BR112012028920A2 - formulações de anticorpo de alta concentração - Google Patents
formulações de anticorpo de alta concentraçãoInfo
- Publication number
- BR112012028920A2 BR112012028920A2 BR112012028920A BR112012028920A BR112012028920A2 BR 112012028920 A2 BR112012028920 A2 BR 112012028920A2 BR 112012028920 A BR112012028920 A BR 112012028920A BR 112012028920 A BR112012028920 A BR 112012028920A BR 112012028920 A2 BR112012028920 A2 BR 112012028920A2
- Authority
- BR
- Brazil
- Prior art keywords
- high concentration
- antibody formulations
- concentration antibody
- formulations
- antisclerostin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Abstract
formulações de anticorpo de alta concentração. neste documento estão divulgadas formulações de anticorpo de alta concentração compreendendo uma imunoglobulina antiesclerostina e um sal de acetato e/ou tampão de acetato e métodos de utilização.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33498610P | 2010-05-14 | 2010-05-14 | |
US61/334,986 | 2010-05-14 | ||
PCT/US2011/036062 WO2011143307A1 (en) | 2010-05-14 | 2011-05-11 | High concentration antibody formulations |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112012028920A2 true BR112012028920A2 (pt) | 2017-03-14 |
BR112012028920B1 BR112012028920B1 (pt) | 2021-03-23 |
Family
ID=44146975
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012028920-9A BR112012028920B1 (pt) | 2010-05-14 | 2011-05-11 | Formulações líquidas estéreis de anticorpo de alta concentração e método para reduzir a viscosidade de uma formulação de proteína |
Country Status (29)
Country | Link |
---|---|
US (4) | US9352043B2 (pt) |
EP (3) | EP2569010B1 (pt) |
JP (6) | JP5889877B2 (pt) |
KR (3) | KR102220879B1 (pt) |
CN (1) | CN102946903B (pt) |
AU (1) | AU2011250920B2 (pt) |
BR (1) | BR112012028920B1 (pt) |
CA (1) | CA2798888C (pt) |
CL (1) | CL2012003172A1 (pt) |
CO (1) | CO6640258A2 (pt) |
CY (2) | CY1119069T1 (pt) |
DK (2) | DK2569010T3 (pt) |
EA (3) | EA027039B1 (pt) |
ES (2) | ES2773031T3 (pt) |
HN (1) | HN2012002446A (pt) |
HR (2) | HRP20170983T1 (pt) |
HU (2) | HUE033315T2 (pt) |
IL (3) | IL264636B (pt) |
LT (2) | LT3195880T (pt) |
ME (1) | ME02819B (pt) |
MX (1) | MX2012013268A (pt) |
PL (2) | PL2569010T3 (pt) |
PT (2) | PT2569010T (pt) |
RS (2) | RS56210B1 (pt) |
SG (3) | SG10201912670XA (pt) |
SI (2) | SI2569010T1 (pt) |
TW (4) | TWI689517B (pt) |
WO (1) | WO2011143307A1 (pt) |
ZA (1) | ZA201208543B (pt) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040002451A1 (en) * | 2002-06-20 | 2004-01-01 | Bruce Kerwin | Compositions of pegylated soluble tumor necrosis factor receptors and methods of preparing |
US7592429B2 (en) * | 2005-05-03 | 2009-09-22 | Ucb Sa | Sclerostin-binding antibody |
WO2008118970A2 (en) | 2007-03-27 | 2008-10-02 | Sea Lane Biotechnologies, Llc | Constructs and libraries comprising antibody surrogate light chain sequences |
CA2761681A1 (en) | 2009-05-13 | 2010-11-18 | Sea Lane Biotechnologies, Llc | Neutralizing molecules to influenza viruses |
CN102946903B (zh) * | 2010-05-14 | 2014-11-26 | 安进公司 | 高浓度抗体制剂 |
US10300140B2 (en) | 2011-07-28 | 2019-05-28 | I2 Pharmaceuticals, Inc. | Sur-binding proteins against ERBB3 |
US9975956B2 (en) | 2011-12-22 | 2018-05-22 | I2 Pharmaceuticals, Inc. | Surrogate binding proteins which bind DR4 and/or DR5 |
SG11201403718YA (en) * | 2011-12-28 | 2014-07-30 | Amgen Inc | Method of treating alveolar bone loss through the use of anti-sclerostin antibodies |
MA37777B1 (fr) * | 2012-06-21 | 2017-07-31 | Ucb Pharma Sa | Préparation pharmaceutique |
FR2994390B1 (fr) | 2012-08-10 | 2014-08-15 | Adocia | Procede d'abaissement de la viscosite de solutions de proteines a concentration elevee |
KR102651018B1 (ko) | 2013-09-11 | 2024-03-27 | 이글 바이오로직스 인코퍼레이티드 | 점도저하제를 함유하는 액체 단백질 제형 |
WO2015196091A1 (en) | 2014-06-20 | 2015-12-23 | Reform Biologics, Llc | Viscosity-reducing excipient compounds for protein formulations |
US10478498B2 (en) | 2014-06-20 | 2019-11-19 | Reform Biologics, Llc | Excipient compounds for biopolymer formulations |
US11357857B2 (en) | 2014-06-20 | 2022-06-14 | Comera Life Sciences, Inc. | Excipient compounds for protein processing |
US9527922B2 (en) | 2014-12-31 | 2016-12-27 | Development Center For Biotechnology | Humanized alpha-enolase specific antibodies and methods of uses in cancer therapy |
WO2016108894A1 (en) * | 2014-12-31 | 2016-07-07 | Develpment Center For Biotechnology | Humanized alpha-enolase specific antibodies and methods of uses in cancer therapy |
TW201726111A (zh) * | 2015-09-30 | 2017-08-01 | 持田製藥股份有限公司 | 含高濃度抗體之液體製劑 |
GB201604124D0 (en) * | 2016-03-10 | 2016-04-27 | Ucb Biopharma Sprl | Pharmaceutical formulation |
WO2018115879A1 (en) | 2016-12-21 | 2018-06-28 | Mereo Biopharma 3 Limited | Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta |
MX2019007916A (es) | 2016-12-29 | 2019-12-05 | Univ Miami | Metodo para modular la actividad de inflamasoma e inflamacion en el pulmon. |
US11840565B2 (en) | 2016-12-29 | 2023-12-12 | University Of Miami | Methods and compositions for treating virus-associated inflammation |
US10646569B2 (en) | 2017-05-16 | 2020-05-12 | Bhami's Research Laboratory, Pvt. Ltd. | High concentration protein formulations with reduced viscosity |
US11590237B2 (en) * | 2017-05-18 | 2023-02-28 | Merck Sharp & Dohme Llc | Pharmaceutical formulation comprising incretin-insulin conjugates |
EP3659586B1 (en) * | 2017-07-27 | 2023-06-21 | Jiangsu Hengrui Medicine Co., Ltd. | Sost antibody pharmaceutical composition and uses thereof |
GB201719447D0 (en) * | 2017-11-23 | 2018-01-10 | Ucb Biopharma Sprl | Pharmaceutical composition |
JP6544669B1 (ja) | 2018-03-16 | 2019-07-17 | ディヴェロップメント センター フォー バイオテクノロジー | アルファエノラーゼに特異的な抗体及びその使用 |
AU2019243595A1 (en) * | 2018-03-30 | 2020-09-17 | Amgen Inc. | C-terminal antibody variants |
WO2020010273A1 (en) * | 2018-07-03 | 2020-01-09 | University Of Miami | Compositions and methods for treating inflammasome related diseases or conditions |
WO2020028401A1 (en) * | 2018-07-31 | 2020-02-06 | Amgen Inc. | Pharmaceutical formulations of masked antibodies |
MA53272A (fr) * | 2018-08-10 | 2021-11-17 | Amgen Inc | Procédé de préparation d'une formulation pharmaceutique d'anticorps |
AU2020225202B2 (en) | 2019-02-18 | 2023-10-26 | Eli Lilly And Company | Therapeutic antibody formulation |
CN114703067B (zh) * | 2022-04-06 | 2023-09-05 | 上海光玥生物科技有限公司 | 一种光合微生物及其用途和质粒 |
Family Cites Families (111)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
US4411993A (en) | 1981-04-29 | 1983-10-25 | Steven Gillis | Hybridoma antibody which inhibits interleukin 2 activity |
US4427115A (en) | 1981-10-19 | 1984-01-24 | Laipply Thomas C | One piece alcohol preparation device |
JPS5889877A (ja) | 1981-11-21 | 1983-05-28 | Nippon Telegr & Teleph Corp <Ntt> | 超伝導回路装置 |
USRE32011E (en) | 1981-12-14 | 1985-10-22 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
US4543439A (en) | 1982-12-13 | 1985-09-24 | Massachusetts Institute Of Technology | Production and use of monoclonal antibodies to phosphotyrosine-containing proteins |
US6054561A (en) | 1984-02-08 | 2000-04-25 | Chiron Corporation | Antigen-binding sites of antibody molecules specific for cancer antigens |
DE3417525C1 (de) | 1984-05-11 | 1986-01-09 | Matter + Siegmann Ag, Wohlen | Vorrichtung zur quantitativen und qualitativen Erfassung von kohlenwasserstoffhaltigen Schwebeteilchen in Gasen |
US4902614A (en) | 1984-12-03 | 1990-02-20 | Teijin Limited | Monoclonal antibody to human protein C |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5571714A (en) | 1988-12-22 | 1996-11-05 | Celtrix Pharmaceuticals, Inc. | Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5549910A (en) | 1989-03-31 | 1996-08-27 | The Regents Of The University Of California | Preparation of liposome and lipid complex compositions |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
US5177197A (en) | 1990-02-27 | 1993-01-05 | Ludwig Institute For Cancer Research | Isolated nucleotide sequence expressing human transforming growth factor-β1-binding protein |
US5466468A (en) | 1990-04-03 | 1995-11-14 | Ciba-Geigy Corporation | Parenterally administrable liposome formulation comprising synthetic lipids |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
JP3218637B2 (ja) | 1990-07-26 | 2001-10-15 | 大正製薬株式会社 | 安定なリポソーム水懸濁液 |
WO1992002551A1 (en) | 1990-08-02 | 1992-02-20 | B.R. Centre Limited | Methods for the production of proteins with a desired function |
JP2958076B2 (ja) | 1990-08-27 | 1999-10-06 | 株式会社ビタミン研究所 | 遺伝子導入用多重膜リポソーム及び遺伝子捕捉多重膜リポソーム製剤並びにその製法 |
US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5698426A (en) | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
JPH04141095A (ja) | 1990-10-02 | 1992-05-14 | Chemo Sero Therapeut Res Inst | 組換え抗hiv改変抗体および改変抗体の調製方法 |
US5070108A (en) | 1990-10-12 | 1991-12-03 | Trustees Of The University Of Pennsylvania | Methods of treating osteoporosis, increasing bone mineral content and preventing the occurrence of compression fractures in a mammal |
JPH06502311A (ja) | 1990-10-22 | 1994-03-17 | フォックス・チェイス・キャンサー・センター | Rna療法を提供するためのdna構造 |
US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
TW205553B (pt) | 1991-04-25 | 1993-05-11 | Chugai Pharmaceutical Co Ltd | |
DE69233528T2 (de) | 1991-11-25 | 2006-03-16 | Enzon, Inc. | Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen |
AU700371B2 (en) | 1993-06-07 | 1999-01-07 | Genentech Inc. | Hiv envelope polypeptides |
US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
US5453492A (en) | 1993-07-28 | 1995-09-26 | La Jolla Cancer Research Foundation | 60 kDa transforming growth factor-β-binding protein and its use to detect or purify TGF-β |
US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
EP0756628B1 (en) | 1994-04-29 | 2007-11-14 | Curis, Inc. | Morphogenic protein-specific cell surface receptors and uses therefor |
DE4427221A1 (de) | 1994-08-01 | 1996-02-08 | Gsf Forschungszentrum Umwelt | Retrovirus-induzierte Osteoklasten-Modulation für die Osteoporose-Therapie |
US5846770A (en) | 1994-11-22 | 1998-12-08 | Genetics Institute, Inc. | DNA molecules encoding human chordin |
US6057421A (en) | 1994-11-30 | 2000-05-02 | Immpheron, Inc. | Variable heavy and light chain regions of murine monoclonal antibody 1F7 |
US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
WO1996039486A1 (en) | 1995-06-05 | 1996-12-12 | Human Genome Sciences, Inc. | Human ccn-like growth factor |
US5738868A (en) | 1995-07-18 | 1998-04-14 | Lipogenics Ltd. | Liposome compositions and kits therefor |
WO1997044461A2 (en) | 1996-05-22 | 1997-11-27 | Novopharm Biotech, Inc. | Antigen binding fragments that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers |
US6133426A (en) | 1997-02-21 | 2000-10-17 | Genentech, Inc. | Humanized anti-IL-8 monoclonal antibodies |
US5989909A (en) | 1997-09-26 | 1999-11-23 | Millennium Biotherapeutics, Inc. | Huchordin and uses thereof |
AU6959898A (en) | 1997-04-11 | 1998-11-11 | David J. Grainger | Compounds and therapies for the prevention of vascular and non-vascular pathol ogies |
US6673901B2 (en) | 1997-06-12 | 2004-01-06 | Research Corporation Technologies, Inc. | Artificial antibody polypeptides |
US6075007A (en) | 1997-07-17 | 2000-06-13 | Regeneron Pharmaceuticals, Inc. | Modified noggin polypeptide and compositions |
CA2297109A1 (en) | 1997-08-01 | 1999-02-11 | Genset | 5' ests for secreted proteins expressed in muscle and other mesodermal tissues |
US6815201B2 (en) | 1997-09-08 | 2004-11-09 | The Public Health Research Institute Of The City Of New York, Inc. | HIV-1 gp120 V1/V2 domain epitopes capable of generating neutralizing antibodies |
US6544485B1 (en) | 2001-01-29 | 2003-04-08 | Sharper Image Corporation | Electro-kinetic device with enhanced anti-microorganism capability |
PT1133558E (pt) | 1998-11-27 | 2007-01-31 | Ucb Sa | Composições e métodos para aumentar a mineralização óssea |
US20040009535A1 (en) | 1998-11-27 | 2004-01-15 | Celltech R&D, Inc. | Compositions and methods for increasing bone mineralization |
EP1151002A4 (en) | 1999-01-29 | 2002-05-02 | Imclone Systems Inc | KDR-SPECIFIC ANTIBODIES AND USES THEREOF |
ATE440109T1 (de) | 1999-06-09 | 2009-09-15 | Genentech Inc | Methoden zur diagnose von tumoren |
US6475220B1 (en) | 1999-10-15 | 2002-11-05 | Whiteside Biomechanics, Inc. | Spinal cable system |
JP4141095B2 (ja) | 1999-10-29 | 2008-08-27 | 三洋電機株式会社 | 半導体装置とその製造方法 |
EP1266000A1 (en) | 2000-03-02 | 2002-12-18 | Amgen Inc. | Chordin-like-2 molecules and uses thereof |
US20020106650A1 (en) | 2000-06-01 | 2002-08-08 | Paszty Christopher J. | Cystine-knot polypeptides: cloaked-2 molecules and uses thereof |
US20040132021A1 (en) | 2000-06-19 | 2004-07-08 | Wendy Balemans | Osteolevin gene polymorphisms |
AU2002216610A1 (en) | 2000-09-01 | 2002-04-02 | Genentech Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
EP1324776B2 (en) * | 2000-10-12 | 2018-03-21 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
CA2374027A1 (en) | 2001-03-13 | 2002-09-13 | The Minister Of National Defence | Cloning, expression, sequencing, and functional enhancement of monoclonal scfv antibody against venezuelan equine encephalitis virus(vee) |
EP1433793A4 (en) | 2001-09-13 | 2006-01-25 | Inst Antibodies Co Ltd | METHOD FOR CREATING A CAMEL ANTIBODY LIBRARY |
DE10145772A1 (de) | 2001-09-17 | 2003-04-10 | Bayer Cropscience Ag | DELTA·1·-Pyrroline |
BR0214680A (pt) | 2001-12-06 | 2006-05-30 | Biocontrol Systems Inc | coleta de amostra e sistema de teste |
US20030186915A1 (en) | 2002-02-11 | 2003-10-02 | Yang Pan | Regulatory polynucleotides and uses thereof |
WO2003073991A2 (en) | 2002-03-01 | 2003-09-12 | Celltech R & D, Inc. | Methods to increase or decrease bone density |
US7799523B2 (en) | 2002-04-03 | 2010-09-21 | Celltech R & D, Inc. | Association of polymorphisms in the SOST gene region with bone mineral density |
US7893218B2 (en) | 2003-06-16 | 2011-02-22 | Stowers Institute For Medical Research | Antibodies that specifically bind SOST peptides |
WO2003106657A2 (en) | 2002-06-14 | 2003-12-24 | Stowers Institute For Medical Research | Wise/sost nucleic acid sequences and amino acid sequences |
AU2003251592A1 (en) | 2002-06-21 | 2004-01-06 | Biogen Idec Inc. | Buffered formulations for concentrating antibodies and methods of use thereof |
AU2003291689A1 (en) | 2002-10-31 | 2004-05-25 | Protein Design Labs, Inc. | Stable liquid pharmaceutical formulation of antibodies that are prone to isomerization |
JP4976653B2 (ja) | 2002-11-01 | 2012-07-18 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンティッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシス | 免疫刺激性CpGオリゴヌクレオチドを用いてバイオテロ病原体による感染症を予防する方法 |
US7642238B2 (en) | 2002-12-05 | 2010-01-05 | Shaughnessy John D | Molecular determinants of myeloma bone disease and uses thereof |
US20040141875A1 (en) | 2003-01-15 | 2004-07-22 | Rajiv Doshi | System and method for treating microorganisms within motor vehicle heating, ventilation, and air conditioning units |
US7226902B2 (en) | 2003-03-14 | 2007-06-05 | Celltech R&D, Inc. | Ligands for TGF-beta binding proteins and uses thereof |
US20050158303A1 (en) | 2003-04-04 | 2005-07-21 | Genentech, Inc. | Methods of treating IgE-mediated disorders comprising the administration of high concentration anti-IgE antibody formulations |
CU23403A1 (es) | 2003-04-23 | 2009-08-04 | Centro Inmunologia Molecular | Anticuerpos recombinantes y fragmentos que reconocen el gangliósido n-glicolil gm3 y su uso para diagnóstico y tratamiento de tumores |
CN1835974A (zh) | 2003-06-16 | 2006-09-20 | 细胞技术研究与发展公司 | 对硬化素特异的抗体和用于增加骨矿化的方法 |
US8461155B2 (en) | 2003-09-22 | 2013-06-11 | University Of Connecticut | Sclerostin and the inhibition of WNT signaling and bone formation |
US20050267233A1 (en) | 2004-05-25 | 2005-12-01 | Joshi Ashok V | Anti-microbial handle system |
EP1786837B1 (en) | 2004-08-04 | 2013-05-01 | Amgen Inc., | Antibodies to dkk-1 |
US7592429B2 (en) | 2005-05-03 | 2009-09-22 | Ucb Sa | Sclerostin-binding antibody |
US8003108B2 (en) | 2005-05-03 | 2011-08-23 | Amgen Inc. | Sclerostin epitopes |
BRPI0620316A2 (pt) | 2005-12-21 | 2011-11-08 | Wyeth Corp | formulações de proteìnas com viscosidades reduzida e seus usos |
EP1981910B1 (en) | 2006-01-13 | 2013-06-26 | A Chan Holding B.V. | Method for identifying inhibitor of the glypican-sclerostin interaction |
EP2094731A2 (en) | 2006-11-10 | 2009-09-02 | UCB Pharma S.A. | Anti human sclerostin antibodies |
WO2008061013A2 (en) | 2006-11-10 | 2008-05-22 | Amgen Inc. | Antibody-based diagnostics and therapeutics |
FI3345607T3 (fi) | 2006-12-29 | 2022-11-30 | Menetelmiä luun kasvun muuttamiseksi antamalla SOST- tai WISE-antagonistia tai antagonistia | |
JP2010526766A (ja) | 2007-02-02 | 2010-08-05 | ノバルティス アーゲー | 骨関連障害を処置するためのスクレロスチン結合パートナーのモジュレーター |
BRPI0809026A2 (pt) | 2007-03-20 | 2014-09-23 | Lilly Co Eli | Anticorpos antiesclerotina |
CL2008002775A1 (es) | 2007-09-17 | 2008-11-07 | Amgen Inc | Uso de un agente de unión a esclerostina para inhibir la resorción ósea. |
AR068767A1 (es) | 2007-10-12 | 2009-12-02 | Novartis Ag | Anticuerpos contra esclerostina, composiciones y metodos de uso de estos anticuerpos para tratar un trastorno patologico mediado por esclerostina |
ES2560532T3 (es) | 2007-11-02 | 2016-02-19 | Novartis Ag | Moléculas y métodos de modulación de la proteína 6 relacionada con el receptor de lipoproteína de baja densidad (LRP6) |
BRPI0819688A2 (pt) * | 2007-12-14 | 2015-06-16 | Amgen Inc | Processo para tratamento de fratura óssea com anticorpos anti-esclerostina. |
JP5642065B2 (ja) * | 2008-05-23 | 2014-12-17 | ノボ ノルディスク ヘルス ケア アーゲー | ペグ化されたgla−ドメイン含有タンパク質を含む低粘度組成物 |
EP3002299A1 (en) | 2008-06-03 | 2016-04-06 | AbbVie Inc. | Dual variable domain immunoglobulins and uses thereof |
WO2010100179A2 (en) | 2009-03-05 | 2010-09-10 | Novartis Ag | Self-forming gel system for sustained drug delivery |
AR075715A1 (es) | 2009-03-05 | 2011-04-20 | Novartis Ag | Formulacion de anticuerpo liofilizado |
WO2010115932A1 (en) | 2009-04-08 | 2010-10-14 | Novartis Ag | Combination for the treatment of bone loss |
WO2010130830A2 (en) | 2009-05-15 | 2010-11-18 | Ablynx N.V. | Amino acid sequences directed against sclerostin and polypeptides comprising the same for the treatment of bone diseases and disorders |
CN102946903B (zh) * | 2010-05-14 | 2014-11-26 | 安进公司 | 高浓度抗体制剂 |
WO2012028683A1 (en) | 2010-09-02 | 2012-03-08 | Novartis Ag | Antibody gel system for sustained drug delivery |
MX354481B (es) | 2010-10-27 | 2018-03-07 | Amgen Inc | Anticuerpos dkk1 y métodos de uso. |
RS57038B1 (sr) * | 2010-11-17 | 2018-05-31 | Chugai Pharmaceutical Co Ltd | Multi-specifičan antigen-vezujući molekul koji ima alternativnu funkciju funkciji faktora viii koagulacije krvi |
US8790651B2 (en) * | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
-
2011
- 2011-05-11 CN CN201180023921.4A patent/CN102946903B/zh active Active
- 2011-05-11 ES ES17158990T patent/ES2773031T3/es active Active
- 2011-05-11 EP EP11720278.8A patent/EP2569010B1/en active Active
- 2011-05-11 RS RS20170674A patent/RS56210B1/sr unknown
- 2011-05-11 PT PT117202788T patent/PT2569010T/pt unknown
- 2011-05-11 LT LTEP17158990.6T patent/LT3195880T/lt unknown
- 2011-05-11 BR BR112012028920-9A patent/BR112012028920B1/pt active IP Right Grant
- 2011-05-11 KR KR1020197027464A patent/KR102220879B1/ko active IP Right Grant
- 2011-05-11 CA CA2798888A patent/CA2798888C/en active Active
- 2011-05-11 WO PCT/US2011/036062 patent/WO2011143307A1/en active Application Filing
- 2011-05-11 AU AU2011250920A patent/AU2011250920B2/en active Active
- 2011-05-11 EP EP17158990.6A patent/EP3195880B1/en active Active
- 2011-05-11 PT PT171589906T patent/PT3195880T/pt unknown
- 2011-05-11 MX MX2012013268A patent/MX2012013268A/es active IP Right Grant
- 2011-05-11 DK DK11720278.8T patent/DK2569010T3/en active
- 2011-05-11 PL PL11720278T patent/PL2569010T3/pl unknown
- 2011-05-11 KR KR1020127032558A patent/KR101861867B1/ko active IP Right Grant
- 2011-05-11 SI SI201131181T patent/SI2569010T1/sl unknown
- 2011-05-11 ES ES11720278.8T patent/ES2626033T3/es active Active
- 2011-05-11 EP EP19202835.5A patent/EP3620175A1/en active Pending
- 2011-05-11 PL PL17158990T patent/PL3195880T3/pl unknown
- 2011-05-11 RS RS20200217A patent/RS59993B1/sr unknown
- 2011-05-11 ME MEP-2017-147A patent/ME02819B/me unknown
- 2011-05-11 EA EA201291226A patent/EA027039B1/ru not_active IP Right Cessation
- 2011-05-11 JP JP2013510274A patent/JP5889877B2/ja active Active
- 2011-05-11 SG SG10201912670XA patent/SG10201912670XA/en unknown
- 2011-05-11 EA EA202092884A patent/EA202092884A1/ru unknown
- 2011-05-11 SG SG2012082202A patent/SG185465A1/en unknown
- 2011-05-11 DK DK17158990.6T patent/DK3195880T3/da active
- 2011-05-11 EA EA201692242A patent/EA037392B1/ru not_active IP Right Cessation
- 2011-05-11 HU HUE11720278A patent/HUE033315T2/en unknown
- 2011-05-11 IL IL264636A patent/IL264636B/en unknown
- 2011-05-11 KR KR1020187014175A patent/KR102026038B1/ko active Application Filing
- 2011-05-11 SI SI201131842T patent/SI3195880T1/sl unknown
- 2011-05-11 LT LTEP11720278.8T patent/LT2569010T/lt unknown
- 2011-05-11 SG SG10201701869YA patent/SG10201701869YA/en unknown
- 2011-05-11 US US13/702,658 patent/US9352043B2/en active Active
- 2011-05-11 IL IL295275A patent/IL295275A/en unknown
- 2011-05-11 HU HUE17158990A patent/HUE047492T2/hu unknown
- 2011-05-13 TW TW105120111A patent/TWI689517B/zh active
- 2011-05-13 TW TW108135531A patent/TWI759634B/zh active
- 2011-05-13 TW TW111107371A patent/TW202241510A/zh unknown
- 2011-05-13 TW TW100116950A patent/TWI617570B/zh active
-
2012
- 2012-11-12 CL CL2012003172A patent/CL2012003172A1/es unknown
- 2012-11-13 IL IL223014A patent/IL223014B/en active IP Right Grant
- 2012-11-13 ZA ZA2012/08543A patent/ZA201208543B/en unknown
- 2012-11-13 HN HN2012002446A patent/HN2012002446A/es unknown
- 2012-12-03 CO CO12218641A patent/CO6640258A2/es unknown
-
2016
- 2016-02-17 JP JP2016027699A patent/JP6174176B2/ja active Active
- 2016-05-02 US US15/144,256 patent/US10064946B2/en active Active
-
2017
- 2017-05-25 CY CY20171100542T patent/CY1119069T1/el unknown
- 2017-06-29 HR HRP20170983TT patent/HRP20170983T1/hr unknown
- 2017-07-05 JP JP2017131572A patent/JP6416336B2/ja active Active
-
2018
- 2018-07-26 US US16/045,928 patent/US11040102B2/en active Active
- 2018-10-03 JP JP2018187831A patent/JP7267707B2/ja active Active
-
2020
- 2020-02-17 CY CY20201100145T patent/CY1122669T1/el unknown
- 2020-02-18 HR HRP20200268TT patent/HRP20200268T1/hr unknown
-
2021
- 2021-05-21 US US17/326,725 patent/US20210275671A1/en active Pending
- 2021-09-13 JP JP2021148735A patent/JP2022000436A/ja not_active Withdrawn
-
2023
- 2023-09-29 JP JP2023169763A patent/JP2023182702A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112012028920A2 (pt) | formulações de anticorpo de alta concentração | |
CY1120398T1 (el) | Ανθρωποποιημενα αντισωματα που αναγνωριζουν αλφα-συνουκλεϊνη | |
CY1123145T1 (el) | Anti-cd40 αντισωματα | |
EA201390929A1 (ru) | Антитела к pcsk9 и способы их применения | |
EA201790664A1 (ru) | Антитела против мезотелина и иммуноконъюгаты | |
EA201490778A1 (ru) | АНТИТЕЛА ПРОТИВ HtrA1 И СПОСОБЫ ПРИМЕНЕНИЯ | |
EA201390669A1 (ru) | Способы и композиции для иммунотерапии заболеваний нервной системы | |
EA201300239A1 (ru) | Антитела к fap и способы их применения | |
EA201491224A1 (ru) | Анти-псф-тау-антитела и их применение | |
CL2015000582A1 (es) | Anticuerpos anti-mcam y métodos asociados de uso | |
BR112016014284A2 (pt) | anticorpo caninizado isolado ou um fragmento de ligação de antígeno do mesmo, ácido nucleico isolado, vetor de expressão, célula hospedeira, composição farmacêutica, e, métodos para aumentar a atividade de uma célula imune e para produzir um anticorpo caninizado ou fragmento de ligação de antígeno do mesmo | |
EA201390145A1 (ru) | Конъюгаты, частицы, композиции и связанные с ними способы | |
UA116873C2 (uk) | Антитіло, яке зв'язується з ox40 | |
EP2970508A4 (en) | GENETICALLY MODIFIED LOADING ANTIBODIES OR ENHANCED ENHANCEMENT ENHANCEMENT TARGETING PROTEIN COMPOSITIONS AND METHODS OF USE | |
BR112014028600A2 (pt) | formulações de anticorpo monoclonal de alta concentração | |
EA201491947A1 (ru) | Антитела и иммуноконъюгаты к ly6e и способы применения | |
EA201600473A1 (ru) | ГУМАНИЗИРОВАННЫЕ АНТИТЕЛА К Tau(PS422) И СПОСОБЫ ПРИМЕНЕНИЯ | |
DK2637690T3 (da) | Flydende ANTI-TNF-alpha-antistofformuleringer med høj koncentration | |
EA201171494A1 (ru) | Миметики белка smac | |
EA201491357A1 (ru) | Анти-lrp5 антитела и способы их применения | |
EA201401065A1 (ru) | Ang2-связывающие молекулы | |
EA201291180A1 (ru) | Композиции и способы применения терапевтических антител против белка, родственного рецептору липопротеинов низкой плотности 6 (lrp6) | |
MX336109B (es) | Formacion de imagenes inmuno-tep de anticuerpos e inmunoconjugados y usos de lo mismo. | |
EA201500054A1 (ru) | Аттенуированные вакцины против streptococcus suis и способы их получения и применения | |
EA201390467A1 (ru) | Композиции антител и способы применения |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 11/05/2011, OBSERVADAS AS CONDICOES LEGAIS. |