BR112014020015A8 - Citômetro de fluxo com microscópio digital holográfico - Google Patents
Citômetro de fluxo com microscópio digital holográficoInfo
- Publication number
- BR112014020015A8 BR112014020015A8 BR112014020015A BR112014020015A BR112014020015A8 BR 112014020015 A8 BR112014020015 A8 BR 112014020015A8 BR 112014020015 A BR112014020015 A BR 112014020015A BR 112014020015 A BR112014020015 A BR 112014020015A BR 112014020015 A8 BR112014020015 A8 BR 112014020015A8
- Authority
- BR
- Brazil
- Prior art keywords
- objects
- fluid system
- dhm
- flow
- liquid sample
- Prior art date
Links
- 239000012530 fluid Substances 0.000 abstract 5
- 239000007788 liquid Substances 0.000 abstract 4
- 238000000684 flow cytometry Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000005286 illumination Methods 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 238000005305 interferometry Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1404—Handling flow, e.g. hydrodynamic focusing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
- G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
- G03H1/0005—Adaptation of holography to specific applications
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
- G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
- G03H1/04—Processes or apparatus for producing holograms
- G03H1/0443—Digital holography, i.e. recording holograms with digital recording means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1404—Handling flow, e.g. hydrodynamic focusing
- G01N2015/1415—Control of particle position
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
- G01N2015/144—Imaging characterised by its optical setup
- G01N2015/1445—Three-dimensional imaging, imaging in different image planes, e.g. under different angles or at different depths, e.g. by a relative motion of sample and detector, for instance by tomography
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
- G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
- G03H1/0005—Adaptation of holography to specific applications
- G03H2001/0033—Adaptation of holography to specific applications in hologrammetry for measuring or analysing
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
- G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
- G03H1/0005—Adaptation of holography to specific applications
- G03H2001/005—Adaptation of holography to specific applications in microscopy, e.g. digital holographic microscope [DHM]
Landscapes
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Computing Systems (AREA)
- Theoretical Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12155139.4A EP2626686A1 (en) | 2012-02-13 | 2012-02-13 | Flow cytometer with digital holographic microscope |
| PCT/EP2013/052852 WO2013120886A1 (en) | 2012-02-13 | 2013-02-13 | Flow cytometer with digital holographic microscope |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112014020015A2 BR112014020015A2 (https=) | 2017-06-20 |
| BR112014020015A8 true BR112014020015A8 (pt) | 2017-07-11 |
Family
ID=47683774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014020015A BR112014020015A8 (pt) | 2012-02-13 | 2013-02-13 | Citômetro de fluxo com microscópio digital holográfico |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10578541B2 (https=) |
| EP (2) | EP2626686A1 (https=) |
| JP (1) | JP2015510592A (https=) |
| CN (1) | CN104204767A (https=) |
| AU (1) | AU2013220469A1 (https=) |
| BR (1) | BR112014020015A8 (https=) |
| CA (1) | CA2864390A1 (https=) |
| HK (1) | HK1205257A1 (https=) |
| IN (1) | IN2014DN07589A (https=) |
| RU (1) | RU2014137177A (https=) |
| WO (1) | WO2013120886A1 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2594334A1 (en) | 2011-11-21 | 2013-05-22 | Drive O2 | Sample vial for digital holographic analysis of a liquid cell sample |
| CN108107197B (zh) | 2011-07-19 | 2020-05-08 | 奥维茨奥成像系统公司 | 用于检测和/或分类细胞样品中的癌细胞的方法和系统 |
| EP2626686A1 (en) | 2012-02-13 | 2013-08-14 | Ovizio Imaging Systems NV/SA | Flow cytometer with digital holographic microscope |
| EP2898310B1 (en) * | 2012-09-20 | 2019-05-01 | Ovizio Imaging Systems NV/SA | Digital holographic microscope with fluid systems |
| WO2015127043A1 (en) | 2014-02-24 | 2015-08-27 | Rambus Inc. | Optical flow sensing and pattern recognition with antisymmetric phase gratings |
| DE102014205535A1 (de) * | 2014-03-25 | 2015-10-01 | Siemens Aktiengesellschaft | Vorrichtung und in-vitro Verfahren zur markierungsfreien Darstellung und Analyse von Zellen und Kristallen in einer biologischen Probe |
| EP3175302B1 (en) | 2014-08-01 | 2021-12-29 | The Regents of the University of California | Device and method for iterative phase recovery based on pixel super-resolved on-chip holography |
| CN107532990B (zh) * | 2015-05-12 | 2021-11-12 | 芯片生物技术株式会社 | 单一粒子解析方法及用于该解析的系统 |
| JP6713730B2 (ja) | 2015-05-20 | 2020-06-24 | シスメックス株式会社 | 細胞検出装置および細胞検出方法 |
| WO2017048960A1 (en) * | 2015-09-18 | 2017-03-23 | New York University | Holographic detection and characterization of large impurity particles in precision slurries |
| FR3046238B1 (fr) * | 2015-12-24 | 2018-01-26 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Procede d’observation d’un echantillon par imagerie sans lentille |
| EP3196631A1 (en) | 2016-01-19 | 2017-07-26 | Ovizio Imaging Systems NV/SA | Digital holographic microscope with electro-fluidic system, said electro-fluidic system and methods of use |
| WO2017141063A1 (en) * | 2016-02-17 | 2017-08-24 | Waterscope International Zrt. | Digital holographic automatic microscope with through flowing cell |
| EP3535056B1 (en) * | 2016-11-07 | 2024-12-11 | Cytochip Inc. | Fluidic cartridge for cytometry and additional analysis |
| CN110199186B (zh) * | 2016-11-22 | 2023-01-10 | 芯易诊有限公司 | 全血细胞计数测量方法 |
| US11092532B2 (en) | 2017-06-23 | 2021-08-17 | Texas Tech University System | Method and device for label-free, high throughput holographic screening and enumeration of tumor cells in blood |
| ES2822915T3 (es) * | 2017-12-11 | 2021-05-05 | Uponor Oyj | Detección de objetos microscópicos en fluidos |
| EP3537150A1 (en) * | 2018-03-09 | 2019-09-11 | Siemens Healthcare Diagnostics Inc. | Method for detecting a dengue virus infection |
| BE1026111B1 (nl) | 2018-03-15 | 2019-10-16 | Ovizio Imaging Systems Nv | Digitale holografische microscopie voor het bepalen van de status van een virale infectie |
| WO2019175386A1 (en) * | 2018-03-15 | 2019-09-19 | Ovizio Imaging Systems NV/SA | Digital holographic microscopy for determining a viral infection status |
| BR112021000339A2 (pt) * | 2018-07-10 | 2021-04-06 | Gerrit Jan Van Den Engh | Sistema, aparelho e método para iluminação fora do eixo em citometria de fluxo |
| US11879830B2 (en) | 2018-09-28 | 2024-01-23 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Quantitative large area binding sensor for detecting biomarkers |
| JP7270907B2 (ja) * | 2019-02-27 | 2023-05-11 | 国立大学法人浜松医科大学 | 細胞観察システムおよび細胞観察方法 |
| JP7026853B2 (ja) | 2019-06-28 | 2022-02-28 | 富士フイルム株式会社 | 画像処理装置、評価システム、画像処理プログラム及び画像処理方法 |
| KR20220073738A (ko) | 2019-08-30 | 2022-06-03 | 주노 쎄러퓨티크스 인코퍼레이티드 | 세포 분류를 위한 기계 학습 방법 |
| JP6745559B1 (ja) * | 2020-03-24 | 2020-08-26 | 株式会社Ｃｙｂｏ | イメージングフローサイトメーター、ソート方法、及びキャリブレーション方法 |
| CN111521547A (zh) * | 2020-05-13 | 2020-08-11 | 洹仪科技(上海)有限公司 | 一种颗粒分析分选装置及方法 |
| JP7042301B2 (ja) * | 2020-06-04 | 2022-03-25 | シスメックス株式会社 | 細胞検出方法 |
| CN111879685B (zh) * | 2020-07-31 | 2022-03-18 | 上海微电子装备（集团）股份有限公司 | 一种颗粒分析分选装置及充电延时设置方法 |
| WO2022032074A1 (en) * | 2020-08-07 | 2022-02-10 | The Regents Of The University Of California | Simple in-line digital holography system for measuring 3d cell shape |
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| EP2626686A1 (en) | 2012-02-13 | 2013-08-14 | Ovizio Imaging Systems NV/SA | Flow cytometer with digital holographic microscope |
| CN202808799U (zh) | 2012-09-14 | 2013-03-20 | 江苏嘉语生物医药技术有限公司 | 一种可控氧环境的微生物培养检测装置 |
| EP2898310B1 (en) | 2012-09-20 | 2019-05-01 | Ovizio Imaging Systems NV/SA | Digital holographic microscope with fluid systems |
| US9675974B2 (en) | 2013-07-31 | 2017-06-13 | Ovizio Imaging Systems NV/SA | Cap for monitoring objects in suspension |
| EP3196631A1 (en) | 2016-01-19 | 2017-07-26 | Ovizio Imaging Systems NV/SA | Digital holographic microscope with electro-fluidic system, said electro-fluidic system and methods of use |
-
2012
- 2012-02-13 EP EP12155139.4A patent/EP2626686A1/en not_active Withdrawn
-
2013
- 2013-02-03 US US14/378,234 patent/US10578541B2/en active Active
- 2013-02-13 IN IN7589DEN2014 patent/IN2014DN07589A/en unknown
- 2013-02-13 EP EP13703623.2A patent/EP2815227A1/en not_active Ceased
- 2013-02-13 RU RU2014137177A patent/RU2014137177A/ru unknown
- 2013-02-13 CA CA2864390A patent/CA2864390A1/en not_active Abandoned
- 2013-02-13 HK HK15105675.4A patent/HK1205257A1/xx unknown
- 2013-02-13 BR BR112014020015A patent/BR112014020015A8/pt not_active IP Right Cessation
- 2013-02-13 JP JP2014557021A patent/JP2015510592A/ja active Pending
- 2013-02-13 WO PCT/EP2013/052852 patent/WO2013120886A1/en not_active Ceased
- 2013-02-13 AU AU2013220469A patent/AU2013220469A1/en not_active Abandoned
- 2013-02-13 CN CN201380018427.8A patent/CN104204767A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20150056607A1 (en) | 2015-02-26 |
| RU2014137177A (ru) | 2016-04-10 |
| CA2864390A1 (en) | 2013-08-22 |
| US10578541B2 (en) | 2020-03-03 |
| AU2013220469A1 (en) | 2014-09-11 |
| BR112014020015A2 (https=) | 2017-06-20 |
| JP2015510592A (ja) | 2015-04-09 |
| WO2013120886A1 (en) | 2013-08-22 |
| CN104204767A (zh) | 2014-12-10 |
| EP2815227A1 (en) | 2014-12-24 |
| IN2014DN07589A (https=) | 2015-04-24 |
| HK1205257A1 (en) | 2015-12-11 |
| EP2626686A1 (en) | 2013-08-14 |
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