BR112015000310A2 - conjugado droga-molécula, e, método para inibir o esgotamento do tecido saudável durante a terapia com células t car - Google Patents

conjugado droga-molécula, e, método para inibir o esgotamento do tecido saudável durante a terapia com células t car

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Publication number
BR112015000310A2
BR112015000310A2 BR112015000310A BR112015000310A BR112015000310A2 BR 112015000310 A2 BR112015000310 A2 BR 112015000310A2 BR 112015000310 A BR112015000310 A BR 112015000310A BR 112015000310 A BR112015000310 A BR 112015000310A BR 112015000310 A2 BR112015000310 A2 BR 112015000310A2
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Brazil
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drug
cell
healthy tissue
conjugate
molecule
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BR112015000310A
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English (en)
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L Levine Bruce
H June Carl
D Kalos Michael
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Univ Pennsylvania
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Publication of BR112015000310A2 publication Critical patent/BR112015000310A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

1 / 1 resumo “conjugado droga-molã‰cula, e, mã‰todo para inibir o esgotamento do tecido saudãvel durante a terapia com cã‰lulas t car” a invenã§ã£o fornece um mã©todo para inibir o esgotamento do tecido saudã¡vel durante a terapia com cã©lula t car compreendendo administrar um conjugado droga-molã©cula compreendendo uma droga e uma molã©cula a um indivã­duo que recebe terapia consistindo em cã©lula t car, em que a molã©cula se liga ao car expresso na superfã­cie de uma cã©lula t. a invenã§ã£o se refere ã  ligaã§ã£o do conjugado ao car, resultando na internalizaã§ã£o do conjugado dentro da cã©lula e na morte da cã©lula mediada pela droga.
BR112015000310A 2012-07-13 2013-07-12 conjugado droga-molécula, e, método para inibir o esgotamento do tecido saudável durante a terapia com células t car BR112015000310A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261671518P 2012-07-13 2012-07-13
PCT/US2013/050272 WO2014011987A1 (en) 2012-07-13 2013-07-12 Compositions and methods for regulating car t cells

Publications (1)

Publication Number Publication Date
BR112015000310A2 true BR112015000310A2 (pt) 2017-06-27

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Family Applications (1)

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BR112015000310A BR112015000310A2 (pt) 2012-07-13 2013-07-12 conjugado droga-molécula, e, método para inibir o esgotamento do tecido saudável durante a terapia com células t car

Country Status (14)

Country Link
US (3) US20150140019A1 (pt)
EP (1) EP2872218A4 (pt)
JP (1) JP2015525765A (pt)
KR (1) KR20150030724A (pt)
CN (1) CN104507537A (pt)
AU (1) AU2013289970A1 (pt)
BR (1) BR112015000310A2 (pt)
CA (1) CA2878856A1 (pt)
EA (1) EA201590207A1 (pt)
IL (1) IL236679A0 (pt)
IN (1) IN2014DN10889A (pt)
MX (1) MX2015000428A (pt)
SG (1) SG11201408398UA (pt)
WO (1) WO2014011987A1 (pt)

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US20190367610A1 (en) 2019-12-05
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AU2013289970A1 (en) 2015-01-22
JP2015525765A (ja) 2015-09-07
MX2015000428A (es) 2015-03-12
IN2014DN10889A (pt) 2015-09-11
EP2872218A1 (en) 2015-05-20
WO2014011987A1 (en) 2014-01-16
CA2878856A1 (en) 2014-01-16
KR20150030724A (ko) 2015-03-20
US20230034117A1 (en) 2023-02-02
CN104507537A (zh) 2015-04-08
EP2872218A4 (en) 2016-07-06
EA201590207A1 (ru) 2015-05-29

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