BR112013026482A2 - captura de amostra em uma única etapa para tiras de teste - Google Patents
captura de amostra em uma única etapa para tiras de testeInfo
- Publication number
- BR112013026482A2 BR112013026482A2 BR112013026482A BR112013026482A BR112013026482A2 BR 112013026482 A2 BR112013026482 A2 BR 112013026482A2 BR 112013026482 A BR112013026482 A BR 112013026482A BR 112013026482 A BR112013026482 A BR 112013026482A BR 112013026482 A2 BR112013026482 A2 BR 112013026482A2
- Authority
- BR
- Brazil
- Prior art keywords
- sample capture
- sample
- test strips
- test
- capture
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
- A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
- A61B5/150167—Adjustable piercing speed of skin piercing element, e.g. blade, needle, lancet or canula, for example with varying spring force or pneumatic drive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150175—Adjustment of penetration depth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150274—Manufacture or production processes or steps for blood sampling devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150358—Strips for collecting blood, e.g. absorbent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
- A61B5/150419—Pointed piercing elements, e.g. needles, lancets for piercing the skin comprising means for capillary action
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
- A61B5/150427—Specific tip design, e.g. for improved penetration characteristics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150503—Single-ended needles
- A61B5/150511—Details of construction of shaft
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
- A61B5/150572—Pierceable protectors, e.g. shields, caps, sleeves or films, e.g. for hygienic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15101—Details
- A61B5/15115—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
- A61B5/15123—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising magnets or solenoids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15146—Devices loaded with multiple lancets simultaneously, e.g. for serial firing without reloading, for example by use of stocking means.
- A61B5/15148—Constructional features of stocking means, e.g. strip, roll, disc, cartridge, belt or tube
- A61B5/15149—Arrangement of piercing elements relative to each other
- A61B5/15151—Each piercing element being stocked in a separate isolated compartment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15146—Devices loaded with multiple lancets simultaneously, e.g. for serial firing without reloading, for example by use of stocking means.
- A61B5/15148—Constructional features of stocking means, e.g. strip, roll, disc, cartridge, belt or tube
- A61B5/15157—Geometry of stocking means or arrangement of piercing elements therein
- A61B5/15159—Piercing elements stocked in or on a disc
- A61B5/15161—Characterized by propelling the piercing element in a radial direction relative to the disc
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0295—Strip shaped analyte sensors for apparatus classified in A61B5/145 or A61B5/157
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150213—Venting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15101—Details
- A61B5/15103—Piercing procedure
- A61B5/15107—Piercing being assisted by a triggering mechanism
- A61B5/15113—Manually triggered, i.e. the triggering requires a deliberate action by the user such as pressing a drive button
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Optics & Photonics (AREA)
- Manufacturing & Machinery (AREA)
- Geometry (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
resumo patente de invenção: "captura de amostra em uma única etapa para tiras de teste". a presente invenção refere-se a uma tira de teste é fornecida com captura de amostra que prevê um processo de uma etapa conseguir um evento punção, captura de amostra e transporte de amostra em um projeto de sensor que oferece suporte a uma etapa de testes. em várias incorporações, a presente invenção fornece para uma etapa teste por, (i) layout de captura de amostra de analito; (ii) configurações de captura e transporte de amostra de analito; (iii) estruturas de tomada de amostra; (iv) processos de formação de transporte da amostra e afins.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/086,453 US20120238841A1 (en) | 2010-04-15 | 2011-04-14 | Sample capture in one step for test strips |
PCT/US2012/033768 WO2012142571A1 (en) | 2011-04-14 | 2012-04-16 | Sample capture in one step for test strips |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112013026482A2 true BR112013026482A2 (pt) | 2016-12-27 |
Family
ID=46001841
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013026482A BR112013026482A2 (pt) | 2011-04-14 | 2012-04-16 | captura de amostra em uma única etapa para tiras de teste |
Country Status (9)
Country | Link |
---|---|
US (1) | US20120238841A1 (pt) |
EP (1) | EP2696762A1 (pt) |
JP (2) | JP2014515829A (pt) |
CN (1) | CN103796585B (pt) |
AU (1) | AU2012242469B2 (pt) |
BR (1) | BR112013026482A2 (pt) |
CA (1) | CA2832495A1 (pt) |
IL (1) | IL228796A0 (pt) |
WO (1) | WO2012142571A1 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014152717A2 (en) | 2013-03-14 | 2014-09-25 | Sano Intelligence, Inc. | On-body microsensor for biomonitoring |
US10820860B2 (en) | 2013-03-14 | 2020-11-03 | One Drop Biosensor Technologies, Llc | On-body microsensor for biomonitoring |
KR20160004394A (ko) * | 2013-05-23 | 2016-01-12 | 킴벌리-클라크 월드와이드, 인크. | 개선된 개방 채널 단면 구조를 갖는 미세침 |
JP6332786B2 (ja) * | 2014-02-14 | 2018-05-30 | 株式会社ライトニックス | 医療用針および穿刺具 |
US10595754B2 (en) | 2014-03-13 | 2020-03-24 | Sano Intelligence, Inc. | System for monitoring body chemistry |
US20170172475A1 (en) * | 2014-03-13 | 2017-06-22 | Sano Intelligence, Inc. | System for monitoring body chemistry |
US20150257687A1 (en) | 2014-03-13 | 2015-09-17 | Sano Intelligence, Inc. | System for monitoring body chemistry |
KR101989310B1 (ko) * | 2017-05-18 | 2019-09-24 | 주식회사 미코바이오메드 | 바이오 측정 장치 및 이를 포함하는 바이오 장치 |
USD988882S1 (en) | 2021-04-21 | 2023-06-13 | Informed Data Systems Inc. | Sensor assembly |
Family Cites Families (38)
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US2896628A (en) * | 1957-06-12 | 1959-07-28 | Propper Mfg Company Inc | Blood lancets |
JP3394262B2 (ja) * | 1997-02-06 | 2003-04-07 | セラセンス、インク. | 小体積インビトロ被検体センサー |
WO1999044507A1 (en) * | 1998-03-06 | 1999-09-10 | Spectrx, Inc. | Integrated tissue poration, fluid harvesting and analysis device, and method therefor |
US6706159B2 (en) * | 2000-03-02 | 2004-03-16 | Diabetes Diagnostics | Combined lancet and electrochemical analyte-testing apparatus |
US6612111B1 (en) * | 2000-03-27 | 2003-09-02 | Lifescan, Inc. | Method and device for sampling and analyzing interstitial fluid and whole blood samples |
US8641644B2 (en) * | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
US7144495B2 (en) * | 2000-12-13 | 2006-12-05 | Lifescan, Inc. | Electrochemical test strip with an integrated micro-needle and associated methods |
JP4736323B2 (ja) * | 2001-07-13 | 2011-07-27 | アークレイ株式会社 | 分析用具を備えた濃度測定装置用の穿刺要素一体装着体、および体液採取用具 |
WO2003020134A2 (en) * | 2001-08-29 | 2003-03-13 | Roche Diagnostics Gmbh | Wicking methods and structures for use in sampling bodily fluids |
JP4246629B2 (ja) * | 2001-09-11 | 2009-04-02 | アークレイ株式会社 | 測定用具 |
US7708701B2 (en) * | 2002-04-19 | 2010-05-04 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device |
US7060192B2 (en) * | 2002-05-09 | 2006-06-13 | Lifescan, Inc. | Methods of fabricating physiological sample collection devices |
US20030143113A2 (en) * | 2002-05-09 | 2003-07-31 | Lifescan, Inc. | Physiological sample collection devices and methods of using the same |
NZ526334A (en) * | 2002-06-25 | 2003-10-31 | Bayer Healthcare Llc | Sensor with integrated lancet for monitoring blood by colorometric or electrochemical test method |
US20060178573A1 (en) * | 2003-03-06 | 2006-08-10 | Kermani Mahyar Z | System and method for piercing dermal tissue |
US7473264B2 (en) * | 2003-03-28 | 2009-01-06 | Lifescan, Inc. | Integrated lance and strip for analyte measurement |
US7374949B2 (en) * | 2003-05-29 | 2008-05-20 | Bayer Healthcare Llc | Diagnostic test strip for collecting and detecting an analyte in a fluid sample |
US7445738B2 (en) * | 2003-09-18 | 2008-11-04 | United States Gypsum Company | Multi-layer process and apparatus for producing high strength fiber-reinforced structural cementitious panels |
US8282576B2 (en) * | 2003-09-29 | 2012-10-09 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for an improved sample capture device |
JP4334969B2 (ja) * | 2003-10-02 | 2009-09-30 | パナソニック株式会社 | 血液成分分析用センサ |
US20050139469A1 (en) * | 2003-10-31 | 2005-06-30 | Davies Oliver W.H. | Electrochemical test strip for reducing the effect of direct and mediated interference current |
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US8668656B2 (en) * | 2003-12-31 | 2014-03-11 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for improving fluidic flow and sample capture |
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US7512432B2 (en) * | 2004-07-27 | 2009-03-31 | Abbott Laboratories | Sensor array |
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US20080214917A1 (en) * | 2004-12-30 | 2008-09-04 | Dirk Boecker | Method and apparatus for analyte measurement test time |
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JP4924925B2 (ja) * | 2006-11-10 | 2012-04-25 | 住友電気工業株式会社 | バイオセンサカートリッジ |
EP2265324B1 (en) * | 2008-04-11 | 2015-01-28 | Sanofi-Aventis Deutschland GmbH | Integrated analyte measurement system |
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-
2011
- 2011-04-14 US US13/086,453 patent/US20120238841A1/en not_active Abandoned
-
2012
- 2012-04-16 BR BR112013026482A patent/BR112013026482A2/pt not_active IP Right Cessation
- 2012-04-16 JP JP2014505396A patent/JP2014515829A/ja active Pending
- 2012-04-16 EP EP12716978.7A patent/EP2696762A1/en not_active Withdrawn
- 2012-04-16 CN CN201280029129.4A patent/CN103796585B/zh not_active Expired - Fee Related
- 2012-04-16 WO PCT/US2012/033768 patent/WO2012142571A1/en active Application Filing
- 2012-04-16 AU AU2012242469A patent/AU2012242469B2/en not_active Ceased
- 2012-04-16 CA CA2832495A patent/CA2832495A1/en not_active Abandoned
-
2013
- 2013-10-08 IL IL228796A patent/IL228796A0/en unknown
-
2015
- 2015-08-03 JP JP2015153174A patent/JP2016013445A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2012142571A1 (en) | 2012-10-18 |
EP2696762A1 (en) | 2014-02-19 |
AU2012242469A1 (en) | 2013-11-07 |
CA2832495A1 (en) | 2012-10-18 |
US20120238841A1 (en) | 2012-09-20 |
AU2012242469B2 (en) | 2015-07-30 |
JP2016013445A (ja) | 2016-01-28 |
CN103796585A (zh) | 2014-05-14 |
IL228796A0 (en) | 2013-12-31 |
CN103796585B (zh) | 2017-11-07 |
JP2014515829A (ja) | 2014-07-03 |
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