BR112014020015A8 - Citômetro de fluxo com microscópio digital holográfico - Google Patents

Citômetro de fluxo com microscópio digital holográfico

Info

Publication number
BR112014020015A8
BR112014020015A8 BR112014020015A BR112014020015A BR112014020015A8 BR 112014020015 A8 BR112014020015 A8 BR 112014020015A8 BR 112014020015 A BR112014020015 A BR 112014020015A BR 112014020015 A BR112014020015 A BR 112014020015A BR 112014020015 A8 BR112014020015 A8 BR 112014020015A8
Authority
BR
Brazil
Prior art keywords
objects
fluid system
dhm
flow
liquid sample
Prior art date
Application number
BR112014020015A
Other languages
English (en)
Other versions
BR112014020015A2 (pt
Inventor
Jooris Serge
Mathuis Philip
Original Assignee
Ovizio Imaging Systems NV/SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ovizio Imaging Systems NV/SA filed Critical Ovizio Imaging Systems NV/SA
Publication of BR112014020015A2 publication Critical patent/BR112014020015A2/pt
Publication of BR112014020015A8 publication Critical patent/BR112014020015A8/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/0005—Adaptation of holography to specific applications
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/04—Processes or apparatus for producing holograms
    • G03H1/0443—Digital holography, i.e. recording holograms with digital recording means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G01N2015/1415—Control of particle position
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N2015/144—Imaging characterised by its optical setup
    • G01N2015/1445—Three-dimensional imaging, imaging in different image planes, e.g. under different angles or at different depths, e.g. by a relative motion of sample and detector, for instance by tomography
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/0005—Adaptation of holography to specific applications
    • G03H2001/0033—Adaptation of holography to specific applications in hologrammetry for measuring or analysing
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/0005—Adaptation of holography to specific applications
    • G03H2001/005—Adaptation of holography to specific applications in microscopy, e.g. digital holographic microscope [DHM]

Landscapes

  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Computing Systems (AREA)
  • Theoretical Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

SISTEMA E MÉTODO DE CITOMETRIA DE FLUXO PARA A OBSERVAÇÃO, ANÁLISE E / OU SEPARAÇÃO DE OBJETOS NUMA AMOSTRA LÍQUIDA. A presente invenção diz respeito a um sistema de citometria de fluxo e um método para a observação, análise e / ou separação de objetos numa amostra líquida, compreendendo um microscópio holográfico digital (DHM) e, pelo menos, um sistema de fluidos, pelo que o DHM compreende meios de iluminação, um sistema de interferometria e meios de gravação digital, pelo que o sistema de fluidos é capaz de guiar os referidos objetos através de um feixe de iluminação dos meios de iluminação do referido DHM, pelo que o sistema de fluidos compreende um mecanismo para a indução de um fluxo de amostra de líquido através do sistema de fluidos, em que de preferência o sistema de fluidos compreende um dispositivo de controle de volume de fluxo, de preferência o dispositivo de controle de volume de fluxo sendo capaz de alinhar de alinhar os objetos, um a um ou vários objetos um de cada vez no fluxo de amostra de líquido.
BR112014020015A 2012-02-13 2013-02-13 Citômetro de fluxo com microscópio digital holográfico BR112014020015A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12155139.4A EP2626686A1 (en) 2012-02-13 2012-02-13 Flow cytometer with digital holographic microscope
PCT/EP2013/052852 WO2013120886A1 (en) 2012-02-13 2013-02-13 Flow cytometer with digital holographic microscope

Publications (2)

Publication Number Publication Date
BR112014020015A2 BR112014020015A2 (pt) 2017-06-20
BR112014020015A8 true BR112014020015A8 (pt) 2017-07-11

Family

ID=47683774

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014020015A BR112014020015A8 (pt) 2012-02-13 2013-02-13 Citômetro de fluxo com microscópio digital holográfico

Country Status (11)

Country Link
US (1) US10578541B2 (pt)
EP (2) EP2626686A1 (pt)
JP (1) JP2015510592A (pt)
CN (1) CN104204767A (pt)
AU (1) AU2013220469A1 (pt)
BR (1) BR112014020015A8 (pt)
CA (1) CA2864390A1 (pt)
HK (1) HK1205257A1 (pt)
IN (1) IN2014DN07589A (pt)
RU (1) RU2014137177A (pt)
WO (1) WO2013120886A1 (pt)

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Also Published As

Publication number Publication date
CA2864390A1 (en) 2013-08-22
IN2014DN07589A (pt) 2015-04-24
EP2815227A1 (en) 2014-12-24
HK1205257A1 (en) 2015-12-11
US10578541B2 (en) 2020-03-03
AU2013220469A1 (en) 2014-09-11
US20150056607A1 (en) 2015-02-26
CN104204767A (zh) 2014-12-10
WO2013120886A1 (en) 2013-08-22
BR112014020015A2 (pt) 2017-06-20
EP2626686A1 (en) 2013-08-14
JP2015510592A (ja) 2015-04-09
RU2014137177A (ru) 2016-04-10

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