BR112014022240A2 - composições compreendendo imunoglobulinas semelhantes à secretoras - Google Patents
composições compreendendo imunoglobulinas semelhantes à secretorasInfo
- Publication number
- BR112014022240A2 BR112014022240A2 BR112014022240A BR112014022240A BR112014022240A2 BR 112014022240 A2 BR112014022240 A2 BR 112014022240A2 BR 112014022240 A BR112014022240 A BR 112014022240A BR 112014022240 A BR112014022240 A BR 112014022240A BR 112014022240 A2 BR112014022240 A2 BR 112014022240A2
- Authority
- BR
- Brazil
- Prior art keywords
- secretory
- compositions
- immunoglobulins
- igm
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
resumo patente de invenção: "composições compreendendo imunoglobulinas semelhantes à secretoras". a presente invenção refere-se a métodos para preparar composições compreendendo imunoglobulina semelhante à secretora, em particular iga semelhante à secretora e/ou igm semelhante à secretora, in vitro, compreendendo as etapas de (a) obter uma composição de proteína derivada de sangue compreendendo imunoglobulina contendo a cadeia j, em particular iga e/ou igm, em uma forma não purificada; e (b) misturar a composição da etapa (a) com um componente secretor e composições obteníveis por esses métodos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20120158931 EP2636682A1 (en) | 2012-03-09 | 2012-03-09 | Compositions comprising secretory-like immunoglobulins |
EP12168343 | 2012-05-16 | ||
PCT/EP2013/054697 WO2013132052A1 (en) | 2012-03-09 | 2013-03-08 | Compositions comprising secretory - like immunoglobulins |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014022240A2 true BR112014022240A2 (pt) | 2017-08-01 |
Family
ID=47846003
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014022240A BR112014022240A2 (pt) | 2012-03-09 | 2013-03-08 | composições compreendendo imunoglobulinas semelhantes à secretoras |
Country Status (18)
Country | Link |
---|---|
US (3) | US10221233B2 (pt) |
EP (1) | EP2822967B1 (pt) |
JP (3) | JP2015510875A (pt) |
KR (1) | KR102142261B1 (pt) |
CN (2) | CN104254542A (pt) |
AU (1) | AU2013201393B2 (pt) |
BR (1) | BR112014022240A2 (pt) |
CA (1) | CA2866634C (pt) |
DK (1) | DK2822967T3 (pt) |
ES (1) | ES2751976T3 (pt) |
HK (1) | HK1204628A1 (pt) |
IL (1) | IL234449B (pt) |
MX (1) | MX360245B (pt) |
NZ (1) | NZ629072A (pt) |
PL (1) | PL2822967T3 (pt) |
RU (1) | RU2644240C2 (pt) |
SG (1) | SG11201404958SA (pt) |
WO (1) | WO2013132052A1 (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2636684A1 (en) * | 2012-03-09 | 2013-09-11 | CSL Behring AG | Prevention of infection |
AU2013201393B2 (en) * | 2012-03-09 | 2015-08-27 | Csl Behring Ag | Compositions |
EP2636681A1 (en) | 2012-03-09 | 2013-09-11 | CSL Behring AG | Process for enriching IgA |
US9458230B2 (en) | 2013-01-04 | 2016-10-04 | Wisconsin Alumni Research Foundation | Secretory IGA compositions, methods of making and methods of use thereof |
US9468674B2 (en) | 2013-09-24 | 2016-10-18 | Wisconsin Alumni Research Foundation | Methods of use of secretory IgA |
DK3125942T3 (da) | 2014-04-03 | 2021-12-20 | Csl Behring Ag | Forstøvning af immunoglobulin |
RU2599029C1 (ru) * | 2015-07-16 | 2016-10-10 | Игорь Геннадьевич Ковшик | Химерный иммуноглобулиновый препарат, обладающий специфическим противовирусным или антибактериальным действием |
CA3013849A1 (en) | 2016-03-14 | 2017-09-21 | Biotest Ag | Treatment of severe community acquired pneumonia |
WO2018115048A1 (en) | 2016-12-20 | 2018-06-28 | Csl Behring Ag | Methods for affecting salmonella infections |
CN111278862A (zh) | 2017-09-21 | 2020-06-12 | Umc乌德勒支控股有限公司 | 用于治疗成神经细胞瘤的抗gd2抗体 |
CN110724176B (zh) * | 2018-07-16 | 2021-10-26 | 北京豪思生物科技有限公司 | 一种治疗阿尔茨海默症的血浆蛋白分离物及其制备方法和应用 |
MX2021006212A (es) | 2018-11-30 | 2021-08-11 | Csl Behring Ag | Metodos y composiciones para prevenir o tratar exacerbaciones agudas con inmunoglobulina policlonal. |
CA3131705A1 (en) | 2019-03-27 | 2020-10-01 | Umc Utrecht Holding B.V. | Engineered iga antibodies and methods of use |
WO2024151506A1 (en) * | 2023-01-13 | 2024-07-18 | Simon Michael R | Process for preparation of secretory iga and secretory igm and use thereof for treating necrotizing enterocolitis |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU745523A1 (ru) * | 1978-06-15 | 1980-07-05 | Всесоюзный научно-исследовательский институт гриппа | Способ профилактики и лечени острых респираторных заболеваний вирусной этиологии |
US4703004A (en) | 1984-01-24 | 1987-10-27 | Immunex Corporation | Synthesis of protein with an identification peptide |
US5500345A (en) | 1989-04-25 | 1996-03-19 | Iatron Laboratories, Inc. | Hybridomas producing monoclonal antibodies specific for C-reactive protein and methods for detection of C-reactive protein |
DE3927111C3 (de) | 1989-08-17 | 1994-09-01 | Biotest Pharma Gmbh | Verfahren zur Herstellung nicht modifizierter intravenös verabreichbarer IgM- und/oderIgA-haltiger Immunglobulinpräparate |
US5258177A (en) | 1991-12-10 | 1993-11-02 | Alpha Therapeutic Corporation | IgA preparation and process of making the same |
FR2706466B1 (fr) | 1993-06-14 | 1995-08-25 | Aetsrn | Concentré d'immunoglobulines G à usage thérapeutique et procédé de production dudit concentré. |
JP3504661B2 (ja) | 1993-07-30 | 2004-03-08 | オラヴァックス インク | 呼吸器合胞体ウイルスに対するモノクローナルIgA抗体 |
JPH10505358A (ja) | 1994-09-06 | 1998-05-26 | ギャラゲン・インコーポレイテッド | クロストリジウム・ディフィシル関連疾患の治療処置 |
DE19600939C1 (de) | 1996-01-12 | 1997-08-28 | Immuno Ag | Verfahren zur Trennung von IgG und IgA |
EP0839915A1 (en) * | 1996-11-01 | 1998-05-06 | Institut Suisse De Recherches Experimentales Sur Le Cancer Isrec | Secretory immunoglobulin A as a mucosal vaccine delivery system |
AU8063798A (en) | 1997-06-19 | 1999-01-04 | Regents Of The University Of California, The | Secretory immunoglobulin produced by single cells and methods for making and using same |
US5886154A (en) | 1997-06-20 | 1999-03-23 | Lebing; Wytold R. | Chromatographic method for high yield purification and viral inactivation of antibodies |
US20020114802A1 (en) * | 1998-02-10 | 2002-08-22 | Tjellstrom Bo Arthur Einar | Oral immunoglobulin treatment for inflammatory bowel disease |
AU753468B2 (en) | 1998-06-09 | 2002-10-17 | Csl Behring Ag | Process for producing immunoglobulins for intravenous administration and other immunoglobulin products |
JP2000103800A (ja) | 1998-09-29 | 2000-04-11 | Yoshitomi Pharmaceut Ind Ltd | 免疫グロブリンaの精製方法 |
AUPP806999A0 (en) | 1999-01-08 | 1999-02-04 | Csl Limited | Process for purifying immunoglobulins |
EP1068871A1 (en) | 1999-07-07 | 2001-01-17 | Jean-Paul Perraudin | Novel methods and medicament for treating infections diseases involving microbial biofilms |
US6974573B2 (en) | 1999-11-01 | 2005-12-13 | Mucovax Holdings, B.V. | Antibody production in farm animals |
DE60036132T2 (de) | 1999-12-13 | 2008-08-21 | Universidad Nacional Autonoma De Mexico | Quantitative immunoenzymatische messmethode |
US6696620B2 (en) | 2000-05-02 | 2004-02-24 | Epicyte Pharmaceutical, Inc. | Immunoglobulin binding protein arrays in eukaryotic cells |
CA2437814C (en) | 2001-02-12 | 2008-05-13 | Medarex, Inc. | Human monoclonal antibodies to fc alpha receptor (cd89) |
US6932967B2 (en) * | 2001-03-22 | 2005-08-23 | Michael R. Simon | Human medical treatment by aerosol inhalation of immunoglobulin A |
FR2824568B1 (fr) | 2001-05-11 | 2004-04-09 | Lab Francais Du Fractionnement | Procede de preparation de concentres d'immunoglobulines humaines a usage therapeutique |
US20060165675A1 (en) | 2002-08-02 | 2006-07-27 | Richman-Eisenstat Janice Beth | Modulation of mesenchymal cells via iga-receptors |
WO2005047334A1 (en) | 2003-11-13 | 2005-05-26 | Hanmi Pharmaceutical. Co., Ltd. | Igg fc fragment for a drug carrier and method for the preparation thereof |
US7597891B2 (en) * | 2006-12-13 | 2009-10-06 | Simon Michael R | Synthesis of human secretory IgA for the treatment of Clostridium difficile associated diseases |
US7794721B2 (en) * | 2006-12-13 | 2010-09-14 | Simon Michael R | Synthesis of human secretory IgM and the treatment of clostridium difficile associated diseases herewith |
US8119104B2 (en) | 2006-12-13 | 2012-02-21 | Michael R. Simon | Treatment of celiac disease with IgA |
US8709413B2 (en) | 2006-12-13 | 2014-04-29 | Michael R. Simon | Treatment of celiac disease with IgA |
US20080145420A1 (en) | 2006-12-13 | 2008-06-19 | Simon Michael R | HUMAN SECRETORY IgA FOR THE TREATMENT OF CLOSTRIDIUM DIFFICILE ASSOCIATED DISEASES |
US8021645B2 (en) * | 2006-12-13 | 2011-09-20 | Simon Michael R | Synthesis of human secretory IgA and IgM and the formation of a medicament therefrom |
US8313730B2 (en) | 2006-12-13 | 2012-11-20 | Michael R. Simon | Treatment of celiac disease with IgA |
CA2734139C (en) | 2007-10-02 | 2019-12-24 | Avaxia Biologics, Inc. | Antibody therapy for use in the digestive tract |
KR101645957B1 (ko) * | 2008-05-15 | 2016-08-05 | 더블유. 헬스 엘.피. | 분비 면역글로블린이 풍부한 우유 분획 제조방법 |
GB201006753D0 (en) * | 2010-04-22 | 2010-06-09 | Biotest Ag | Process for preparing an immunolobulin composition |
JP5753998B2 (ja) | 2010-11-02 | 2015-07-22 | 国立大学法人三重大学 | ウレタン硬化性組成物、その硬化体、キットおよび硬化体の製造方法 |
EP2465536A1 (en) | 2010-12-14 | 2012-06-20 | CSL Behring AG | CD89 activation in therapy |
EP2748194A4 (en) | 2011-08-22 | 2015-01-28 | Cangene Corp | ANTIBODIES OF THE DIFFICULT CLOSTRIDIUM |
CN104136121B (zh) | 2012-02-14 | 2017-04-19 | 生物辐射实验室股份有限公司 | 减少离子交换色谱中的pH漂移 |
EP2636681A1 (en) | 2012-03-09 | 2013-09-11 | CSL Behring AG | Process for enriching IgA |
EP2636684A1 (en) | 2012-03-09 | 2013-09-11 | CSL Behring AG | Prevention of infection |
AU2013201393B2 (en) | 2012-03-09 | 2015-08-27 | Csl Behring Ag | Compositions |
EP2636683A1 (en) | 2012-03-09 | 2013-09-11 | CSL Behring AG | Treatment of mucositis with Immunoglobulin |
WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
-
2013
- 2013-03-08 AU AU2013201393A patent/AU2013201393B2/en active Active
- 2013-03-08 CA CA2866634A patent/CA2866634C/en active Active
- 2013-03-08 CN CN201380013073.8A patent/CN104254542A/zh active Pending
- 2013-03-08 RU RU2014140744A patent/RU2644240C2/ru not_active IP Right Cessation
- 2013-03-08 PL PL13708786T patent/PL2822967T3/pl unknown
- 2013-03-08 BR BR112014022240A patent/BR112014022240A2/pt not_active IP Right Cessation
- 2013-03-08 NZ NZ629072A patent/NZ629072A/en not_active IP Right Cessation
- 2013-03-08 SG SG11201404958SA patent/SG11201404958SA/en unknown
- 2013-03-08 WO PCT/EP2013/054697 patent/WO2013132052A1/en active Application Filing
- 2013-03-08 KR KR1020147028261A patent/KR102142261B1/ko active IP Right Grant
- 2013-03-08 ES ES13708786T patent/ES2751976T3/es active Active
- 2013-03-08 DK DK13708786.2T patent/DK2822967T3/da active
- 2013-03-08 MX MX2014010754A patent/MX360245B/es active IP Right Grant
- 2013-03-08 US US14/380,521 patent/US10221233B2/en active Active
- 2013-03-08 EP EP13708786.2A patent/EP2822967B1/en active Active
- 2013-03-08 CN CN201911079922.5A patent/CN111116735A/zh active Pending
- 2013-03-08 JP JP2014560387A patent/JP2015510875A/ja active Pending
-
2014
- 2014-09-03 US US14/476,559 patent/US10385117B2/en active Active
- 2014-09-03 IL IL234449A patent/IL234449B/en active IP Right Grant
-
2015
- 2015-05-28 HK HK15105089.4A patent/HK1204628A1/xx unknown
-
2018
- 2018-10-31 JP JP2018204590A patent/JP2019038834A/ja active Pending
-
2019
- 2019-05-02 US US16/401,322 patent/US11623948B2/en active Active
-
2020
- 2020-11-20 JP JP2020192922A patent/JP2021038246A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US10385117B2 (en) | 2019-08-20 |
RU2014140744A (ru) | 2016-04-27 |
CN104254542A (zh) | 2014-12-31 |
RU2644240C2 (ru) | 2018-02-08 |
NZ629072A (en) | 2016-03-31 |
WO2013132052A1 (en) | 2013-09-12 |
US10221233B2 (en) | 2019-03-05 |
CN111116735A (zh) | 2020-05-08 |
JP2019038834A (ja) | 2019-03-14 |
US20190256577A1 (en) | 2019-08-22 |
JP2021038246A (ja) | 2021-03-11 |
AU2013201393B2 (en) | 2015-08-27 |
AU2013201393A1 (en) | 2013-09-26 |
EP2822967A1 (en) | 2015-01-14 |
SG11201404958SA (en) | 2014-11-27 |
JP2015510875A (ja) | 2015-04-13 |
EP2822967B1 (en) | 2019-08-07 |
CA2866634C (en) | 2022-07-19 |
US20150056180A1 (en) | 2015-02-26 |
IL234449B (en) | 2018-07-31 |
MX2014010754A (es) | 2014-12-05 |
CA2866634A1 (en) | 2013-09-12 |
DK2822967T3 (da) | 2019-10-07 |
US11623948B2 (en) | 2023-04-11 |
MX360245B (es) | 2018-10-26 |
US20170058018A2 (en) | 2017-03-02 |
HK1204628A1 (en) | 2015-11-27 |
ES2751976T3 (es) | 2020-04-02 |
US20140371431A1 (en) | 2014-12-18 |
PL2822967T3 (pl) | 2020-01-31 |
KR102142261B1 (ko) | 2020-08-11 |
KR20140132770A (ko) | 2014-11-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112014022240A2 (pt) | composições compreendendo imunoglobulinas semelhantes à secretoras | |
BR112017016636A2 (pt) | formulação líquida estável para anticorpos monoclonais | |
CY1123145T1 (el) | Anti-cd40 αντισωματα | |
CY1122278T1 (el) | Αντι il-36r αντισωματα | |
EA201491571A1 (ru) | МОДИФИЦИРОВАННЫЕ БИСПЕЦИФИЧЕСКИЕ АНТИТЕЛА IgG4 С АСИММЕТРИЧНОЙ ПОСЛЕДОВАТЕЛЬНОСТЬЮ | |
UY37290A (es) | Anticuerpos anti-ige | |
EA201391175A1 (ru) | Гетеродимерные иммуноглобулины | |
CL2015001472A1 (es) | Composiciones y métodos para anticuerpos dirigidos epo. | |
CO6551721A2 (es) | Moduladores de cinasa novedosos | |
UY34701A (es) | Formas sólidas de un profármaco de nucleótidos de tiofosforamidato | |
BR112016002199B8 (pt) | Anticorpo que se liga a um complexo de hgarp e tgf-b1 latente, composição compreendendo o mesmo, uso e linhagem celular de hibridoma | |
BR112015012987A2 (pt) | composições compreendendo anticorpos anti-cd38 e lenalidomida | |
MX356337B (es) | Anticuerpos contra csf-1r humano y sus usos. | |
CL2016001256A1 (es) | Composiciones y métodos para anticuerpos dirigidos factor de p (divisional de sol. n° 1640-14). | |
ECSP13013050A (es) | Formulación para anticuerpo anti- 4 7 | |
BR112013020500A8 (pt) | anticorpo isolado, recombinante ou purificado | |
BR112012029517A2 (pt) | formulações de fragrância, métodos de fabricação e artigos compreendendo as mesmas. | |
CO7111276A2 (es) | Compuestos de 3,5 disustituido-3h imidazo[4,5-b] piridina y 3,5 disustituido - 3h-[1,2,3] triaolo [4,5-b] piridina novedosos como moduladores d proteínas cinasas c-met | |
AU2016219704A1 (en) | Anti-Notch1 antibodies | |
BR112014026740A2 (pt) | anticorpo, composição, métodos para tratar um mamífero e para fornecer um anticorpo com adcc realçada, e, uso de um anticorpo | |
AR088920A1 (es) | Purificacion de anticuerpos anti-c-met | |
EA201590887A1 (ru) | Композиция | |
MX2013008702A (es) | Composiciones que contienen anticuerpos glicosilados y sus usos. | |
BR112014009866A2 (pt) | formulações de anticorpos e métodos | |
CO6741218A2 (es) | Composición pesticida y procesos relacionados con el mismo |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2661 DE 04-01-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |