BR112013028296A2 - métodos para detecção de variantes de sequências de ácido nucléico - Google Patents
métodos para detecção de variantes de sequências de ácido nucléicoInfo
- Publication number
- BR112013028296A2 BR112013028296A2 BR112013028296A BR112013028296A BR112013028296A2 BR 112013028296 A2 BR112013028296 A2 BR 112013028296A2 BR 112013028296 A BR112013028296 A BR 112013028296A BR 112013028296 A BR112013028296 A BR 112013028296A BR 112013028296 A2 BR112013028296 A2 BR 112013028296A2
- Authority
- BR
- Brazil
- Prior art keywords
- nucleic acid
- methods
- target region
- acid sequence
- sequence variants
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/185—Modifications characterised by incorporating bases where the precise position of the bases in the nucleic acid string is important
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/186—Modifications characterised by incorporating a non-extendable or blocking moiety
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/197—Modifications characterised by incorporating a spacer/coupling moiety
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/10—Detection mode being characterised by the assay principle
- C12Q2565/102—Multiple non-interacting labels
- C12Q2565/1025—Multiple non-interacting labels labels being on the same oligonucleotide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
Abstract
resumo patente de invenção: "métodos para detecção de variantes de sequências de ácido nucléico". a presente invenção refere-se a métodos para detecção da presença ou ausência de uma variante de ácido nucléico em uma região alvo. estes métodos incluem amplificação da região alvo com um primer avançado para frente e um primer reverso na presença de um bloqueador de seletor. o bloqueador de seletor inclui uma sequência complementar à região alvo na ausência da variante de ácido nucléico. os métodos incluem adicionalmente detecção de amplificação da região alvo onde amplificação da região alvo indica a presença da variante de ácido nucléico na região alvo. a variante de ácido nucléico pode incluir eliminações, mutações ou inserções.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161482576P | 2011-05-04 | 2011-05-04 | |
US61/482,576 | 2011-05-04 | ||
PCT/US2012/036678 WO2012151560A2 (en) | 2011-05-04 | 2012-05-04 | Methods for detecting nucleic acid sequence variants |
Publications (2)
Publication Number | Publication Date |
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BR112013028296A2 true BR112013028296A2 (pt) | 2016-09-06 |
BR112013028296B1 BR112013028296B1 (pt) | 2020-03-24 |
Family
ID=47108269
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013028296-7A BR112013028296B1 (pt) | 2011-05-04 | 2012-05-04 | Métodos para detecção de variantes de sequências de ácido nucléico |
Country Status (8)
Country | Link |
---|---|
US (4) | US9834817B2 (pt) |
EP (2) | EP3382039B1 (pt) |
JP (4) | JP6404118B2 (pt) |
KR (3) | KR102252447B1 (pt) |
CN (2) | CN103635593B (pt) |
AU (3) | AU2012250516B2 (pt) |
BR (1) | BR112013028296B1 (pt) |
WO (1) | WO2012151560A2 (pt) |
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CN102301005A (zh) | 2008-12-17 | 2011-12-28 | 生命技术公司 | 用于检测等位基因变体的方法、组合物和试剂盒 |
EP2411543B1 (en) | 2009-03-27 | 2017-04-19 | Life Technologies Corporation | Methods, compositions, and kits for detecting allelic variants |
KR102252447B1 (ko) * | 2011-05-04 | 2021-05-17 | 바이오셉트 인코포레이티드 | 핵산 서열 변이체를 검출하는 방법 |
WO2014164874A2 (en) * | 2013-03-13 | 2014-10-09 | Becton, Dickinson And Company | Methods and compositions for modulation of amplification efficiency |
WO2014152091A2 (en) * | 2013-03-15 | 2014-09-25 | Carnegie Institution Of Washington | Methods of genome sequencing and epigenetic analysis |
EP2971134B1 (en) | 2013-03-15 | 2023-10-25 | Aegea Biotechnologies, Inc. | Methods for amplifying fragmented target nucleic acids utilizing an assembler sequence |
EP2981623A4 (en) | 2013-04-05 | 2016-11-23 | Robert A Akins | SYSTEMS AND METHOD FOR THE ASSESSMENT OF MICROBIOMES AND TREATMENTS THEREOF |
US9410172B2 (en) | 2013-09-16 | 2016-08-09 | General Electric Company | Isothermal amplification using oligocation-conjugated primer sequences |
KR20160064192A (ko) | 2013-10-03 | 2016-06-07 | 얀센 바이오테크 인코포레이티드 | 프로톡신-ii 변이체 및 사용 방법 |
DK3146080T3 (en) * | 2014-05-19 | 2021-04-12 | Univ Rice William M | Allele-specific amplification using a composition of overlapping non-allele-specific primer and allele-specific blocker oligonucleotides |
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CN107577921A (zh) * | 2017-08-25 | 2018-01-12 | 云壹生物技术(大连)有限公司 | 一种肿瘤靶向基因测序数据解析方法 |
CN108048531B (zh) * | 2017-11-16 | 2021-06-18 | 苏州吉玛基因股份有限公司 | 一种高灵敏度检测稀有突变的超阻滞荧光定量pcr方法 |
AU2019311015A1 (en) * | 2018-07-24 | 2021-02-18 | Salish Bioscience Inc. | Methods and composition for targeted genomic analysis |
CN109136345A (zh) * | 2018-09-21 | 2019-01-04 | 北京知光基因科技有限公司 | 一种扩增并检测低含量基因突变的pcr方法及其应用 |
US11921049B2 (en) * | 2018-11-09 | 2024-03-05 | Shaofeng Ding | Pyrophosphorolysis activated fluorescence to measure PAP amplification of nucleic acid |
CN110004219A (zh) * | 2019-04-19 | 2019-07-12 | 格尚微(上海)生物科技有限公司 | 一种egfr t790m和c797s顺式突变的检测方法 |
WO2021151395A1 (zh) * | 2020-01-30 | 2021-08-05 | 上海快灵生物科技有限公司 | 基于双标记寡核苷酸探针熔解曲线的多重检测靶核苷酸序列的方法及其试剂盒 |
CN111647650B (zh) * | 2020-07-06 | 2023-06-27 | 河南赛诺特生物技术有限公司 | 检测人B-raf基因V600E突变的引物、引物探针组合物及试剂盒 |
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2012
- 2012-05-04 KR KR1020197022982A patent/KR102252447B1/ko active IP Right Grant
- 2012-05-04 CN CN201280032293.0A patent/CN103635593B/zh active Active
- 2012-05-04 AU AU2012250516A patent/AU2012250516B2/en active Active
- 2012-05-04 CN CN201810150712.XA patent/CN108220406B/zh active Active
- 2012-05-04 EP EP18172421.2A patent/EP3382039B1/en active Active
- 2012-05-04 EP EP12779445.1A patent/EP2705162B1/en active Active
- 2012-05-04 BR BR112013028296-7A patent/BR112013028296B1/pt active IP Right Grant
- 2012-05-04 JP JP2014509501A patent/JP6404118B2/ja active Active
- 2012-05-04 WO PCT/US2012/036678 patent/WO2012151560A2/en active Application Filing
- 2012-05-04 KR KR1020217014073A patent/KR20210056458A/ko not_active Application Discontinuation
- 2012-05-04 KR KR1020137032060A patent/KR102010601B1/ko active IP Right Grant
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2013
- 2013-03-15 US US13/841,842 patent/US9834817B2/en active Active
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2017
- 2017-10-30 US US15/796,982 patent/US10745749B2/en active Active
- 2017-11-27 AU AU2017268486A patent/AU2017268486B2/en active Active
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2018
- 2018-04-19 JP JP2018080526A patent/JP6734887B2/ja active Active
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2020
- 2020-02-21 AU AU2020201291A patent/AU2020201291B2/en active Active
- 2020-07-10 JP JP2020119137A patent/JP7111773B2/ja active Active
- 2020-07-13 US US16/927,353 patent/US20200340052A1/en active Pending
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2021
- 2021-07-15 US US17/376,575 patent/US20220017957A1/en active Pending
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- 2022-07-21 JP JP2022116372A patent/JP2022137291A/ja active Pending
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