=)
BR (1) BR112015001020B1 (https=)
CA (1) CA2879228C (https=)
DK (1) DK2874656T3 (https=)
EA (1) EA033027B1 (https=)
ES (1) ES2662022T3 (https=)
HU (1) HUE036110T2 (https=)
MX (1) MX365880B (https=)
MY (1) MY166879A (https=)
NZ (2) NZ712713A (https=)
PH (1) PH12015500095A1 (https=)
PL (1) PL2874656T3 (https=)
PT (1) PT2874656T (https=)
WO (1) WO2014014726A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2874656T3 (pl) * 2012-07-17 2018-04-30 Merial, Inc. Atenuowane szczepionki przeciw grypie świń oraz ich sposoby wytwarzania i zastosowanie
JP6839714B2 (ja) * 2015-12-28 2021-03-10 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド Ｍ Ｈｙｏ多重ワクチン及びその使用
EA201991319A1 (ru) * 2016-11-30 2019-11-29 Вакцины аттенуированного свиного гриппа и способы их изготовления и применения
CN106939355A (zh) * 2017-03-01 2017-07-11 苏州系统医学研究所 一种流感病毒弱毒活疫苗毒株的筛选和鉴定方法
CN107064499B (zh) * 2017-03-15 2019-06-18 青岛蔚蓝生物制品有限公司 禽流感病毒np蛋白抗原表位多肽及其胶体金试纸盒
JP2021508696A (ja) 2017-12-22 2021-03-11 コーダ−ジェニックス・インコーポレイテッドＣｏｄａ−Ｇｅｎｉｘ， Ｉｎｃ． がん処置のためのコドン対脱最適化領域を有する組換え型ウイルス及びその使用法
CN112040977A (zh) 2018-03-08 2020-12-04 科达金尼克斯有限公司 减毒黄病毒

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011091376A2 (en) * 2010-01-24 2011-07-28 Biological Mimetics, Inc. Immunogenic influenza composition

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708871A (en) 1983-03-08 1987-11-24 Commonwealth Serum Laboratories Commission Antigenically active amino acid sequences
US5585250A (en) 1993-08-20 1996-12-17 The United States Of America As Represented By The Department Of Health & Human Services Dampening of an immunodominant epitope of an antigen for use in plant, animal and human compositions and immunotherapies
ES2241042T3 (es) 1996-10-11 2005-10-16 The Regents Of The University Of California Conjugados de polinucleotido inmunoestimulador/ molecula inmunomoduladora.
US5980912A (en) 1997-03-25 1999-11-09 Zonagen, Inc. Chitosan induced immunopotentiation
KR20060026854A (ko) 2003-05-28 2006-03-24 위스콘신 얼럼나이 리서어치 화운데이션 ＰｏｌⅡ 프로모터 및 리보자임을 갖는 재조합 인플루엔자벡터
US7871626B2 (en) * 2005-08-04 2011-01-18 St. Jude Children's Research Hospital Modified influenza virus for monitoring and improving vaccine efficiency
CA2690196A1 (en) * 2007-06-18 2008-12-24 Medimmune, Llc Influenza b viruses having alterations in the hemaglutinin polypeptide
CA2716340A1 (en) 2008-02-21 2009-08-27 Biological Mimetics, Inc. Immunogenic influenza composition
PL2874656T3 (pl) * 2012-07-17 2018-04-30 Merial, Inc. Atenuowane szczepionki przeciw grypie świń oraz ich sposoby wytwarzania i zastosowanie

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011091376A2 (en) * 2010-01-24 2011-07-28 Biological Mimetics, Inc. Immunogenic influenza composition

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Effect of the Addition of Oligosaccharides on the Biological Activities and Antigenicity of Influenza A/H3N2 Virus Hemagglutinin;Yasuhiro Abe,et al;《JOURNAL OF VIROLOGY》;20041231;第78卷(第18期);9605-9611页 *

Also Published As

Publication number Publication date
CA2879228A1 (en) 2014-01-23
HK1209325A1 (en) 2016-04-01
PT2874656T (pt) 2018-03-09
EA201500140A1 (ru) 2016-02-29
KR20150036685A (ko) 2015-04-07
HUE036110T2 (hu) 2018-06-28
ES2662022T3 (es) 2018-04-05
US9216211B2 (en) 2015-12-22
BR112015001020B1 (pt) 2022-04-19
US9623105B2 (en) 2017-04-18
CA2879228C (en) 2021-07-13
BR112015001020A2 (https=) 2017-08-15
WO2014014726A1 (en) 2014-01-23
MX365880B (es) 2019-06-18
AU2016202693A1 (en) 2016-05-19
AU2016202693B2 (en) 2017-11-16
NZ712713A (en) 2017-05-26
US20160120973A1 (en) 2016-05-05
DK2874656T3 (en) 2018-01-15
EA033027B1 (ru) 2019-08-30
AU2013290597B2 (en) 2016-02-04
PH12015500095B1 (en) 2015-03-02
JP2015524266A (ja) 2015-08-24
EP2874656A1 (en) 2015-05-27
KR102027758B1 (ko) 2019-10-02
NZ704188A (en) 2016-04-29
PL2874656T3 (pl) 2018-04-30
CN104582725A (zh) 2015-04-29
JP6467672B2 (ja) 2019-02-13
PH12015500095A1 (en) 2015-03-02
US20140023681A1 (en) 2014-01-23
MY166879A (en) 2018-07-24
AU2013290597A1 (en) 2015-02-19
EP2874656B1 (en) 2017-12-06
MX2015000713A (es) 2015-10-12

Similar Documents

Publication Publication Date Title
AU2016202693B2 (en) Attenuated swine influenza vaccines and methods of making the use thereof
JP7627911B2 (ja) 卵内複製のための安定化されたｈａを持つ組換えインフルエンザウイルス
JP7655849B2 (ja) ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター
CN107949636B (zh) 活减毒病毒以及生产和使用方法
JP2021500891A (ja) 卵における複製のための安定化されたｈａを有する組換えインフルエンザウイルス
PL220281B1 (pl) Szczepionka DNA, sposób indukowania odpowiedzi immunologicznej, przeciwciała specyficznie rozpoznające białko hemaglutyniny H5 wirusa grypy i zastosowanie szczepionki DNA
CN104232594A (zh) 重组类禽型h1n1流感病毒灭活疫苗株(js40/pr8)及其制备方法和应用
Parys et al. Alternating 3 different influenza vaccines for swine in Europe for a broader antibody response and protection
US10548967B2 (en) Attenuated swine influenza vaccines and methods of making and use thereof
US12606804B2 (en) Influenza virus backbone
TWI620819B (zh) 抗大流行性感冒病毒ａ／ｈ１ｎ１之新穎疫苗
HK1209325B (en) Attenuated swine influenza vaccines and methods of making and use thereof
KR101582490B1 (ko) 인플루엔자 바이러스의 다중 아형에 대한 교차 면역반응을 형성하는 신규한 재조합 바이러스 백신
Chen et al. Evaluation of the Protective Efficacy of Swine Influenza Bivalent Inactivated Vaccine Against Epidemic Strains of H1N1 and H3N2 Swine Influenza Viruses.
Lu Development of Pre-pandemic Influenza Vaccines against Highly Pathogenic H5 Strains

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20160205

Address after: Georgia

Applicant after: Cimmeria limited-liability company

Address before: Georgia

Applicant before: Merial Ltd.

GR01 Patent grant
GR01 Patent grant
TR01 Transfer of patent right

Effective date of registration: 20190717

Address after: Georgia

Patentee after: Bollinger Ingham Animal Health USA

Address before: Georgia

Patentee before: Cimmeria limited-liability company

TR01 Transfer of patent right