SG11201407945SA - Cladosporium peptides - Google Patents

Cladosporium peptides

Info

Publication number
SG11201407945SA
SG11201407945SA SG11201407945SA SG11201407945SA SG11201407945SA SG 11201407945S A SG11201407945S A SG 11201407945SA SG 11201407945S A SG11201407945S A SG 11201407945SA SG 11201407945S A SG11201407945S A SG 11201407945SA SG 11201407945S A SG11201407945S A SG 11201407945SA
Authority
SG
Singapore
Prior art keywords
oxford
international
seq
circassia
science park
Prior art date
Application number
SG11201407945SA
Inventor
Roderick Peter Hafner
Paul Laidler
Pascal Hickey
Mark Larche
Original Assignee
Circassia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Circassia Ltd filed Critical Circassia Ltd
Publication of SG11201407945SA publication Critical patent/SG11201407945SA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0002—Fungal antigens, e.g. Trichophyton, Aspergillus, Candida
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01138—Mannitol 2-dehydrogenase (NADP+) (1.1.1.138)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01003—Aldehyde dehydrogenase (NAD+) (1.2.1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01011—Phosphopyruvate hydratase (4.2.1.11), i.e. enolase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders

Abstract

(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 5 December 2013 (05.12.2013) WIPOIPCT (10) International Publication Number WO 2013/179044 A2 (51) International Patent Classification: C07K14/37 ( 2006.01) A61K 39/35 (2006.01) CI2N 9/64 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/GB2013/051440 30 May 2013 (30.05.2013) English English (30) Priority Data: 1209862.0 1 June 2012 (01.06.2012) GB (71) Applicant: CIRCASSIA LIMITED [GB/GB]; The Ox­ ford Science Park, Oxford, Oxfordshire OX4 4GA (GB). (72) Inventors: HAFNER, Roderick Peter; Circassia Ltd, Magdalen Centre, The Oxford Science Park, Oxford, Ox­ fordshire OX4 4GA (GB). LAIDLER, Paul; Circassia Ltd, Magdalen Centre, The Oxford Science Park, Oxford, Ox­ fordshire OX4 4GA (GB). HICKEY, Pascal; Circassia Ltd, Magdalen Centre, The Oxford Science Park, Oxford, Oxfordshire OX4 4GA (GB). LARCHE, Mark; Depart­ ment of Medicine HSC, 4H20 McMaster University, 1200 Main Street, West Hamilton, Ontario L8N 3Z5 (CA). (74) Agent: WOODS, Geoffrey Corlett; 14 South Square, Gray's Inn, London, Greater London WC1R 5JJ (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — without international search report and to be republished upon receipt of that report (Rule 48.2(g)) — with sequence listing part of description (Rule 5.2(a)) CJ •t •t o o\ l> i-H cn i-H o CJ o & (54) Title: CLADOSPORIUM PEPTIDES (57) Abstract: Polypeptides which may be used for preventing or treating allergy to moulds of the Cladosporium and/or Alternaria genus, have up to 30 amino acids in length and comprise: (I) the amino acid sequence: (a) GGYKAAVRPTMLE (SEQ ID NO : 35; Cla35), (b) AE V YQKLK SLTKK (SEQ ID NO: 31; Clal6), (c) VAITYASRAQGAE (SEQ ID NO: 32; Cla25), (d) GHHFKERGT - GSLVIT (SEQ ID NO: 33; Cla26), or (e) ANYTQTKTVSIRL (SEQ ID NO: 34; Cla29); or (II) a T cell epitope-containing variant sequence which is a said amino acid sequence (I) having up to six amino acid modifications, each of which is independently a dele - tion, substitution or insertion.
SG11201407945SA 2012-06-01 2013-05-30 Cladosporium peptides SG11201407945SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1209862.0A GB201209862D0 (en) 2012-06-01 2012-06-01 Cladosporium peptides
PCT/GB2013/051440 WO2013179044A2 (en) 2012-06-01 2013-05-30 Cladosporium peptides

Publications (1)

Publication Number Publication Date
SG11201407945SA true SG11201407945SA (en) 2014-12-30

Family

ID=46582262

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201407945SA SG11201407945SA (en) 2012-06-01 2013-05-30 Cladosporium peptides

Country Status (16)

Country Link
US (1) US9850281B2 (en)
EP (1) EP2855514A2 (en)
JP (1) JP2015520171A (en)
KR (1) KR20150016622A (en)
CN (1) CN104507960A (en)
AU (1) AU2013269327A1 (en)
BR (1) BR112014029834A2 (en)
CA (1) CA2875131A1 (en)
CL (1) CL2014003289A1 (en)
EA (1) EA201492270A1 (en)
GB (2) GB201209862D0 (en)
HK (1) HK1202554A1 (en)
IL (1) IL235842A0 (en)
MX (1) MX2014014460A (en)
SG (1) SG11201407945SA (en)
WO (1) WO2013179044A2 (en)

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400722B (en) * 1993-08-27 1996-03-25 Biomay Prod & Handel RECOMBINANT CLADOSPORIUM HERBARUM ALLERGENS
AT401181B (en) 1994-11-02 1996-07-25 Biomay Prod & Handel RECOMBINANT DNA MOLECULES
AT403166B (en) * 1995-03-02 1997-11-25 Biomay Prod & Handel RECOMBINANT DNA MOLECULES ENCODING POLYPEPTIDES THAT HAVE THE ANTIGENSITY OF THE ALLERGENS CLAH8 AND CLAH12
CA2217173C (en) 1997-11-25 2008-04-01 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Health Isolation of a cdna clone encoding a subunit of the alternaria alternata major allergen alt a 1, and production of recombinant protein thereof
EP1495115B1 (en) 2002-03-28 2011-10-05 Biomay Ag Nucleic acid sequence and protein in addition to polypeptides coding for mannitol-dehydrogenases or parts thereof and the production and use thereof in diagnosis and therapy
CN101820907B (en) 2007-08-15 2013-05-01 切尔卡西亚有限公司 Peptide with multiple epitopes
CN101178406A (en) 2007-12-05 2008-05-14 杭州浙大生物基因工程有限公司 Allergen specificity antibody IgE ELISA detection reagent box and method of producing the same
EP2331124A1 (en) * 2008-08-15 2011-06-15 Circassia Limited T-cell antigen peptide from allergen for stimulation of il-10 production
CN101387643A (en) 2008-10-20 2009-03-18 杭州浙大生物基因工程有限公司 Multichannel allergen rapid detection kit and method for making same
CN101393215A (en) 2008-11-17 2009-03-25 杭州浙大生物基因工程有限公司 Multichannel attractive type allergen rapid detection kit and method for making same
GB0821806D0 (en) 2008-11-28 2009-01-07 Circassia Ltd Compositions with reduced dimer formation
GB201002559D0 (en) 2010-02-15 2010-03-31 Circassia Ltd Birch peptides for vaccine
CN102212531A (en) 2010-04-02 2011-10-12 复旦大学 Preparation method and application of recombinant Cladosporium herbarum allergen Cla h8 protein
CN103547287A (en) 2010-10-15 2014-01-29 爱尔开-阿贝优公司 Suppression of a hypersensitivity immune response with unrelated antigen derived from allergen source material
EP2812028A4 (en) * 2012-02-07 2016-01-06 Jolla Inst Allergy Immunolog Epitopes from allergen proteins and methods and uses for immune response modulation

Also Published As

Publication number Publication date
CA2875131A1 (en) 2013-12-05
US20150218215A1 (en) 2015-08-06
EA201492270A1 (en) 2015-09-30
BR112014029834A2 (en) 2017-07-25
KR20150016622A (en) 2015-02-12
HK1202554A1 (en) 2015-10-02
JP2015520171A (en) 2015-07-16
AU2013269327A1 (en) 2014-12-18
CN104507960A (en) 2015-04-08
EP2855514A2 (en) 2015-04-08
GB201209862D0 (en) 2012-07-18
US9850281B2 (en) 2017-12-26
CL2014003289A1 (en) 2015-05-22
MX2014014460A (en) 2015-02-12
IL235842A0 (en) 2015-01-29
GB2518092A (en) 2015-03-11
WO2013179044A2 (en) 2013-12-05
WO2013179044A3 (en) 2014-03-06

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