BR112012024826B8 - processo para purificação de pneumocandina - Google Patents

processo para purificação de pneumocandina

Info

Publication number
BR112012024826B8
BR112012024826B8 BR112012024826A BR112012024826A BR112012024826B8 BR 112012024826 B8 BR112012024826 B8 BR 112012024826B8 BR 112012024826 A BR112012024826 A BR 112012024826A BR 112012024826 A BR112012024826 A BR 112012024826A BR 112012024826 B8 BR112012024826 B8 BR 112012024826B8
Authority
BR
Brazil
Prior art keywords
pneumocandin
purification process
purification
renovation
crystallization
Prior art date
Application number
BR112012024826A
Other languages
English (en)
Other versions
BR112012024826A2 (pt
BR112012024826B1 (pt
Inventor
Rakesh Bhaiyyaram Mendhe
Nitin Sopanrao Patil
Kushal Rastogi
Onkar Prakash Santan
Original Assignee
Biocon Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocon Ltd filed Critical Biocon Ltd
Publication of BR112012024826A2 publication Critical patent/BR112012024826A2/pt
Publication of BR112012024826B1 publication Critical patent/BR112012024826B1/pt
Publication of BR112012024826B8 publication Critical patent/BR112012024826B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

processo para purificação de pneumocandina. o processo descrito pela presente patente revela o processo de purificação de um metabolito secundário produzido via de fermentação. o processo envolve renovação seletiva de impurezas em vários estágios de lavagens, aquecido com carvão seguido pela cristalização. o produto está muito relacionado à classe das equinocandinas e é considerado ser um composto antifúngico potente e um ingrediente-chave na síntese de medicamentos antifúngicos.
BR112012024826A 2010-03-29 2010-05-17 processo para purificação de pneumocandina BR112012024826B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN00861/CHE/2010 2010-03-29
IN861CH2010 2010-03-29
PCT/IN2010/000313 WO2011121599A1 (en) 2010-03-29 2010-05-17 A process for purification of pneumocandin

Publications (3)

Publication Number Publication Date
BR112012024826A2 BR112012024826A2 (pt) 2016-06-07
BR112012024826B1 BR112012024826B1 (pt) 2021-02-02
BR112012024826B8 true BR112012024826B8 (pt) 2021-05-25

Family

ID=44711425

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012024826A BR112012024826B8 (pt) 2010-03-29 2010-05-17 processo para purificação de pneumocandina

Country Status (6)

Country Link
US (1) US9399664B2 (pt)
EP (1) EP2552937B1 (pt)
BR (1) BR112012024826B8 (pt)
CA (1) CA2794688C (pt)
WO (1) WO2011121599A1 (pt)
ZA (1) ZA201207356B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104558123A (zh) * 2014-12-01 2015-04-29 江苏汉邦科技有限公司 一种采用动态轴向压缩柱系统制备纽莫康定b0的方法
CN106162922B (zh) * 2015-01-27 2021-01-26 中兴通讯股份有限公司 发现信号的处理方法及装置
CN107778357B (zh) * 2016-08-27 2020-10-30 鲁南制药集团股份有限公司 一种纽莫康定b0的提取、纯化方法
CN106589073A (zh) * 2017-01-20 2017-04-26 信泰制药（苏州）有限公司 提纯纽莫康定b0的方法
WO2020086931A1 (en) * 2018-10-25 2020-04-30 Cidara Therapeutics, Inc. Polymorph of echinocandin antifungal agent
CN109400680A (zh) * 2018-12-07 2019-03-01 成都雅途生物技术有限公司 一种卡泊芬净前体pneumocandinB0的结晶纯化方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5310873A (en) * 1990-03-12 1994-05-10 Merck & Co., Inc. Cyclohexapeptide compound
ES2280119T3 (es) * 1998-04-23 2007-09-01 Aventis Pharma Deutschland Gmbh Un procedimiento para la conversion de peptidos de la clase de las equinocandinas en sus analogos monodesoxi de c4-homotirosina.
US6610822B2 (en) 2000-09-01 2003-08-26 Merck & Co., Inc. Purification process
EP1663275A2 (en) * 2003-09-05 2006-06-07 Merck & Co., Inc. Stationary phases and a purification process using the stationary phases
TW200826957A (en) * 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
US20090291996A1 (en) * 2008-05-21 2009-11-26 Ferenc Korodi Caspofungin free of caspofungin Co

Also Published As

Publication number Publication date
EP2552937A4 (en) 2013-11-13
CA2794688C (en) 2018-07-03
US20130030149A1 (en) 2013-01-31
EP2552937B1 (en) 2018-01-17
CA2794688A1 (en) 2011-10-06
WO2011121599A1 (en) 2011-10-06
ZA201207356B (en) 2013-06-26
US9399664B2 (en) 2016-07-26
EP2552937A1 (en) 2013-02-06
BR112012024826A2 (pt) 2016-06-07
BR112012024826B1 (pt) 2021-02-02

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS.

B07E Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 02/02/2021, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/05/2010 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF