BR112012007635A2 - derivados de feniloxadiazol como inibidores de pgds - Google Patents

derivados de feniloxadiazol como inibidores de pgds

Info

Publication number
BR112012007635A2
BR112012007635A2 BR112012007635A BR112012007635A BR112012007635A2 BR 112012007635 A2 BR112012007635 A2 BR 112012007635A2 BR 112012007635 A BR112012007635 A BR 112012007635A BR 112012007635 A BR112012007635 A BR 112012007635A BR 112012007635 A2 BR112012007635 A2 BR 112012007635A2
Authority
BR
Brazil
Prior art keywords
compound
pgds inhibitors
phenyloxadiazole
derivatives
phenyloxadiazole derivatives
Prior art date
Application number
BR112012007635A
Other languages
English (en)
Other versions
BR112012007635B1 (pt
Inventor
Hillegass Andrea
L Vandeusen Christopher
J Weiberth Franz
Lee George
S Gill Harpal
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of BR112012007635A2 publication Critical patent/BR112012007635A2/pt
Publication of BR112012007635B1 publication Critical patent/BR112012007635B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

derivados de feniloxadiazol como inibidores de pgds. a presente invenção refere-se a um composto de fórmula (i): em que r1, r2 e r3 são tal como aqui definidos, uma composição farmacêutica compreendendo o composto, intermediários e processos para a produção dos ditos compostos, e ao uso do composto para tratar distúrbios alérgicos e/ou inflamatórios, particularmente distúrbios como rinite alérgica, asma, doença pulmonar obstrutiva crônica (copd) e degeneração macular relacionada com a idade (amd).
BR112012007635-3A 2009-10-08 2010-10-07 Compostos derivados de feniloxadiazol como inibidores de pgds, composição farmacêutica compreendendo os mesmos e seus processos de preparação BR112012007635B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US24969309P 2009-10-08 2009-10-08
US61/249,693 2009-10-08
FR1056094 2010-07-26
FR1056094 2010-07-26
PCT/US2010/051727 WO2011044307A1 (en) 2009-10-08 2010-10-07 Phenyloxadiazole derivatives as pgds inhibitors

Publications (2)

Publication Number Publication Date
BR112012007635A2 true BR112012007635A2 (pt) 2017-06-20
BR112012007635B1 BR112012007635B1 (pt) 2019-07-09

Family

ID=43606440

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012007635-3A BR112012007635B1 (pt) 2009-10-08 2010-10-07 Compostos derivados de feniloxadiazol como inibidores de pgds, composição farmacêutica compreendendo os mesmos e seus processos de preparação

Country Status (21)

Country Link
US (5) US9469627B2 (pt)
EP (1) EP2486024B1 (pt)
JP (2) JP5753176B2 (pt)
KR (1) KR101701135B1 (pt)
CN (3) CN107875155A (pt)
AR (1) AR078552A1 (pt)
AU (1) AU2010303439B2 (pt)
BR (1) BR112012007635B1 (pt)
CA (1) CA2776242C (pt)
DK (1) DK2486024T3 (pt)
ES (1) ES2543011T3 (pt)
HK (1) HK1173441A1 (pt)
IL (1) IL218967A (pt)
MA (1) MA33725B1 (pt)
MX (1) MX2012003021A (pt)
NZ (1) NZ599099A (pt)
RU (2) RU2015151129A (pt)
SG (1) SG179199A1 (pt)
TW (1) TWI508960B (pt)
UY (1) UY32938A (pt)
WO (1) WO2011044307A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2012003021A (es) * 2009-10-08 2012-04-10 Sanofi Sa Derivados de feniloxadiazol como agentes inhibidores de las pgds.
US9320723B2 (en) * 2010-05-03 2016-04-26 University Of Rochester Methods of treating thyroid eye disease
WO2017103851A1 (en) 2015-12-17 2017-06-22 Astex Therapeutics Limited Quinoline-3-carboxamides as h-pgds inhibitors
JOP20190072A1 (ar) 2016-10-13 2019-04-07 Glaxosmithkline Ip Dev Ltd مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم
HUE064642T2 (hu) * 2017-05-22 2024-04-28 Egyt Gyogyszervegyeszeti Gyar Eljárás ozanimod elõállítására
EP3638672A1 (en) 2017-06-13 2020-04-22 GlaxoSmithKline Intellectual Property Development Limited Chemical compounds as h-pgds inhibitors
WO2019116256A1 (en) 2017-12-13 2019-06-20 Glaxosmithkline Intellectual Property Development Limited Fused pyridines which act as inhibitors of h-pgds
BR112021008976A2 (pt) 2018-11-08 2021-08-03 Glaxosmithkline Intellectual Property Development Limited compostos químicos
JPWO2021256569A1 (pt) 2020-06-19 2021-12-23
WO2023113023A1 (ja) * 2021-12-17 2023-06-22 佐藤製薬株式会社 Ｈ－ｐｇｄｓを阻害するアザインドール誘導体

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US5176132A (en) 1989-05-31 1993-01-05 Fisons Plc Medicament inhalation device and formulation
DE10117823A1 (de) 2001-04-10 2002-10-17 Merck Patent Gmbh Oxalsäurederivate
BR0308518A (pt) * 2002-03-19 2005-02-22 Ono Pharmaceutical Co Compostos ácidos carboxìlicos e drogas contendo os compostos como o ingrediente ativo
WO2004016223A2 (en) 2002-08-16 2004-02-26 Aventis Pharmaceuticals Inc. Assaying compounds or agents for microsomal prostaglandin e synthase or hematopoietic prostaglandin d synthase activity
GB0222023D0 (en) 2002-09-21 2002-10-30 Aventis Pharma Ltd Inhaler
WO2005094805A1 (ja) 2004-04-01 2005-10-13 Institute Of Medicinal Molecular Design. Inc. イミン誘導体及びアミド誘導体
WO2005103055A1 (en) * 2004-04-21 2005-11-03 Schering Corporation PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO-[1,5-c]-PYRIMIDINE ADENOSINE A2A RECEPTOR ANTAGONISTS
JP5209181B2 (ja) * 2005-03-15 2013-06-12 富士フイルム株式会社 化合物、組成物、位相差板、楕円偏光板および液晶表示装置
TW200720255A (en) 2005-07-13 2007-06-01 Taiho Pharmaceutical Co Ltd Benzoimidazole compound capable of inhibiting prostaglandin d synthetase
JP2007051121A (ja) * 2005-07-22 2007-03-01 Taiho Yakuhin Kogyo Kk プロスタグランジンｄ合成酵素を阻害するピリミジン化合物
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PE20110118A1 (es) * 2005-10-04 2011-03-08 Aventis Pharma Inc Compuestos de pirimidina amida como inhibidores de pgds
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Also Published As

Publication number Publication date
JP5897186B2 (ja) 2016-03-30
EP2486024B1 (en) 2015-04-22
JP2013507376A (ja) 2013-03-04
US20170231990A1 (en) 2017-08-17
HK1173441A1 (en) 2013-05-16
UY32938A (es) 2011-05-31
JP2015178516A (ja) 2015-10-08
WO2011044307A1 (en) 2011-04-14
IL218967A (en) 2015-05-31
CN107875155A (zh) 2018-04-06
NZ599099A (en) 2013-05-31
US20190000845A1 (en) 2019-01-03
IL218967A0 (en) 2012-07-31
CA2776242A1 (en) 2011-04-14
CN106943407A (zh) 2017-07-14
KR20120094910A (ko) 2012-08-27
DK2486024T3 (en) 2015-07-27
CA2776242C (en) 2014-09-02
KR101701135B1 (ko) 2017-02-01
US20120190695A1 (en) 2012-07-26
EP2486024A1 (en) 2012-08-15
TWI508960B (zh) 2015-11-21
AR078552A1 (es) 2011-11-16
MX2012003021A (es) 2012-04-10
RU2015151129A3 (pt) 2019-07-17
BR112012007635B1 (pt) 2019-07-09
AU2010303439A1 (en) 2012-04-26
ES2543011T3 (es) 2015-08-13
MA33725B1 (fr) 2012-11-01
US20230190747A1 (en) 2023-06-22
US9937175B2 (en) 2018-04-10
US20190262338A1 (en) 2019-08-29
SG179199A1 (en) 2012-04-27
CN102666508A (zh) 2012-09-12
RU2012118756A (ru) 2013-11-20
JP5753176B2 (ja) 2015-07-22
AU2010303439B2 (en) 2015-10-29
TW201127835A (en) 2011-08-16
RU2572608C2 (ru) 2016-01-20
US9469627B2 (en) 2016-10-18
RU2015151129A (ru) 2019-01-15

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 07/10/2010, OBSERVADAS AS CONDICOES LEGAIS. (CO) 20 (VINTE) ANOS CONTADOS A PARTIR DE 07/10/2010, OBSERVADAS AS CONDICOES LEGAIS