BR112012023621A2 - composição dos peptídeos associados a tumor e vacina anticâncer relacionada para o tratamento do câncer gástrico e outros cânceres - Google Patents
composição dos peptídeos associados a tumor e vacina anticâncer relacionada para o tratamento do câncer gástrico e outros cânceresInfo
- Publication number
- BR112012023621A2 BR112012023621A2 BR112012023621A BR112012023621A BR112012023621A2 BR 112012023621 A2 BR112012023621 A2 BR 112012023621A2 BR 112012023621 A BR112012023621 A BR 112012023621A BR 112012023621 A BR112012023621 A BR 112012023621A BR 112012023621 A2 BR112012023621 A2 BR 112012023621A2
- Authority
- BR
- Brazil
- Prior art keywords
- tumor
- gastric cancer
- cancers
- treatment
- vaccine
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 4
- 208000005718 Stomach Neoplasms Diseases 0.000 title abstract 3
- 206010017758 gastric cancer Diseases 0.000 title abstract 3
- 201000011549 stomach cancer Diseases 0.000 title abstract 3
- 229940022399 cancer vaccine Drugs 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 229960005486 vaccine Drugs 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000005975 antitumor immune response Effects 0.000 abstract 1
- 238000002619 cancer immunotherapy Methods 0.000 abstract 1
- 210000002443 helper t lymphocyte Anatomy 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001024 immunotherapeutic effect Effects 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/828—Stomach
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
Abstract
composição dos peptídeos associados a tumor e vacina anticâncer relacionada para o tratamento do câncer gástrico e outros cânceres. a presente invenção refere-se a peptídeos imunoterápicos e seu uso em imunoterapia, em particular na imunoterapia do câncer. a presente invenção divulga epítopos peptídicos de célula t auxiliar associado a tumor, isoladamente ou em combinação com outros peptídeos associados a tumores, que servem como ingredientes farmacêuticamente ativos em coposições de vacinas estimuladoras das respostas imunes antitumorais. em particula, a composição dos peptídeos da presente invenção pode ser usada em composições de vacina para extrair respostas antitumorais imunes contra câncer gástrico (cg).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31571510P | 2010-03-19 | 2010-03-19 | |
GB201004575A GB201004575D0 (en) | 2010-03-19 | 2010-03-19 | Composition of tumor associated peptides and related anti cancer vaccine for the treatment of gastric cancer and other cancers |
PCT/EP2011/053996 WO2011113872A1 (en) | 2010-03-19 | 2011-03-16 | Composition of tumor-associated peptides and related anti-cancer vaccine for the treatment of gastric cancer and other cancers |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112012023621A2 true BR112012023621A2 (pt) | 2017-07-18 |
Family
ID=42227968
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012023621A BR112012023621A2 (pt) | 2010-03-19 | 2011-03-16 | composição dos peptídeos associados a tumor e vacina anticâncer relacionada para o tratamento do câncer gástrico e outros cânceres |
Country Status (21)
Country | Link |
---|---|
US (2) | US10159725B2 (pt) |
EP (1) | EP2547691B1 (pt) |
JP (1) | JP5689140B2 (pt) |
KR (1) | KR101620132B1 (pt) |
CN (1) | CN102892777B (pt) |
AU (1) | AU2011229177B2 (pt) |
BR (1) | BR112012023621A2 (pt) |
CA (1) | CA2793389A1 (pt) |
EA (1) | EA022743B1 (pt) |
ES (1) | ES2593409T3 (pt) |
GB (1) | GB201004575D0 (pt) |
HK (1) | HK1180701A1 (pt) |
HU (1) | HUE030000T2 (pt) |
MX (1) | MX2012010814A (pt) |
MY (1) | MY162850A (pt) |
NZ (1) | NZ601818A (pt) |
PL (1) | PL2547691T3 (pt) |
SG (1) | SG183938A1 (pt) |
TW (1) | TWI533882B (pt) |
UA (1) | UA109891C2 (pt) |
WO (1) | WO2011113872A1 (pt) |
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EP2872532A4 (en) * | 2012-07-10 | 2016-04-13 | Oncotherapy Science Inc | CDCA1-EPITOPPEPTIDES FOR TH1 CELLS AND VACCINES THEREWITH |
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TWI777196B (zh) * | 2013-08-05 | 2022-09-11 | 德商伊瑪提克斯生物科技有限公司 | 新穎肽類,細胞及其用於治療多種腫瘤的用途,其製造方法及包含其等之醫藥組成物(五) |
US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
WO2016011432A2 (en) * | 2014-07-17 | 2016-01-21 | Czerniecki Brian J | Identification of immunogenic mhc class ii peptides for immune-based therapy |
WO2016115253A1 (en) | 2015-01-14 | 2016-07-21 | The Regents Of The University Ofcolordo, A Body Corporate | Insulin mimotopes and methods of using the same |
GB201507030D0 (en) * | 2015-04-24 | 2015-06-10 | Immatics Biotechnologies Gmbh | Immunotherapy against lung cancers, in particular NSCLC |
WO2017023840A1 (en) | 2015-08-03 | 2017-02-09 | Globeimmune, Inc. | Modified yeast-brachyury immunotherapeutic compositions |
WO2017070632A2 (en) | 2015-10-23 | 2017-04-27 | President And Fellows Of Harvard College | Nucleobase editors and uses thereof |
GB201520597D0 (en) * | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
RU2729116C2 (ru) | 2015-12-16 | 2020-08-04 | Гритстоун Онколоджи, Инк. | Идентификация, производство и применение неоантигенов |
GB201603568D0 (en) * | 2016-03-01 | 2016-04-13 | Immatics Biotechnologies Gmbh | Efficient treatment options including peptides and combination of peptide and cell based medicaments for use in immunotherapy against urinary bladder cancer |
IL302705A (en) | 2016-03-01 | 2023-07-01 | Immatics Biotechnologies Gmbh | Peptides, combinations of peptides, cell-based drugs for use in immunotherapy against bladder cancer and other types of cancer |
US11045534B2 (en) | 2016-03-28 | 2021-06-29 | Toray Industries, Inc. | Immunity-inducing agent |
WO2018044369A2 (en) * | 2016-05-19 | 2018-03-08 | The Regents Of The University Of California | Triple drug combination (metformin, simvastatin, digoxin) for targeted treatment of pancreatic cancer |
CA3032699A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harvard College | Adenosine nucleobase editors and uses thereof |
WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
TW202304970A (zh) * | 2016-08-26 | 2023-02-01 | 德商英麥提克生物技術股份有限公司 | 用於頭頸鱗狀細胞癌和其他癌症免疫治療的新型肽和支架 |
CN109963584B (zh) * | 2016-09-06 | 2024-03-15 | 豪夫迈·罗氏有限公司 | 结合mhc的肽阵列及其使用方法 |
NZ754222A (en) | 2016-12-08 | 2022-02-25 | Immatics Biotechnologies Gmbh | T cell receptors with improved pairing |
DE102016123893A1 (de) | 2016-12-08 | 2018-06-14 | Immatics Biotechnologies Gmbh | T-Zellrezeptoren mit verbesserter Bindung |
US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
KR102549625B1 (ko) * | 2017-03-03 | 2023-06-28 | 트레오스 바이오 리미티드 | 개인화된 면역원성 펩타이드 확인 플랫폼 |
WO2018165631A1 (en) * | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Cancer vaccine |
EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
US11911451B2 (en) * | 2017-08-22 | 2024-02-27 | ImmuLogix Ltd | Composition of tumor-associated proliferative peptides and related anti-cancer immunogen for the treatment of lung cancers and other cancers |
WO2019139645A2 (en) | 2017-08-30 | 2019-07-18 | President And Fellows Of Harvard College | High efficiency base editors comprising gam |
KR20200087143A (ko) | 2017-10-10 | 2020-07-20 | 그릿스톤 온콜로지, 인코포레이티드 | 핫스팟을 이용한 신생항원 동정 |
US11885815B2 (en) | 2017-11-22 | 2024-01-30 | Gritstone Bio, Inc. | Reducing junction epitope presentation for neoantigens |
US11052060B2 (en) | 2018-02-12 | 2021-07-06 | The Regents Of The University Of Colorado, A Body Corporate | Compounds and methods for treating autoimmunity |
US11013707B2 (en) | 2018-03-23 | 2021-05-25 | The Regents Of The University Of Colorado, A Body Corporate | Administration of oral methyldopa |
EP4169528A1 (en) * | 2018-04-11 | 2023-04-26 | Enterome S.A. | Antigenic peptides for prevention and treatment of cancer |
TW202023581A (zh) * | 2018-08-02 | 2020-07-01 | 日商腫瘤療法 科學股份有限公司 | 來自cdca1的胜肽及含有此的疫苗 |
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WO2021155501A1 (zh) * | 2020-02-05 | 2021-08-12 | 瓦克斯恩有限公司 | 生存素与gm-csf的融合体、编码dna、重组表达载体、抗肿瘤疫苗及其应用 |
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CA725596A (en) | 1960-08-26 | 1966-01-11 | J. Wretlind Arvid | Method of preparing intravenously injectable fat emulsions free from side reactions or complications |
US4897445A (en) | 1986-06-27 | 1990-01-30 | The Administrators Of The Tulane Educational Fund | Method for synthesizing a peptide containing a non-peptide bond |
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GB201004551D0 (en) * | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer |
GB201019331D0 (en) * | 2010-03-19 | 2010-12-29 | Immatics Biotechnologies Gmbh | Methods for the diagnosis and treatment of cancer based on AVL9 |
-
2010
- 2010-03-19 GB GB201004575A patent/GB201004575D0/en not_active Ceased
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2011
- 2011-03-16 AU AU2011229177A patent/AU2011229177B2/en not_active Ceased
- 2011-03-16 SG SG2012066098A patent/SG183938A1/en unknown
- 2011-03-16 US US13/635,898 patent/US10159725B2/en active Active
- 2011-03-16 EP EP11708860.9A patent/EP2547691B1/en active Active
- 2011-03-16 PL PL11708860.9T patent/PL2547691T3/pl unknown
- 2011-03-16 MY MYPI2012700610A patent/MY162850A/en unknown
- 2011-03-16 CN CN201180014643.6A patent/CN102892777B/zh not_active Expired - Fee Related
- 2011-03-16 MX MX2012010814A patent/MX2012010814A/es active IP Right Grant
- 2011-03-16 HU HUE11708860A patent/HUE030000T2/en unknown
- 2011-03-16 WO PCT/EP2011/053996 patent/WO2011113872A1/en active Application Filing
- 2011-03-16 UA UAA201209878A patent/UA109891C2/uk unknown
- 2011-03-16 NZ NZ60181811A patent/NZ601818A/en not_active IP Right Cessation
- 2011-03-16 KR KR1020127027319A patent/KR101620132B1/ko not_active IP Right Cessation
- 2011-03-16 EA EA201201305A patent/EA022743B1/ru not_active IP Right Cessation
- 2011-03-16 JP JP2012557545A patent/JP5689140B2/ja not_active Expired - Fee Related
- 2011-03-16 BR BR112012023621A patent/BR112012023621A2/pt not_active IP Right Cessation
- 2011-03-16 CA CA2793389A patent/CA2793389A1/en not_active Abandoned
- 2011-03-16 ES ES11708860.9T patent/ES2593409T3/es active Active
- 2011-03-18 US US13/051,568 patent/US9132177B2/en active Active
- 2011-03-18 TW TW100109442A patent/TWI533882B/zh not_active IP Right Cessation
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2013
- 2013-07-10 HK HK13108074.7A patent/HK1180701A1/zh unknown
Also Published As
Publication number | Publication date |
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TW201201834A (en) | 2012-01-16 |
EA201201305A1 (ru) | 2013-02-28 |
EP2547691B1 (en) | 2016-06-29 |
CN102892777B (zh) | 2017-02-08 |
KR20130057428A (ko) | 2013-05-31 |
NZ601818A (en) | 2014-09-26 |
UA109891C2 (uk) | 2015-10-26 |
EA022743B1 (ru) | 2016-02-29 |
JP5689140B2 (ja) | 2015-03-25 |
WO2011113872A1 (en) | 2011-09-22 |
TWI533882B (zh) | 2016-05-21 |
AU2011229177B2 (en) | 2014-09-25 |
KR101620132B1 (ko) | 2016-05-12 |
CN102892777A (zh) | 2013-01-23 |
EP2547691A1 (en) | 2013-01-23 |
HK1180701A1 (zh) | 2013-10-25 |
US20110229524A1 (en) | 2011-09-22 |
HUE030000T2 (en) | 2017-04-28 |
JP2013522276A (ja) | 2013-06-13 |
ES2593409T3 (es) | 2016-12-09 |
PL2547691T3 (pl) | 2016-12-30 |
CA2793389A1 (en) | 2011-09-22 |
MY162850A (en) | 2017-07-31 |
GB201004575D0 (en) | 2010-05-05 |
US10159725B2 (en) | 2018-12-25 |
SG183938A1 (en) | 2012-10-30 |
MX2012010814A (es) | 2012-11-12 |
US20130115188A1 (en) | 2013-05-09 |
US9132177B2 (en) | 2015-09-15 |
AU2011229177A1 (en) | 2012-09-06 |
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