BR112012030678A2 - células-tronco da geleia de wharton nativa e sua purificação - Google Patents

células-tronco da geleia de wharton nativa e sua purificação

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Publication number
BR112012030678A2
BR112012030678A2 BR112012030678A BR112012030678A BR112012030678A2 BR 112012030678 A2 BR112012030678 A2 BR 112012030678A2 BR 112012030678 A BR112012030678 A BR 112012030678A BR 112012030678 A BR112012030678 A BR 112012030678A BR 112012030678 A2 BR112012030678 A2 BR 112012030678A2
Authority
BR
Brazil
Prior art keywords
purification
stem cells
wharton jelly
native wharton
native
Prior art date
Application number
BR112012030678A
Other languages
English (en)
Other versions
BR112012030678B1 (pt
Inventor
R Taghizadeh Rouzbeh
Original Assignee
Auxocell Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Auxocell Laboratories Inc filed Critical Auxocell Laboratories Inc
Publication of BR112012030678A2 publication Critical patent/BR112012030678A2/pt
Publication of BR112012030678B1 publication Critical patent/BR112012030678B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/70—Undefined extracts
    • C12N2500/80—Undefined extracts from animals
    • C12N2500/84—Undefined extracts from animals from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/02—Coculture with; Conditioned medium produced by embryonic cells
    • C12N2502/025—Coculture with; Conditioned medium produced by embryonic cells extra-embryonic cells, e.g. amniotic epithelium, placental cells, Wharton's jelly

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pregnancy & Childbirth (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Botany (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Detergent Compositions (AREA)

Abstract

células-tronco da geleia de wharton e sua purificação. a presente invenção refere-se às células-tronco da geleia de wharton não cultivadas e os métodos de sua purificação, armazenamento e utilização.
BR112012030678-2A 2010-06-01 2011-06-01 Método para purificação de células-tronco da geleia de wharton e método de cultivo de células-tronco mesenquimais BR112012030678B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35030310P 2010-06-01 2010-06-01
US61/350,303 2010-06-01
PCT/US2011/038710 WO2011153205A1 (en) 2010-06-01 2011-06-01 Native wharton's jelly stem cells and their purification

Publications (2)

Publication Number Publication Date
BR112012030678A2 true BR112012030678A2 (pt) 2017-07-25
BR112012030678B1 BR112012030678B1 (pt) 2021-10-19

Family

ID=44225995

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012030678-2A BR112012030678B1 (pt) 2010-06-01 2011-06-01 Método para purificação de células-tronco da geleia de wharton e método de cultivo de células-tronco mesenquimais

Country Status (12)

Country Link
US (6) US20130121972A1 (pt)
EP (1) EP2576768B1 (pt)
BR (1) BR112012030678B1 (pt)
CA (2) CA2801009C (pt)
CY (1) CY1119382T1 (pt)
DK (1) DK2576768T3 (pt)
ES (1) ES2634545T3 (pt)
LT (1) LT2576768T (pt)
PL (1) PL2576768T3 (pt)
PT (1) PT2576768T (pt)
SG (1) SG185811A1 (pt)
WO (1) WO2011153205A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1933852B1 (en) 2005-09-27 2018-12-19 TissueTech, Inc. Amniotic membrane preparations and purified compositions and methods of use
BR112012030678B1 (pt) 2010-06-01 2021-10-19 Auxocell Laboratories, INC Método para purificação de células-tronco da geleia de wharton e método de cultivo de células-tronco mesenquimais
CA2837878A1 (en) 2011-06-10 2012-12-13 Tissuetech, Inc. Methods of processing fetal support tissues, fetal support tissue powder products, and uses thereof
SG11201501024QA (en) * 2012-08-15 2015-03-30 Univ Singapore Wound dressing nanomesh impregnated with human umbilical cord wharton's jelly stem cells
JP2017509112A (ja) 2014-02-11 2017-03-30 コーニング インコーポレイテッド 安定化リチウム複合粒子を含むリチウムイオン電池
TW201603818A (zh) 2014-06-03 2016-02-01 組織科技股份有限公司 組成物及方法
US9993748B2 (en) 2014-08-11 2018-06-12 Auxocell Laboratories, Inc. Centrifuge clip and method
USD748462S1 (en) 2014-08-11 2016-02-02 Auxocell Laboratories, Inc. Centrifuge clip
WO2016138025A2 (en) 2015-02-23 2016-09-01 Tissuetech, Inc. Apparatuses and methods for treating ophthalmic diseases and disorders
CN107847526A (zh) 2015-05-20 2018-03-27 组织技术公司 用于预防上皮细胞的增殖和上皮‑间充质转换的组合物和方法
TW201733600A (zh) 2016-01-29 2017-10-01 帝聖工業公司 胎兒扶持組織物及使用方法
CA3015517A1 (en) 2016-03-04 2017-09-08 The Board Of Regents Of The University Of Texas System Devices and methods for umbilical cord processing
EP3589298B1 (fr) * 2017-02-28 2022-06-22 Université de Lorraine Cellules souches mesenchymateuses issues de la gelée de wharton pour le traitement du sepsis
WO2019050882A1 (en) 2017-09-05 2019-03-14 Board Of Regents Of The University Of Texas System DEVICES AND METHODS FOR TREATMENT OF UMBILICAL CORD
EP3909593A1 (en) 2020-05-15 2021-11-17 Rigshospitalet Stem cells for treating skin lesions

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811094A (en) 1990-11-16 1998-09-22 Osiris Therapeutics, Inc. Connective tissue regeneration using human mesenchymal stem cell preparations
IT1260682B (it) 1993-09-28 1996-04-22 Consult T S S N C Di Roggero G Dispositivo trituratore meccanico di materiale biologico
US5919702A (en) 1996-10-23 1999-07-06 Advanced Tissue Science, Inc. Production of cartilage tissue using cells isolated from Wharton's jelly
AU749675B2 (en) 1998-03-13 2002-07-04 Mesoblast International Sarl Uses for human non-autologous mesenchymal stem cells
US6835377B2 (en) 1998-05-13 2004-12-28 Osiris Therapeutics, Inc. Osteoarthritis cartilage regeneration
AU4221399A (en) 1998-05-29 1999-12-13 Osiris Therapeutics, Inc. Human cd45+ and/or fibroblast + mesenchymal stem cells
US6663870B2 (en) 1998-12-07 2003-12-16 Zymogenetics, Inc. Methods for promoting growth of bone using zvegf3
US20030161818A1 (en) 2002-02-25 2003-08-28 Kansas State University Research Foundation Cultures, products and methods using stem cells
US7736892B2 (en) 2002-02-25 2010-06-15 Kansas State University Research Foundation Cultures, products and methods using umbilical cord matrix cells
WO2004069172A2 (en) 2003-01-30 2004-08-19 The Government of the United States of America as represented by the Department of Veterans Affairs Multilineage-inducible cells and uses thereof
ES2351386T3 (es) 2003-02-11 2011-02-03 John E. Davies Células progenitoras procedentes de la gelatina de wharton de cordón umbilical humano .
US7794408B2 (en) 2003-03-28 2010-09-14 Ethicon, Inc. Tissue collection device and methods
TWI255738B (en) 2003-12-31 2006-06-01 Ind Tech Res Inst Tissue pulverizer
CN101575590B (zh) * 2005-02-28 2012-05-23 中国医学科学院血液学研究所泰达生命科学技术研究中心 人脐带间充质干细胞的制备方法
CN100344757C (zh) * 2005-10-18 2007-10-24 天津昂赛细胞基因工程有限公司 人胎盘、脐带间充质干细胞库及其构建方法
CN101627112A (zh) 2006-06-28 2010-01-13 堪萨斯大学 将来自脐带基质的干细胞分化为肝细胞谱系细胞
WO2008021391A1 (en) 2006-08-15 2008-02-21 Anthrogenesis Corporation Umbilical cord biomaterial for medical use
US8071135B2 (en) * 2006-10-04 2011-12-06 Anthrogenesis Corporation Placental tissue compositions
US20080118477A1 (en) * 2006-11-09 2008-05-22 Rush University Medical Center Umbilical cord mesenchymal stem cells support cord blood hematopoiesis
EP2630959A1 (en) 2007-02-12 2013-08-28 Anthrogenesis Corporation Treatment of inflammatory diseases using placental stem cells
CA2630708C (en) * 2007-09-13 2017-08-01 Clifford L. Librach Method of isolation and use of cells derived from first trimester umbilical cord tissue
PT103843B (pt) 2007-10-04 2008-08-12 Medinfar Produtos Farmaceutico Método de isolamento de células precursoras a partir do cordão umbilical humano
ES2525718T3 (es) 2007-10-05 2014-12-29 DePuy Synthes Products, LLC Reparación y regeneración de tejido renal mediante células derivadas de tejido de cordón umbilical humano
JP2011529706A (ja) 2008-08-04 2011-12-15 アローキュア インコーポレイテッド 間充織間質細胞集団、ならびにそれを単離および使用する方法
BRPI0822802A2 (pt) * 2008-10-10 2015-09-01 Histocell Sl Biomaterial na forma de hidrogel injetável, biomaterial derivado do cordão umbilical humano, processo para a obtenção do biomaterial, processo para a obtenção do biomaterial obtido e uso do biomaterial
US20100111908A1 (en) 2008-11-03 2010-05-06 Fangming Lin Induction of Renal Cells for Treatment of Kidney Disease
CN101629165B (zh) * 2009-07-24 2012-12-26 中国人民解放军海军总医院 一种原始间充质干细胞的制备方法
CN101643719B (zh) * 2009-07-27 2013-07-24 北京大学人民医院 一种简化的脐带间充质干细胞分离培养方法及其在类风湿关节炎治疗中的应用
CN101642469B (zh) * 2009-09-09 2012-05-23 中国人民解放军海军总医院 脐带华通胶来源的间充质干细胞在急性心肌梗死细胞移植治疗中的应用
US20120276070A1 (en) 2009-11-17 2012-11-01 Vitro Diagnositics, Inc. Induced Pluripotent Stem Cells and Related Methods
JP2013514072A (ja) 2009-12-18 2013-04-25 シー．ビー．ビー．ライフライン バイオテク リミテッド 臍帯組織から間葉系前駆細胞の亜集団を含む単核細胞および内皮前駆細胞の亜集団を含む血管細胞を単離する方法
BR112012030678B1 (pt) 2010-06-01 2021-10-19 Auxocell Laboratories, INC Método para purificação de células-tronco da geleia de wharton e método de cultivo de células-tronco mesenquimais
KR101210988B1 (ko) 2010-06-08 2012-12-11 동국대학교 산학협력단 전자기장을 이용한 성체 줄기세포의 신경세포 분화유도 방법
WO2012131618A1 (en) 2011-03-30 2012-10-04 Stempeutics Research Private Limited A composition comprising pooled wharton's jelly derived mesenchymal stem cells and methods thereof
TWI535377B (zh) 2011-09-01 2016-06-01 Storage, culture and application of umbilical cord tissue and its derived cells
AU2012335746B2 (en) 2011-11-08 2017-04-27 Auxocell Laboratories, Inc. Systems and methods for processing cells

Also Published As

Publication number Publication date
SG185811A1 (en) 2013-01-30
CA3056049A1 (en) 2011-12-08
US20130183273A1 (en) 2013-07-18
CY1119382T1 (el) 2018-02-14
LT2576768T (lt) 2017-08-25
US9012222B2 (en) 2015-04-21
CA2801009C (en) 2021-10-26
DK2576768T3 (en) 2017-08-28
US9920301B2 (en) 2018-03-20
US20130121972A1 (en) 2013-05-16
EP2576768B1 (en) 2017-05-10
WO2011153205A1 (en) 2011-12-08
BR112012030678B1 (pt) 2021-10-19
US20170044490A1 (en) 2017-02-16
US9441201B2 (en) 2016-09-13
US20170107496A1 (en) 2017-04-20
PT2576768T (pt) 2017-08-11
ES2634545T3 (es) 2017-09-28
US20150197728A1 (en) 2015-07-16
EP2576768A1 (en) 2013-04-10
CA2801009A1 (en) 2011-12-08
PL2576768T3 (pl) 2017-10-31
US20200332261A1 (en) 2020-10-22

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