BR112014010479A2 - composto, método para preparar um composto, método para a preparação de icotinib a partir de um composto e método para a preparação de cloridrato de icotinib a partir de um composto - Google Patents
composto, método para preparar um composto, método para a preparação de icotinib a partir de um composto e método para a preparação de cloridrato de icotinib a partir de um compostoInfo
- Publication number
- BR112014010479A2 BR112014010479A2 BR112014010479A BR112014010479A BR112014010479A2 BR 112014010479 A2 BR112014010479 A2 BR 112014010479A2 BR 112014010479 A BR112014010479 A BR 112014010479A BR 112014010479 A BR112014010479 A BR 112014010479A BR 112014010479 A2 BR112014010479 A2 BR 112014010479A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- preparing
- icotinib
- hydrochloride
- preparing icotinib
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D325/00—Heterocyclic compounds containing rings having oxygen as the only ring hetero atom according to more than one of groups C07D303/00 - C07D323/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011081586 | 2011-10-31 | ||
| PCT/CN2012/087802 WO2013064128A1 (zh) | 2011-10-31 | 2012-12-28 | 埃克替尼和盐酸埃克替尼的制备方法及其中间体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014010479A2 true BR112014010479A2 (pt) | 2017-04-25 |
Family
ID=48191387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014010479A BR112014010479A2 (pt) | 2011-10-31 | 2012-12-28 | composto, método para preparar um composto, método para a preparação de icotinib a partir de um composto e método para a preparação de cloridrato de icotinib a partir de um composto |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9085588B2 (pt) |
| EP (1) | EP2796461B1 (pt) |
| CN (2) | CN104024262B (pt) |
| AU (1) | AU2012331547C1 (pt) |
| BR (1) | BR112014010479A2 (pt) |
| CA (1) | CA2854083C (pt) |
| ES (1) | ES2641953T3 (pt) |
| HK (1) | HK1213894A1 (pt) |
| IN (1) | IN2014MN00842A (pt) |
| SG (1) | SG11201401953WA (pt) |
| WO (1) | WO2013064128A1 (pt) |
| ZA (1) | ZA201403858B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201401953WA (en) * | 2011-10-31 | 2014-09-26 | Betta Pharmaceuticals Co Ltd | Methods of preparing icotinib and icotinib hydrochloride, and intermediates thereof |
| BR112015030591B1 (pt) | 2013-06-09 | 2022-09-13 | Betta Pharmaceuticals Co., Ltd | Formas de polimorfos de maleato de icotinib, processo de preparação das referidas formas, composição farmacêutica e usos das mesmas |
| CN104470526B (zh) * | 2013-06-09 | 2016-07-13 | 贝达药业股份有限公司 | 埃克替尼磷酸盐的晶型及其用途 |
| JP6216869B2 (ja) | 2013-06-09 | 2017-10-18 | ベータ ファーマシューティカルズ カンパニー リミテッド | イコチニブの多形及びその使用 |
| CN104487443B (zh) * | 2013-06-09 | 2016-03-23 | 贝达药业股份有限公司 | 埃克替尼马来酸盐的晶型及其用途 |
| AU2014280710B2 (en) * | 2013-06-09 | 2016-12-22 | Betta Pharmaceuticals Co., Ltd | New polymorphic forms of Icotinib phosphate and uses thereof |
| CN104470929B (zh) * | 2013-06-09 | 2018-11-30 | 贝达药业股份有限公司 | 埃克替尼的晶型及其应用 |
| CN103724376A (zh) * | 2013-12-31 | 2014-04-16 | 同济大学 | 新型潜在抗肿瘤药物铂配合物及其制备方法 |
| WO2021094379A1 (en) | 2019-11-12 | 2021-05-20 | Astrazeneca Ab | Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer |
| EP4093394A1 (en) | 2020-01-20 | 2022-11-30 | Astrazeneca AB | Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer |
| CN111763214B (zh) * | 2020-08-10 | 2022-03-15 | 苏州富士莱医药股份有限公司 | 一种埃克替尼的制备方法 |
| CN114276324A (zh) * | 2021-12-31 | 2022-04-05 | 浙江拓普药业股份有限公司 | 一种埃克替尼中间体的制备方法及其应用 |
| WO2023187037A1 (en) | 2022-03-31 | 2023-10-05 | Astrazeneca Ab | Epidermal growth factor receptor (egfr) tyrosine kinase inhibitors in combination with an akt inhibitor for the treatment of cancer |
| WO2024002938A1 (en) | 2022-06-27 | 2024-01-04 | Astrazeneca Ab | Combinations involving epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7078409B2 (en) * | 2002-03-28 | 2006-07-18 | Beta Pharma, Inc. | Fused quinazoline derivatives useful as tyrosine kinase inhibitors |
| CN1305468C (zh) | 2003-05-29 | 2007-03-21 | 中国人民解放军第三○二医院 | 波棱素化合物及其制法和其药物组合物与用途 |
| WO2007138613A2 (en) * | 2006-05-25 | 2007-12-06 | Vittal Mallya Scientific Research Foundation | A process for synthesis of [6,7-bis-(2-methoxyethoxy)-quinazolin-4-yl]-(3-ethynylphenyl)amine hydrochloride |
| NZ590334A (en) | 2008-07-08 | 2012-12-21 | Beta Pharma Inc | ICOTINIB HYDROCHLORIDE (4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crownquinazoline hydrochloride), SYNTHESIS, CRYSTALLOGRAPHIC FORM, MEDICAL COMBINATION, AND USES THEREOF |
| US9242991B2 (en) * | 2010-07-14 | 2016-01-26 | Betta Pharmaceuticals Co., Ltd | Substituted fused heterocycles as c-Met tyrosine kinase inhibitors |
| SG11201401953WA (en) * | 2011-10-31 | 2014-09-26 | Betta Pharmaceuticals Co Ltd | Methods of preparing icotinib and icotinib hydrochloride, and intermediates thereof |
-
2012
- 2012-12-28 SG SG11201401953WA patent/SG11201401953WA/en unknown
- 2012-12-28 IN IN842MUN2014 patent/IN2014MN00842A/en unknown
- 2012-12-28 BR BR112014010479A patent/BR112014010479A2/pt not_active Application Discontinuation
- 2012-12-28 EP EP12846055.7A patent/EP2796461B1/en active Active
- 2012-12-28 AU AU2012331547A patent/AU2012331547C1/en active Active
- 2012-12-28 CN CN201280055394.XA patent/CN104024262B/zh active Active
- 2012-12-28 US US14/355,142 patent/US9085588B2/en active Active
- 2012-12-28 WO PCT/CN2012/087802 patent/WO2013064128A1/zh active Application Filing
- 2012-12-28 CN CN201510388082.6A patent/CN105237510A/zh active Pending
- 2012-12-28 ES ES12846055.7T patent/ES2641953T3/es active Active
- 2012-12-28 CA CA2854083A patent/CA2854083C/en active Active
-
2014
- 2014-05-27 ZA ZA2014/03858A patent/ZA201403858B/en unknown
-
2016
- 2016-02-22 HK HK16101929.6A patent/HK1213894A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US9085588B2 (en) | 2015-07-21 |
| CA2854083A1 (en) | 2013-05-10 |
| AU2012331547C1 (en) | 2016-04-21 |
| HK1213894A1 (zh) | 2016-07-15 |
| EP2796461B1 (en) | 2017-09-06 |
| WO2013064128A1 (zh) | 2013-05-10 |
| AU2012331547A1 (en) | 2014-05-29 |
| AU2012331547B2 (en) | 2015-07-16 |
| ES2641953T3 (es) | 2017-11-14 |
| IN2014MN00842A (pt) | 2015-07-03 |
| EP2796461A1 (en) | 2014-10-29 |
| US20140343283A1 (en) | 2014-11-20 |
| CA2854083C (en) | 2016-12-13 |
| EP2796461A4 (en) | 2015-05-27 |
| CN105237510A (zh) | 2016-01-13 |
| ZA201403858B (en) | 2015-12-23 |
| CN104024262A (zh) | 2014-09-03 |
| SG11201401953WA (en) | 2014-09-26 |
| CN104024262B (zh) | 2017-03-22 |
| RU2014121337A (ru) | 2015-12-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112014010479A2 (pt) | composto, método para preparar um composto, método para a preparação de icotinib a partir de um composto e método para a preparação de cloridrato de icotinib a partir de um composto | |
| BR112014003798A2 (pt) | método para fabricar um composto, e, composto | |
| CO7020928A2 (es) | Método para producir derivados 4,4- difluoro- 3,4- dihidroisoquinolina | |
| BR112014008603A2 (pt) | tablete, e, método para produzir um tablete | |
| BR112014007645A2 (pt) | composto heterocíclico, métodos para a preparação de um composto heterocíclico, e, composição farmacêutica | |
| BRPI0906906A2 (pt) | Método para preparar um composto e composto | |
| BR112014003503A2 (pt) | ferramenta para a formação de um recipiente a partir de uma blanqueta, método de formar um recipiente a partir de uma blanqueta, e recipiente | |
| BRPI0917196A2 (pt) | método para a preparação de um complexo, e, forma cristalina de um composto. | |
| BR112013022559A2 (pt) | cartão, e, método para fabricar um cartão | |
| DK2732131T3 (da) | Positioneringsfremgangsmåde | |
| BR112014015997A8 (pt) | método para produzir um sequestrante de sulfeto, sequestrante de sulfeto e método para a redução de sulfetos | |
| BR112014003111A2 (pt) | processo para preparar um composto de 1h-pirazol-5- carbonilcloreto n-substituído e processo para preparar um composto de sulfimina | |
| BR112013019076A2 (pt) | conjunto de peneira e um método para a respectiva construção | |
| BR112014011685A2 (pt) | composto, utilização de um composto e método | |
| BR112013008008A2 (pt) | composto, composição farmacêutica e processo para preparar um composto | |
| BR112014005310A2 (pt) | compósito fibroso, método para formar um compósito fibroso, e compósito | |
| BR112014014232A2 (pt) | composto e método para a preparação de um composto | |
| BR112013022749A2 (pt) | método para produzir um composto de cálcio-arsênico fracamente solúvel | |
| BR112013032690A2 (pt) | método para produzir um composto, composto, e, uso do mesmo | |
| BR112013031360A2 (pt) | método para produzir um composto, e, composto | |
| BR112014005307A2 (pt) | artigo resistente balístico, método para produzir um artigo resistente balístico | |
| BRPI1009816A2 (pt) | "método para preparar um composto." | |
| BR112014013188A2 (pt) | documento de segurança, e método para fabricar um documento de segurança | |
| BR112013007040A2 (pt) | "método para preparar um composto e composto" | |
| BR112014014291A2 (pt) | processo para preparar um catalisador |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B15I | Others concerning applications: loss of priority | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B12B | Appeal against refusal [chapter 12.2 patent gazette] |