BR112014020015A8 - Citômetro de fluxo com microscópio digital holográfico - Google Patents
Citômetro de fluxo com microscópio digital holográficoInfo
- Publication number
- BR112014020015A8 BR112014020015A8 BR112014020015A BR112014020015A BR112014020015A8 BR 112014020015 A8 BR112014020015 A8 BR 112014020015A8 BR 112014020015 A BR112014020015 A BR 112014020015A BR 112014020015 A BR112014020015 A BR 112014020015A BR 112014020015 A8 BR112014020015 A8 BR 112014020015A8
- Authority
- BR
- Brazil
- Prior art keywords
- objects
- fluid system
- dhm
- flow
- liquid sample
- Prior art date
Links
- 239000012530 fluid Substances 0.000 abstract 5
- 239000007788 liquid Substances 0.000 abstract 4
- 238000000684 flow cytometry Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000005286 illumination Methods 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 238000005305 interferometry Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1404—Handling flow, e.g. hydrodynamic focusing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
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- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
- G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
- G03H1/0005—Adaptation of holography to specific applications
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
- G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
- G03H1/04—Processes or apparatus for producing holograms
- G03H1/0443—Digital holography, i.e. recording holograms with digital recording means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1404—Handling flow, e.g. hydrodynamic focusing
- G01N2015/1415—Control of particle position
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
- G01N2015/144—Imaging characterised by its optical setup
- G01N2015/1445—Three-dimensional imaging, imaging in different image planes, e.g. under different angles or at different depths, e.g. by a relative motion of sample and detector, for instance by tomography
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
- G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
- G03H1/0005—Adaptation of holography to specific applications
- G03H2001/0033—Adaptation of holography to specific applications in hologrammetry for measuring or analysing
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
- G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
- G03H1/0005—Adaptation of holography to specific applications
- G03H2001/005—Adaptation of holography to specific applications in microscopy, e.g. digital holographic microscope [DHM]
Landscapes
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Computing Systems (AREA)
- Theoretical Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
SISTEMA E MÉTODO DE CITOMETRIA DE FLUXO PARA A OBSERVAÇÃO, ANÁLISE E / OU SEPARAÇÃO DE OBJETOS NUMA AMOSTRA LÍQUIDA. A presente invenção diz respeito a um sistema de citometria de fluxo e um método para a observação, análise e / ou separação de objetos numa amostra líquida, compreendendo um microscópio holográfico digital (DHM) e, pelo menos, um sistema de fluidos, pelo que o DHM compreende meios de iluminação, um sistema de interferometria e meios de gravação digital, pelo que o sistema de fluidos é capaz de guiar os referidos objetos através de um feixe de iluminação dos meios de iluminação do referido DHM, pelo que o sistema de fluidos compreende um mecanismo para a indução de um fluxo de amostra de líquido através do sistema de fluidos, em que de preferência o sistema de fluidos compreende um dispositivo de controle de volume de fluxo, de preferência o dispositivo de controle de volume de fluxo sendo capaz de alinhar de alinhar os objetos, um a um ou vários objetos um de cada vez no fluxo de amostra de líquido.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12155139.4A EP2626686A1 (en) | 2012-02-13 | 2012-02-13 | Flow cytometer with digital holographic microscope |
PCT/EP2013/052852 WO2013120886A1 (en) | 2012-02-13 | 2013-02-13 | Flow cytometer with digital holographic microscope |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112014020015A2 BR112014020015A2 (pt) | 2017-06-20 |
BR112014020015A8 true BR112014020015A8 (pt) | 2017-07-11 |
Family
ID=47683774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014020015A BR112014020015A8 (pt) | 2012-02-13 | 2013-02-13 | Citômetro de fluxo com microscópio digital holográfico |
Country Status (11)
Country | Link |
---|---|
US (1) | US10578541B2 (pt) |
EP (2) | EP2626686A1 (pt) |
JP (1) | JP2015510592A (pt) |
CN (1) | CN104204767A (pt) |
AU (1) | AU2013220469A1 (pt) |
BR (1) | BR112014020015A8 (pt) |
CA (1) | CA2864390A1 (pt) |
HK (1) | HK1205257A1 (pt) |
IN (1) | IN2014DN07589A (pt) |
RU (1) | RU2014137177A (pt) |
WO (1) | WO2013120886A1 (pt) |
Families Citing this family (29)
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EP2594334A1 (en) | 2011-11-21 | 2013-05-22 | Drive O2 | Sample vial for digital holographic analysis of a liquid cell sample |
BR112014001238A2 (pt) | 2011-07-19 | 2017-06-13 | Ovizio Imaging Systems N V | método para a detecção de células cancerosas e/ou classificação de células numa amostra de células de líquido; sistema para a detecção de células e/ou a classificação de células cancerosas numa amostra de células; método de atualização e/ou melhoria de uma base de dados que compreende os limiares ligados á informação holográfica; e base de dados de objetos |
EP2626686A1 (en) | 2012-02-13 | 2013-08-14 | Ovizio Imaging Systems NV/SA | Flow cytometer with digital holographic microscope |
EP2898310B1 (en) | 2012-09-20 | 2019-05-01 | Ovizio Imaging Systems NV/SA | Digital holographic microscope with fluid systems |
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EP3175302B1 (en) * | 2014-08-01 | 2021-12-29 | The Regents of the University of California | Device and method for iterative phase recovery based on pixel super-resolved on-chip holography |
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JP7270907B2 (ja) * | 2019-02-27 | 2023-05-11 | 国立大学法人浜松医科大学 | 細胞観察システムおよび細胞観察方法 |
JP7026853B2 (ja) * | 2019-06-28 | 2022-02-28 | 富士フイルム株式会社 | 画像処理装置、評価システム、画像処理プログラム及び画像処理方法 |
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BR112014001238A2 (pt) | 2011-07-19 | 2017-06-13 | Ovizio Imaging Systems N V | método para a detecção de células cancerosas e/ou classificação de células numa amostra de células de líquido; sistema para a detecção de células e/ou a classificação de células cancerosas numa amostra de células; método de atualização e/ou melhoria de uma base de dados que compreende os limiares ligados á informação holográfica; e base de dados de objetos |
WO2013010595A1 (en) | 2011-07-19 | 2013-01-24 | Ovizio Imaging Systems N.V. | An object database and object database improving method |
US20140195568A1 (en) | 2011-07-19 | 2014-07-10 | Ovizio Imaging Systems NV/SA | Object database and object database improving method |
US20140347672A1 (en) | 2011-07-29 | 2014-11-27 | Ecole Polytechnique Federale De Lausanne (Epfl) | Apparatus and method for quantitive phase tomography through linear scanning with coherent and non-coherent detection |
EP2602608B1 (en) * | 2011-12-07 | 2016-09-14 | Imec | Analysis and sorting of biological cells in flow |
EP2626686A1 (en) | 2012-02-13 | 2013-08-14 | Ovizio Imaging Systems NV/SA | Flow cytometer with digital holographic microscope |
CN202808799U (zh) | 2012-09-14 | 2013-03-20 | 江苏嘉语生物医药技术有限公司 | 一种可控氧环境的微生物培养检测装置 |
EP2898310B1 (en) | 2012-09-20 | 2019-05-01 | Ovizio Imaging Systems NV/SA | Digital holographic microscope with fluid systems |
EP3027723A1 (en) | 2013-07-31 | 2016-06-08 | Ovizio Imaging Systems NV/SA | Improved cap for monitoring objects in suspension |
EP3196631A1 (en) | 2016-01-19 | 2017-07-26 | Ovizio Imaging Systems NV/SA | Digital holographic microscope with electro-fluidic system, said electro-fluidic system and methods of use |
-
2012
- 2012-02-13 EP EP12155139.4A patent/EP2626686A1/en not_active Withdrawn
-
2013
- 2013-02-03 US US14/378,234 patent/US10578541B2/en active Active
- 2013-02-13 WO PCT/EP2013/052852 patent/WO2013120886A1/en active Application Filing
- 2013-02-13 JP JP2014557021A patent/JP2015510592A/ja active Pending
- 2013-02-13 EP EP13703623.2A patent/EP2815227A1/en not_active Ceased
- 2013-02-13 CN CN201380018427.8A patent/CN104204767A/zh active Pending
- 2013-02-13 IN IN7589DEN2014 patent/IN2014DN07589A/en unknown
- 2013-02-13 CA CA2864390A patent/CA2864390A1/en not_active Abandoned
- 2013-02-13 AU AU2013220469A patent/AU2013220469A1/en not_active Abandoned
- 2013-02-13 BR BR112014020015A patent/BR112014020015A8/pt not_active IP Right Cessation
- 2013-02-13 RU RU2014137177A patent/RU2014137177A/ru unknown
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2015
- 2015-06-16 HK HK15105675.4A patent/HK1205257A1/xx unknown
Also Published As
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JP2015510592A (ja) | 2015-04-09 |
AU2013220469A1 (en) | 2014-09-11 |
CN104204767A (zh) | 2014-12-10 |
RU2014137177A (ru) | 2016-04-10 |
EP2815227A1 (en) | 2014-12-24 |
EP2626686A1 (en) | 2013-08-14 |
US20150056607A1 (en) | 2015-02-26 |
IN2014DN07589A (pt) | 2015-04-24 |
HK1205257A1 (en) | 2015-12-11 |
CA2864390A1 (en) | 2013-08-22 |
WO2013120886A1 (en) | 2013-08-22 |
US10578541B2 (en) | 2020-03-03 |
BR112014020015A2 (pt) | 2017-06-20 |
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