BR112013018875A2 - métodos e composições para a preparação de noribogaína a partir de voacangina - Google Patents

métodos e composições para a preparação de noribogaína a partir de voacangina

Info

Publication number
BR112013018875A2
BR112013018875A2 BR112013018875A BR112013018875A BR112013018875A2 BR 112013018875 A2 BR112013018875 A2 BR 112013018875A2 BR 112013018875 A BR112013018875 A BR 112013018875A BR 112013018875 A BR112013018875 A BR 112013018875A BR 112013018875 A2 BR112013018875 A2 BR 112013018875A2
Authority
BR
Brazil
Prior art keywords
voacangin
noribogain
compositions
preparation
methods
Prior art date
Application number
BR112013018875A
Other languages
English (en)
Inventor
C Mash Deborah
D Gless Richard
M Moriarty Robert
Original Assignee
Demerx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Demerx Inc filed Critical Demerx Inc
Publication of BR112013018875A2 publication Critical patent/BR112013018875A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
BR112013018875A 2011-01-26 2012-01-23 métodos e composições para a preparação de noribogaína a partir de voacangina BR112013018875A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161436511P 2011-01-26 2011-01-26
US201161453884P 2011-03-17 2011-03-17
US201161454904P 2011-03-21 2011-03-21
PCT/US2012/022255 WO2012103028A2 (en) 2011-01-26 2012-01-23 Methods and compositions for preparing noribogaine from voacangine

Publications (1)

Publication Number Publication Date
BR112013018875A2 true BR112013018875A2 (pt) 2017-01-31

Family

ID=43977940

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013018875A BR112013018875A2 (pt) 2011-01-26 2012-01-23 métodos e composições para a preparação de noribogaína a partir de voacangina

Country Status (14)

Country Link
US (2) US8859764B2 (pt)
EP (1) EP2481740B1 (pt)
JP (2) JP6093310B2 (pt)
KR (2) KR20140022000A (pt)
AU (1) AU2012209332B2 (pt)
BR (1) BR112013018875A2 (pt)
CA (1) CA2825298C (pt)
IL (1) IL227593A (pt)
MX (1) MX2013008572A (pt)
RU (1) RU2592698C2 (pt)
SG (1) SG192099A1 (pt)
UA (1) UA111186C2 (pt)
WO (1) WO2012103028A2 (pt)
ZA (1) ZA201306316B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
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US9394294B2 (en) 2010-05-11 2016-07-19 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
US8802832B2 (en) 2010-06-22 2014-08-12 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
EP2481740B1 (en) 2011-01-26 2015-11-04 DemeRx, Inc. Methods and compositions for preparing noribogaine from voacangine
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
MX2014001933A (es) 2011-09-15 2014-03-27 Demerx Inc Ansolvatos de sal de noribogaina.
EP2788003A4 (en) 2011-12-09 2015-05-27 Demerx Inc PHOSPHATESTER OF NORIBOGAIN
US9150584B2 (en) 2012-01-25 2015-10-06 Demerx, Inc. Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
AU2013212139A1 (en) 2012-01-25 2014-06-26 Demerx, Inc. Synthetic voacangine
JP2016508979A (ja) * 2012-12-20 2016-03-24 デメレックス， インコーポレイテッド 置換ノルイボガイン
WO2014143201A1 (en) 2013-03-15 2014-09-18 Demerx, Inc. Method for noribogaine treatment of addiction in patients on methadone
US9345711B2 (en) 2014-02-18 2016-05-24 Demerx, Inc. Methods for acute and long-term treatment of drug addiction
JP2017509612A (ja) 2014-02-18 2017-04-06 デメルクス，インコーポレイテッド 薬物中毒の急性および長期間での治療方法。
US9561232B2 (en) 2014-02-18 2017-02-07 Demerx, Inc. Low dose noribogaine for treating nicotine addiction and preventing relapse of nicotine use
US9591978B2 (en) 2014-03-13 2017-03-14 Demerx, Inc. Methods and compositions for pre-screening patients for treatment with noribogaine
US9549935B2 (en) 2014-07-14 2017-01-24 Demerx, Inc. Methods and compositions for treating migraines using noribogaine
EP4279134A1 (en) 2014-11-26 2023-11-22 DemeRx, Inc. Methods and compostions for potentiating the action of opioid analgesics using iboga alkaloids
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
AU2020257625A1 (en) 2019-04-17 2021-11-04 Compass Pathfinder Limited Methods for treating anxiety disorders, headache disorders, and eating disorders with psilocybin

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Also Published As

Publication number Publication date
RU2013139382A (ru) 2015-03-10
RU2592698C2 (ru) 2016-07-27
US20130303756A1 (en) 2013-11-14
CA2825298A1 (en) 2012-08-02
AU2012209332B2 (en) 2017-03-02
IL227593A0 (en) 2013-09-30
JP2014503584A (ja) 2014-02-13
EP2481740A1 (en) 2012-08-01
EP2481740B1 (en) 2015-11-04
AU2012209332A1 (en) 2013-09-05
WO2012103028A3 (en) 2012-12-06
KR102076464B1 (ko) 2020-02-11
AU2012209332A8 (en) 2013-09-12
ZA201306316B (en) 2014-04-30
IL227593A (en) 2016-11-30
JP6093310B2 (ja) 2017-03-08
KR20140022000A (ko) 2014-02-21
UA111186C2 (uk) 2016-04-11
US9403817B2 (en) 2016-08-02
CA2825298C (en) 2020-03-31
KR20190089228A (ko) 2019-07-30
JP2017061492A (ja) 2017-03-30
WO2012103028A2 (en) 2012-08-02
SG192099A1 (en) 2013-08-30
US20150133655A1 (en) 2015-05-14
MX2013008572A (es) 2013-09-26
NZ614366A (en) 2015-11-27
US8859764B2 (en) 2014-10-14

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]