BR112013020533A2 - silicato de zircônio microporoso para o tratamento de hipercalemia - Google Patents

silicato de zircônio microporoso para o tratamento de hipercalemia

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Publication number
BR112013020533A2
BR112013020533A2 BR112013020533A BR112013020533A BR112013020533A2 BR 112013020533 A2 BR112013020533 A2 BR 112013020533A2 BR 112013020533 A BR112013020533 A BR 112013020533A BR 112013020533 A BR112013020533 A BR 112013020533A BR 112013020533 A2 BR112013020533 A2 BR 112013020533A2
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BR
Brazil
Prior art keywords
treatment
hyperkalemia
zirconium silicate
microporous zirconium
compositions
Prior art date
Application number
BR112013020533A
Other languages
English (en)
Inventor
Alvaro F Guillem
Donald Jeffrey Keyser
Original Assignee
Zs Pharma Inc
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46639226&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112013020533(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zs Pharma Inc filed Critical Zs Pharma Inc
Publication of BR112013020533A2 publication Critical patent/BR112013020533A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G25/00—Compounds of zirconium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/244—Lanthanides; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J19/0013—Controlling the temperature of the process
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    • B01J19/18—Stationary reactors having moving elements inside
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/02—Processes using inorganic exchangers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/14—Base exchange silicates, e.g. zeolites
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B33/00—Silicon; Compounds thereof
    • C01B33/20—Silicates
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
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    • C01B39/00—Compounds having molecular sieve and base-exchange properties, e.g. crystalline zeolites; Their preparation; After-treatment, e.g. ion-exchange or dealumination
    • C01B39/02—Crystalline aluminosilicate zeolites; Isomorphous compounds thereof; Direct preparation thereof; Preparation thereof starting from a reaction mixture containing a crystalline zeolite of another type, or from preformed reactants; After-treatment thereof
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    • C01B39/00—Compounds having molecular sieve and base-exchange properties, e.g. crystalline zeolites; Their preparation; After-treatment, e.g. ion-exchange or dealumination
    • C01B39/02—Crystalline aluminosilicate zeolites; Isomorphous compounds thereof; Direct preparation thereof; Preparation thereof starting from a reaction mixture containing a crystalline zeolite of another type, or from preformed reactants; After-treatment thereof
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
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    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Life Sciences & Earth Sciences (AREA)
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  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

silicato de zircônio microporoso para o tratamento de hipercalemia a presente invenção refere-se a novas composições de silicato de zircônio microporosos que são formulados para remover toxinas, por exemplo, íons de potássio, a partir do tratamento gastrointestinal, a uma taxa elevada, sem causar efeitos colaterais indesejáveis. as formulações preferidas são concebidos evitar o aumento do ph da urina de pacientes e / ou evitar a entrada potencial de partículas para a corrente sanguínea do paciente. também é revelado um método para a preparação de cristais de elevada pureza de uzsi-9 exibindo um maior nível de capacidade de troca de potássio. estas composições são particularmente úteis no tratamento terapêutico de hipercalemia.
BR112013020533A 2011-02-11 2012-02-10 silicato de zircônio microporoso para o tratamento de hipercalemia BR112013020533A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161441893P 2011-02-11 2011-02-11
PCT/US2012/024727 WO2012109590A2 (en) 2011-02-11 2012-02-10 Microporous zirconium silicate for the treatment of hyperkalemia

Publications (1)

Publication Number Publication Date
BR112013020533A2 true BR112013020533A2 (pt) 2016-10-18

Family

ID=46639226

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013020533A BR112013020533A2 (pt) 2011-02-11 2012-02-10 silicato de zircônio microporoso para o tratamento de hipercalemia

Country Status (30)

Country Link
US (15) US8802152B2 (pt)
EP (3) EP2673237B1 (pt)
JP (3) JP6071906B2 (pt)
KR (1) KR101896732B1 (pt)
CN (3) CN109106725A (pt)
AU (3) AU2012214224B2 (pt)
BR (1) BR112013020533A2 (pt)
CA (1) CA2827056C (pt)
CL (2) CL2013002337A1 (pt)
CO (1) CO6801733A2 (pt)
CY (2) CY1121310T1 (pt)
DK (1) DK2673237T3 (pt)
ES (1) ES2709004T3 (pt)
HK (1) HK1247178A1 (pt)
HR (1) HRP20190146T1 (pt)
HU (2) HUE041828T2 (pt)
IL (3) IL227907A (pt)
LT (2) LT2673237T (pt)
LU (1) LUC00111I2 (pt)
ME (1) ME03294B (pt)
MX (2) MX341822B (pt)
NL (1) NL300976I2 (pt)
NO (1) NO2019022I1 (pt)
PL (1) PL2673237T3 (pt)
PT (1) PT2673237T (pt)
RS (1) RS58490B1 (pt)
SI (1) SI2673237T1 (pt)
TR (1) TR201901002T4 (pt)
WO (1) WO2012109590A2 (pt)
ZA (1) ZA201306240B (pt)

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KR101896732B1 (ko) 2011-02-11 2018-09-07 제트에스 파마, 인코포레이티드 고칼륨혈증의 치료를 위한 미세다공성 규산지르코늄
US9943637B2 (en) 2012-06-11 2018-04-17 ZS Pharma, Inc. Microporous zirconium silicate and its method of production
MX2015000381A (es) 2012-07-11 2015-11-23 Zs Pharma Inc Silicato de zirconio microporoso para el tratamiento de la hipercalemia en pacientes hipercalcemicos y composiciones con calcio mejoradas para el tratamiento de la hipercalemia.
WO2014058905A2 (en) * 2012-10-08 2014-04-17 Relypsa, Inc. Potassium-binding agents for treating hypertension and hyperkalemia
MX360684B (es) 2012-10-22 2018-11-13 Zs Pharma Inc Silicato de zirconio microporoso para el tratamiento de la hipercalemia.
US10695365B2 (en) 2012-10-22 2020-06-30 ZS Pharma, Inc. Microporous zirconium silicate for the treatment of hyperkalemia
US20150359821A1 (en) * 2012-10-22 2015-12-17 ZS Pharma, Inc. Microporous Zirconium Silicate for the Treatment of Hyperkalemia
TWI655948B (zh) * 2013-03-15 2019-04-11 美商Ｚｓ藥品公司 用於高血鉀治療之微孔矽酸鋯
PT2981272T (pt) * 2013-04-05 2023-05-03 Zs Pharma Inc Silicato de zircónio microporoso e diuréticos para a redução de potássio e tratamento de doença renal crónica e/ou cardíaca crónica
US20160038538A1 (en) * 2013-11-08 2016-02-11 ZS Pharma, Inc. Microporous zirconium silicate for the treatment of hyperkalemia
JP2016535749A (ja) * 2013-11-08 2016-11-17 ズィーエス・ファーマ，インコーポレーテッド 高カリウム血症治療用細孔性ケイ酸ジルコニウム
CA2929978C (en) * 2013-11-08 2021-11-30 ZS Pharma, Inc. Microporous zirconium silicate for the treatment of hyperkalemia
JP2016540010A (ja) * 2013-12-10 2016-12-22 ズィーエス・ファーマ，インコーポレーテッド リチウム非共投与における高カリウム血症治療用ケイ酸ジルコニウム
US9592253B1 (en) * 2015-10-14 2017-03-14 ZS Pharma, Inc. Extended use zirconium silicate compositions and methods of use thereof
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US11964266B2 (en) 2019-07-09 2024-04-23 Uop Llc Process for removing cobalt, lead, cadmium and chromium ions from bodily fluids using metallate ion exchange compositions
US11484875B2 (en) 2019-07-09 2022-11-01 Uop Llc Process for removing mercury ions from bodily fluids using titanium metallate ion exchange compositions
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