BR112014029834A2 - polipeptídeo ou um sal, formulação farmacêutica, polipeptídeo ou sal, métodos de determinação se as células t reconhecem um polipeptídeo ou sal, de tratamento de um indivíduo ou de prevenção de uma alergia em um indivíduo a cladosporium e/ou alternaria, e para preparar uma formulação farmacêutica, e, uso de um polipeptídeo ou sal - Google Patents

polipeptídeo ou um sal, formulação farmacêutica, polipeptídeo ou sal, métodos de determinação se as células t reconhecem um polipeptídeo ou sal, de tratamento de um indivíduo ou de prevenção de uma alergia em um indivíduo a cladosporium e/ou alternaria, e para preparar uma formulação farmacêutica, e, uso de um polipeptídeo ou sal

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Publication number
BR112014029834A2
BR112014029834A2 BR112014029834A BR112014029834A BR112014029834A2 BR 112014029834 A2 BR112014029834 A2 BR 112014029834A2 BR 112014029834 A BR112014029834 A BR 112014029834A BR 112014029834 A BR112014029834 A BR 112014029834A BR 112014029834 A2 BR112014029834 A2 BR 112014029834A2
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BR
Brazil
Prior art keywords
polypeptide
salt
individual
pharmaceutical formulation
seq
Prior art date
Application number
BR112014029834A
Other languages
English (en)
Inventor
Larche Mark
Hickey Pascal
Laidler Paul
Peter Hafner Roderick
Original Assignee
Circassia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Circassia Ltd filed Critical Circassia Ltd
Publication of BR112014029834A2 publication Critical patent/BR112014029834A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0002—Fungal antigens, e.g. Trichophyton, Aspergillus, Candida
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01138—Mannitol 2-dehydrogenase (NADP+) (1.1.1.138)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01003—Aldehyde dehydrogenase (NAD+) (1.2.1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01011—Phosphopyruvate hydratase (4.2.1.11), i.e. enolase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)

Abstract

1 / 1 resumo “polipeptãdeo ou um sal, formulaã‡ãƒo farmacãšutica, polipeptãdeo ou sal, mã‰todos de determinaã‡ãƒo se as cã‰lulas t reconhecem um polipeptãdeo ou sal, de tratamento de um indivãduo ou de prevenã‡ãƒo de uma alergia em um indivãduo a cladosporium e/ou alternaria, e para preparar uma formulaã‡ãƒo farmacãšutica, e, uso de um polipeptãdeo ou sal” polipeptã­deos que podem ser usados para a prevenã§ã£o ou tratamento de alergia aos mofos dos gãªneros cladosporium e/ou alternaria, tãªm atã© 30 aminoã¡cidos de comprimento e compreendem: (i) a sequãªncia de aminoã¡cidos: (a) ggykaavrptmle (seq id no: 35; cla35), (b) aevyqklksltkk (seq id no: 31; cla16), (c) vaityasraqgae (seq id no: 32; cla25), (d) ghhfkergtgslvit (seq id no: 33; cla26), ou (e) anytqtktvsirl (seq id no: 34; cla29); ou (ii) uma sequãªncia variante contendo epã­topo de cã©lulas t que ã© uma referida sequãªncia de aminoã¡cidos (i) tendo atã© seis modificaã§ãµes de aminoã¡cido, cada sendo independentemente uma deleã§ã£o, substituiã§ã£o ou inserã§ã£o.
BR112014029834A 2012-06-01 2013-05-30 polipeptídeo ou um sal, formulação farmacêutica, polipeptídeo ou sal, métodos de determinação se as células t reconhecem um polipeptídeo ou sal, de tratamento de um indivíduo ou de prevenção de uma alergia em um indivíduo a cladosporium e/ou alternaria, e para preparar uma formulação farmacêutica, e, uso de um polipeptídeo ou sal BR112014029834A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1209862.0A GB201209862D0 (en) 2012-06-01 2012-06-01 Cladosporium peptides
PCT/GB2013/051440 WO2013179044A2 (en) 2012-06-01 2013-05-30 Cladosporium peptides

Publications (1)

Publication Number Publication Date
BR112014029834A2 true BR112014029834A2 (pt) 2017-07-25

Family

ID=46582262

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014029834A BR112014029834A2 (pt) 2012-06-01 2013-05-30 polipeptídeo ou um sal, formulação farmacêutica, polipeptídeo ou sal, métodos de determinação se as células t reconhecem um polipeptídeo ou sal, de tratamento de um indivíduo ou de prevenção de uma alergia em um indivíduo a cladosporium e/ou alternaria, e para preparar uma formulação farmacêutica, e, uso de um polipeptídeo ou sal

Country Status (16)

Country Link
US (1) US9850281B2 (pt)
EP (1) EP2855514A2 (pt)
JP (1) JP2015520171A (pt)
KR (1) KR20150016622A (pt)
CN (1) CN104507960A (pt)
AU (1) AU2013269327A1 (pt)
BR (1) BR112014029834A2 (pt)
CA (1) CA2875131A1 (pt)
CL (1) CL2014003289A1 (pt)
EA (1) EA201492270A1 (pt)
GB (2) GB201209862D0 (pt)
HK (1) HK1202554A1 (pt)
IL (1) IL235842A0 (pt)
MX (1) MX2014014460A (pt)
SG (1) SG11201407945SA (pt)
WO (1) WO2013179044A2 (pt)

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400722B (de) * 1993-08-27 1996-03-25 Biomay Prod & Handel Rekombinante cladosporium herbarum allergene
AT401181B (de) 1994-11-02 1996-07-25 Biomay Prod & Handel Rekombinante dna moleküle
AT403166B (de) * 1995-03-02 1997-11-25 Biomay Prod & Handel Rekombinante dna moleküle, die für polypeptide kodieren, die die antigenität der allergene clah8 und clah12 besitzen
CA2217173C (en) 1997-11-25 2008-04-01 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Health Isolation of a cdna clone encoding a subunit of the alternaria alternata major allergen alt a 1, and production of recombinant protein thereof
WO2003083098A2 (de) 2002-03-28 2003-10-09 Biomay Produktions- Und Handels-Aktiengesellschaft Nucleinsäuresequenz und protein sowie polypeptide kodierend für mannit-dehydrogenasen oder deren teile sowie deren herstellung und verwendung in diagnostik und therapie
WO2009022154A2 (en) 2007-08-15 2009-02-19 Circassia Limited Peptide with multiple epitopes
CN101178406A (zh) 2007-12-05 2008-05-14 杭州浙大生物基因工程有限公司 过敏原特异性抗体IgE ELISA检测试剂盒及其制备方法
WO2010018384A1 (en) * 2008-08-15 2010-02-18 Circassia Limited T-cell antigen peptide from allergen for stimulation of il-10 production
CN101387643A (zh) 2008-10-20 2009-03-18 杭州浙大生物基因工程有限公司 多通道过敏原快速检测试剂盒及其制备方法
CN101393215A (zh) 2008-11-17 2009-03-25 杭州浙大生物基因工程有限公司 多通道吸入型过敏原快速检测试剂盒及其制备方法
GB0821806D0 (en) 2008-11-28 2009-01-07 Circassia Ltd Compositions with reduced dimer formation
GB201002559D0 (en) 2010-02-15 2010-03-31 Circassia Ltd Birch peptides for vaccine
CN102212531A (zh) 2010-04-02 2011-10-12 复旦大学 一种重组多主枝孢霉变应原Cla h8蛋白的制备方法及其用途
BR112013009068A2 (pt) 2010-10-15 2016-07-19 Alk Abelló As supressão de uma resposta imune de hipersensibilidade com antígeno não relacionado derivado de material fonte de alérgeno
US20150004189A1 (en) * 2012-02-07 2015-01-01 La Jolla Institute For Allergy And Immunology Epitopes from allergen proteins and methods and uses for immune response modulation

Also Published As

Publication number Publication date
EA201492270A1 (ru) 2015-09-30
GB2518092A (en) 2015-03-11
JP2015520171A (ja) 2015-07-16
US20150218215A1 (en) 2015-08-06
WO2013179044A3 (en) 2014-03-06
KR20150016622A (ko) 2015-02-12
AU2013269327A1 (en) 2014-12-18
SG11201407945SA (en) 2014-12-30
US9850281B2 (en) 2017-12-26
GB201209862D0 (en) 2012-07-18
CN104507960A (zh) 2015-04-08
CL2014003289A1 (es) 2015-05-22
CA2875131A1 (en) 2013-12-05
WO2013179044A2 (en) 2013-12-05
IL235842A0 (en) 2015-01-29
EP2855514A2 (en) 2015-04-08
HK1202554A1 (en) 2015-10-02
MX2014014460A (es) 2015-02-12

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