BR112012008332A8 - Intermediário de cinacalcet, seu processo de preparação e processo para preparação de cinacalcet - Google Patents

Intermediário de cinacalcet, seu processo de preparação e processo para preparação de cinacalcet

Info

Publication number
BR112012008332A8
BR112012008332A8 BR112012008332A BR112012008332A BR112012008332A8 BR 112012008332 A8 BR112012008332 A8 BR 112012008332A8 BR 112012008332 A BR112012008332 A BR 112012008332A BR 112012008332 A BR112012008332 A BR 112012008332A BR 112012008332 A8 BR112012008332 A8 BR 112012008332A8
Authority
BR
Brazil
Prior art keywords
cinacalcet
preparation
formula
propan
trifluoromethyl
Prior art date
Application number
BR112012008332A
Other languages
English (en)
Other versions
BR112012008332B8 (pt
BR112012008332B1 (pt
BR112012008332A2 (pt
Inventor
Catozzi Nicola
Cotarca Livius
Foletto Johnny
Forcato Massimiliano
Giovanetti Roberto
Soriato Giorgio
Verzini Massimo
Original Assignee
Zach System Spa
Fis Fabbrica Italiana Sintetici Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zach System Spa, Fis Fabbrica Italiana Sintetici Spa filed Critical Zach System Spa
Publication of BR112012008332A2 publication Critical patent/BR112012008332A2/pt
Publication of BR112012008332A8 publication Critical patent/BR112012008332A8/pt
Publication of BR112012008332B1 publication Critical patent/BR112012008332B1/pt
Publication of BR112012008332B8 publication Critical patent/BR112012008332B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C07C209/74—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by halogenation, hydrohalogenation, dehalogenation, or dehydrohalogenation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCESSO PARA PREPARAÇÃO DE CINACALCET. Um processo para a preparação de sal de cloridrato de fórmula (I), N- [ (1R) -1-(1-naftil)etil] -3-(trifluorometil)-fenil]propan-1-amina, isto é, Cinacalcet. HC1 e seu intermediário de fórmula (IX).
BR112012008332A 2009-09-10 2010-09-08 intermediário de cinacalcet, seu processo de preparação e processo para preparação de cinacalcet BR112012008332B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09169934.8 2009-09-10
EP09169934 2009-09-10
PCT/EP2010/063154 WO2011029833A1 (en) 2009-09-10 2010-09-08 Process for preparing cinacalcet

Publications (4)

Publication Number Publication Date
BR112012008332A2 BR112012008332A2 (pt) 2016-03-22
BR112012008332A8 true BR112012008332A8 (pt) 2017-07-11
BR112012008332B1 BR112012008332B1 (pt) 2021-02-23
BR112012008332B8 BR112012008332B8 (pt) 2021-05-25

Family

ID=42790570

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012008332A BR112012008332B8 (pt) 2009-09-10 2010-09-08 intermediário de cinacalcet, seu processo de preparação e processo para preparação de cinacalcet

Country Status (10)

Country Link
US (1) US8637708B2 (pt)
EP (1) EP2475641B1 (pt)
JP (1) JP5685594B2 (pt)
CN (1) CN102548955B (pt)
AU (1) AU2010294283B2 (pt)
BR (1) BR112012008332B8 (pt)
CA (1) CA2769659C (pt)
ES (1) ES2445532T3 (pt)
IL (1) IL217802A0 (pt)
WO (1) WO2011029833A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010215520B2 (en) * 2009-02-19 2016-07-21 F.I.S. - Fabbrica Italiana Sintetici S.P.A. Process for preparing Cinacalcet hydrochloride
CN106831441B (zh) * 2017-01-23 2019-04-02 江苏康思尔医药科技有限公司 一种盐酸西那卡塞的制备方法
CN108047056A (zh) * 2017-12-29 2018-05-18 山东泰和水处理科技股份有限公司 一种双(2-氯乙基)胺盐酸盐的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6011068A (en) 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5504253A (en) 1994-07-15 1996-04-02 Nps Pharmaceuticals, Inc. Amine preparation
CZ290670B6 (cs) 1994-10-21 2002-09-11 Nps Pharmaceuticals, Inc. Sloučeniny modulující receptory anorganických iontů a farmaceutický prostředek, který je obsahuje
CA2603145A1 (en) 2005-05-16 2006-11-23 Teva Pharmaceutical Industries Ltd. Process for preparing cinacalcet hydrochloride
EP1883618B1 (en) 2005-05-23 2009-10-14 Teva Pharmaceutical Industries Ltd. Processes for preparing cinacalcet hydrochloride crystal form i
US7449603B2 (en) 2006-04-27 2008-11-11 Teva Pharmaceutical Industries Ltd. Process for the preparation of cinacalcet base
US7393967B2 (en) 2006-04-27 2008-07-01 Teva Pharmaceutical Industries Ltd. Process for the preparation of cinacalcet base
WO2008035212A2 (en) 2006-06-08 2008-03-27 Medichem, S.A. Processes for preparing intermediate compounds useful for the preparation of cinacalcet
EP1990333A1 (en) 2007-05-11 2008-11-12 Sandoz AG Process for the preparation of cinacalcet hydrochloride
JP5358566B2 (ja) 2007-06-21 2013-12-04 アムジエン・インコーポレーテツド シナカルセトおよびその塩を合成する方法
ITMI20071261A1 (it) 2007-06-22 2008-12-23 Dipharma Francis Srl Procedimento per la preparazione di cinacalcet
WO2009025792A2 (en) 2007-08-16 2009-02-26 Teva Pharmaceutical Industries Ltd. Crystalline forms cinacalcet fumarate and cinacalcet succinate and processes for preparation thereof
WO2009039241A2 (en) 2007-09-18 2009-03-26 Medichem, S.A. Improved process for preparing cinacalcet hydrochloride
BRPI0919635B8 (pt) 2008-10-28 2021-05-25 Fis Fabbrica Italiana Sintetici Spa processo para preparação de cinacalcet
AU2010215520B2 (en) 2009-02-19 2016-07-21 F.I.S. - Fabbrica Italiana Sintetici S.P.A. Process for preparing Cinacalcet hydrochloride

Also Published As

Publication number Publication date
BR112012008332B8 (pt) 2021-05-25
CA2769659A1 (en) 2011-03-17
JP5685594B2 (ja) 2015-03-18
WO2011029833A1 (en) 2011-03-17
JP2013504535A (ja) 2013-02-07
AU2010294283A1 (en) 2012-02-23
AU2010294283B2 (en) 2016-09-29
CN102548955B (zh) 2014-06-04
ES2445532T3 (es) 2014-03-03
BR112012008332B1 (pt) 2021-02-23
EP2475641A1 (en) 2012-07-18
US20120238778A1 (en) 2012-09-20
US8637708B2 (en) 2014-01-28
BR112012008332A2 (pt) 2016-03-22
IL217802A0 (en) 2012-03-29
EP2475641B1 (en) 2013-11-06
CN102548955A (zh) 2012-07-04
CA2769659C (en) 2017-10-24

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT)

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/02/2021, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/09/2010 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF