BR112012008790A2 - sequências de polinucleotídeos, vetor, proteína de fusão, método de produção de uma proteína de fusão, célula hospedeira, composição imunogênica, método de estímulo ou indução de reação imunológica e usos de uma sequência de polinucleotídeos, de um vetor, de uma proteína de fusão ou de uma composição imunogênica - Google Patents

sequências de polinucleotídeos, vetor, proteína de fusão, método de produção de uma proteína de fusão, célula hospedeira, composição imunogênica, método de estímulo ou indução de reação imunológica e usos de uma sequência de polinucleotídeos, de um vetor, de uma proteína de fusão ou de uma composição imunogênica

Info

Publication number
BR112012008790A2
BR112012008790A2 BR112012008790A BR112012008790A BR112012008790A2 BR 112012008790 A2 BR112012008790 A2 BR 112012008790A2 BR 112012008790 A BR112012008790 A BR 112012008790A BR 112012008790 A BR112012008790 A BR 112012008790A BR 112012008790 A2 BR112012008790 A2 BR 112012008790A2
Authority
BR
Brazil
Prior art keywords
fusion protein
vector
immunogenic composition
stimulating
producing
Prior art date
Application number
BR112012008790A
Other languages
English (en)
Portuguese (pt)
Inventor
Vivian Sinton Hill Adrian
Jane Spencer Alexandra
Hill Fergal
Guy Cottingham Matthew
Original Assignee
Imaxio Sa
Isis Innovation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imaxio Sa, Isis Innovation filed Critical Imaxio Sa
Publication of BR112012008790A2 publication Critical patent/BR112012008790A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1289—Mycobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
BR112012008790A 2009-10-16 2010-10-15 sequências de polinucleotídeos, vetor, proteína de fusão, método de produção de uma proteína de fusão, célula hospedeira, composição imunogênica, método de estímulo ou indução de reação imunológica e usos de uma sequência de polinucleotídeos, de um vetor, de uma proteína de fusão ou de uma composição imunogênica BR112012008790A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0918154.6A GB0918154D0 (en) 2009-10-16 2009-10-16 Mycobacterial vaccines
PCT/GB2010/051741 WO2011045612A1 (en) 2009-10-16 2010-10-15 Mycobacterial vaccines

Publications (1)

Publication Number Publication Date
BR112012008790A2 true BR112012008790A2 (pt) 2019-09-24

Family

ID=41462453

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012008790A BR112012008790A2 (pt) 2009-10-16 2010-10-15 sequências de polinucleotídeos, vetor, proteína de fusão, método de produção de uma proteína de fusão, célula hospedeira, composição imunogênica, método de estímulo ou indução de reação imunológica e usos de uma sequência de polinucleotídeos, de um vetor, de uma proteína de fusão ou de uma composição imunogênica

Country Status (14)

Country Link
US (1) US9181311B2 (cg-RX-API-DMAC10.html)
EP (1) EP2488549B1 (cg-RX-API-DMAC10.html)
JP (1) JP2013507907A (cg-RX-API-DMAC10.html)
KR (1) KR20120083899A (cg-RX-API-DMAC10.html)
CN (1) CN102666575B (cg-RX-API-DMAC10.html)
AU (1) AU2010308120B2 (cg-RX-API-DMAC10.html)
BR (1) BR112012008790A2 (cg-RX-API-DMAC10.html)
CA (1) CA2776001A1 (cg-RX-API-DMAC10.html)
EA (1) EA201270517A1 (cg-RX-API-DMAC10.html)
GB (1) GB0918154D0 (cg-RX-API-DMAC10.html)
NZ (1) NZ599259A (cg-RX-API-DMAC10.html)
PH (1) PH12012500849A1 (cg-RX-API-DMAC10.html)
WO (1) WO2011045612A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201202363B (cg-RX-API-DMAC10.html)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201006405D0 (en) 2010-04-16 2010-06-02 Isis Innovation Poxvirus expression system
WO2013119763A1 (en) 2012-02-07 2013-08-15 Intuitive Biosciences, Inc. Mycobacterium tuberculosis specific peptides for detection of infection or immunization in non-human primates
SG11201500171YA (en) * 2012-07-10 2015-02-27 Transgene Sa Mycobacterial antigen vaccine
RU2677799C2 (ru) 2012-12-11 2019-01-21 Озивакс Сас Модифицированные суперспиральные белки с улучшенными свойствами
JP2016520534A (ja) * 2013-03-18 2016-07-14 イマクシオＩｍａｘｉｏ インフルエンザ核タンパク質ワクチン
CN103290053A (zh) * 2013-05-17 2013-09-11 中国人民解放军第四军医大学 唾液腺导管细胞特异性启动子的腺病毒载体及其构建方法
EP3013364B1 (en) * 2013-06-25 2022-08-03 International AIDS Vaccine Initiative, Inc. Tuberculosis compositions and methods of using the same
TWI654200B (zh) 2013-08-30 2019-03-21 環球免疫公司 治療或預防結核病的組合物及方法
WO2015109265A1 (en) * 2014-01-16 2015-07-23 Calysta, Inc. Microorganisms for the enhanced production of amino acids and related methods
CN104805063A (zh) * 2014-01-24 2015-07-29 中国人民解放军第三〇九医院 结核分枝杆菌潜伏感染相关蛋白及其制备和应用
WO2015157561A1 (en) * 2014-04-09 2015-10-15 La Jolla Institute For Allergy And Immunology Specific and unique t cell responses and molecular signatures for treatment and diagnosis of mycobacterium tuberculosis
EP3194969B1 (en) * 2014-08-29 2023-06-07 Centre National de la Recherche Scientifique (C.N.R.S.) Compositions useful in the diagnostic of latently infected mycobacterium tuberculosis
US10342863B2 (en) 2015-03-24 2019-07-09 Fred Hutchinson Cancer Research Center Engineered and multimerized human immunodeficiency virus envelope glycoproteins and uses thereof
CN106237317A (zh) * 2015-06-15 2016-12-21 复旦大学 由结核分枝杆菌抗原组成的结核疫苗
GB201513176D0 (en) 2015-07-27 2015-09-09 Glaxosmithkline Biolog Sa Novel methods for inducing an immune response
US10428122B2 (en) 2016-06-16 2019-10-01 International Aids Vaccine Initiative, Inc. Tuberculosis compositions and methods of treating or preventing tuberculosis
CN108239660B (zh) * 2016-12-26 2021-08-10 上海生物制品研究所有限责任公司 一种重组结核病疫苗，其制备方法及应用
KR102945203B1 (ko) 2017-05-08 2026-03-31 시애틀 프로젝트 코포레이션 알파바이러스 신생항원 벡터
WO2019144139A1 (en) * 2018-01-22 2019-07-25 Oregon State University Immunogenic compositions comprising mycobacterium bovis surface proteins and uses thereof
KR20210090650A (ko) 2018-11-07 2021-07-20 그릿스톤 바이오, 인코포레이티드 알파바이러스 신생항원 벡터 및 인터페론 억제제
SG11202113187WA (en) 2019-05-30 2021-12-30 Gritstone Bio Inc Modified adenoviruses
CN110240637A (zh) * 2019-06-04 2019-09-17 华中农业大学 牛分枝杆菌免疫相关的分子伴侣蛋白GroEL2及其编码基因与应用
KR102193304B1 (ko) * 2019-10-24 2020-12-22 충남대학교산학협력단 Rv2299c-ESAT6-HspX-RipA 융합단백질의 BCG 백신 booster용 조성물
CN110724182B (zh) * 2019-11-15 2022-04-08 上海交通大学 提高菌阴结核感染检测敏感性的标志物组合及应用
WO2021119545A1 (en) * 2019-12-11 2021-06-17 Gritstone Bio, Inc. Durable vaccination
IL300026A (en) 2020-08-06 2023-03-01 Gritstone Bio Inc Multiepitope vaccine cassettes
CN112979825A (zh) * 2021-02-04 2021-06-18 兰州大学 结核分枝杆菌融合蛋白lt29构建及其表达纯化方法和应用
CN113999865B (zh) * 2021-10-09 2023-06-16 安徽理工大学 结核分枝杆菌融合蛋白ar2及其构建与表达纯化方法和应用
CN115920003B (zh) * 2022-08-31 2024-11-29 中国医学科学院病原生物学研究所 脂蛋白LprG及其基因作为抗结核分枝杆菌药物靶点的应用
CN116041543B (zh) * 2022-12-07 2023-12-26 中国疾病预防控制中心传染病预防控制所 结核分枝杆菌多抗原融合蛋白及其编码基因和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2049964A1 (en) 1990-01-26 1991-07-27 Biogen, Inc. C4 binding protein fusion proteins
CN1284854C (zh) * 2003-03-06 2006-11-15 钟森 用于预防结核病和免疫治疗的嵌合型dna疫苗
AU2004263387A1 (en) 2003-08-12 2005-02-17 Avidis Sa Product comprising a C4bp core protein and a monomeric antigen, and its use
SI1957528T1 (sl) * 2005-11-30 2013-02-28 University Of Copenhagen Nukleotidno cepivo
EP1795540A1 (en) * 2005-11-30 2007-06-13 Imaxio Multimeric complexes of antigens and an adjuvant
GB0706912D0 (en) * 2007-04-10 2007-05-16 Isis Innovation Novel viral vaccines
CN101428143B (zh) * 2008-12-09 2011-05-11 武汉大学 携带结核基因的减毒细菌载体结核疫苗及制备方法和应用

Also Published As

Publication number Publication date
US20120282290A1 (en) 2012-11-08
EP2488549A1 (en) 2012-08-22
CN102666575A (zh) 2012-09-12
EP2488549B1 (en) 2015-07-29
PH12012500849A1 (en) 2014-03-24
GB0918154D0 (en) 2009-12-02
ZA201202363B (en) 2013-01-30
AU2010308120B2 (en) 2015-01-22
KR20120083899A (ko) 2012-07-26
WO2011045612A1 (en) 2011-04-21
JP2013507907A (ja) 2013-03-07
CA2776001A1 (en) 2011-04-21
NZ599259A (en) 2014-03-28
CN102666575B (zh) 2015-07-15
EA201270517A1 (ru) 2012-12-28
AU2010308120A1 (en) 2012-05-03
US9181311B2 (en) 2015-11-10

Similar Documents

Publication Publication Date Title
ZA202308845B (en) Cx3cr1-binding polypeptides
BR112014028476A2 (pt) fragmento imunogênico de um polipeptídeo, polinucleotídeo isolado, composição farmacêutica imunogênica, métodos para tratar uma infecção, para gerar uma resposta imune em um sujeito, e para imunizar um sujeito
CO6781540A2 (es) Protéinas de fusión y vacunas de combinación que comprenden proteína e y pilina a de haemophilus influenzae
AR090047A1 (es) Dominio variable dual de inmunoglobulinas y sus usos
MX2018008135A (es) Moleculas de acido nucleico de influenza y vacunas elaboradas a partir de las mismas.
WO2012047679A3 (en) Consensus antigen constructs and vaccines made there form, and methods of using same to treat malaria
HK1207111A1 (en) Methods and compositions for controlling gene expression by rna processing
WO2014093894A3 (en) Dna antibody constructs and method of using same
EA201300585A1 (ru) Иммуномодулирующие олигонуклеотиды
BR112013030396A2 (pt) polipeptídeo, polinucleotídeo, vetor, célula hospedeira, composição imunogênica, vacina, e, uso de uma composição imunogênica ou de uma vacina
MX2021013104A (es) Variantes de lipasa y polinucleotidos que las codifican.
WO2014017493A9 (ja) ワクチン
IL223256A0 (en) Method of dna sequencing by polymerisation
BR112015003724A2 (pt) polipeptídeo isolado, composição, uso de uma composição, polinucleotídeo isolado, constructo de ácido nucleico ou vetor de expressão, célula hospedeira recombinante, e, métodos de produção de um polipeptídeo e de produção de uma proteína.
ZA201201714B (en) Protein matrix vaccines of improved immunogenicity
HK1250662A1 (zh) 用於治疗癌症的免疫原性融合蛋白
HRP20210031T1 (hr) Pripravci i metode mutantskog faktora viii
GEP20197052B (en) Hyr1-derived compositions and methods of treatment using same
WO2014170460A3 (en) Method for the production of collagen proteins derived from marine sponges and an organism able to produce said proteins
BR112014012682A2 (pt) polinucleotídeo, unidade e vetor de expressão de gene estranho, célula trasnformada, método para produzir uma proteína, usos de uma sequência de polinucleotídeo e de um vetor de expressão de gene estranho
WO2008143713A3 (en) Plant-made west nile virus (wnv) vaccines, vectors and plant codon optimized sequences
WO2015070207A3 (en) Ama-1 epitopes, antibodies, compositions, and methods of making and using the same
ZA201200046B (en) Therapeutic peptides, polypeptides and nucleic acid sequences
BRPI1006281A2 (pt) Polinucleotídeo isolado ou recombinante,vetor, célula hospedeira e método de produção de um ácido dicarboxílico c4
GB0912155D0 (en) Therapeutic peptides, polypeptides and nucleic acid sequences

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.