BR112014026424B1 - Composto, di-idrato, composição, uso do composto diidrato, e, composição farmacêutica - Google Patents

Composto, di-idrato, composição, uso do composto diidrato, e, composição farmacêutica Download PDF

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Publication number
BR112014026424B1
BR112014026424B1 BR112014026424-4A BR112014026424A BR112014026424B1 BR 112014026424 B1 BR112014026424 B1 BR 112014026424B1 BR 112014026424 A BR112014026424 A BR 112014026424A BR 112014026424 B1 BR112014026424 B1 BR 112014026424B1
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BR
Brazil
Prior art keywords
dihydrate
ppm
disorder
compound
present
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BR112014026424-4A
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English (en)
Portuguese (pt)
Other versions
BR112014026424A2 (pt
Inventor
Tetsuya Sato
Takuya Minowa
Yusuke Hoshika
Hidekazu Toyofuku
Hiroshi Yamashita
Tatsuya Yamaguchi
Masahiro Sota
Shuuji Kawano
Takayuki Nakamura
Ryohei Eto
Takuma Ikebuchi
Kei Moriyama
Nobuaki Ito
Original Assignee
Otsuka Pharmaceutical Co., Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48428584&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112014026424(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Otsuka Pharmaceutical Co., Ltd filed Critical Otsuka Pharmaceutical Co., Ltd
Publication of BR112014026424A2 publication Critical patent/BR112014026424A2/pt
Publication of BR112014026424B1 publication Critical patent/BR112014026424B1/pt

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Otolaryngology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
BR112014026424-4A 2012-04-23 2013-04-23 Composto, di-idrato, composição, uso do composto diidrato, e, composição farmacêutica BR112014026424B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261636920P 2012-04-23 2012-04-23
US61/636,920 2012-04-23
US201361791378P 2013-03-15 2013-03-15
US61/791,378 2013-03-15
PCT/JP2013/062681 WO2013162046A1 (en) 2012-04-23 2013-04-23 Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same

Publications (2)

Publication Number Publication Date
BR112014026424A2 BR112014026424A2 (pt) 2017-06-27
BR112014026424B1 true BR112014026424B1 (pt) 2022-09-13

Family

ID=48428584

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014026424-4A BR112014026424B1 (pt) 2012-04-23 2013-04-23 Composto, di-idrato, composição, uso do composto diidrato, e, composição farmacêutica

Country Status (36)

Country Link
US (5) US9499525B2 (enExample)
EP (1) EP2841431B2 (enExample)
JP (1) JP5952917B2 (enExample)
KR (1) KR102160395B1 (enExample)
CN (1) CN104254530B (enExample)
AR (1) AR090774A1 (enExample)
AU (1) AU2013253372B2 (enExample)
BR (1) BR112014026424B1 (enExample)
CA (1) CA2870000C (enExample)
CO (1) CO7111315A2 (enExample)
CY (1) CY1119103T1 (enExample)
DK (1) DK2841431T4 (enExample)
EA (1) EA026541B1 (enExample)
ES (1) ES2617881T5 (enExample)
FI (1) FI2841431T4 (enExample)
HR (1) HRP20170242T4 (enExample)
HU (1) HUE031997T2 (enExample)
IL (1) IL235044B (enExample)
IN (1) IN2014DN08867A (enExample)
JO (1) JO3325B1 (enExample)
LT (1) LT2841431T (enExample)
ME (1) ME02619B (enExample)
MX (1) MX361723B (enExample)
MY (1) MY170220A (enExample)
NZ (1) NZ630260A (enExample)
PH (1) PH12014502324B1 (enExample)
PL (1) PL2841431T5 (enExample)
PT (1) PT2841431T (enExample)
RS (1) RS55742B2 (enExample)
SG (1) SG11201406790VA (enExample)
SI (1) SI2841431T2 (enExample)
SM (2) SMT201700130T1 (enExample)
TW (1) TWI562991B (enExample)
UA (1) UA117456C2 (enExample)
WO (1) WO2013162046A1 (enExample)
ZA (1) ZA201407477B (enExample)

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JOP20200109A1 (ar) 2012-04-23 2017-06-16 Otsuka Pharma Co Ltd مستحضر قابل للحقن
AR090775A1 (es) * 2012-04-23 2014-12-03 Otsuka Pharma Co Ltd Preparado inyectable
TWI562991B (en) * 2012-04-23 2016-12-21 Otsuka Pharma Co Ltd Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same
JOP20210047A1 (ar) * 2012-10-25 2017-06-16 Otsuka Pharma Co Ltd عامل وقائي و/أو علاجي للأعراض السلوكية والنفسية المصحوبة بمرض تنكسي عصبي أو الأعراض الإندفاعية المصحوبة بمرض ذهني، يحتوي على بريكسبيرازول أو ملحه
SG10201809280PA (en) 2014-04-22 2018-11-29 Otsuka Pharma Co Ltd Combination of brexpiprazole and nalmefene and use thereof for treating substance-related disorders
CN104447723A (zh) * 2014-11-28 2015-03-25 瑞阳制药有限公司 7-(4-(4-(苯并[b]噻吩基)-1-哌嗪基)丁氧基)-2(1H)-喹啉酮的制备方法
CN104829603A (zh) * 2015-05-19 2015-08-12 杭州新博思生物医药有限公司 A晶型依匹唑派盐酸盐及其制备方法
CN106883223B (zh) * 2015-12-16 2021-11-23 北京福元医药股份有限公司 一种Brexpiprazole盐酸盐的纯化方法
WO2017106641A1 (en) 2015-12-17 2017-06-22 Assia Chemical Industries Ltd. Solid state forms of brexpiprazole
JP2019059672A (ja) * 2015-12-28 2019-04-18 大日本住友製薬株式会社 治療抵抗性うつ病等の治療薬
US10464931B2 (en) 2015-12-28 2019-11-05 Honour (R&D) Process for the preparation of Quinolin-2(1H)-one derivatives
WO2017134038A1 (en) 2016-02-01 2017-08-10 Hexal Ag Anhydrate-free polymorphically pure micronized crystalline brexpiprazole dihydrate for use in intramuscular injectable sustained release formulations
US20170320862A1 (en) 2016-05-03 2017-11-09 Cadila Healthcare Limited Process for the preparation of brexpiprazole and intermediates thereof
CN107365305A (zh) 2016-05-12 2017-11-21 上海奥博生物医药技术有限公司 一种依匹哌唑新晶型及其制备方法
WO2017208251A1 (en) * 2016-05-31 2017-12-07 Cipla Limited A new stable polymorph of brexpiprazole and process for preparation thereof
CN106188023A (zh) * 2016-07-04 2016-12-07 山东川成医药股份有限公司 一种依匹唑派的精制方法
PL233778B1 (pl) 2016-07-19 2019-11-29 Adamed Spolka Z Ograniczona Odpowiedzialnoscia Sposob wytwarzania brekspiprazolu oraz zastosowanie zwiazkow posrednich w sposobie wytwarzania brekspiprazolu
EP3500247B1 (en) 2016-08-16 2020-05-27 H e x a l Aktiengesellschaft Immediate release tablet of a benzothiophene compound
EP3500249A1 (en) 2016-08-16 2019-06-26 Hexal Aktiengesellschaft Pharmaceutical compositions of a benzothiophene compound
CN107936005A (zh) * 2016-10-13 2018-04-20 上海科胜药物研发有限公司 一种依匹哌唑新晶型ii及其制备方法
CN106699745A (zh) * 2016-12-14 2017-05-24 上海博志研新药物技术有限公司 一种依匹哌唑甲醇合物、晶型a、及其制备方法和应用
US11072605B2 (en) 2017-02-02 2021-07-27 Hexal Ag Crystalline brexpiprazole
EP3501506B1 (en) 2017-12-19 2019-10-09 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising brexpiprazole
CN111440158A (zh) * 2020-03-24 2020-07-24 石药集团中奇制药技术(石家庄)有限公司 一种盐酸依匹哌唑新晶型及其制备方法
US11229644B1 (en) * 2020-12-31 2022-01-25 Lake O'hara Llc Methods of treating psychiatric disorders in obese patients with brexpiprazole
WO2022176017A1 (ja) * 2021-02-16 2022-08-25 大塚製薬株式会社 非晶質体及び当該非晶質体を含む組成物
WO2023067664A1 (ja) * 2021-10-18 2023-04-27 大塚製薬株式会社 ベンゾチオフェン化合物の新規結晶形及びその製造方法

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AR033485A1 (es) * 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
AU2004285448C1 (en) 2003-10-23 2021-08-19 Otsuka Pharmaceutical Co., Ltd. Controlled release sterile injectable aripiprazole formulation and method
EP1797039A1 (en) 2004-09-13 2007-06-20 Matrix Laboratories Ltd Process for the preparation of polymorphs, solvates of aripiprazole using aripiprazole acid salts
DE102005001989A1 (de) * 2005-01-15 2006-07-20 Bayer Healthcare Ag Intravenöse Formulierungen von PDE-Inhibitoren
JP4315393B2 (ja) 2005-04-14 2009-08-19 大塚製薬株式会社 複素環化合物
TWI320783B (en) * 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
AR066677A1 (es) * 2007-05-24 2009-09-02 Novartis Ag Formulacion de pasireotida. composicion farmaceutica para liberacion prolongada. microparticulas.
EP2214483B1 (en) * 2007-10-26 2012-06-20 Repligen Corporation Methods of identifying histone deacetylase inhibitors useful for neurological disorders
WO2009095450A1 (en) * 2008-01-30 2009-08-06 Novartis Ag Sustained release formulation comprising octreotide and three linear polylactide-co-glycolide polymers
EP2233471A1 (en) * 2009-02-06 2010-09-29 Adamed Sp. z o.o. A salt of 7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy}-3,4.dihydro-2(1h)-quinolinone with 5-sulfosalicylic acid and its preparation process
NZ603076A (en) 2010-08-24 2014-12-24 Otsuka Pharma Co Ltd Suspension and cake composition containing carbostyril derivative and silicone oil and/or silicone oil derivative
FI3156056T3 (fi) * 2011-03-18 2024-03-01 Alkermes Pharma Ireland Ltd Sorbitaaniestereitä käsittäviä farmaseuttisia koostumuksia
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EP2736894B1 (en) * 2011-07-28 2016-08-31 Otsuka Pharmaceutical Co., Ltd. Method for producing benzo[b] thiophene compounds
JO3227B1 (ar) * 2011-09-08 2018-03-08 Otsuka Pharma Co Ltd مشتقات بنزو ثيوفين بها استبدال ببرازين كعوامل مضادة للذهان
TWI562991B (en) * 2012-04-23 2016-12-21 Otsuka Pharma Co Ltd Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same
JOP20200109A1 (ar) * 2012-04-23 2017-06-16 Otsuka Pharma Co Ltd مستحضر قابل للحقن
AR090775A1 (es) * 2012-04-23 2014-12-03 Otsuka Pharma Co Ltd Preparado inyectable

Also Published As

Publication number Publication date
HRP20170242T1 (hr) 2017-04-07
CA2870000A1 (en) 2013-10-31
IN2014DN08867A (enExample) 2015-05-22
RS55742B2 (sr) 2024-04-30
ES2617881T5 (es) 2024-05-22
HRP20170242T4 (hr) 2024-03-01
RS55742B1 (sr) 2017-07-31
CY1119103T1 (el) 2018-02-14
SG11201406790VA (en) 2014-11-27
AR090774A1 (es) 2014-12-03
IL235044B (en) 2019-05-30
US20150087655A1 (en) 2015-03-26
MY170220A (en) 2019-07-10
CO7111315A2 (es) 2014-11-10
HUE031997T2 (en) 2017-08-28
EP2841431A1 (en) 2015-03-04
EA026541B1 (ru) 2017-04-28
DK2841431T4 (da) 2024-02-12
TW201348229A (zh) 2013-12-01
JP5952917B2 (ja) 2016-07-13
ES2617881T3 (es) 2017-06-20
UA117456C2 (uk) 2018-08-10
DK2841431T3 (en) 2017-03-06
NZ630260A (en) 2015-09-25
SMT201700130B (it) 2017-03-08
AU2013253372A1 (en) 2014-10-30
JO3325B1 (ar) 2019-03-13
US20210115030A1 (en) 2021-04-22
TWI562991B (en) 2016-12-21
US20230049327A1 (en) 2023-02-16
WO2013162046A1 (en) 2013-10-31
BR112014026424A2 (pt) 2017-06-27
ZA201407477B (en) 2015-12-23
US20200140424A1 (en) 2020-05-07
SI2841431T2 (sl) 2024-03-29
HRP20170242T8 (hr) 2017-09-22
LT2841431T (lt) 2017-03-27
PH12014502324A1 (en) 2015-01-12
HK1203073A1 (en) 2015-10-16
KR102160395B1 (ko) 2020-09-28
CN104254530B (zh) 2016-09-21
KR20150013189A (ko) 2015-02-04
US20170066752A1 (en) 2017-03-09
EP2841431B2 (en) 2024-01-24
SMT201700130T1 (it) 2017-03-08
FI2841431T4 (fi) 2024-04-18
PT2841431T (pt) 2017-03-07
EP2841431B1 (en) 2017-01-04
IL235044A0 (en) 2014-12-31
EA201491933A1 (ru) 2015-03-31
ME02619B (me) 2017-06-20
MX361723B (es) 2018-12-14
AU2013253372B2 (en) 2016-12-08
US10407415B2 (en) 2019-09-10
PL2841431T5 (pl) 2024-07-15
PH12014502324B1 (en) 2015-01-12
CA2870000C (en) 2021-02-16
MX2014012527A (es) 2015-03-19
CN104254530A (zh) 2014-12-31
JP2015514677A (ja) 2015-05-21
US9499525B2 (en) 2016-11-22
PL2841431T3 (pl) 2017-06-30
SI2841431T1 (sl) 2017-03-31

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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