BR112014032074A2 - construções de tecido conjuntivo tridimensionais engendradas e métodos de fabricar as mesmas - Google Patents

construções de tecido conjuntivo tridimensionais engendradas e métodos de fabricar as mesmas

Info

Publication number
BR112014032074A2
BR112014032074A2 BR112014032074A BR112014032074A BR112014032074A2 BR 112014032074 A2 BR112014032074 A2 BR 112014032074A2 BR 112014032074 A BR112014032074 A BR 112014032074A BR 112014032074 A BR112014032074 A BR 112014032074A BR 112014032074 A2 BR112014032074 A2 BR 112014032074A2
Authority
BR
Brazil
Prior art keywords
connective tissue
cells
engineered
methods
dimensional
Prior art date
Application number
BR112014032074A
Other languages
English (en)
Portuguese (pt)
Inventor
J Evinger Albert
R Shepherd Benjamin
c presnell Sharon
Original Assignee
Organovo Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organovo Inc filed Critical Organovo Inc
Publication of BR112014032074A2 publication Critical patent/BR112014032074A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/08—Muscles; Tendons; Ligaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1352—Mesenchymal stem cells
    • C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/28—Vascular endothelial cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dispersion Chemistry (AREA)
BR112014032074A 2012-06-19 2013-06-19 construções de tecido conjuntivo tridimensionais engendradas e métodos de fabricar as mesmas BR112014032074A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261661768P 2012-06-19 2012-06-19
US13/801,780 US20140099709A1 (en) 2012-06-19 2013-03-13 Engineered three-dimensional connective tissue constructs and methods of making the same
PCT/US2013/046519 WO2013192290A1 (en) 2012-06-19 2013-06-19 Engineered three-dimensional connective tissue constructs and methods of making the same

Publications (1)

Publication Number Publication Date
BR112014032074A2 true BR112014032074A2 (pt) 2017-06-27

Family

ID=49769324

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014032074A BR112014032074A2 (pt) 2012-06-19 2013-06-19 construções de tecido conjuntivo tridimensionais engendradas e métodos de fabricar as mesmas

Country Status (13)

Country Link
US (2) US20140099709A1 (https=)
EP (1) EP2861270A4 (https=)
JP (1) JP2015523142A (https=)
KR (1) KR20150020702A (https=)
CN (1) CN104717987A (https=)
AU (2) AU2013277275B2 (https=)
BR (1) BR112014032074A2 (https=)
HK (1) HK1210439A1 (https=)
IL (1) IL236183A0 (https=)
IN (1) IN2015DN00017A (https=)
RU (1) RU2015100977A (https=)
SG (1) SG11201408405WA (https=)
WO (1) WO2013192290A1 (https=)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005081970A2 (en) 2004-02-24 2005-09-09 The Curators Of The University Of Missouri Self-assembling cell aggregates and methods of making engineered tissue using the same
KR101711354B1 (ko) 2008-06-24 2017-02-28 더 큐레이터스 오브 더 유니버시티 오브 미주리 자가-조립가능 다세포체 및 이들을 이용하여 3차원 생물학적 구조체를 생산하는 방법
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
WO2012054195A2 (en) 2010-10-21 2012-04-26 Organovo, Inc. Devices, systems, and methods for the fabrication of tissue
WO2012068170A2 (en) 2010-11-15 2012-05-24 Jau-Nan Lee Generation of neural stem cells from human trophoblast stem cells
HK1200483A1 (en) 2011-09-12 2015-08-07 奥加诺沃公司 Engineered tissues for in vitro research uses, arrays thereof, and methods of making the same
US9499779B2 (en) 2012-04-20 2016-11-22 Organovo, Inc. Devices, systems, and methods for the fabrication of tissue utilizing UV cross-linking
CA2891272C (en) 2012-11-15 2022-11-22 Allosource Minced cartilage systems and methods
CN113604423B (zh) 2012-11-30 2025-06-03 艾克塞利瑞提德生物技术公司 通过调节mir-124分化干细胞的方法
AU2014218734B2 (en) * 2013-02-22 2018-03-15 Allosource Cartilage mosaic compositions and methods
WO2014151939A1 (en) 2013-03-15 2014-09-25 Allosource Perforated osteochondral allograft compositions
US9442105B2 (en) 2013-03-15 2016-09-13 Organovo, Inc. Engineered liver tissues, arrays thereof, and methods of making the same
DK3028042T3 (da) 2013-07-31 2021-10-04 Organovo Inc Automatiserede anordninger, systemer og fremgangsmåder til fremstilling af væv
CN106536720B (zh) * 2014-04-04 2021-04-30 奥加诺沃公司 工程化的三维乳腺组织，脂肪组织和肿瘤疾病模型
CN106661548B (zh) 2014-05-28 2020-12-11 儿童医院医疗中心 用于经由定向分化将前体细胞转化为胃组织的方法和系统
KR101690872B1 (ko) 2014-08-19 2016-12-29 이화여자대학교 산학협력단 편도 유래 중간엽 줄기세포로부터 인슐린 분비 세포의 분화 방법
MA40495A (fr) 2014-10-06 2016-04-14 Organovo Inc Tissus rénaux produits par génie génétique, réseaux correspondants, et procédés de production
JP6804438B2 (ja) 2014-10-17 2020-12-23 チルドレンズ ホスピタル メディカル センター 多能性幹細胞を使用するヒト小腸のｉｎ ｖｉｖｏモデル、並びにそれを作製、及び使用する方法
EP3215603B1 (en) 2014-11-05 2021-09-22 Organovo, Inc. Engineered three-dimensional skin tissues, arrays thereof, and methods of making the same
US10538725B1 (en) 2014-11-14 2020-01-21 Autodesk, Inc. Multi-dimensional bioprinting system
SG10202009095VA (en) 2014-11-26 2020-10-29 Accelerated Biosciences Corp Induced hepatocytes and uses thereof
KR20160115204A (ko) * 2015-03-26 2016-10-06 포항공과대학교 산학협력단 3차원 프린팅용 조성물, 이의 제조방법, 및 이를 사용한 3차원 구조체의 제조방법
KR102311639B1 (ko) * 2015-03-26 2021-10-12 주식회사 티앤알바이오팹 심근조직 재생용 3차원 구조체의 제조방법
WO2017008035A1 (en) * 2015-07-08 2017-01-12 The Trustees Of The University Of Pennesylvania Decellularized organ-derived tissue engineering scaffolds
CN107835697A (zh) * 2015-07-10 2018-03-23 富士胶片株式会社 细胞结构体及细胞结构体的制造方法
KR102078602B1 (ko) * 2015-07-23 2020-02-19 한국화학연구원 지방세포와 마크로파지의 3차원 공동 배양 방법
NZ776411A (en) 2015-10-09 2023-09-29 Deka Products Lp Fluid pumping and bioreactor system
EP3374495B1 (en) 2015-11-09 2023-02-15 Organovo, Inc. Improved methods for tissue fabrication
WO2017123722A1 (en) 2016-01-12 2017-07-20 Cleveland State University 3d-printed miniature biological constructs
ES2929758T3 (es) 2016-05-05 2022-12-01 Childrens Hospital Med Ct Métodos para la fabricación in vitro de tejido del fondo gástrico y composiciones relacionadas con el mismo
WO2018013727A1 (en) 2016-07-12 2018-01-18 Deka Products Limited Partnership System and method for applying force to a device
US11254901B2 (en) 2016-07-12 2022-02-22 Deka Products Limited Partnership System and method for printing tissue
US11850324B2 (en) 2016-10-12 2023-12-26 Advanced Biomatrix, Inc. Three-dimensional (3-D) printing inks made from natural extracellular matrix molecules
KR102729404B1 (ko) 2016-11-04 2024-11-14 칠드런즈 호스피탈 메디칼 센터 간 유사 장기 조성물 및 이를 제조 및 사용하는 방법
US11299705B2 (en) 2016-11-07 2022-04-12 Deka Products Limited Partnership System and method for creating tissue
EP3541518A4 (en) 2016-11-17 2020-09-30 Cleveland State University CHIP PLATFORMS FOR MICRO-NETWORK 3D BIO-PRINTING
JP7068305B2 (ja) 2016-12-05 2022-05-16 チルドレンズ ホスピタル メディカル センター 結腸オルガノイドならびにその作製方法および使用方法
US12281334B2 (en) 2017-04-14 2025-04-22 Children's Hospital Medical Center Multi donor stem cell compositions and methods of making same
US10570362B2 (en) 2017-07-12 2020-02-25 Deka Products Limited Partnership System and method for transferring tissue
US12297416B2 (en) 2017-07-12 2025-05-13 Deka Products Limited Partneship System and method for transferring tissue
EP3694603B1 (en) 2017-10-10 2026-04-08 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
US11262349B2 (en) 2017-10-11 2022-03-01 Cleveland State University Multiplexed immune cell assays on a micropillar/microwell chip platform
WO2019079424A1 (en) * 2017-10-20 2019-04-25 Indiana University Research And Technology Corporation BIO-3D PRINTING OF PORCINE CELLS WITHOUT SCAFFOLDING
US12379372B2 (en) 2017-12-21 2025-08-05 Children's Hospital Medical Center Digitalized human organoids and methods of using same
SG11202007127QA (en) * 2018-01-31 2020-08-28 Rokit Healthcare Inc Bioink composition for dermis regeneration sheet, method for manufacturing customized dermis regeneration sheet using same, and customized dermis regeneration sheet manufactured using manufacturing method
CN108409917B (zh) * 2018-03-07 2021-03-30 广州锐澄医疗技术有限公司 一种羊膜固定器的制备方法
CO2018004340A1 (es) * 2018-04-24 2018-07-19 Univ Del Valle Implante para la regeneración de tejidos
KR102887406B1 (ko) 2018-07-26 2025-11-19 칠드런즈 호스피탈 메디칼 센터 간-담도-췌장 조직 및 이를 제조하는 방법
AU2019339410A1 (en) 2018-09-12 2021-04-15 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
US20210386790A1 (en) * 2019-01-16 2021-12-16 University Of Utah Research Foundation Use of mesenchymal stem cell sheets for preventing uterine scar formation
WO2020160371A1 (en) 2019-02-01 2020-08-06 The University Of Hong Kong Innervated organoid compositions and methods of making same
CN113924104A (zh) * 2019-03-29 2022-01-11 可隆组织基因有限公司 椎间盘退变的治疗
WO2020243613A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
WO2020243633A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
US11718823B2 (en) * 2020-02-03 2023-08-08 Purdue Research Foundation Methods and materials for rapid preparation of 3D spheroids/organoids
WO2021247907A1 (en) * 2020-06-03 2021-12-09 Northeastern University Biodegradable implant for sustained trans-nasal delivery of therapeutic agents to the brain
CN113941029B (zh) * 2020-07-17 2022-11-18 四川大学华西医院 一种3d打印神经导管及其应用
CN112251352B (zh) * 2020-09-29 2022-06-07 中国肉类食品综合研究中心 一种3d生物组织专用培养装置和块状培育肉的制备方法
US20240124845A1 (en) 2021-02-26 2024-04-18 University Of Rochester Skeletal stem cell isolation and uses thereof
CN113403268B (zh) * 2021-08-20 2022-01-07 北京大学第三医院（北京大学第三临床医学院） 一种含干细胞外泌体的生物墨水及其制造方法
US20250137072A1 (en) 2022-02-18 2025-05-01 Ada Forsyth Institute, Inc. Markers for skeletal stem cell and uses thereof
KR102670562B1 (ko) * 2022-10-13 2024-05-29 바오밥헬스케어 주식회사 3차원 바이오프린팅 기술을 이용한 생선근육 형태 모사 근육을 포함하는 배양생선의 제조방법 및 이에 의해 제조된 배양생선
WO2024091824A1 (en) 2022-10-26 2024-05-02 Ada Forsyth Institute, Inc. Differentiation and reprogramming of chondrocyte
EP4375362A1 (en) 2022-11-28 2024-05-29 Universität Zürich A rotating tissue culture insert for the position inside a rotatable roller bottle partially filled with a liquid for the cultivation of cells

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060270032A1 (en) * 2005-05-24 2006-11-30 The Regents Of The University Of California Microscale micropatterened engineered in vitro tissue
US6998264B2 (en) * 2002-11-19 2006-02-14 Huntington Medical Research Institutes Replication of biological tissue
US20040197375A1 (en) * 2003-04-02 2004-10-07 Alireza Rezania Composite scaffolds seeded with mammalian cells
US8043614B2 (en) * 2004-03-09 2011-10-25 Ahlfors Jan-Eric W Autogenic living scaffolds and living tissue matrices: methods and uses thereof
US20090142307A1 (en) * 2004-07-09 2009-06-04 Athanasiou Kyriacos A Shape-Based Approach for Scaffoldless Tissue Engineering
KR101711354B1 (ko) * 2008-06-24 2017-02-28 더 큐레이터스 오브 더 유니버시티 오브 미주리 자가-조립가능 다세포체 및 이들을 이용하여 3차원 생물학적 구조체를 생산하는 방법
US20110250688A1 (en) * 2008-11-24 2011-10-13 Immunotrex Corporation Three Dimensional Tissue Generation
HUP0900819A2 (en) * 2009-05-05 2011-01-28 Pecsi Tudomanyegyetem Lung tissue culture
US9592255B2 (en) * 2010-07-01 2017-03-14 The Regents Of The University Of Michigan Scaffold-free three dimensional nerve fibroblast constructs
WO2012054195A2 (en) * 2010-10-21 2012-04-26 Organovo, Inc. Devices, systems, and methods for the fabrication of tissue
HUE029316T2 (en) * 2010-11-04 2017-03-28 Univ Of Pecs Lung tissue model
US10072257B2 (en) * 2012-02-29 2018-09-11 Massachusetts Institute Of Technology Inverse patterning process for three-dimensional multi-compartmental micro-organization of multiple cell types
CN106536720B (zh) * 2014-04-04 2021-04-30 奥加诺沃公司 工程化的三维乳腺组织，脂肪组织和肿瘤疾病模型

Also Published As

Publication number Publication date
AU2017200162A1 (en) 2017-02-02
KR20150020702A (ko) 2015-02-26
CN104717987A (zh) 2015-06-17
US20190062707A1 (en) 2019-02-28
EP2861270A1 (en) 2015-04-22
IN2015DN00017A (https=) 2015-05-22
JP2015523142A (ja) 2015-08-13
RU2015100977A (ru) 2016-08-10
WO2013192290A1 (en) 2013-12-27
CA2876659A1 (en) 2013-12-27
US20140099709A1 (en) 2014-04-10
AU2013277275B2 (en) 2016-10-13
HK1210439A1 (en) 2016-04-22
IL236183A0 (en) 2015-01-29
AU2013277275A1 (en) 2015-01-29
SG11201408405WA (en) 2015-01-29
EP2861270A4 (en) 2016-01-20

Similar Documents

Publication Publication Date Title
BR112014032074A2 (pt) construções de tecido conjuntivo tridimensionais engendradas e métodos de fabricar as mesmas
MX2025015455A (es) Metodos biologicos para preparar terpenos
WO2014186469A3 (en) Human application of engineered chimeric antigen receptor (car) t-cells
BR112013002811A8 (pt) meios básicos simplificados para cultura celular pluripotente de humano
BR112015017174A2 (pt) preparação de enxertos de nervo de tecido manipulado com matriz extracelular modificada para reparo de lesão de nervo periférico
ES3060533T3 (en) Cell suspension and use thereof
MY159971A (en) Multipotent/pluripotent cells and methods
WO2013040078A3 (en) Engineered tissues for in vitro research uses, arrays thereof, and methods of making the same
MX2017010377A (es) Andamios e implantes de tejidos suaves biológicamente funcionales.
EP4292600A3 (en) Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
GB201019119D0 (en) A porous fiber, methods of making the same and uses thereof
MX2020005849A (es) Células madre y progenitoras hematopoyéticas humanas cd34+ modificadas con crispr-cas9 y sus usos.
EP2603227A4 (en) IMPROVED HEMATOPOETIC TRIBE AND PRECURSOR CELL THERAPY
MX390739B (es) Composicion de hueso comprimido y metodo para usar la misma.
CR20160576A (es) Anticuerpos dirigidos contra cd127
MX2019008872A (es) Prevencion y tratamiento de da?o o enfermedad osea y cartilago.
BR112015021993A2 (pt) composições de cultura celular com antioxidantes e métodos para produção de polipeptídeo
BR112012013664A2 (pt) rabdovírus oncolítico
WO2011140137A3 (en) Smooth muscle cell constructs
SG10201906304TA (en) Use of perfusion decellularized liver for islet cell recellularization
MX2016008448A (es) Conjugados de var2csa-farmaco.
BR112017001550A2 (pt) enxerto de tecido
MX2015012729A (es) Celulas discogenicas aisladas, metodos de uso y metodos de preparacion de las mismas a partir de tejido de mamiferos.
MX2013005140A (es) Medios de cultivo de celulas granulados en seco.
MX361428B (es) Formas polimorficas st-246 y metodos de preparacion.

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]