BR112014004389A2 - métodos e composições para diagnóstico de lesão renal e insuficiência renal - Google Patents
métodos e composições para diagnóstico de lesão renal e insuficiência renalInfo
- Publication number
- BR112014004389A2 BR112014004389A2 BR112014004389A BR112014004389A BR112014004389A2 BR 112014004389 A2 BR112014004389 A2 BR 112014004389A2 BR 112014004389 A BR112014004389 A BR 112014004389A BR 112014004389 A BR112014004389 A BR 112014004389A BR 112014004389 A2 BR112014004389 A2 BR 112014004389A2
- Authority
- BR
- Brazil
- Prior art keywords
- renal
- diagnosis
- compositions
- methods
- injury
- Prior art date
Links
- 208000001647 Renal Insufficiency Diseases 0.000 title 1
- 206010061481 Renal injury Diseases 0.000 title 1
- 238000003745 diagnosis Methods 0.000 title 1
- 201000006370 kidney failure Diseases 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/34—Genitourinary disorders
- G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Pregnancy & Childbirth (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161528000P | 2011-08-26 | 2011-08-26 | |
| US201161528003P | 2011-08-26 | 2011-08-26 | |
| PCT/US2012/052298 WO2013043310A1 (en) | 2011-08-26 | 2012-08-24 | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014004389A2 true BR112014004389A2 (pt) | 2017-03-28 |
Family
ID=47914751
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014004389A BR112014004389A2 (pt) | 2011-08-26 | 2012-08-24 | métodos e composições para diagnóstico de lesão renal e insuficiência renal |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US9459261B2 (enExample) |
| EP (2) | EP2748605B1 (enExample) |
| JP (2) | JP2014529073A (enExample) |
| KR (1) | KR20140074307A (enExample) |
| CN (2) | CN106443011A (enExample) |
| AU (1) | AU2012312907A1 (enExample) |
| BR (1) | BR112014004389A2 (enExample) |
| CA (1) | CA2846602A1 (enExample) |
| EA (1) | EA201490384A1 (enExample) |
| ES (1) | ES2721907T3 (enExample) |
| IN (1) | IN2014MN00377A (enExample) |
| MX (1) | MX346096B (enExample) |
| PL (1) | PL2748605T4 (enExample) |
| PT (1) | PT2748605T (enExample) |
| TR (1) | TR201903235T4 (enExample) |
| WO (1) | WO2013043310A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ592358A (en) | 2008-10-21 | 2013-05-31 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure using tissue inhibitor of metalloproteinase 2 (timp-2) |
| EP3112871B1 (en) | 2009-12-20 | 2020-07-29 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CA2804297A1 (en) | 2010-06-23 | 2011-12-29 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CN106443011A (zh) * | 2011-08-26 | 2017-02-22 | 阿斯图特医药公司 | 用于肾损伤和肾衰竭的诊断及预后的方法和组合物 |
| EP3540440B1 (en) | 2011-12-08 | 2022-09-28 | Astute Medical, Inc. | Methods and uses for evaluating renal injury and renal status |
| EP3361255B1 (en) | 2013-01-17 | 2020-03-11 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| ES2696075T3 (es) | 2013-01-28 | 2019-01-14 | Diasorin S P A | Procedimiento y kit para detectar 1,25-dihidroxivitamina D y anticuerpos relacionados |
| US10983136B2 (en) | 2013-01-28 | 2021-04-20 | Diasorin S.P.A. | Use of 1,25-dihydroxyvitamin D values in ratio with PTH as a prognostic biomarker |
| US11261257B2 (en) | 2013-01-28 | 2022-03-01 | Diasorin S.P.A. | Methods for detecting 1,25-dihydroxyvitamin D and related antibodies |
| JP2016540759A (ja) | 2013-12-03 | 2016-12-28 | アスチュート メディカル，インコーポレイテッド | 腎損傷および腎不全の診断および予後のための方法および組成物 |
| JP6792553B2 (ja) * | 2014-10-20 | 2020-11-25 | アスチュート メディカル，インコーポレイテッド | 腎障害および腎不全の診断および予後のための方法および組成物 |
| EP3245515A1 (en) * | 2015-01-18 | 2017-11-22 | DiaSorin S.p.A. | Use of 1,25-dihydroxyvitamin d values in ratio with pth as a prognostic biomarker |
| EP3281011B1 (en) | 2015-04-09 | 2024-06-05 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CN105466984B (zh) * | 2016-01-14 | 2018-12-28 | 郑以山 | 用于肾脏非显性损伤的预警装置及其使用方法 |
| CA3026502A1 (en) | 2016-06-06 | 2017-12-14 | Astute Medical, Inc. | Management of acute kidney injury using insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 |
| CN114088950A (zh) | 2017-01-12 | 2022-02-25 | 机敏医药股份有限公司 | 基于c-c基序趋化因子配体14测量结果评价和治疗肾损伤和肾衰竭的方法和组合物 |
| EP3577458A4 (en) | 2017-02-06 | 2021-04-07 | Astute Medical, Inc. | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PREDICTION OF RENAL LESION AND RENAL INSUFFICIENCY |
| US11718682B2 (en) | 2017-04-05 | 2023-08-08 | Astute Medical, Inc. | Assays for TIMP2 having improved performance in biological samples |
| SG11202011502VA (en) | 2018-05-24 | 2020-12-30 | Renibus Therapeutics Inc | Methods of treating patients at risk for renal injury and renal failure |
| CN109251956A (zh) * | 2018-09-18 | 2019-01-22 | 青岛大学 | 糖尿病大鼠胰岛内MyD88 mRNA表达及黄芪的调节作用 |
| US20220178946A1 (en) * | 2018-11-02 | 2022-06-09 | Prevencio, Inc. | Prognostic and diagnostic methods for risk of acute kidney injury |
| CN114113575B (zh) * | 2020-08-28 | 2023-06-02 | 菲鹏生物股份有限公司 | 标记复合物及其制备方法与应用 |
| CN116434960B (zh) * | 2023-06-13 | 2023-10-13 | 中国人民解放军总医院 | 一种心源性休克临床决策支持系统、设备及可存储介质 |
| WO2025033619A1 (ko) * | 2023-08-07 | 2025-02-13 | 경상국립대학교병원 | 신 대체요법 개시 결정을 위한 정보 제공 방법 및 이의 결정을 위한 말기 신질환 진단용 조성물 |
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| CA2735587A1 (en) * | 2008-08-28 | 2010-03-04 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CN105021826A (zh) * | 2008-08-29 | 2015-11-04 | 阿斯图特医药公司 | 用于诊断和预后肾损伤和肾衰竭的方法和组合物 |
| NZ592358A (en) * | 2008-10-21 | 2013-05-31 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure using tissue inhibitor of metalloproteinase 2 (timp-2) |
| WO2010054389A1 (en) * | 2008-11-10 | 2010-05-14 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US9229010B2 (en) * | 2009-02-06 | 2016-01-05 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| JP2012529015A (ja) * | 2009-06-02 | 2012-11-15 | バイオクラテス ライフ サイエンシーズ アーゲー | 腎臓疾患評価用新規バイオマーカー |
| EP2462440B1 (en) * | 2009-08-07 | 2017-05-17 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| EP2470904A4 (en) * | 2009-09-18 | 2013-05-01 | Astute Medical Inc | METHODS AND COMPOSITION FOR DIAGNOSIS AND PROGNOSIS OF RENAL LESION AND FAILURE |
| MX2009012633A (es) * | 2009-11-23 | 2011-05-24 | Univ Mexico Nacional Autonoma | Metodo de diagnostico para detectar la lesion renal aguda a traves del uso de la proteina de choque termico de 72 kda como un biomarcador sensible. |
| EP3112871B1 (en) * | 2009-12-20 | 2020-07-29 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| AU2011220413B2 (en) | 2010-02-26 | 2015-07-23 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CN106443011A (zh) * | 2011-08-26 | 2017-02-22 | 阿斯图特医药公司 | 用于肾损伤和肾衰竭的诊断及预后的方法和组合物 |
-
2012
- 2012-08-24 CN CN201610804095.1A patent/CN106443011A/zh active Pending
- 2012-08-24 PT PT12832845T patent/PT2748605T/pt unknown
- 2012-08-24 EP EP12832845.7A patent/EP2748605B1/en active Active
- 2012-08-24 US US14/241,005 patent/US9459261B2/en active Active
- 2012-08-24 IN IN377MUN2014 patent/IN2014MN00377A/en unknown
- 2012-08-24 AU AU2012312907A patent/AU2012312907A1/en not_active Abandoned
- 2012-08-24 TR TR2019/03235T patent/TR201903235T4/tr unknown
- 2012-08-24 CN CN201280049909.5A patent/CN103874923B/zh active Active
- 2012-08-24 MX MX2014002146A patent/MX346096B/es active IP Right Grant
- 2012-08-24 EA EA201490384A patent/EA201490384A1/ru unknown
- 2012-08-24 EP EP18209718.8A patent/EP3489690A1/en active Pending
- 2012-08-24 ES ES12832845T patent/ES2721907T3/es active Active
- 2012-08-24 BR BR112014004389A patent/BR112014004389A2/pt not_active IP Right Cessation
- 2012-08-24 KR KR1020147007890A patent/KR20140074307A/ko not_active Withdrawn
- 2012-08-24 PL PL12832845T patent/PL2748605T4/pl unknown
- 2012-08-24 WO PCT/US2012/052298 patent/WO2013043310A1/en not_active Ceased
- 2012-08-24 CA CA2846602A patent/CA2846602A1/en not_active Abandoned
- 2012-08-24 JP JP2014527328A patent/JP2014529073A/ja active Pending
-
2016
- 2016-10-03 US US15/284,197 patent/US9784750B2/en active Active
- 2016-10-19 JP JP2016204848A patent/JP2017032586A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2846602A1 (en) | 2013-03-28 |
| US9459261B2 (en) | 2016-10-04 |
| PL2748605T3 (pl) | 2019-08-30 |
| AU2012312907A1 (en) | 2014-03-13 |
| US20140213477A1 (en) | 2014-07-31 |
| US9784750B2 (en) | 2017-10-10 |
| MX346096B (es) | 2017-03-07 |
| EA201490384A1 (ru) | 2014-08-29 |
| NZ621716A (en) | 2016-04-29 |
| TR201903235T4 (tr) | 2019-03-21 |
| ES2721907T3 (es) | 2019-08-06 |
| US20170016917A1 (en) | 2017-01-19 |
| PL2748605T4 (pl) | 2019-08-30 |
| PT2748605T (pt) | 2019-05-03 |
| EP2748605A1 (en) | 2014-07-02 |
| JP2014529073A (ja) | 2014-10-30 |
| EP2748605A4 (en) | 2015-12-02 |
| MX2014002146A (es) | 2014-08-21 |
| NZ706242A (en) | 2016-07-29 |
| CN103874923B (zh) | 2016-09-14 |
| WO2013043310A1 (en) | 2013-03-28 |
| JP2017032586A (ja) | 2017-02-09 |
| EP3489690A1 (en) | 2019-05-29 |
| EP2748605B1 (en) | 2018-12-05 |
| KR20140074307A (ko) | 2014-06-17 |
| IN2014MN00377A (enExample) | 2015-06-19 |
| CN106443011A (zh) | 2017-02-22 |
| CN103874923A (zh) | 2014-06-18 |
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