BR112012032185A2 - anticorpos úteis na imunização passiva de influenza. - Google Patents
anticorpos úteis na imunização passiva de influenza.Info
- Publication number
- BR112012032185A2 BR112012032185A2 BR112012032185A BR112012032185A BR112012032185A2 BR 112012032185 A2 BR112012032185 A2 BR 112012032185A2 BR 112012032185 A BR112012032185 A BR 112012032185A BR 112012032185 A BR112012032185 A BR 112012032185A BR 112012032185 A2 BR112012032185 A2 BR 112012032185A2
- Authority
- BR
- Brazil
- Prior art keywords
- influenza
- passive immunization
- antibodies useful
- antibodies
- useful
- Prior art date
Links
- 206010022000 influenza Diseases 0.000 title abstract 4
- 230000003053 immunization Effects 0.000 title abstract 2
- 238000002649 immunization Methods 0.000 title abstract 2
- 239000012634 fragment Substances 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000001932 seasonal effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 241000712461 unidentified influenza virus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1018—Orthomyxoviridae, e.g. influenza virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Inorganic Chemistry (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
anticorpos úteis na imunização passiva de influenza. os articorpos monoclonais e seus fragmentos que são reação cruzada com múltiplos subtipos de vírus da gripe, incluindo tanto o grupo 1 e grupo 2 representantes são divulgados. estes anticorpos são úteis no controlo de epidemias de gripe e pandemias, bem como o fornecimento de proteção profilática ou terapêutica contra a gripe sazonal.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35597810P | 2010-06-17 | 2010-06-17 | |
US201161443103P | 2011-02-15 | 2011-02-15 | |
US201161445455P | 2011-02-22 | 2011-02-22 | |
PCT/US2011/040982 WO2011160083A1 (en) | 2010-06-17 | 2011-06-17 | Antibodies useful in passive influenza immuization |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112012032185A2 true BR112012032185A2 (pt) | 2016-10-11 |
Family
ID=45348575
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012032185A BR112012032185A2 (pt) | 2010-06-17 | 2011-06-17 | anticorpos úteis na imunização passiva de influenza. |
Country Status (12)
Country | Link |
---|---|
US (1) | US10676520B2 (pt) |
EP (1) | EP2582721B1 (pt) |
JP (1) | JP6050747B2 (pt) |
KR (1) | KR101849738B1 (pt) |
CN (2) | CN106397584A (pt) |
AU (2) | AU2011268072C1 (pt) |
BR (1) | BR112012032185A2 (pt) |
CA (1) | CA2839421C (pt) |
DK (1) | DK2582721T3 (pt) |
ES (1) | ES2687706T3 (pt) |
RU (1) | RU2635999C2 (pt) |
WO (1) | WO2011160083A1 (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2861515A1 (en) | 2011-12-05 | 2013-06-13 | Trellis Bioscience, Llc | Antibodies useful in passive influenza immunization |
US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
MX2015005860A (es) | 2012-11-13 | 2015-08-10 | Genentech Inc | Anticuerpos de antihemaglutinina y metodo de uso. |
AU2014236508A1 (en) | 2013-03-14 | 2015-09-17 | Contrafect Corporation | Composition and methods based on neutralizing antibodies delivered intranasally for enhanced therapeutic efficacy |
US10639370B2 (en) | 2014-02-04 | 2020-05-05 | Contrafect Corporation | Antibodies useful in passive influenza immunization, and compositions, combinations and methods for use thereof |
EP3102598A2 (en) | 2014-02-04 | 2016-12-14 | Contrafect Corporation | Antibodies useful in passive influenza immunization, and compositions, combinations and methods for use thereof |
CN106132982A (zh) * | 2014-03-20 | 2016-11-16 | 因弗拉克斯有限责任公司 | 用于治疗病毒性肺炎的C5a抑制剂 |
TWI702229B (zh) | 2014-12-19 | 2020-08-21 | 美商再生元醫藥公司 | 流行性感冒病毒血球凝集素之人類抗體 |
WO2017083627A1 (en) | 2015-11-13 | 2017-05-18 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
JP2019529345A (ja) * | 2016-07-14 | 2019-10-17 | バイオアークティック アクティエボラーグ | 脳送達タンパク質 |
CN111989115A (zh) * | 2017-12-29 | 2020-11-24 | 财团法人生物技术开发中心 | 针对流感的通用疫苗 |
WO2019147867A1 (en) | 2018-01-26 | 2019-08-01 | Regeneron Pharmaceuticals, Inc. | Human antibodies to influenza hemagglutinin |
JP2022521819A (ja) | 2019-03-25 | 2022-04-12 | ビステラ, インコーポレイテッド | インフルエンザを処置および予防するための組成物および方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6235708B1 (en) | 1998-11-20 | 2001-05-22 | Zymogenetics, Inc | Testis-specific cystatin-like protein cystatin T |
US20020006656A1 (en) | 1999-12-23 | 2002-01-17 | Holloway James L. | Zcys5: a member of the cystatin superfamily |
WO2003080672A1 (en) | 2002-03-22 | 2003-10-02 | Aprogen, Inc. | Humanized antibody and process for preparing same |
EP1603590A4 (en) | 2003-03-07 | 2008-08-27 | Merck & Co Inc | INFLUENZA VIRUS VACCINE |
KR101206206B1 (ko) | 2003-07-22 | 2012-11-29 | 크루셀 홀란드 비.브이. | 사스-코로나바이러스에 대한 결합분자 및 그것의 용도 |
RU2366662C2 (ru) * | 2003-07-23 | 2009-09-10 | Фуджирибайо Инк. | Моноклональное антитело к вирусу типа а гриппа и устройство для иммунного анализа с использованием антитела |
US7413868B2 (en) | 2003-11-05 | 2008-08-19 | Trellis Bioscience, Inc. | Use of particulate labels in bioanalyte detection methods |
EP2024393A2 (en) | 2006-05-15 | 2009-02-18 | Sea Lane Biotechnologies,llc. | Neutralizing antibodies to influenza viruses |
MY170607A (en) * | 2006-09-07 | 2019-08-20 | Crucell Holland Bv | Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof |
NO347649B1 (no) * | 2006-12-14 | 2024-02-12 | Regeneron Pharma | Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse. |
EP2222701B1 (en) * | 2007-12-06 | 2017-11-01 | Dana-Farber Cancer Institute, Inc. | Antibodies against influenza virus and methods of use thereof |
WO2009121004A2 (en) * | 2008-03-28 | 2009-10-01 | Sea Lane Biotechnologies, Llc | Neutralizing molecules to viral antigens |
JP2011528902A (ja) | 2008-07-25 | 2011-12-01 | インスティテュート・フォー・リサーチ・イン・バイオメディシン | 抗a型インフルエンザウイルス中和抗体およびその使用 |
CL2009001735A1 (es) * | 2008-08-19 | 2010-02-19 | Regeneron Pharma | Anticuerpo humano o fragmento de union a antigeno del mismo que une e inhibe actividad de ligando del activador del receptor de nf-kb (rankl); adn codificante; vector de expresion; metodo para producir dicho anticuerpo; composicion farmaceutica que lo comprende; uso para atenuar o inhibir enfermedad o condicion mediada por rankl |
AU2008365616A1 (en) | 2008-12-24 | 2011-08-11 | Temasek Life Sciences Laboratory Limited | Monoclonal antibodies specific to the fusion peptide from hemagglutinin from influenza A viruses and uses thereof |
EA029198B1 (ru) | 2010-03-26 | 2018-02-28 | Помона Ричерка С.Р.Л. | Полноразмерные иммуноглобулины изотипа igg, способные к распознаванию нейтрализующего эпитопа в области стебля гемагглютинина различных подтипов и их использование в качестве лекарственного средства против гриппа |
JP2013540701A (ja) * | 2010-08-12 | 2013-11-07 | セラクローン サイエンシーズ, インコーポレイテッド | 抗赤血球凝集素抗体組成物およびその使用方法 |
US20130289246A1 (en) * | 2010-09-30 | 2013-10-31 | Vanderbilt University | Influenza virus antibodies and immunogens and uses therefor |
-
2011
- 2011-06-17 WO PCT/US2011/040982 patent/WO2011160083A1/en active Application Filing
- 2011-06-17 DK DK11796555.8T patent/DK2582721T3/en active
- 2011-06-17 ES ES11796555.8T patent/ES2687706T3/es active Active
- 2011-06-17 JP JP2013515568A patent/JP6050747B2/ja active Active
- 2011-06-17 BR BR112012032185A patent/BR112012032185A2/pt not_active IP Right Cessation
- 2011-06-17 KR KR1020137001292A patent/KR101849738B1/ko active IP Right Grant
- 2011-06-17 CN CN201610806357.8A patent/CN106397584A/zh active Pending
- 2011-06-17 RU RU2013102073A patent/RU2635999C2/ru active
- 2011-06-17 CN CN201180035923.5A patent/CN103209994B/zh not_active Expired - Fee Related
- 2011-06-17 CA CA2839421A patent/CA2839421C/en not_active Expired - Fee Related
- 2011-06-17 AU AU2011268072A patent/AU2011268072C1/en not_active Ceased
- 2011-06-17 EP EP11796555.8A patent/EP2582721B1/en active Active
- 2011-06-17 US US13/163,489 patent/US10676520B2/en active Active
-
2017
- 2017-06-09 AU AU2017203924A patent/AU2017203924B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP2582721A1 (en) | 2013-04-24 |
JP2013531993A (ja) | 2013-08-15 |
KR20130137584A (ko) | 2013-12-17 |
WO2011160083A1 (en) | 2011-12-22 |
DK2582721T3 (en) | 2018-10-01 |
EP2582721B1 (en) | 2018-08-22 |
US20120020971A1 (en) | 2012-01-26 |
KR101849738B1 (ko) | 2018-04-17 |
US10676520B2 (en) | 2020-06-09 |
AU2011268072A1 (en) | 2013-01-31 |
EP2582721A4 (en) | 2013-11-20 |
AU2017203924A1 (en) | 2017-07-06 |
JP6050747B2 (ja) | 2016-12-21 |
RU2635999C2 (ru) | 2017-11-17 |
CN103209994A (zh) | 2013-07-17 |
CA2839421C (en) | 2019-12-03 |
CN103209994B (zh) | 2016-10-12 |
CA2839421A1 (en) | 2011-12-22 |
CN106397584A (zh) | 2017-02-15 |
AU2011268072B2 (en) | 2017-03-09 |
AU2011268072C1 (en) | 2017-10-19 |
AU2011268072A2 (en) | 2013-02-28 |
RU2013102073A (ru) | 2014-07-27 |
AU2017203924B2 (en) | 2019-08-08 |
ES2687706T3 (es) | 2018-10-26 |
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Legal Events
Date | Code | Title | Description |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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