BR112014017141A2 - método de tratamento de diabetes usando-se apolipoproteína a-iv não glicosilada - Google Patents
método de tratamento de diabetes usando-se apolipoproteína a-iv não glicosiladaInfo
- Publication number
- BR112014017141A2 BR112014017141A2 BR112014017141A BR112014017141A BR112014017141A2 BR 112014017141 A2 BR112014017141 A2 BR 112014017141A2 BR 112014017141 A BR112014017141 A BR 112014017141A BR 112014017141 A BR112014017141 A BR 112014017141A BR 112014017141 A2 BR112014017141 A2 BR 112014017141A2
- Authority
- BR
- Brazil
- Prior art keywords
- apolipoprotein
- unglycosylated
- methods
- individual
- expression system
- Prior art date
Links
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 4
- 102100037320 Apolipoprotein A-IV Human genes 0.000 title abstract 3
- 108010073614 apolipoprotein A-IV Proteins 0.000 title abstract 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 2
- 239000008103 glucose Substances 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 108010071619 Apolipoproteins Proteins 0.000 abstract 1
- 102000007592 Apolipoproteins Human genes 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 102000035122 glycosylated proteins Human genes 0.000 abstract 1
- 108091005608 glycosylated proteins Proteins 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Marine Sciences & Fisheries (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2012/021802 WO2012100010A1 (en) | 2011-01-19 | 2012-01-19 | Apolipoprotein aiv as an antidiabetic peptide |
| US201261675692P | 2012-07-25 | 2012-07-25 | |
| PCT/US2012/066314 WO2013109342A1 (en) | 2012-01-19 | 2012-11-21 | Method of treating diabetes using non-glycosylated apolipoprotein a-iv |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014017141A2 true BR112014017141A2 (pt) | 2019-09-24 |
Family
ID=48799573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014017141A BR112014017141A2 (pt) | 2012-01-19 | 2012-11-21 | método de tratamento de diabetes usando-se apolipoproteína a-iv não glicosilada |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9951120B2 (https=) |
| EP (1) | EP2804618B1 (https=) |
| JP (1) | JP6310398B2 (https=) |
| KR (1) | KR20140117565A (https=) |
| CN (1) | CN104066436B (https=) |
| AU (1) | AU2012366182B2 (https=) |
| BR (1) | BR112014017141A2 (https=) |
| CA (1) | CA2860782A1 (https=) |
| EA (1) | EA028230B1 (https=) |
| HK (1) | HK1203823A1 (https=) |
| IL (1) | IL233351A (https=) |
| MX (1) | MX357071B (https=) |
| WO (1) | WO2013109342A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9051394B2 (en) | 2011-01-19 | 2015-06-09 | University Of Cincinnati | Apolipoprotein AIV as an antidiabetic peptide |
| HK1203823A1 (en) | 2012-01-19 | 2015-11-06 | University Of Cincinnati | Method of treating diabetes using non-glycosylated apolipoprotein a-iv |
| WO2014018079A1 (en) | 2012-07-25 | 2014-01-30 | University Of Cincinnati | Method of treating hyperglycemic disorders using apoliprotein aiv |
| JP2015524808A (ja) * | 2012-07-25 | 2015-08-27 | ユニバーシティ・オブ・シンシナティ | アポリポタンパク質ａｉｖを用いたｉ型糖尿病の治療法 |
| US10138469B2 (en) * | 2014-06-23 | 2018-11-27 | Toagosei Co., Ltd. | Synthetic peptide and use thereof |
| CN112546201A (zh) * | 2019-09-26 | 2021-03-26 | 中国科学院生物物理研究所 | 人工脂蛋白颗粒apoA-Ⅳ脂肪体在治疗和/或预防糖尿病中的应用 |
| CN112891561A (zh) * | 2021-03-09 | 2021-06-04 | 百码科技(深圳)有限公司 | 一种基因治疗脂肪肝的生物药剂及其制备方法 |
| CN113018459A (zh) * | 2021-03-09 | 2021-06-25 | 百码科技(深圳)有限公司 | 一种基因治疗减肥的生物药剂及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
| FR2686605B1 (fr) * | 1992-01-27 | 1994-03-11 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides, leur preparation et leur utilisation. |
| AU7242394A (en) | 1993-05-28 | 1994-12-20 | Merck & Co., Inc. | Method to control appetite and treat obesity |
| US6729075B2 (en) * | 2000-10-19 | 2004-05-04 | Wenger Corporation | Audience seating system |
| BR0310100A (pt) | 2002-05-17 | 2007-04-27 | Esperion Therapeutics Inc | métodos para tratar, prevenir ou reduzir a lesão de reperfusão isquêmica em um tecido ou órgão, e para prevenir ou tratar de uma condição associada com a privação de oxigênio, seguida por suprimento de oxigênio aumentado a um tecido ou órgão em necessidade disto |
| EP2051725A4 (en) * | 2006-07-11 | 2011-06-15 | Harkness Pharmaceuticals Inc | METHOD FOR THE TREATMENT OF GRAIN WITH SATURATION FACTORS |
| US20100267052A1 (en) | 2006-09-01 | 2010-10-21 | American Type Culture Collection | Compositions and methods for diagnosis and treatment of type 2 diabetes |
| EP2257814B1 (en) | 2008-03-21 | 2012-08-29 | Podiceps B.v. | Diagnostic of pre-symptomatic metabolic syndrome |
| CN103833712B (zh) | 2008-11-28 | 2016-02-03 | 中国医学科学院药物研究所 | 硝克柳胺化合物晶ii型、其制法和其药物组合物与用途 |
| BR112013004396A2 (pt) * | 2010-08-30 | 2016-05-17 | Hoffmann La Roche | alimentação alcalina |
| US9051394B2 (en) | 2011-01-19 | 2015-06-09 | University Of Cincinnati | Apolipoprotein AIV as an antidiabetic peptide |
| HK1203823A1 (en) | 2012-01-19 | 2015-11-06 | University Of Cincinnati | Method of treating diabetes using non-glycosylated apolipoprotein a-iv |
| WO2014018079A1 (en) | 2012-07-25 | 2014-01-30 | University Of Cincinnati | Method of treating hyperglycemic disorders using apoliprotein aiv |
| JP2015524808A (ja) | 2012-07-25 | 2015-08-27 | ユニバーシティ・オブ・シンシナティ | アポリポタンパク質ａｉｖを用いたｉ型糖尿病の治療法 |
-
2012
- 2012-11-21 HK HK15104317.1A patent/HK1203823A1/xx unknown
- 2012-11-21 MX MX2014008829A patent/MX357071B/es active IP Right Grant
- 2012-11-21 EP EP12795976.5A patent/EP2804618B1/en active Active
- 2012-11-21 JP JP2014553292A patent/JP6310398B2/ja not_active Expired - Fee Related
- 2012-11-21 AU AU2012366182A patent/AU2012366182B2/en not_active Expired - Fee Related
- 2012-11-21 EA EA201491369A patent/EA028230B1/ru not_active IP Right Cessation
- 2012-11-21 US US14/373,259 patent/US9951120B2/en active Active
- 2012-11-21 CN CN201280067554.2A patent/CN104066436B/zh not_active Expired - Fee Related
- 2012-11-21 CA CA2860782A patent/CA2860782A1/en not_active Abandoned
- 2012-11-21 BR BR112014017141A patent/BR112014017141A2/pt not_active IP Right Cessation
- 2012-11-21 KR KR1020147023031A patent/KR20140117565A/ko not_active Withdrawn
- 2012-11-21 WO PCT/US2012/066314 patent/WO2013109342A1/en not_active Ceased
-
2014
- 2014-06-24 IL IL233351A patent/IL233351A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EA201491369A1 (ru) | 2015-03-31 |
| MX357071B (es) | 2018-06-22 |
| KR20140117565A (ko) | 2014-10-07 |
| US9951120B2 (en) | 2018-04-24 |
| WO2013109342A1 (en) | 2013-07-25 |
| CN104066436B (zh) | 2016-12-14 |
| EP2804618B1 (en) | 2018-03-07 |
| AU2012366182A8 (en) | 2015-06-18 |
| EA028230B1 (ru) | 2017-10-31 |
| WO2013109342A8 (en) | 2014-09-04 |
| AU2012366182A1 (en) | 2014-08-07 |
| MX2014008829A (es) | 2014-10-24 |
| CN104066436A (zh) | 2014-09-24 |
| EP2804618A1 (en) | 2014-11-26 |
| IL233351A0 (en) | 2014-08-31 |
| JP2015506942A (ja) | 2015-03-05 |
| AU2012366182B2 (en) | 2017-08-17 |
| US20150011469A1 (en) | 2015-01-08 |
| HK1203823A1 (en) | 2015-11-06 |
| JP6310398B2 (ja) | 2018-04-11 |
| IL233351A (en) | 2016-12-29 |
| CA2860782A1 (en) | 2013-07-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |