BR112013003366A2 - terapia aperfeiçoada de células tronco hematopoiéticas e progenitoras - Google Patents
terapia aperfeiçoada de células tronco hematopoiéticas e progenitoras Download PDFInfo
- Publication number
- BR112013003366A2 BR112013003366A2 BR112013003366-5A BR112013003366A BR112013003366A2 BR 112013003366 A2 BR112013003366 A2 BR 112013003366A2 BR 112013003366 A BR112013003366 A BR 112013003366A BR 112013003366 A2 BR112013003366 A2 BR 112013003366A2
- Authority
- BR
- Brazil
- Prior art keywords
- hematopoietic
- cell population
- expression
- stem cells
- cells
- Prior art date
Links
- 230000003394 haemopoietic effect Effects 0.000 title claims abstract description 44
- 238000009168 stem cell therapy Methods 0.000 title description 2
- 238000009580 stem-cell therapy Methods 0.000 title description 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims abstract description 14
- 238000000034 method Methods 0.000 claims abstract description 10
- 210000000777 hematopoietic system Anatomy 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims abstract 16
- 230000001225 therapeutic effect Effects 0.000 claims abstract 16
- 210000004027 cell Anatomy 0.000 claims description 70
- 210000000130 stem cell Anatomy 0.000 claims description 38
- 210000001185 bone marrow Anatomy 0.000 claims description 13
- 210000004700 fetal blood Anatomy 0.000 claims description 10
- 210000005259 peripheral blood Anatomy 0.000 claims description 8
- 239000011886 peripheral blood Substances 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 5
- 206010033128 Ovarian cancer Diseases 0.000 claims description 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 206010006187 Breast cancer Diseases 0.000 claims description 3
- 208000026310 Breast neoplasm Diseases 0.000 claims description 3
- 206010028980 Neoplasm Diseases 0.000 claims description 3
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 3
- 208000032839 leukemia Diseases 0.000 claims description 3
- 208000028529 primary immunodeficiency disease Diseases 0.000 claims description 2
- 238000011282 treatment Methods 0.000 claims description 2
- 230000014509 gene expression Effects 0.000 claims 33
- 108090000623 proteins and genes Proteins 0.000 claims 33
- 239000003795 chemical substances by application Substances 0.000 claims 25
- 102000007299 Amphiregulin Human genes 0.000 claims 16
- 108010033760 Amphiregulin Proteins 0.000 claims 16
- 102100033601 Collagen alpha-1(I) chain Human genes 0.000 claims 16
- 102000004134 Fos-related antigen 2 Human genes 0.000 claims 16
- 108090000641 Fos-related antigen 2 Proteins 0.000 claims 16
- 102100025626 GTP-binding protein GEM Human genes 0.000 claims 16
- 101000945357 Homo sapiens Collagen alpha-1(I) chain Proteins 0.000 claims 16
- 102000003918 Hyaluronan Synthases Human genes 0.000 claims 16
- 108090000320 Hyaluronan Synthases Proteins 0.000 claims 16
- 102100028255 Renin Human genes 0.000 claims 16
- 108090000783 Renin Proteins 0.000 claims 16
- 102100027085 Dual specificity protein phosphatase 4 Human genes 0.000 claims 15
- 102000005228 Cyclic AMP Response Element Modulator Human genes 0.000 claims 14
- 108010056281 Cyclic AMP Response Element Modulator Proteins 0.000 claims 14
- 101001057621 Homo sapiens Dual specificity protein phosphatase 4 Proteins 0.000 claims 13
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 9
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 9
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 claims 9
- 108020005497 Nuclear hormone receptor Proteins 0.000 claims 8
- 102000006255 nuclear receptors Human genes 0.000 claims 8
- 108020004017 nuclear receptors Proteins 0.000 claims 8
- QAOBBBBDJSWHMU-WMBBNPMCSA-N 16,16-dimethylprostaglandin E2 Chemical compound CCCCC(C)(C)[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O QAOBBBBDJSWHMU-WMBBNPMCSA-N 0.000 claims 6
- 101150066398 CXCR4 gene Proteins 0.000 claims 6
- 229960002986 dinoprostone Drugs 0.000 claims 5
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 claims 5
- 150000003166 prostaglandin E2 derivatives Chemical class 0.000 claims 5
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 4
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 4
- 101710116158 GTP-binding protein GEM Proteins 0.000 claims 4
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 4
- 208000000733 Paroxysmal Hemoglobinuria Diseases 0.000 claims 4
- 102100036050 Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Human genes 0.000 claims 4
- 201000003045 paroxysmal nocturnal hemoglobinuria Diseases 0.000 claims 4
- 206010010099 Combined immunodeficiency Diseases 0.000 claims 3
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 claims 3
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 claims 3
- 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 claims 3
- 102100040485 HLA class II histocompatibility antigen, DRB1 beta chain Human genes 0.000 claims 3
- 108010075704 HLA-A Antigens Proteins 0.000 claims 3
- 108010058607 HLA-B Antigens Proteins 0.000 claims 3
- 108010052199 HLA-C Antigens Proteins 0.000 claims 3
- 108010039343 HLA-DRB1 Chains Proteins 0.000 claims 3
- 239000003623 enhancer Substances 0.000 claims 3
- 238000001727 in vivo Methods 0.000 claims 3
- 208000002491 severe combined immunodeficiency Diseases 0.000 claims 3
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 201000011452 Adrenoleukodystrophy Diseases 0.000 claims 2
- 208000032467 Aplastic anaemia Diseases 0.000 claims 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 206010010356 Congenital anomaly Diseases 0.000 claims 2
- 206010053138 Congenital aplastic anaemia Diseases 0.000 claims 2
- 101710132801 Dual specificity protein phosphatase 4 Proteins 0.000 claims 2
- 201000004939 Fanconi anemia Diseases 0.000 claims 2
- 208000017604 Hodgkin disease Diseases 0.000 claims 2
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 2
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 102000009030 Member 1 Subfamily D ATP Binding Cassette Transporter Human genes 0.000 claims 2
- 108010049137 Member 1 Subfamily D ATP Binding Cassette Transporter Proteins 0.000 claims 2
- 201000011442 Metachromatic leukodystrophy Diseases 0.000 claims 2
- 206010056886 Mucopolysaccharidosis I Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 2
- 208000033833 Myelomonocytic Chronic Leukemia Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010055006 Pancreatic sarcoma Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000003670 Pure Red-Cell Aplasia Diseases 0.000 claims 2
- 208000009527 Refractory anemia Diseases 0.000 claims 2
- 206010072684 Refractory cytopenia with unilineage dysplasia Diseases 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 208000006110 Wiskott-Aldrich syndrome Diseases 0.000 claims 2
- 239000012190 activator Substances 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- 201000010902 chronic myelomonocytic leukemia Diseases 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 206010028537 myelofibrosis Diseases 0.000 claims 2
- 201000002526 pancreas sarcoma Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 208000003476 primary myelofibrosis Diseases 0.000 claims 2
- 238000001959 radiotherapy Methods 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 206010043554 thrombocytopenia Diseases 0.000 claims 2
- 238000005406 washing Methods 0.000 claims 2
- 108050000299 Chemokine receptor Proteins 0.000 claims 1
- 102000009410 Chemokine receptor Human genes 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 102100036241 HLA class II histocompatibility antigen, DQ beta 1 chain Human genes 0.000 claims 1
- 102100040482 HLA class II histocompatibility antigen, DR beta 3 chain Human genes 0.000 claims 1
- 108010065026 HLA-DQB1 antigen Proteins 0.000 claims 1
- 108010061311 HLA-DRB3 Chains Proteins 0.000 claims 1
- 208000036066 Hemophagocytic Lymphohistiocytosis Diseases 0.000 claims 1
- 206010061598 Immunodeficiency Diseases 0.000 claims 1
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 1
- 208000035809 Lymphohistiocytosis Diseases 0.000 claims 1
- 208000037538 Myelomonocytic Juvenile Leukemia Diseases 0.000 claims 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims 1
- 101150109738 Ptger4 gene Proteins 0.000 claims 1
- 208000002903 Thalassemia Diseases 0.000 claims 1
- 230000003416 augmentation Effects 0.000 claims 1
- 208000005980 beta thalassemia Diseases 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000009977 dual effect Effects 0.000 claims 1
- 230000003511 endothelial effect Effects 0.000 claims 1
- 208000029944 familial hemophagocytic lymphohistiocytosis type 1 Diseases 0.000 claims 1
- 210000002768 hair cell Anatomy 0.000 claims 1
- 230000007813 immunodeficiency Effects 0.000 claims 1
- 230000000366 juvenile effect Effects 0.000 claims 1
- 201000005992 juvenile myelomonocytic leukemia Diseases 0.000 claims 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 238000002659 cell therapy Methods 0.000 abstract description 4
- 238000011476 stem cell transplantation Methods 0.000 abstract 1
- 230000000735 allogeneic effect Effects 0.000 description 2
- 230000003211 malignant effect Effects 0.000 description 2
- 230000001172 regenerating effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 206010025323 Lymphomas Diseases 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 238000010322 bone marrow transplantation Methods 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 208000024908 graft versus host disease Diseases 0.000 description 1
- 208000033065 inborn errors of immunity Diseases 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/02—Compounds of the arachidonic acid pathway, e.g. prostaglandins, leukotrienes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Diabetes (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37321210P | 2010-08-12 | 2010-08-12 | |
| US61/373,212 | 2010-08-12 | ||
| PCT/US2011/047657 WO2012021845A2 (en) | 2010-08-12 | 2011-08-12 | Improved hematopoietic stem and progenitor cell therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013003366A2 true BR112013003366A2 (pt) | 2020-08-04 |
Family
ID=45568224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013003366-5A BR112013003366A2 (pt) | 2010-08-12 | 2011-08-12 | terapia aperfeiçoada de células tronco hematopoiéticas e progenitoras |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20140030232A1 (https=) |
| EP (2) | EP2603227B1 (https=) |
| JP (7) | JP6047489B2 (https=) |
| CN (5) | CN112501118A (https=) |
| AU (1) | AU2011289245B2 (https=) |
| BR (1) | BR112013003366A2 (https=) |
| CA (1) | CA2807944C (https=) |
| ES (1) | ES2654994T3 (https=) |
| WO (1) | WO2012021845A2 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2603227B1 (en) * | 2010-08-12 | 2017-10-04 | Fate Therapeutics, Inc. | Improved hematopoietic stem and progenitor cell therapy |
| US10111907B2 (en) | 2011-12-02 | 2018-10-30 | Fate Therapeutics, Inc. | Methods of treating ischemia |
| EP3785767A1 (en) * | 2011-12-02 | 2021-03-03 | Fate Therapeutics, Inc. | Enhanced stem cell composition |
| WO2014078617A1 (en) * | 2012-11-16 | 2014-05-22 | Albert Einstein College Of Medicine Of Yeshiva University | Identification and use of new tumor-promoting gene in hematological malignancies |
| CN113913366B (zh) * | 2013-02-18 | 2025-01-10 | 大学健康网络 | 由多能干细胞生成肝细胞和胆管细胞的方法 |
| EP2970881A4 (en) * | 2013-03-14 | 2017-01-25 | Children's Medical Center Corporation | Compositions and methods for reprogramming hematopoietic stem cell lineages |
| US10851412B2 (en) | 2013-03-15 | 2020-12-01 | Fate Therapeutics, Inc. | Cell potency assay for therapeutic potential |
| US9943545B2 (en) | 2013-03-15 | 2018-04-17 | Fate Therapeutics, Inc. | Stem cell culture media and methods of enhancing cell survival |
| WO2014140921A2 (en) | 2013-03-15 | 2014-09-18 | Larsson Marcus Kare Torleif | Cells, methods and apparatuses for umbilical cord blood collection and isolation of cells |
| RU2525143C1 (ru) * | 2013-03-22 | 2014-08-10 | Федеральное государственное бюджетное учреждение науки Государственный научный центр Российской Федерации-Институт медико-биологических проблем Российской академии наук | СПОСОБ ЭКСПАНСИИ МОНОНУКЛЕАРНЫХ КЛЕТОК ПУПОВИННОЙ КРОВИ (пкМНК) ex vivo В ПРИСУТСТВИИ МУЛЬТИПОТЕНТНЫХ СТРОМАЛЬНЫХ МЕЗЕНХИМАЛЬНЫХ КЛЕТОК (ММСК) |
| WO2015077691A2 (en) * | 2013-11-22 | 2015-05-28 | Washington University | Biomarkers for multiple myeloma |
| US11278572B2 (en) | 2014-07-18 | 2022-03-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Reducing CXCR4 expression and/or function to enhance engraftment of hematopoietic stem cells |
| AU2016211671B2 (en) | 2015-01-26 | 2022-05-26 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| US20180112180A1 (en) * | 2015-01-26 | 2018-04-26 | Fate Therapeutics, Inc. | Cells with increased immuno-regulatory properties and methods for their use and manufacture |
| HK1249534A1 (zh) * | 2015-04-06 | 2018-11-02 | 哈佛大学校长及研究员协会 | 用於非清髓性预处理的组合物和方法 |
| EP4202036A1 (en) * | 2015-07-20 | 2023-06-28 | Angiocrine Bioscience, Inc. | Methods and compositions for stem cell transplantation |
| RU2018106515A (ru) | 2015-07-21 | 2019-08-21 | Зе Чилдрен'С Медикал Сентер Корпорейшн | Pd-l1-экспрессирующие гемопоэтические стволовые клетки и применения |
| CA3003152A1 (en) | 2015-11-04 | 2017-05-11 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| JP6928604B2 (ja) | 2015-11-04 | 2021-09-01 | フェイト セラピューティクス，インコーポレイテッド | 万能性細胞のゲノム改変 |
| EP3411475B1 (en) * | 2016-02-06 | 2025-08-27 | President and Fellows of Harvard College | Recapitulating the hematopoietic niche to reconstitute immunity |
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