BR112014006283A2 - novos derivados de dihidroquinolina-2-ona - Google Patents
novos derivados de dihidroquinolina-2-onaInfo
- Publication number
- BR112014006283A2 BR112014006283A2 BR112014006283A BR112014006283A BR112014006283A2 BR 112014006283 A2 BR112014006283 A2 BR 112014006283A2 BR 112014006283 A BR112014006283 A BR 112014006283A BR 112014006283 A BR112014006283 A BR 112014006283A BR 112014006283 A2 BR112014006283 A2 BR 112014006283A2
- Authority
- BR
- Brazil
- Prior art keywords
- derivatives
- compounds
- dihydroquinoline
- new
- new dihydroquinoline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
resumo novos derivados de dihidro quinolin a - 2 - on a a invenção fornece novos compostos t endo a fórmula geral (i) (i) a3a1nor1na2r6r3r2r4r5r7 em que r 1 , r 2 , r 3 , r 4 ¸ r 5 , r 6 , r 7 , a 1 , a 2 e a 3 são conforme 5 descrito no presente documento, composições inclu indo os compostos e métodos de uso dos compostos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2011/079673 | 2011-09-15 | ||
| CN2011079673 | 2011-09-15 | ||
| PCT/EP2012/067744 WO2013037779A1 (en) | 2011-09-15 | 2012-09-12 | New dihydroquinoline-2-one derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112014006283A2 true BR112014006283A2 (pt) | 2017-04-11 |
| BR112014006283B1 BR112014006283B1 (pt) | 2021-11-03 |
Family
ID=46829775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014006283-8A BR112014006283B1 (pt) | 2011-09-15 | 2012-09-12 | Novos derivados de dihidroquinolina-2-ona |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US9260408B2 (pt) |
| EP (2) | EP2755963B1 (pt) |
| JP (1) | JP6012735B2 (pt) |
| KR (1) | KR101785143B1 (pt) |
| CN (1) | CN103814021B (pt) |
| AR (1) | AR087901A1 (pt) |
| AU (1) | AU2012307509B2 (pt) |
| BR (1) | BR112014006283B1 (pt) |
| CA (1) | CA2846785C (pt) |
| CL (1) | CL2014000604A1 (pt) |
| CO (1) | CO6890099A2 (pt) |
| CR (1) | CR20140091A (pt) |
| DK (1) | DK2755963T3 (pt) |
| EA (1) | EA035757B1 (pt) |
| EC (1) | ECSP14013245A (pt) |
| ES (1) | ES2763332T3 (pt) |
| HR (1) | HRP20192323T1 (pt) |
| HU (1) | HUE047771T2 (pt) |
| IL (1) | IL231229A0 (pt) |
| LT (1) | LT2755963T (pt) |
| MX (1) | MX358376B (pt) |
| MY (1) | MY169043A (pt) |
| PE (1) | PE20141372A1 (pt) |
| PL (1) | PL2755963T3 (pt) |
| PT (1) | PT2755963T (pt) |
| RS (1) | RS59737B1 (pt) |
| SG (1) | SG11201400679WA (pt) |
| SI (1) | SI2755963T1 (pt) |
| TW (1) | TWI462914B (pt) |
| UA (1) | UA111626C2 (pt) |
| WO (1) | WO2013037779A1 (pt) |
| ZA (1) | ZA201401884B (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015020834A2 (pt) * | 2013-03-08 | 2017-07-18 | Hoffmann La Roche | novos derivados hidroquinolina-2-ona como inibidores de aldosterona sintetase (cyp1 1 b2 ou cyp1 1 b1) |
| WO2014160203A2 (en) | 2013-03-14 | 2014-10-02 | The Brigham And Women's Hospital, Inc. | Bmp inhibitors and methods of use thereof |
| CN105073732B (zh) * | 2013-03-14 | 2017-07-21 | 豪夫迈·罗氏有限公司 | 用作醛固酮合酶抑制剂的二氢喹啉‑2‑酮衍生物 |
| RU2015138961A (ru) * | 2013-03-14 | 2017-04-18 | Ф. Хоффманн-Ля Рош Аг | Производные дигидрохинолин-2-она для применения в качестве ингибиторов альдостеронсинтазы |
| WO2014179186A1 (en) * | 2013-04-30 | 2014-11-06 | Boehringer Ingelheim International Gmbh | Aldosterone synthase inhibitors |
| HUE046773T2 (hu) * | 2013-05-27 | 2020-03-30 | Hoffmann La Roche | Új 3,4-dihidro-2H-izokinolin-1-on és 2,3-dihidro-izoindol-1-on vegyületek |
| TWI642668B (zh) * | 2013-05-27 | 2018-12-01 | 赫孚孟拉羅股份公司 | 新穎３，４－二氫－２ｈ－異喹啉－１－酮及２，３－二氫異吲哚－１－酮化合物 |
| PL3004076T3 (pl) * | 2013-05-27 | 2020-04-30 | F.Hoffmann-La Roche Ag | Nowe związki 3,4-dihydro-2h-izochinolin-1-onowe i 2,3-dihydroizoindol-1-onowe |
| WO2015125858A1 (ja) * | 2014-02-24 | 2015-08-27 | 日本曹達株式会社 | ヘテロアリール化合物およびその用途 |
| JP2017514793A (ja) * | 2014-03-26 | 2017-06-08 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． | Ｂｍｐ阻害用組成物及びｂｍｐ阻害方法 |
| MY176401A (en) * | 2014-04-24 | 2020-08-05 | Mitsubishi Tanabe Pharma Corp | Novel disubstituted 1,2,4-triazine compound |
| WO2016011019A1 (en) | 2014-07-15 | 2016-01-21 | The Brigham And Women's Hospital, Inc. | Compositions and methods for inhibiting bmp |
| JP6622300B2 (ja) * | 2014-10-31 | 2019-12-18 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 新規なジヒドロキノリンピラゾリル化合物 |
| EP3212638B1 (en) | 2014-10-31 | 2019-11-20 | F.Hoffmann-La Roche Ag | New dihydroquinoline pyrazolyl compounds as aldosterone synthase inhibitors |
| CN106660998B (zh) * | 2014-10-31 | 2019-10-25 | 豪夫迈·罗氏有限公司 | 吡唑基-3,4-二氢喹啉-2-酮醛固酮合酶抑制剂 |
| MX2018002574A (es) | 2015-08-31 | 2019-02-25 | Dong A Socio Holdings Co Ltd | Compuestos heteroarilo y su uso como farmacos terapeuticos. |
| JP6314196B2 (ja) * | 2015-10-22 | 2018-04-18 | 田辺三菱製薬株式会社 | 医薬組成物 |
| EP3381904B1 (en) * | 2015-10-23 | 2021-07-28 | Mitsubishi Tanabe Pharma Corporation | Novel nitrogen-containing aromatic heterocyclic compound |
| ES2903528T3 (es) * | 2016-10-10 | 2022-04-04 | Dong A Socio Holdings Co Ltd | Compuestos de heteroarilo y su uso como inhibidores de MER |
| UA125524C2 (uk) * | 2016-12-08 | 2022-04-13 | Ф. Хоффманн-Ля Рош Аг | Ефірні похідні ізоксазолу як позитивні алостеричні модулятори рецептора гамк а альфа-5 |
| US11958818B2 (en) | 2019-05-01 | 2024-04-16 | Boehringer Ingelheim International Gmbh | (R)-(2-methyloxiran-2-yl)methyl 4-bromobenzenesulfonate |
| WO2023063851A1 (en) * | 2021-10-13 | 2023-04-20 | «Target Medicals» Limited Liability Company | Inhibitors of human aldosterone synthase (cyp11b2) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT79699B (en) * | 1983-12-22 | 1986-12-10 | Pfizer | Process for preparing quinolone inotropic agents |
| GB8334282D0 (en) * | 1983-12-22 | 1984-02-01 | Pfizer Ltd | Quinolone inotropic agents |
| CN85100796A (zh) * | 1985-04-01 | 1986-10-01 | 辉瑞公司 | 喹啉酮衍生物的制备方法 |
| FR2580646A1 (fr) * | 1985-04-19 | 1986-10-24 | Synthelabo | Derives de 2(1h)-quinolinone, leur preparation et leur application en therapeutique |
| US20080176830A1 (en) | 2005-04-14 | 2008-07-24 | Adams Nicholas D | Compounds, Compositions, and Methods |
| DE102008022221A1 (de) | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| ES2459468T3 (es) | 2009-05-15 | 2014-05-09 | Novartis Ag | Arilpiridinas como inhibidores de aldosterona sintasa |
| EP2430018B1 (en) | 2009-05-15 | 2013-07-03 | Novartis AG | Benzoxazolone derivatives as aldosterone symthase inhibitors |
| US8541404B2 (en) * | 2009-11-09 | 2013-09-24 | Elexopharm Gmbh | Inhibitors of the human aldosterone synthase CYP11B2 |
-
2012
- 2012-09-12 AU AU2012307509A patent/AU2012307509B2/en active Active
- 2012-09-12 ES ES12756741T patent/ES2763332T3/es active Active
- 2012-09-12 BR BR112014006283-8A patent/BR112014006283B1/pt active IP Right Grant
- 2012-09-12 CA CA2846785A patent/CA2846785C/en active Active
- 2012-09-12 MX MX2014002770A patent/MX358376B/es active IP Right Grant
- 2012-09-12 PT PT127567410T patent/PT2755963T/pt unknown
- 2012-09-12 LT LTEP12756741.0T patent/LT2755963T/lt unknown
- 2012-09-12 EA EA201490596A patent/EA035757B1/ru not_active IP Right Cessation
- 2012-09-12 KR KR1020147009761A patent/KR101785143B1/ko active IP Right Grant
- 2012-09-12 HU HUE12756741A patent/HUE047771T2/hu unknown
- 2012-09-12 SG SG11201400679WA patent/SG11201400679WA/en unknown
- 2012-09-12 WO PCT/EP2012/067744 patent/WO2013037779A1/en active Application Filing
- 2012-09-12 DK DK12756741.0T patent/DK2755963T3/da active
- 2012-09-12 PL PL12756741T patent/PL2755963T3/pl unknown
- 2012-09-12 MY MYPI2014700616A patent/MY169043A/en unknown
- 2012-09-12 TW TW101133381A patent/TWI462914B/zh active
- 2012-09-12 JP JP2014530184A patent/JP6012735B2/ja active Active
- 2012-09-12 EP EP12756741.0A patent/EP2755963B1/en active Active
- 2012-09-12 RS RS20191655A patent/RS59737B1/sr unknown
- 2012-09-12 SI SI201231713T patent/SI2755963T1/sl unknown
- 2012-09-12 PE PE2014000328A patent/PE20141372A1/es active IP Right Grant
- 2012-09-12 CN CN201280045041.1A patent/CN103814021B/zh active Active
- 2012-09-12 EP EP19204552.4A patent/EP3653618A1/en active Pending
- 2012-09-13 US US13/612,956 patent/US9260408B2/en active Active
- 2012-09-17 AR ARP120103420A patent/AR087901A1/es active IP Right Grant
- 2012-12-09 UA UAA201404030A patent/UA111626C2/uk unknown
-
2014
- 2014-02-25 CR CR20140091A patent/CR20140091A/es unknown
- 2014-02-26 CO CO14040934A patent/CO6890099A2/es unknown
- 2014-02-27 IL IL231229A patent/IL231229A0/en active IP Right Grant
- 2014-03-13 CL CL2014000604A patent/CL2014000604A1/es unknown
- 2014-03-14 ZA ZA201401884A patent/ZA201401884B/en unknown
- 2014-03-14 EC ECSP14013245 patent/ECSP14013245A/es unknown
-
2019
- 2019-12-23 HR HRP20192323TT patent/HRP20192323T1/hr unknown
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
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