BR112012008843A2 - Composto, composição farmacêutica, uso do composto, e. mistura - Google Patents

Composto, composição farmacêutica, uso do composto, e. mistura

Info

Publication number
BR112012008843A2
BR112012008843A2 BR112012008843A BR112012008843A BR112012008843A2 BR 112012008843 A2 BR112012008843 A2 BR 112012008843A2 BR 112012008843 A BR112012008843 A BR 112012008843A BR 112012008843 A BR112012008843 A BR 112012008843A BR 112012008843 A2 BR112012008843 A2 BR 112012008843A2
Authority
BR
Brazil
Prior art keywords
compound
mixture
pharmaceutical composition
treatment
abnormalities
Prior art date
Application number
BR112012008843A
Other languages
English (en)
Other versions
BR112012008843B1 (pt
Inventor
Andrea Pfeifer
Andreas Muhs
Heiko Kroth
Wolfgang Froestl
Original Assignee
Ac Immune Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ac Immune Sa filed Critical Ac Immune Sa
Publication of BR112012008843A2 publication Critical patent/BR112012008843A2/pt
Publication of BR112012008843B1 publication Critical patent/BR112012008843B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

composto, composição farmacêutica, uso do composto, e, mistura. a presente invenção diz respeito aos compostos de 2,6-diaminopiridina que podem ser utilizados no tratamento de um grupo de distúrbios e anormalidades associadas com a proteína de amilóide e de doenças ou condições associadas com as proteínas equivalentes ao amilóide. os compostos da presente invenção também podem ser usados no tratamento de doenças oculares associadas com anormalidades/ mudanças patológicas nos tecidos do sistema visual.
BR112012008843-2A 2009-10-15 2010-10-14 Composto, composição farmacêutica, uso do composto, e, mistura BR112012008843B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09173184.4 2009-10-15
EP09173184A EP2311823A1 (en) 2009-10-15 2009-10-15 2,6-Diaminopyridine compounds for treating diseases associated with amyloid proteins or for treating ocular diseases
PCT/EP2010/065439 WO2011045383A2 (en) 2009-10-15 2010-10-14 2, 6 -diaminopyridine compounds for treating diseases associated with amyloid proteins or for treating ocular diseases

Publications (2)

Publication Number Publication Date
BR112012008843A2 true BR112012008843A2 (pt) 2022-02-08
BR112012008843B1 BR112012008843B1 (pt) 2022-08-30

Family

ID=41800516

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012008843-2A BR112012008843B1 (pt) 2009-10-15 2010-10-14 Composto, composição farmacêutica, uso do composto, e, mistura

Country Status (13)

Country Link
US (2) US8916590B2 (pt)
EP (2) EP2311823A1 (pt)
JP (1) JP5662460B2 (pt)
CN (2) CN102656161B (pt)
AU (1) AU2010305770B2 (pt)
BR (1) BR112012008843B1 (pt)
CA (1) CA2777509C (pt)
DK (1) DK2488513T3 (pt)
ES (1) ES2657701T3 (pt)
MX (1) MX2012004388A (pt)
NO (1) NO2488513T3 (pt)
RU (1) RU2538208C2 (pt)
WO (1) WO2011045383A2 (pt)

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* Cited by examiner, † Cited by third party
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MX2014014308A (es) * 2012-05-30 2015-02-12 Hoffmann La Roche Pirrolidino heterociclos.
CN109073660B (zh) * 2016-02-29 2022-10-28 麦恩泰科特有限公司 可用于治疗湿性年龄相关性黄斑变性的预测性标志物
CN106986876B (zh) * 2017-03-20 2019-02-19 北京理工大学 一种靶向标记眼晶体上皮细胞的荧光探针、其制备及应用
WO2020097155A1 (en) 2018-11-06 2020-05-14 Alsatech, Inc. Cell-based gene therapy for neurodegenerative diseases
US20230087342A1 (en) 2019-09-30 2023-03-23 Nippon Chemiphar Co., Ltd. Azepane derivative

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Also Published As

Publication number Publication date
WO2011045383A2 (en) 2011-04-21
CN104262243A (zh) 2015-01-07
NO2488513T3 (pt) 2018-05-26
AU2010305770A1 (en) 2012-05-03
EP2311823A1 (en) 2011-04-20
EP2488513B1 (en) 2017-12-27
WO2011045383A3 (en) 2011-06-30
CN102656161A (zh) 2012-09-05
MX2012004388A (es) 2012-06-08
EP2488513A2 (en) 2012-08-22
RU2538208C2 (ru) 2015-01-10
DK2488513T3 (da) 2018-01-29
CA2777509A1 (en) 2011-04-21
JP5662460B2 (ja) 2015-01-28
CN104262243B (zh) 2017-04-12
ES2657701T3 (es) 2018-03-06
US8916590B2 (en) 2014-12-23
RU2012119757A (ru) 2013-11-20
CN102656161B (zh) 2015-02-18
US20110092537A1 (en) 2011-04-21
US20150023950A1 (en) 2015-01-22
AU2010305770B2 (en) 2014-05-22
US9701660B2 (en) 2017-07-11
CA2777509C (en) 2015-06-02
BR112012008843B1 (pt) 2022-08-30
JP2013507428A (ja) 2013-03-04

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/10/2010, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 14A ANUIDADE.