BR112012019520A2 - macromoleculas multivalentes polianionicas para alvejamento intracelular da sintese de proteina e proliferacao - Google Patents

macromoleculas multivalentes polianionicas para alvejamento intracelular da sintese de proteina e proliferacao

Info

Publication number
BR112012019520A2
BR112012019520A2 BR112012019520-4A BR112012019520A BR112012019520A2 BR 112012019520 A2 BR112012019520 A2 BR 112012019520A2 BR 112012019520 A BR112012019520 A BR 112012019520A BR 112012019520 A2 BR112012019520 A2 BR 112012019520A2
Authority
BR
Brazil
Prior art keywords
proliferation
polyanionic
protein synthesis
intracellular targeting
targeting
Prior art date
Application number
BR112012019520-4A
Other languages
English (en)
Inventor
Licha Kai
Schirner Michael
Welker Pia
Haag Rainer
Weinhart Marie
Paulus Florian
Original Assignee
Mivenion Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mivenion Gmbh filed Critical Mivenion Gmbh
Publication of BR112012019520A2 publication Critical patent/BR112012019520A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
    • A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/14—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyethers (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

macromoléculas multivalentes polianiônicas para alvejamento intracelular da síntese de proteína e proliferação. a presente invenção refere-se a métodos e composições para alvejar moléculas intracelulares envolvidas na proliferação e síntese de proteína de células ativadas macromoléculas multivalentes polianiônicas. em um aspecto particular, grupos sulfato múltiplos ligados ao poliol são especificamente alvejados ao citoplasma e núlceo de células proliferadoras e ativadas. a invenção também compreende novos compostos e formulações macromoleculares polianiônicos.
BR112012019520-4A 2010-02-03 2011-01-31 macromoleculas multivalentes polianionicas para alvejamento intracelular da sintese de proteina e proliferacao BR112012019520A2 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP10001104.8 2010-02-03
EP10001104 2010-02-03
EP10001655 2010-02-18
EP10001655.9 2010-02-18
EP10002121 2010-03-02
EP10002121.1 2010-03-02
PCT/EP2011/000425 WO2011095311A1 (en) 2010-02-03 2011-01-31 Polyanionic multivalent macromolecules for intracellular targeting of proliferation and protein synthesis

Publications (1)

Publication Number Publication Date
BR112012019520A2 true BR112012019520A2 (pt) 2018-03-13

Family

ID=43981117

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012019520-4A BR112012019520A2 (pt) 2010-02-03 2011-01-31 macromoleculas multivalentes polianionicas para alvejamento intracelular da sintese de proteina e proliferacao

Country Status (13)

Country Link
US (1) US8877171B2 (pt)
EP (1) EP2531221B1 (pt)
JP (2) JP5866301B2 (pt)
CN (1) CN102781478A (pt)
AU (1) AU2011212742B2 (pt)
BR (1) BR112012019520A2 (pt)
CA (1) CA2788736C (pt)
DK (1) DK2531221T3 (pt)
ES (1) ES2730744T3 (pt)
HU (1) HUE045311T2 (pt)
NZ (1) NZ601550A (pt)
PL (1) PL2531221T3 (pt)
WO (1) WO2011095311A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014051109A1 (ja) * 2012-09-28 2014-04-03 協和発酵キリン株式会社 抗ヒトｂｍｐ９抗体および該抗体を有効成分とする異所性骨化疾患の治療剤
WO2014114183A1 (zh) * 2013-01-23 2014-07-31 北京市丰硕维康技术开发有限责任公司 一种治疗肿瘤细胞增生性疾病的铂（ii）类化合物
EP2923695A1 (en) 2014-03-25 2015-09-30 DendroPharm GmbH Hyperbranched polyglycerol sulfates with hydrophobic cores
WO2015170573A1 (ja) * 2014-05-08 2015-11-12 公立大学法人大阪府立大学 リンパ節イメージング剤
EP3142641B1 (de) 2014-05-13 2020-11-25 DendroPharm GmbH Formulierungen zur behandlung von hyperthyreose
EP3145984B1 (en) * 2014-05-21 2022-02-23 ICD-Therapeutics GmbH Therapeutic conjugates with sulfated dendrimers for intracellular targeting
EP3048130A1 (en) * 2015-01-20 2016-07-27 Freie Universität Berlin Anionic linear polyglycerol derivatives, a method for manufacturing and applications
WO2016166317A1 (en) * 2015-04-15 2016-10-20 Freie Universität Berlin Polyglycerol derivative and a method for manufacturing the same
DE102015121366A1 (de) 2015-12-08 2017-06-08 Dendropharm Gmbh Analgetische Zusammensetzungen mit Nanocarriern und ihre Verwendung
EP3484527A1 (en) 2016-07-13 2019-05-22 Freie Universität Berlin Polyglycerol derivative for use in diagnosing a disease at an early stage
EP4134073A1 (en) 2021-08-11 2023-02-15 HM HerbaMedica GmbH Pharmaceutical compositions comprising dendritic nanocarriers and cannabis active agents

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474765A (en) 1992-03-23 1995-12-12 Ut Sw Medical Ctr At Dallas Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells
AU678469B2 (en) * 1993-05-03 1997-05-29 Genentech Inc. Inhibition of leukocyte adhesion
CA2210500A1 (en) 1995-01-16 1996-07-25 Commonwealth Scientific And Industrial Research Organisation Therapeutic compound - fatty acid conjugates
ATE264694T1 (de) 1995-01-30 2004-05-15 Daiichi Pure Chemicals Co Ltd Diagnostisches markierungsmittel
JPH11140038A (ja) * 1997-11-04 1999-05-25 Kanebo Ltd カルボン酸誘導体
JPH11246503A (ja) * 1998-03-04 1999-09-14 Sumitomo Pharmaceut Co Ltd シクロヘキサン誘導体
DE10056136A1 (de) * 2000-11-07 2002-05-16 Nemod New Modalities Verwendung von Schwangerschaftsproteinen, Liposomen, nativen Muzin-Fragmenten und Mimikry-Verbindungen zur Behandlung und Prophylaxe von entzündlichen Erkrankungen, zur Verhinderung der Metastasierung und zur Prophylaxe von Tumorerkrankungen
CA2462261A1 (en) 2001-10-03 2003-04-10 Miravant Pharmaceuticals, Inc. Chlorin photosensitizing agents for use in photodynamic therapy
AU2002336636A1 (en) 2001-10-03 2003-04-14 Miravant Pharmaceuticals, Inc. Photosensitizing carbamate derivatives
DE102006036326A1 (de) * 2006-08-03 2008-02-07 Charité - Universitätsmedizin Berlin Dendritische Polyglycerolsulfate und -sulfonate und deren Verwendung bei entzündlichen Erkrankungen
EP2100621A1 (en) * 2008-03-10 2009-09-16 mivenion GmbH Polyether polyol dendron conjugates with effector molecules for biological targeting
US8389768B2 (en) 2008-05-19 2013-03-05 The University Of North Carolina At Chapel Hill Methods and compositions comprising novel cationic lipids

Also Published As

Publication number Publication date
JP2013518841A (ja) 2013-05-23
CN102781478A (zh) 2012-11-14
JP2016026191A (ja) 2016-02-12
HUE045311T2 (hu) 2019-12-30
WO2011095311A1 (en) 2011-08-11
PL2531221T3 (pl) 2020-05-18
US20130095035A1 (en) 2013-04-18
CA2788736C (en) 2020-03-31
ES2730744T3 (es) 2019-11-12
EP2531221A1 (en) 2012-12-12
JP5866301B2 (ja) 2016-02-17
NZ601550A (en) 2014-03-28
CA2788736A1 (en) 2011-08-11
DK2531221T3 (da) 2019-06-17
US8877171B2 (en) 2014-11-04
AU2011212742A1 (en) 2012-08-30
EP2531221B1 (en) 2019-03-13
AU2011212742B2 (en) 2014-09-04

Similar Documents

Publication Publication Date Title
BR112012019520A2 (pt) macromoleculas multivalentes polianionicas para alvejamento intracelular da sintese de proteina e proliferacao
AR114031A2 (es) Moléculas de unión a 4-1bb
CU20200089A7 (es) Moléculas de unión contra bcma
BR112012025568A2 (pt) proteínas de ligação ao tnf-<244>.
UY31533A1 (es) Moleculas de enlace al receptor humano ox40
BR112014000324A8 (pt) reagentes reticulantes, macromoléculas, conjugados terapêuticos e métodos sintéticos dos mesmos
BR112015009931A2 (pt) gene, proteína, molécula de ácido nucleico, vetor, célula hospedeira, métodos para a preparação in vitro de um gene mutante e para gerar uma planta, planta mutante, produto, semente de planta mutante, anticorpo, uso de um anticorpo, sonda genética, par de oligonucleotídeos iniciadores, e, uso de sonda genética
BR112013020338A2 (pt) proteína de ligação de antígeno monovalente, composição farmacêutica, uso da proteína de ligação de antígeno monovalente, método para o tratamento de um paciente com necessidade de terapia, método para a preparação de uma proteína de ligação de antígeno monovalente, ácido nucleico, vetor e célula hospedeira
MX2010005830A (es) Conjugado de anticuerpo monoclonal anti-b7h4 - farmaco y metodos de uso del mismo.
AR093377A1 (es) Anticuerpos anti-notch y conjugados de anticuerpo-farmaco
BR112013021134A8 (pt) Anticorpo isolado que se liga especificamente a ptk7 humano, seu uso, composição farmacêutica que o compreende, e ácido nucleico
BRPI0922106A2 (pt) anticorpo monoclonal isolado, molécula de ácido nucleico isolada, célula hospedeira, método para produzir um anticorpo monoclonal isolado, composição farmacêutica, e, uso da composição
EA201690492A1 (ru) Проникающие в клетку конъюгаты и способы их применения
EA201390642A1 (ru) Цитотоксические агенты, содержащие новые производные анзамитоцина
BRPI1006368A2 (pt) proteína de fusão. molécula de ácido nucleico, vetor, célula modificada geneticamente, método para produção da proteína de fusão, usos da proteína de fusão, composição, método para preparação de uma composição, kits, método e uso da proteína de fusão
BR112012020693A8 (pt) Derivados de ciclobutano e metilciclobutano como inibidores de janus quinase e composição que os compreende
AR079551A1 (es) Anticuerpos anti-her3 y usos de los mismos
WO2012075040A3 (en) mRNA FOR USE IN TREATMENT OF HUMAN GENETIC DISEASES
BR112013003825A2 (pt) conjugados, partículas, composições e métodos relacionados
CL2011002756A1 (es) Anticuerpo que se enlaza a la proteina del complemento c3b humana o de cinomolgo; composicion farmaceutica, acido nucleico, vector y celula huesped que comprenden dicho anticuerpo; uso para tratar degeneracion macular relacionada con la edad.
MX341416B (es) Profarmacos de metilfenidato, procesos de elaboracion y uso de los mismos.
MX2009012358A (es) Agentes de formacion de imagenes opticas.
CU20130047A7 (es) Conjugado de naloxol-peg cristalino
MX2014008373A (es) Conjugados antagonistas de integrina para suministro dirigido a celulas que expresan alfa-v-beta-3.
AR080680A1 (es) Proteinas de union a basigina

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 4A, 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]