BR112013024148A2 - dispositivos e métodos para separar partes marcadas magneticamente em uma amostra - Google Patents

dispositivos e métodos para separar partes marcadas magneticamente em uma amostra

Info

Publication number
BR112013024148A2
BR112013024148A2 BR112013024148A BR112013024148A BR112013024148A2 BR 112013024148 A2 BR112013024148 A2 BR 112013024148A2 BR 112013024148 A BR112013024148 A BR 112013024148A BR 112013024148 A BR112013024148 A BR 112013024148A BR 112013024148 A2 BR112013024148 A2 BR 112013024148A2
Authority
BR
Brazil
Prior art keywords
devices
sample
methods
magnetic field
parts
Prior art date
Application number
BR112013024148A
Other languages
English (en)
Other versions
BR112013024148B1 (pt
Inventor
Liping Yu
Original Assignee
Becton Dickinson Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson Co filed Critical Becton Dickinson Co
Publication of BR112013024148A2 publication Critical patent/BR112013024148A2/pt
Publication of BR112013024148B1 publication Critical patent/BR112013024148B1/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/34—Purifying; Cleaning
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/025—High gradient magnetic separators
    • B03C1/031—Component parts; Auxiliary operations
    • B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/0332—Component parts; Auxiliary operations characterised by the magnetic circuit using permanent magnets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/035—Open gradient magnetic separators, i.e. separators in which the gap is unobstructed, characterised by the configuration of the gap
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical applications
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

resumo patente de invenção: "dispositivos e métodos para separar partes marcadas magneticamente em uma amostra". a presente invenção refere-se a dispositivos para separar partes marcadas magneticamente em uma amostra que são fornecidos. aspectos dos dispositivos incluem uma fonte de campo magnético, um primeiro guia de campo magnético tendo uma parte em forma de cunha com uma borda de ápice, e um segundo guia de campo magnético tendo uma parte em forma de cunha com uma borda de ápice. a borda de ápice do primeiro guia de campo magnético é substancialmente alinhada e paralela à borda de ápice do segundo guia de campo magnético, e o dispositivo é configurado para separar partes marcadas magneticamente de partes não marcadas magneticamente na amostra. também são fornecidos métodos de usar os dispositivos, assim como sistemas e kits configurados para uso com os dispositivos e métodos.
BR112013024148-9A 2011-04-27 2012-04-05 Dispositivo, método e sistema para separar partes marcadas magneticamente em uma amostra, método de separar partes marcadas magneticamente em uma amostra BR112013024148B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161479778P 2011-04-27 2011-04-27
US61/479,778 2011-04-27
PCT/US2012/032423 WO2012148648A2 (en) 2011-04-27 2012-04-05 Devices and methods for separating magnetically labeled moieties in a sample

Publications (2)

Publication Number Publication Date
BR112013024148A2 true BR112013024148A2 (pt) 2016-12-20
BR112013024148B1 BR112013024148B1 (pt) 2022-01-25

Family

ID=47072995

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013024148-9A BR112013024148B1 (pt) 2011-04-27 2012-04-05 Dispositivo, método e sistema para separar partes marcadas magneticamente em uma amostra, método de separar partes marcadas magneticamente em uma amostra

Country Status (9)

Country Link
US (2) US9885642B2 (pt)
EP (1) EP2701850B1 (pt)
JP (1) JP6333719B2 (pt)
CN (1) CN103501912B (pt)
AU (1) AU2012250179B2 (pt)
BR (1) BR112013024148B1 (pt)
CA (1) CA2827226C (pt)
ES (1) ES2690784T3 (pt)
WO (1) WO2012148648A2 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6178335B2 (ja) 2011-12-21 2017-08-09 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 磁気標識サンプル成分の無菌分離のためのフローサイトメトリーシステム
CN110595987A (zh) * 2012-10-26 2019-12-20 贝克顿·迪金森公司 用于操纵流体样品中的组分的装置和方法
JP2017526162A (ja) * 2014-06-02 2017-09-07 モナシュ、ユニバーシティＭｏｎａｓｈ Ｕｎｉｖｅｒｓｉｔｙ 集中磁場を発生させるための磁気回路
CN107076738A (zh) 2014-10-20 2017-08-18 克里斯多夫·戈登·阿特伍德 用包含荧光基团和磁性基团的结构物分析样品的方法和系统
CN105543092B (zh) * 2016-01-06 2018-02-23 西北工业大学 动态非接触式细胞力学刺激加载装置
US11478150B2 (en) * 2016-03-28 2022-10-25 Becton, Dickinson And Company Optical fiber sensor
WO2017180325A1 (en) 2016-04-15 2017-10-19 Becton, Dickinson And Company Enclosed droplet sorter and methods of using the same
KR101888636B1 (ko) * 2017-06-02 2018-08-14 지트로닉스 주식회사 자기 영동 바이오 칩
US10449553B2 (en) 2018-03-03 2019-10-22 Yuchen Zhou Magnetic biological entity separation device and method of use
US11571696B2 (en) 2018-03-03 2023-02-07 Applied Cells Inc. Biological entity separation device and method of use
JP7366931B2 (ja) 2018-04-27 2023-10-23 ベクトン・ディキンソン・アンド・カンパニー 制御されたエアロゾル含有量を有する密閉された液滴ソータを有するフローサイトメータおよびそれを使用する方法
US11275075B2 (en) 2018-04-27 2022-03-15 Becton, Dickinson And Company Collection systems for flow cytometrically sorted samples and methods of using the same
WO2020091866A1 (en) 2018-10-30 2020-05-07 Becton, Dickinson And Company Particle sorting module with alignment window, systems and methods of use thereof
KR102375921B1 (ko) * 2020-04-03 2022-03-17 사회복지법인 삼성생명공익재단 분리 장치 및 방법

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK111582A (da) 1982-03-12 1983-09-13 Niro Atomizer As Hoejgradient magnetisk separator
US4664796A (en) 1985-09-16 1987-05-12 Coulter Electronics, Inc. Flux diverting flow chamber for high gradient magnetic separation of particles from a liquid medium
JPH07111430B2 (ja) * 1987-10-22 1995-11-29 日本電信電話株式会社 レーザ磁気免疫測定方法及び測定装置
AU4746590A (en) 1988-12-28 1990-08-01 Stefan Miltenyi Methods and materials for high gradient magnetic separation of biological materials
US5279936A (en) 1989-12-22 1994-01-18 Syntex (U.S.A.) Inc. Method of separation employing magnetic particles and second medium
US5200084A (en) 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
US5622831A (en) 1990-09-26 1997-04-22 Immunivest Corporation Methods and devices for manipulation of magnetically collected material
US5541072A (en) 1994-04-18 1996-07-30 Immunivest Corporation Method for magnetic separation featuring magnetic particles in a multi-phase system
US6013532A (en) 1990-09-26 2000-01-11 Immunivest Corporation Methods for magnetic immobilization and manipulation of cells
US5147562A (en) 1990-12-17 1992-09-15 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Acoustophoresis method and apparatus
US5795470A (en) 1991-03-25 1998-08-18 Immunivest Corporation Magnetic separation apparatus
US6120735A (en) 1992-02-26 2000-09-19 The Ohio States University Fractional cell sorter
GB2265004B (en) 1992-03-10 1996-01-10 Univ Cardiff Immuno-agglutination assay using ultrasonic standing wave field
US5897783A (en) * 1992-09-24 1999-04-27 Amersham International Plc Magnetic separation method
US6216538B1 (en) 1992-12-02 2001-04-17 Hitachi, Ltd. Particle handling apparatus for handling particles in fluid by acoustic radiation pressure
AT398707B (de) 1993-05-11 1995-01-25 Trampler Felix Mehrschichtiger piezoelektrischer resonator für die separation von suspendierten teilchen
US5626767A (en) 1993-07-02 1997-05-06 Sonosep Biotech Inc. Acoustic filter for separating and recycling suspended particles
JPH08252723A (ja) * 1995-03-18 1996-10-01 Sodick Co Ltd 粉末混入加工液を用いる放電加工方法及び方法の実施に使用する放電加工用の磁気吸着装置
DE19520298A1 (de) 1995-06-02 1996-12-05 Bayer Ag Sortiervorrichtung für biologische Zellen oder Viren
US5803270A (en) 1995-10-31 1998-09-08 Institute Of Paper Science & Technology, Inc. Methods and apparatus for acoustic fiber fractionation
JP3487699B2 (ja) 1995-11-08 2004-01-19 株式会社日立製作所 超音波処理方法および装置
US5945281A (en) 1996-02-02 1999-08-31 Becton, Dickinson And Company Method and apparatus for determining an analyte from a sample fluid
US5688405A (en) 1996-02-28 1997-11-18 The United States Of America As Represented By The Secretary Of The Navy Method and apparatus for separating particulate matter from a fluid
US5688406A (en) 1996-02-28 1997-11-18 The United States Of America As Represented By The Secretary Of The Navy Method and apparatus for separating particulate from a flowing fluid
US5918272A (en) 1996-04-12 1999-06-29 General Electric Company Magnetic and ultrasonic discriminator for particle size distribution analyzer
US6890426B2 (en) 1996-06-07 2005-05-10 Immunivest Corporation Magnetic separation apparatus and methods
US6660159B1 (en) 1996-06-07 2003-12-09 Immunivest Corporation Magnetic separation apparatus and methods
US6790366B2 (en) 1996-06-07 2004-09-14 Immunivest Corporation Magnetic separation apparatus and methods
AU3374597A (en) 1996-06-07 1998-01-05 Immunivest Corporation Magnetic separation employing external and internal gradients
US7666308B2 (en) 1996-06-07 2010-02-23 Veridex, Llc. Magnetic separation apparatus and methods
US6136182A (en) 1996-06-07 2000-10-24 Immunivest Corporation Magnetic devices and sample chambers for examination and manipulation of cells
US6074827A (en) 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
DK0925494T3 (da) 1996-09-04 2002-07-01 Scandinavian Micro Biodevices Mikrostrømningssystem til partikelseparation og analyse
US5968820A (en) 1997-02-26 1999-10-19 The Cleveland Clinic Foundation Method for magnetically separating cells into fractionated flow streams
GB9708984D0 (en) 1997-05-03 1997-06-25 Univ Cardiff Particle manipulation
JP2001518624A (ja) 1997-09-26 2001-10-16 ユニバーシティ・オブ・ワシントン 同時の粒子分離および化学反応
US6241894B1 (en) * 1997-10-10 2001-06-05 Systemix High gradient magnetic device and method for cell separation or purification
CA2260991C (en) 1997-11-18 2009-03-24 Bio-Rad Laboratories, Inc. Multiplex flow immunoassays with magnetic particles as solid phase
US6036027A (en) 1998-01-30 2000-03-14 Beloit Technologies, Inc. Vibratory cleaner
DE19820466C2 (de) 1998-05-07 2002-06-13 Fraunhofer Ges Forschung Vorrichtung und Verfahren zur gezielten Beaufschlagung einer biologischen Probe mit Schallwellen
US6126835A (en) 1998-05-15 2000-10-03 Biocrystal Ltd. Device and method for magnetic separation of biological molecules
JP2000024431A (ja) 1998-07-14 2000-01-25 Hitachi Ltd 微粒子処理装置
US6361749B1 (en) 1998-08-18 2002-03-26 Immunivest Corporation Apparatus and methods for magnetic separation
WO2000025125A1 (en) 1998-10-28 2000-05-04 Covaris, Inc. Apparatus and methods for controlling sonic treatment
US6623982B1 (en) 1999-07-12 2003-09-23 Immunivest Corporation Increased separation efficiency via controlled aggregation of magnetic nanoparticles
IL148090A (en) 1999-09-03 2005-08-31 Cleveland Clinic Foundation Continuous particle and molecule separation with an annular flow channel
US6254830B1 (en) 1999-11-05 2001-07-03 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations Magnetic focusing immunosensor for the detection of pathogens
US6645777B1 (en) 1999-11-05 2003-11-11 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantation Tapered tubular optical waveguide probe for magnetic focusing immunosensors
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US6506584B1 (en) 2000-04-28 2003-01-14 Battelle Memorial Institute Apparatus and method for ultrasonic treatment of a liquid
CA2413634A1 (en) 2000-06-14 2001-12-20 Peter R. C. Gascoyne Method and apparatus for combined magnetophoretic and dielectrophoretic manipulation of analyte mixtures
US6854338B2 (en) 2000-07-14 2005-02-15 The Board Of Trustees Of The Leland Stanford Junior University Fluidic device with integrated capacitive micromachined ultrasonic transducers
JP3513591B2 (ja) 2000-09-13 2004-03-31 大阪大学長 磁気勾配下液中微粒子磁気トラップ分離方法及び装置
EP1366356B1 (en) 2001-02-14 2010-07-21 Picoliter, Inc. Acoustic sample introduction for analysis and/or processing
SE522801C2 (sv) 2001-03-09 2004-03-09 Erysave Ab Anordning för att separera suspenderade partiklar från en fluid med ultraljud samt metod för sådan separering
US6467350B1 (en) 2001-03-15 2002-10-22 The Regents Of The University Of California Cylindrical acoustic levitator/concentrator
US7232691B2 (en) 2001-11-27 2007-06-19 Los Alamos National Security, Llc Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres
US7148778B2 (en) * 2001-11-30 2006-12-12 The Regents Of The University Of California High performance hybrid magnetic structure for biotechnology applications
US7486166B2 (en) * 2001-11-30 2009-02-03 The Regents Of The University Of California High performance hybrid magnetic structure for biotechnology applications
JP3828818B2 (ja) 2002-03-01 2006-10-04 株式会社日立ハイテクノロジーズ 化学分析装置及び化学分析方法
US6749666B2 (en) 2002-04-26 2004-06-15 Board Of Regents, The University Of Texas System Modulated acoustic aggiomeration system and method
JP2004099584A (ja) * 2002-05-02 2004-04-02 Keio Gijuku Ｈｓｖを用いた抗腫瘍剤
US6932097B2 (en) 2002-06-18 2005-08-23 Picoliter Inc. Acoustic control of the composition and/or volume of fluid in a reservoir
WO2003102737A2 (en) 2002-06-04 2003-12-11 Protasis Corporation Method and device for ultrasonically manipulating particles within a fluid
GB0221391D0 (en) 2002-09-16 2002-10-23 Secr Defence Apparatus for directing particles in a fluid
US7108137B2 (en) 2002-10-02 2006-09-19 Wisconsin Alumni Research Foundation Method and apparatus for separating particles by size
DE10318062A1 (de) * 2003-04-17 2004-11-11 Robert Bosch Gmbh Getriebe-Antriebseinheit mit Elektronik-Schnittstelle
US7340957B2 (en) 2004-07-29 2008-03-11 Los Alamos National Security, Llc Ultrasonic analyte concentration and application in flow cytometry
SE528313C2 (sv) 2004-09-24 2006-10-17 Spectronic Ab Metod och apparat för separering av partiklar med hjälp av ultraljudvågor
CN101099082B (zh) 2004-12-03 2013-03-27 塞通诺米/St有限责任公司 用于粒子处理的整体式盒
JP2008525789A (ja) * 2004-12-23 2008-07-17 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 磁気センサに印加された磁場を評価する方法及び装置
JP2006218442A (ja) * 2005-02-14 2006-08-24 Jeol Ltd 免疫測定におけるｂ／ｆ分離装置および方法
US7474184B1 (en) * 2005-02-15 2009-01-06 The Regents Of The University Of California Hybrid magnet devices for molecule manipulation and small scale high gradient-field applications
US7256661B2 (en) * 2005-04-08 2007-08-14 The Boeing Company Multi-channel circulator/isolator apparatus and method
JP4948786B2 (ja) * 2005-06-09 2012-06-06 Ｎｅｃエナジーデバイス株式会社 磁気分離装置
CN1901194A (zh) * 2005-07-20 2007-01-24 松下电器产业株式会社 半导体装置及其制造方法
US7484414B2 (en) 2005-11-30 2009-02-03 Nanoalert Ltd. Method and apparatus for determination of the concentration of particles in multi-component fluid systems
AU2007274748A1 (en) 2006-06-21 2008-01-24 Spinomix S.A. A device and method for manipulating and mixing magnetic particles in a liquid medium
US7807454B2 (en) 2006-10-18 2010-10-05 The Regents Of The University Of California Microfluidic magnetophoretic device and methods for using the same
DE602007007420D1 (de) 2006-10-26 2010-08-12 Imec Handhabung von magnetischen oder magnetisierbaren Objekten unter Verwendung von kombinierter Magnetophorese und Dielektrophorese
JP2008209330A (ja) * 2007-02-28 2008-09-11 Hitachi High-Technologies Corp 磁気分離器およびそれを用いた分析装置
WO2008122051A1 (en) 2007-04-02 2008-10-09 Acoustic Cytometry Systems, Inc. Methods and devices for enhanced analysis of field focused cells and particles
US7837040B2 (en) 2007-04-09 2010-11-23 Los Alamos National Security, Llc Acoustic concentration of particles in fluid flow
US8083068B2 (en) 2007-04-09 2011-12-27 Los Alamos National Security, Llc Apparatus for separating particles utilizing engineered acoustic contrast capture particles
WO2008130618A1 (en) 2007-04-19 2008-10-30 The Charles Stark Draper Laboratory, Inc. Method and apparatus for separating particles, cells, molecules and particulates
US8268177B2 (en) 2007-08-13 2012-09-18 Agency For Science, Technology And Research Microfluidic separation system
US20090052272A1 (en) 2007-08-20 2009-02-26 Artann Laboratories, Inc. Ultrasonic stirring of liquids in small volumes
US7828968B2 (en) * 2007-08-30 2010-11-09 Veridex, Llc Method and apparatus for imaging target components in a biological sample using permanent magnets
DE102007043281A1 (de) * 2007-09-11 2009-05-28 Sebastian Dr. med. Chakrit Bhakdi Vorrichtung, Materialien und Verfahren zur Hochgradientenmagnetseparation biologischen Materials
US8263407B2 (en) 2007-10-24 2012-09-11 Los Alamos National Security, Llc Method for non-contact particle manipulation and control of particle spacing along an axis
CA2708256A1 (en) 2007-12-05 2009-06-18 Zyomyx, Inc. Cell concentration assay and kit
US8071395B2 (en) 2007-12-12 2011-12-06 The Board Of Trustees Of The Leland Stanford Junior University Methods and apparatus for magnetic separation of cells
US8266950B2 (en) 2007-12-19 2012-09-18 Los Alamos National Security, LLP Particle analysis in an acoustic cytometer
US8372590B2 (en) 2008-01-07 2013-02-12 Luminex Corporation Isolation and enumeration of cells from a complex sample matrix
US8323568B2 (en) 2008-06-13 2012-12-04 Honeywell International Inc. Magnetic bead assisted sample conditioning system
US8166819B2 (en) 2008-07-24 2012-05-01 Northrop Grumman Systems Corporation Standing wave field induced force
DK2440941T3 (en) 2009-06-10 2017-08-28 Cynvenio Biosystems Inc Sheath flow devices and methods
US8300303B1 (en) 2010-01-07 2012-10-30 The United States Of America As Represented By The Secretaryof The Navy Acoustically focused optical lens

Also Published As

Publication number Publication date
US20130330739A1 (en) 2013-12-12
WO2012148648A2 (en) 2012-11-01
EP2701850A2 (en) 2014-03-05
EP2701850A4 (en) 2015-01-21
AU2012250179B2 (en) 2016-08-18
US9885642B2 (en) 2018-02-06
US20180136098A1 (en) 2018-05-17
WO2012148648A3 (en) 2012-12-27
JP6333719B2 (ja) 2018-05-30
CA2827226A1 (en) 2012-11-01
CA2827226C (en) 2019-02-12
AU2012250179A1 (en) 2013-09-05
BR112013024148B1 (pt) 2022-01-25
CN103501912A (zh) 2014-01-08
CN103501912B (zh) 2017-10-24
EP2701850B1 (en) 2018-08-15
JP2014514152A (ja) 2014-06-19
US10444125B2 (en) 2019-10-15
ES2690784T3 (es) 2018-11-22

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