BR112012001061A2 - glicosídeos 2,3-fluorados como inibidores de neuraminidase e seu uso como antivirais - Google Patents
glicosídeos 2,3-fluorados como inibidores de neuraminidase e seu uso como antiviraisInfo
- Publication number
- BR112012001061A2 BR112012001061A2 BR112012001061A BR112012001061A BR112012001061A2 BR 112012001061 A2 BR112012001061 A2 BR 112012001061A2 BR 112012001061 A BR112012001061 A BR 112012001061A BR 112012001061 A BR112012001061 A BR 112012001061A BR 112012001061 A2 BR112012001061 A2 BR 112012001061A2
- Authority
- BR
- Brazil
- Prior art keywords
- antivirals
- neuraminidase inhibitors
- glycosides
- fluorinated
- fluorinated glycosides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21378609P | 2009-07-15 | 2009-07-15 | |
| US61/213,786 | 2009-07-15 | ||
| PCT/CA2010/001063 WO2011006237A1 (en) | 2009-07-15 | 2010-07-15 | 2,3-fluorinated glycosides as neuraminidase inhibitors and their use as anti-virals |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112012001061A2 true BR112012001061A2 (pt) | 2016-03-29 |
| BR112012001061B1 BR112012001061B1 (pt) | 2020-10-27 |
| BR112012001061B8 BR112012001061B8 (pt) | 2021-05-25 |
Family
ID=43448829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012001061A BR112012001061B8 (pt) | 2009-07-15 | 2010-07-15 | glicosídeos 2,3-fluorados como inibidores de neuraminidase, seu método de preparação, composição farmacêutica que os compreende e embalagem comercial |
Country Status (8)
| Country | Link |
|---|---|
| US (8) | US8815941B2 (pt) |
| EP (1) | EP2454268B1 (pt) |
| JP (1) | JP5855566B2 (pt) |
| CN (2) | CN105949158A (pt) |
| AU (1) | AU2010273118B2 (pt) |
| BR (1) | BR112012001061B8 (pt) |
| CA (1) | CA2767453C (pt) |
| WO (1) | WO2011006237A1 (pt) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
| EP2318832B1 (en) | 2008-07-15 | 2013-10-09 | Academia Sinica | Glycan arrays on ptfe-like aluminum coated glass slides and related methods |
| JP5855566B2 (ja) | 2009-07-15 | 2016-02-09 | ザ ユニヴァーシティ オヴ ブリティッシュ コロンビア | ノイラミニダーゼ阻害剤としての２，３−フッ化グリコシド及び抗ウイルス薬としてのその使用 |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| WO2011130332A1 (en) | 2010-04-12 | 2011-10-20 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
| CN107954963A (zh) * | 2012-01-19 | 2018-04-24 | 不列颠哥伦比亚大学 | 3’平伏氟取代的神经氨酸酶抑制剂化合物、组合物及其用作抗病毒剂的方法 |
| US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
| AU2013306098A1 (en) | 2012-08-18 | 2015-02-12 | Academia Sinica | Cell-permeable probes for identification and imaging of sialidases |
| WO2014031762A1 (en) | 2012-08-21 | 2014-02-27 | Academia Sinica | Benzocyclooctyne compounds and uses thereof |
| US10086054B2 (en) | 2013-06-26 | 2018-10-02 | Academia Sinica | RM2 antigens and use thereof |
| WO2014210564A1 (en) | 2013-06-27 | 2014-12-31 | Academia Sinica | Glycan conjugates and use thereof |
| US9782476B2 (en) | 2013-09-06 | 2017-10-10 | Academia Sinica | Human iNKT cell activation using glycolipids with altered glycosyl groups |
| EP3094352B1 (en) | 2014-01-16 | 2020-09-23 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| WO2015148915A1 (en) | 2014-03-27 | 2015-10-01 | Academia Sinica | Reactive labelling compounds and uses thereof |
| CA2950577A1 (en) | 2014-05-27 | 2015-12-03 | Academia Sinica | Fucosidase from bacteroides and methods using the same |
| KR20220151036A (ko) | 2014-05-27 | 2022-11-11 | 아카데미아 시니카 | 항-ｃｄ20 글리코항체 및 이의 용도 |
| AU2015267045B2 (en) | 2014-05-27 | 2021-02-25 | Academia Sinica | Anti-HER2 glycoantibodies and uses thereof |
| US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| KR102494193B1 (ko) | 2014-05-28 | 2023-01-31 | 아카데미아 시니카 | 항-ｔｎｆ-알파 글리코항체 및 이의 용도 |
| NL2013420B1 (en) * | 2014-09-05 | 2016-09-27 | Univ Griffith | Antiviral agents and uses thereof. |
| EP3191500A4 (en) | 2014-09-08 | 2018-04-11 | Academia Sinica | HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS |
| JP6515497B2 (ja) * | 2014-11-17 | 2019-05-22 | スズキ株式会社 | 車体前部構造 |
| US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| EP3248005B1 (en) | 2015-01-24 | 2020-12-09 | Academia Sinica | Novel glycan conjugates and methods of use thereof |
| WO2017156192A1 (en) | 2016-03-08 | 2017-09-14 | Academia Sinica | Methods for modular synthesis of n-glycans and arrays thereof |
| CN109963868B (zh) | 2016-08-22 | 2023-11-14 | 醣基生医股份有限公司 | 抗体、结合片段及使用方法 |
| CN106986901B (zh) * | 2017-03-13 | 2020-06-16 | 华东理工大学 | 唾液酸-羧酸类化合物偶联物及其制备方法 |
| EP3667322A1 (en) | 2018-12-14 | 2020-06-17 | Euroimmun Medizinische Labordiagnostika AG | Serological detection of plasmodium antibodies |
| BR102020000922A2 (pt) | 2019-01-24 | 2021-11-30 | Euroimmun Medizinische Labordiagnostika Ag | Detecção sorológica de anticorpos de plasmodium |
| CN114190092B (zh) * | 2020-07-14 | 2023-07-18 | 四川大学 | 3-去氧-2-酮糖酸含氮衍生物及其制备方法和用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK282950B6 (sk) * | 1990-04-24 | 2003-01-09 | Biota Scientific Management Pty Ltd | Deriváty alfa-D-neuramínovej kyseliny, spôsob ich prípravy, ich použitie a farmaceutické prípravky na ich báze |
| EP0746564B1 (en) * | 1994-02-25 | 1998-12-02 | E.I. Du Pont De Nemours And Company | 4-n-substituted sialic acids and their sialosides |
| US6284494B1 (en) * | 1995-12-12 | 2001-09-04 | The University Of British Columbia | Methods and compositions for synthesis of oligosaccharides using mutant glycosidase enzymes |
| US5952203A (en) * | 1997-04-11 | 1999-09-14 | The University Of British Columbia | Oligosaccharide synthesis using activated glycoside derivative, glycosyl transferase and catalytic amount of nucleotide phosphate |
| DK200201741A (da) | 2002-11-12 | 2003-09-16 | Statens Seruminstitut | Vaccine comprising chimeric malaria proteins derived from Plasmodium falciparum |
| CA2517104A1 (en) * | 2003-02-25 | 2004-09-10 | The Kitasato Institute | Anti-influenza virus compounds comprising biflavonoid-sialic acid conjugates |
| CN100471848C (zh) * | 2006-06-05 | 2009-03-25 | 中国医学科学院医药生物技术研究所 | 一组长链烷氧烷基取代唾液酸衍生物及其制备方法 |
| GB0816679D0 (en) * | 2008-09-11 | 2008-10-22 | Univ Bath | Compounds for treating viral infections |
| JP5855566B2 (ja) | 2009-07-15 | 2016-02-09 | ザ ユニヴァーシティ オヴ ブリティッシュ コロンビア | ノイラミニダーゼ阻害剤としての２，３−フッ化グリコシド及び抗ウイルス薬としてのその使用 |
| CN107954963A (zh) | 2012-01-19 | 2018-04-24 | 不列颠哥伦比亚大学 | 3’平伏氟取代的神经氨酸酶抑制剂化合物、组合物及其用作抗病毒剂的方法 |
-
2010
- 2010-07-15 JP JP2012519854A patent/JP5855566B2/ja not_active Expired - Fee Related
- 2010-07-15 EP EP10799312.3A patent/EP2454268B1/en not_active Not-in-force
- 2010-07-15 CA CA2767453A patent/CA2767453C/en not_active Expired - Fee Related
- 2010-07-15 BR BR112012001061A patent/BR112012001061B8/pt not_active IP Right Cessation
- 2010-07-15 AU AU2010273118A patent/AU2010273118B2/en not_active Ceased
- 2010-07-15 WO PCT/CA2010/001063 patent/WO2011006237A1/en active Application Filing
- 2010-07-15 CN CN201610285580.2A patent/CN105949158A/zh active Pending
- 2010-07-15 US US13/382,284 patent/US8815941B2/en active Active
- 2010-07-15 CN CN201080031428.2A patent/CN102471361B/zh not_active Expired - Fee Related
-
2012
- 2012-01-19 US US13/354,254 patent/US8907111B2/en active Active
-
2014
- 2014-07-14 US US14/330,855 patent/US9221859B2/en active Active
- 2014-11-05 US US14/533,903 patent/US9382284B2/en active Active
-
2015
- 2015-11-19 US US14/946,132 patent/US9604954B2/en active Active
-
2016
- 2016-05-23 US US15/162,055 patent/US9834534B2/en active Active
-
2017
- 2017-02-16 US US15/435,075 patent/US20180057474A1/en not_active Abandoned
- 2017-10-30 US US15/798,169 patent/US20180282293A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN102471361B (zh) | 2016-06-01 |
| US20120184606A1 (en) | 2012-07-19 |
| US20180057474A1 (en) | 2018-03-01 |
| US9834534B2 (en) | 2017-12-05 |
| BR112012001061B1 (pt) | 2020-10-27 |
| US20160068501A1 (en) | 2016-03-10 |
| BR112012001061B8 (pt) | 2021-05-25 |
| US9382284B2 (en) | 2016-07-05 |
| US20170022177A1 (en) | 2017-01-26 |
| US9221859B2 (en) | 2015-12-29 |
| AU2010273118B2 (en) | 2015-10-29 |
| EP2454268B1 (en) | 2014-09-10 |
| JP2012532895A (ja) | 2012-12-20 |
| US20120178802A1 (en) | 2012-07-12 |
| EP2454268A1 (en) | 2012-05-23 |
| JP5855566B2 (ja) | 2016-02-09 |
| CA2767453A1 (en) | 2011-01-20 |
| WO2011006237A1 (en) | 2011-01-20 |
| US20180282293A1 (en) | 2018-10-04 |
| US8907111B2 (en) | 2014-12-09 |
| CN102471361A (zh) | 2012-05-23 |
| CA2767453C (en) | 2018-10-09 |
| US20150216838A1 (en) | 2015-08-06 |
| US9604954B2 (en) | 2017-03-28 |
| US20150158899A1 (en) | 2015-06-11 |
| EP2454268A4 (en) | 2013-05-22 |
| US8815941B2 (en) | 2014-08-26 |
| CN105949158A (zh) | 2016-09-21 |
| AU2010273118A1 (en) | 2012-02-02 |
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Legal Events
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| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2679 DE 10-05-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |