SMT201600464B - Procedimento per la preparazione di esterolo - Google Patents

Procedimento per la preparazione di esterolo

Info

Publication number
SMT201600464B
SMT201600464B SM201600464T SM201600464T SMT201600464B SM T201600464 B SMT201600464 B SM T201600464B SM 201600464 T SM201600464 T SM 201600464T SM 201600464 T SM201600464 T SM 201600464T SM T201600464 B SMT201600464 B SM T201600464B
Authority
SM
San Marino
Prior art keywords
esterol
procedure
preparation
Prior art date
Application number
SM201600464T
Other languages
English (en)
Inventor
Johannes Jan Platteeuw
Bennink Herman Jan Tijmen Coelingh
Franciscus Wilhelmus Petrus Damen
Vliet Michiel Christian Alexander Van
Original Assignee
Donesta Bioscience B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44582248&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SMT201600464(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Donesta Bioscience B V filed Critical Donesta Bioscience B V
Publication of SMT201600464B publication Critical patent/SMT201600464B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
SM201600464T 2011-07-19 2016-12-21 Procedimento per la preparazione di esterolo SMT201600464B (it)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161509168P 2011-07-19 2011-07-19
EP11174509A EP2383279A1 (en) 2011-07-19 2011-07-19 Process for the preparation of estetrol
PCT/NL2012/050514 WO2013012328A1 (en) 2011-07-19 2012-07-18 Process for the preparation of estetrol
EP12742968.6A EP2734536B1 (en) 2011-07-19 2012-07-18 Process for the preparation of estetrol

Publications (1)

Publication Number Publication Date
SMT201600464B true SMT201600464B (it) 2017-03-08

Family

ID=44582248

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201600464T SMT201600464B (it) 2011-07-19 2016-12-21 Procedimento per la preparazione di esterolo

Country Status (16)

Country Link
US (2) US20140235882A1 (it)
EP (2) EP2383279A1 (it)
CN (1) CN103781795B (it)
CA (1) CA2842035C (it)
CY (1) CY1118288T1 (it)
DK (1) DK2734536T3 (it)
ES (1) ES2602227T3 (it)
HR (1) HRP20161467T1 (it)
HU (1) HUE029783T2 (it)
LT (1) LT2734536T (it)
PL (1) PL2734536T3 (it)
PT (1) PT2734536T (it)
RS (1) RS55384B1 (it)
SI (1) SI2734536T1 (it)
SM (1) SMT201600464B (it)
WO (1) WO2013012328A1 (it)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2835979C (en) 2011-06-01 2018-05-01 Estetra S.A. Process for the production of estetrol intermediates
PT2714710T (pt) * 2011-06-01 2016-07-12 Estetra Sprl Processo para a produção de intermediários de estetrol
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
BR112014008196B8 (pt) * 2011-10-07 2020-12-15 Estetra Sprl processo para a preparação de um composto da fórmula (i)
WO2013034780A2 (en) 2012-12-20 2013-03-14 Crystal Pharma, S.A.U. Process for the preparation of estetrol and related compounds
JP6254289B2 (ja) * 2013-09-18 2017-12-27 クリスタル ファルマ、エセ、ア、ウＣｒｙｓｔａｌ Ｐｈａｒｍａ，Ｓ．Ａ．Ｕ． エステトロールの製造プロセス
EP3310346B1 (en) 2015-06-18 2021-03-24 Estetra SPRL Orodispersible tablet containing estetrol
SI3310333T1 (sl) 2015-06-18 2020-08-31 Estetra Sprl Orodisperzibilna enota odmerka, ki vsebuje komponento estetrola
KR102664563B1 (ko) 2015-06-18 2024-05-09 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 에스테트롤 성분을 함유하는 구강분해성 투여 단위
CA2988485A1 (en) 2015-06-18 2016-12-22 Mithra Pharmaceuticals S.A. Orodispersible tablet containing estetrol
CA3178291A1 (en) 2016-08-05 2018-04-12 Estetra Srl Method for the management of dysmenorrhea and menstrual pain
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
HU231240B1 (hu) * 2019-09-03 2022-04-28 Richter Gedeon Nyrt. Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására
JP2022549585A (ja) * 2019-09-27 2022-11-28 インダストリアレ チミカ ソシエタ ア レスポンサビリタ リミタータ （１５α，１６α，１７β）－エストラ－１，３，５（１０）－トリエン－３，１５，１６，１７－テトロール（エステトロール）および当該製法の中間体を調製するためのプロセス
IT202100019631A1 (it) 2021-07-23 2023-01-23 Newchem S P A Metodo per produrre estetrolo e i suoi intermedi
WO2023021026A1 (en) 2021-08-17 2023-02-23 Aspen Oss B.V. A synthetic pathway to estra-1,3,5(10)-triene-3,15a,16a,17b-tetrol

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE144266C (it)
US3138588A (en) 1962-08-24 1964-06-23 American Home Prod 17-ketals of estrone and derivatives thereof
US3177206A (en) 1963-03-07 1965-04-06 American Home Prod Selective bromination of a-ring aromatic 17-ketalized steroids
US3433785A (en) 1966-07-11 1969-03-18 Sterling Drug Inc 15,16-disubstituted aromatic steroids,intermediates and processes
US3673180A (en) 1970-06-18 1972-06-27 Merck & Co Inc 19-nor-6,6-ethylene-20-spiroxenes
US4792620A (en) * 1983-10-14 1988-12-20 Bp Chemicals Limited Carbonylation catalysts
US4739078A (en) 1984-02-17 1988-04-19 The Upjohn Company Use of borohydride-salt lanthanide salt reagents for stereo selective reduction of C-15-keto prostaglandin precursors
IE60780B1 (en) 1987-01-23 1994-08-10 Akzo Nv New 11-aryl steroid derivatives
DE3710728A1 (de) 1987-03-31 1988-10-13 Schering Ag Verfahren zur herstellung von 17(alpha)-ethinyl-17ss-hydroxy-18-methyl-4,15-estradien-3-on und die neuen zwischenprodukte fuer dieses verfahren
US5073374A (en) 1988-11-30 1991-12-17 Schering Corporation Fast dissolving buccal tablet
US5340586A (en) 1991-04-12 1994-08-23 University Of Southern California Methods and formulations for use in treating oophorectomized women
JPH07101977A (ja) 1993-10-05 1995-04-18 Kureha Chem Ind Co Ltd ホルモン作用を軽減した新規なエストラジオール誘導体及びその増殖因子阻害剤
DE4344405C2 (de) 1993-12-24 1995-12-07 Marika Dr Med Ehrlich Ovulationshemmendes Mittel und Verfahren zur hormonalen Kontrazeption
WO1997004752A1 (en) 1995-07-26 1997-02-13 Duramed Pharmaceuticals, Inc. Pharmaceutical compositions of conjugated estrogens and methods for their use
US6117446A (en) 1999-01-26 2000-09-12 Place; Virgil A. Drug dosage unit for buccal administration of steroidal active agents
TW548277B (en) 1999-07-16 2003-08-21 Akzo Nobel Nv Orally active androgens
DE60025958T2 (de) 1999-12-02 2006-07-27 Akzo Nobel N.V. 14,15-beta-methylen substituierte androgene
US20020132801A1 (en) 2001-01-11 2002-09-19 Schering Aktiengesellschaft Drospirenone for hormone replacement therapy
EP1216713A1 (en) 2000-12-20 2002-06-26 Schering Aktiengesellschaft Compositions of estrogen-cyclodextrin complexes
EP1260225A1 (en) 2001-05-18 2002-11-27 Pantarhei Bioscience B.V. A pharmaceutical composition for use in hormone replacement therapy
DE60217324T2 (de) 2001-05-18 2007-04-26 Pantarhei Bioscience B.V. Pharmazeutische zusammensetzung für die hormonersatztherapie
DK1390042T3 (da) 2001-05-23 2008-03-31 Pantarhei Bioscience Bv System for administration af et lægemiddel omfattende tetrahydroxyleret östrogen til anvendelse i hormonal svangerskabsforebyggelse
ES2337129T3 (es) 2001-05-23 2010-04-21 Pantarhei Bioscience B.V. Sistema de administracion de medicamento comprendiendo un estrogeno tetrahidroxilado para el uso en la anticoncepcion hormonal.
WO2003018026A1 (en) 2001-08-31 2003-03-06 Pantarhei Bioscience B.V. Use of estrogenic compounds in combination with progestogenic compounds in hormone-replacement therapy
DE60216630T2 (de) 2001-11-15 2007-09-20 Pantarhei Bioscience B.V. Verwendung von östrogen in kombination mit progestogen für die hormonsubstitutiionstherapie
US6723348B2 (en) 2001-11-16 2004-04-20 Ethypharm Orodispersible tablets containing fexofenadine
HU227198B1 (en) 2001-11-27 2010-10-28 Richter Gedeon Nyrt Pharmaceutical composition for emergency contraception containing levonorgestrel
MXPA04008185A (es) 2002-02-21 2004-11-26 Schering Ag Composiciones farmaceuticas que comprenden uno o mas esteroides, uno o mas componentes de tetrahidrofolato y vitamina b12.
US20050147670A1 (en) 2002-05-29 2005-07-07 Impax Laboratories Inc. Oral disintegrating dosage forms
CA2489271C (en) 2002-06-11 2011-12-06 Pantarhei Bioscience B.V. Method of treating or preventing immune mediated disorders and pharmaceutical formulation for use therein
AU2003274941A1 (en) 2002-06-11 2003-12-22 Pantarhei Bioscience B.V. A method of treating human skin and a skin care composition for use in such a method
ES2299730T3 (es) 2002-07-12 2008-06-01 Pantarhei Bioscience B.V. Composicion farmaceutica que comprende derivados de estetrol para el uso en la terapia del cancer.
US8946198B2 (en) 2002-08-28 2015-02-03 Robert Casper Estrogen replacement regimen
SI1556058T1 (sl) 2002-10-23 2008-02-29 Pantarhei Bioscience Bv Farmacevtski sestavki, ki obsegajo estetrolne derivate, za uporabo pri zdravljenju raka
AU2003278434A1 (en) 2002-11-05 2004-06-07 Schering Aktiengesellschaft Cardiovascular protection using anti-aldosteronic progestins
PT1562976E (pt) 2002-11-08 2010-08-12 Pantarhei Bioscience Bv Síntese do estetrol via esteróides derivados da estrona
PT1624878E (pt) 2003-05-22 2007-01-31 Pantarhei Bioscience Bv Utilização de composições que compreendem um componente estrogénico para o tratamento e prevenção da dor musculoesquelética
DK1670440T3 (da) 2003-09-29 2014-07-07 Novo Nordisk As HRT formuleringer
EP1673071A1 (en) 2003-09-29 2006-06-28 Novo Nordisk Femcare AG Improved stability of progestogen formulations
EP1535618A1 (en) 2003-11-26 2005-06-01 Schering Aktiengesellschaft Pharmaceutical preparation for continuous hormonal treatment over a period of longer than 21-28 days comprising two estrogen and/or progestin compositions
MY151322A (en) 2004-04-30 2014-05-15 Bayer Ip Gmbh Management of breakthrough bleeding in extended hormonal contraceptive regimens
DE102004026670A1 (de) 2004-05-28 2005-12-15 Grünenthal GmbH Hormonales Kontrazeptivum enthaltend eine Kombination aus Ethinylestradiol und Chlormadinonacetat
EP2263659A1 (de) 2004-05-28 2010-12-22 Grünenthal GmbH Folsäurehaltiges Kontrazeptivum
UA89964C2 (ru) 2004-09-08 2010-03-25 Н.В. Органон 15β-ЗАМЕЩЕННЫЕ СТЕРОИДЫ, КОТОРЫЕ ИМЕЮТ СЕЛЕКТИВНУЮ ЭСТРОГЕННУЮ АКТИВНОСТЬ
UY29527A1 (es) 2005-05-13 2006-12-29 Schering Ag Composicinn farmaccutica que contienen gestrgenos y/o estrngenos y 5-metil - (6s) - tetrhidrofolato.
ES2388297T3 (es) 2005-05-26 2012-10-11 Abbott Products Gmbh Inhibidores de 17-HSD1 y STS
EP2098592A3 (de) 2005-07-25 2009-09-30 Technische Universität Dresden RNA-abhängige RNA-Polymerase, Verfahren und Kits zur Amplifikation und/oder Markierung von RNA
US20070048369A1 (en) 2005-08-26 2007-03-01 National Starch And Chemical Investment Holding Corporation Mucosal delivery tablet
WO2007081206A1 (en) 2006-01-09 2007-07-19 Pantarhei Bioscience B.V. A method of treating an acute vascular disorder
ES2558030T3 (es) 2006-03-02 2016-02-01 Warner Chilcott Company, Llc Método anticonceptivo oral multifásico de ciclo prolongado
MX2008014941A (es) 2006-06-08 2008-12-10 Warner Chilcott Co Inc Metodos para administrar formas de dosificacion solida de etinil estradiol y profarmacos del mismo con biodisponibilidad mejorada.
US20080113953A1 (en) 2006-06-08 2008-05-15 Warner Chilcott Company, Inc. Methods to administer solid dosage forms of ethinyl estradiol and prodrugs thereof with improved bioavailability
US20070286819A1 (en) 2006-06-08 2007-12-13 Warner Chilcott Company, Inc. Methods to administer ethinyl estradiol and prodrugs thereof with improved bioavailability
CN101489563A (zh) 2006-07-06 2009-07-22 拜耳先灵医药股份有限公司 用于避孕和预防先天性畸形风险的药物制剂
CA2665788A1 (en) 2006-07-06 2008-01-10 Bayer Schering Pharma Aktiengesellschaft Pharmaceutical preparations for contraception and for preventing the risk of congenital malformations
GB0621926D0 (en) 2006-11-03 2006-12-13 Medlock Medical Ltd Multi directional stretch tubular bandages
CN101541326A (zh) 2006-11-29 2009-09-23 惠氏公司 雌激素/选择性雌激素受体调节剂（serm）和雌激素/孕酮双层药片
BRPI0719486A2 (pt) 2006-12-20 2014-02-18 Duramed Pharmaceuticals Inc "forma farmacêutica sólida oral desitegrante, não-efervescente, métodos para tratar uma mulher que necessite de um contraceptivo de emergência, pacote terapêutico para tratar uma mulher que necessite de contracepção de emergência e processo para a preparação de uma forma sólida de dosagem farmacêutica oral desintegrante, não-efervescente"
DE602008001783D1 (de) 2007-01-08 2010-08-26 Pantarhei Bioscience Bv Verfahren zur behandlung oder prävention von unfruchtbarkeit bei weiblichen säugern und pharmazeutisches kit zur anwendung dieses verfahrens
CN101631536A (zh) 2007-01-12 2010-01-20 惠氏公司 片中片组合物
WO2008156365A1 (en) 2007-06-21 2008-12-24 Pantarhei Bioscience B.V. Treatment of meconium aspiration syndrome with estrogens
ATE533492T1 (de) 2007-07-19 2011-12-15 Pantarhei Bioscience Bv Behandlung oder prävention von hypertensiven erkrankungen in der schwangerschaft oder von wachstumsverzögerung des foeten
EP2085373B8 (en) 2007-08-31 2013-06-26 National University Corporation Nagoya University Method for producing carbonyl compound and pro-oxidant used for production of carbonyl compound
EP2077272A1 (en) 2007-12-21 2009-07-08 Affibody AB Polypeptide libraries with a predetermined scaffold
EP2077273B1 (en) 2007-12-31 2011-09-14 Animal Technology Institute Taiwan Methods for separating casein from soluble proteins in a composition
US8530636B2 (en) 2008-05-07 2013-09-10 The Board Of Trustees Of The Leland Stanford Junior University Method for regulating protein function in cells in vivo using synthetic small molecules
WO2010033832A2 (en) 2008-09-19 2010-03-25 Evestra, Inc. Estriol formulations
DE102009007771B4 (de) 2009-02-05 2012-02-16 Bayer Schering Pharma Aktiengesellschaft Bukkales Applikationssystem, 17α-Estradiol enthaltend
MX2011013959A (es) 2009-06-23 2012-01-25 Bayer Pharma AG Composicion farmaceutica para la anticoncepcion de emergencia.
CN102058604A (zh) 2009-11-17 2011-05-18 北京万全阳光医学技术有限公司 一种含有地诺孕素和戊酸雌二醇的药物组合物及其制备方法
WO2011128336A1 (en) 2010-04-15 2011-10-20 Bayer Pharma Aktiengesellschaft Very low-dosed solid oral dosage forms for hrt
AR081670A1 (es) 2010-06-29 2012-10-10 Leon Farma Sa Lab Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US9603860B2 (en) 2010-07-28 2017-03-28 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
WO2012055840A1 (en) 2010-10-28 2012-05-03 Bayer Pharma Aktiengesellschaft Composition and preparation for treatment of dysmenorrhea and menstrual pain and use of a hormonal agent and a zinc salt for treatment of menstrual disorders
CA2835979C (en) 2011-06-01 2018-05-01 Estetra S.A. Process for the production of estetrol intermediates
PT2714710T (pt) 2011-06-01 2016-07-12 Estetra Sprl Processo para a produção de intermediários de estetrol
ES2545337T3 (es) 2011-07-19 2015-09-10 Pantarhei Bioscience B.V. Comprimido que contiene dehidroepiandrosterona (DHEA)
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
WO2013021025A1 (en) 2011-08-11 2013-02-14 Estetra S.A. Use of estetrol as emergency contraceptive
EP2755632A1 (en) 2011-09-16 2014-07-23 Ferring BV A fast dissolving pharmaceutical composition
BR112014008196B8 (pt) 2011-10-07 2020-12-15 Estetra Sprl processo para a preparação de um composto da fórmula (i)
WO2013090117A1 (en) 2011-12-13 2013-06-20 Arstat, Inc. A multiphasic contraceptive regimen for oral combination drug formulation of progestin and estrogen
EP2653163A1 (en) 2012-04-19 2013-10-23 Université de Liège Estrogenic components for use in the treatment of neurological disorders
WO2014159377A1 (en) 2013-03-14 2014-10-02 Teva Women's Health, Inc. Compositions containing tanaproget and natural estrogens
CA2913149A1 (en) 2013-05-21 2014-11-27 Predictive Therapeutics, LLC Therapeutic and method of use
JP6254289B2 (ja) 2013-09-18 2017-12-27 クリスタル ファルマ、エセ、ア、ウＣｒｙｓｔａｌ Ｐｈａｒｍａ，Ｓ．Ａ．Ｕ． エステトロールの製造プロセス
CN105979935B (zh) 2013-12-12 2019-07-26 多内斯塔生物科学股份有限公司 包含雌四醇组分的口崩固体剂量单位
CA2962921A1 (en) 2014-09-29 2016-04-07 The Regents Of The University Of California Compositions and methods for maintaining cognitive function
MX2017014768A (es) 2015-05-18 2018-03-23 Agile Therapeutics Inc Composiciones anticonceptivas y metodos para mejorar la eficacia y modulacion de los efectos secundarios.
SI3310333T1 (sl) 2015-06-18 2020-08-31 Estetra Sprl Orodisperzibilna enota odmerka, ki vsebuje komponento estetrola
CA2988485A1 (en) 2015-06-18 2016-12-22 Mithra Pharmaceuticals S.A. Orodispersible tablet containing estetrol
KR102664563B1 (ko) 2015-06-18 2024-05-09 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 에스테트롤 성분을 함유하는 구강분해성 투여 단위
EP3310346B1 (en) 2015-06-18 2021-03-24 Estetra SPRL Orodispersible tablet containing estetrol
AU2016282863B2 (en) 2015-06-23 2021-05-27 Laboratorios Leon Farma Sa Drospirenone-based contraceptive for a female patient affected with excess weight
US10863492B2 (en) 2015-07-16 2020-12-08 Qualcomm Incorporated Low latency device-to-device communication
JP2018533542A (ja) 2016-10-28 2018-11-15 エステトラ ソシエテ プリーヴ ア レスポンサビリテ リミテ 月経困難症および月経痛の管理のための方法
CA3178291A1 (en) 2016-08-05 2018-04-12 Estetra Srl Method for the management of dysmenorrhea and menstrual pain

Also Published As

Publication number Publication date
CA2842035A1 (en) 2013-01-24
HRP20161467T1 (hr) 2017-01-27
CN103781795B (zh) 2016-08-17
LT2734536T (lt) 2016-12-27
PT2734536T (pt) 2017-01-02
US10844088B2 (en) 2020-11-24
HUE029783T2 (en) 2017-04-28
PL2734536T3 (pl) 2017-03-31
EP2734536B1 (en) 2016-09-28
EP2734536A1 (en) 2014-05-28
CY1118288T1 (el) 2017-06-28
DK2734536T3 (en) 2016-12-12
ES2602227T3 (es) 2017-02-20
US20140235882A1 (en) 2014-08-21
US20170369521A1 (en) 2017-12-28
WO2013012328A1 (en) 2013-01-24
SI2734536T1 (sl) 2017-01-31
CN103781795A (zh) 2014-05-07
EP2383279A1 (en) 2011-11-02
CA2842035C (en) 2020-06-23
RS55384B1 (sr) 2017-03-31

Similar Documents

Publication Publication Date Title
SMT201600464B (it) Procedimento per la preparazione di esterolo
SMT201600254B (it) Procedimento per la preparazione di idromagnesite
SMT201600375B (it) Procedimento per la produzione di estetrolo
ES2603028T8 (es) Procedimiento para la preparación de (Z)-alfa-fluoro-beta-amino-acrilaldehídos sustituidos
ZA201305972B (en) Method for the preparation of biphephos
SMT201400044B (it) Formulazione di impianto di paliperidone
BR112013018875A2 (pt) métodos e composições para a preparação de noribogaína a partir de voacangina
DK3050972T3 (da) Fremgangsmåder til fremstilling af eicosapentaensyre i thraustochytrider
BR112014003878A2 (pt) síntese de r-bifenilalaninol
DK3299356T3 (da) Fremgangsmåde til fremstilling af pleuromutiliner
BR112014013850A2 (pt) conjunto de prateleiras
CO6900117A2 (es) Formulaciones peptídicas de liberación controlada
SMT201600380B (it) Formulazioni di darunavir
CO6940426A2 (es) Formulaciones farmacéuticas
SMT201600425B (it) Preparazione per colonscopia
ES2547827T8 (es) Procedimiento para la purificación de la micafungina
SG11201400939YA (en) Process for the preparation of methoxymelonal
HK1198584A1 (en) Process for the preparation of travoprost
CO7020857A2 (es) Procedimiento para la preparación de complejos de 68ga
BR112013024413A2 (pt) compostos e métodos para a preparação de diarilpropanos
IT1403282B1 (it) Procedimento per la preparazione di linagliptin
FR2966150B1 (fr) Procede de preparation de la 2-hydroxybutyrolactone
BR112014015885A8 (pt) preparação farmacêutica
NO20110238A1 (no) Fremgangsmåte for fremstilling av aminoalkoholer
ITMI20120351A1 (it) Procedimento per la produzione di bicarbonato di sodio