BR102013031270A8 - processo para a síntese de 3-(2-bromo-4,5-dimetoxifenil) propanonitrila, e aplicação na síntese de ivabradina e seus sais de adição com um ácido farmaceuticamente aceitável - Google Patents

processo para a síntese de 3-(2-bromo-4,5-dimetoxifenil) propanonitrila, e aplicação na síntese de ivabradina e seus sais de adição com um ácido farmaceuticamente aceitável

Info

Publication number
BR102013031270A8
BR102013031270A8 BR102013031270A BR102013031270A BR102013031270A8 BR 102013031270 A8 BR102013031270 A8 BR 102013031270A8 BR 102013031270 A BR102013031270 A BR 102013031270A BR 102013031270 A BR102013031270 A BR 102013031270A BR 102013031270 A8 BR102013031270 A8 BR 102013031270A8
Authority
BR
Brazil
Prior art keywords
synthesis
ivabradine
pharmaceutically acceptable
application
addition salts
Prior art date
Application number
BR102013031270A
Other languages
English (en)
Other versions
BR102013031270A2 (pt
Inventor
Sanchez Frédéric
Lorenzo Gonzalez José
Del Pilar Carranza Maria
Isabel Garcia Aranda Maria
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of BR102013031270A2 publication Critical patent/BR102013031270A2/pt
Publication of BR102013031270A8 publication Critical patent/BR102013031270A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/14—Preparation of carboxylic acid nitriles by reaction of cyanides with halogen-containing compounds with replacement of halogen atoms by cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/02—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C255/03—Mononitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

processo para a síntese de 3-(2-bromo-4,5-dimetoxifenil)propanonitrila, e aplicação na síntese de ivabradina e seus sais de adição com um ácido farmaceuticamente aceitável. a presente invenção refere-se a processo para a síntese do composto da fórmula (i): aplicação na síntese de ivabradina, seus sais de adição com um ácido farmaceuticamente aceitável e hidratos dos mesmos.
BR102013031270A 2012-12-06 2013-12-05 processo para a síntese de 3-(2-bromo-4,5-dimetoxifenil) propanonitrila, e aplicação na síntese de ivabradina e seus sais de adição com um ácido farmaceuticamente aceitável BR102013031270A8 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1261714A FR2999178B1 (fr) 2012-12-06 2012-12-06 Nouveau procede de synthese du 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (2)

Publication Number Publication Date
BR102013031270A2 BR102013031270A2 (pt) 2014-09-16
BR102013031270A8 true BR102013031270A8 (pt) 2021-02-23

Family

ID=47714347

Family Applications (1)

Application Number Title Priority Date Filing Date
BR102013031270A BR102013031270A8 (pt) 2012-12-06 2013-12-05 processo para a síntese de 3-(2-bromo-4,5-dimetoxifenil) propanonitrila, e aplicação na síntese de ivabradina e seus sais de adição com um ácido farmaceuticamente aceitável

Country Status (26)

Country Link
US (1) US8779123B2 (pt)
EP (1) EP2740725A1 (pt)
JP (1) JP5863757B2 (pt)
KR (1) KR101575736B1 (pt)
CN (1) CN103848757B (pt)
AR (1) AR093807A1 (pt)
AU (1) AU2013257530B2 (pt)
BR (1) BR102013031270A8 (pt)
CA (1) CA2835459C (pt)
EA (1) EA023329B1 (pt)
FR (1) FR2999178B1 (pt)
GE (1) GEP20156413B (pt)
HK (1) HK1199013A1 (pt)
JO (1) JO3320B1 (pt)
MA (1) MA35806B1 (pt)
MD (1) MD4477C1 (pt)
MX (1) MX349425B (pt)
MY (1) MY159691A (pt)
NZ (1) NZ618644A (pt)
SA (1) SA113350048B1 (pt)
SG (1) SG2013085709A (pt)
TW (1) TWI519507B (pt)
UA (1) UA117900C2 (pt)
UY (1) UY35149A (pt)
WO (1) WO2014087105A1 (pt)
ZA (1) ZA201309038B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3101010A1 (en) 2015-06-03 2016-12-07 Urquima S.A. New method for the preparation of highly pure ivabradine base and salts thereof
KR101702468B1 (ko) 2015-07-27 2017-02-06 충남대학교산학협력단 암 예방 및 치료용 조성물

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
JP2003519127A (ja) * 1999-12-29 2003-06-17 ワイス 三環系タンパクキナーゼ阻害薬
US7365197B2 (en) * 2000-12-29 2008-04-29 Wyeth Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines
CN101407474B (zh) * 2008-11-18 2011-12-14 东华大学 一种2-溴-4,5-二甲氧基苯丙腈的制备方法
CN102464595B (zh) * 2010-11-17 2015-02-25 山东新时代药业有限公司 一种伊伐布雷定中间体的合成方法

Also Published As

Publication number Publication date
SG2013085709A (en) 2014-07-30
MD4477C1 (ro) 2017-11-30
NZ618644A (en) 2015-02-27
UY35149A (es) 2014-06-30
EP2740725A1 (fr) 2014-06-11
MD4477B1 (ro) 2017-04-30
KR101575736B1 (ko) 2015-12-08
AR093807A1 (es) 2015-06-24
CA2835459C (fr) 2016-08-16
JP2014114285A (ja) 2014-06-26
CN103848757A (zh) 2014-06-11
AU2013257530B2 (en) 2017-04-27
MX2013013766A (es) 2014-06-23
WO2014087105A1 (fr) 2014-06-12
BR102013031270A2 (pt) 2014-09-16
SA113350048B1 (ar) 2015-10-07
CA2835459A1 (fr) 2014-06-06
ZA201309038B (en) 2016-01-27
MD20130092A2 (ro) 2014-06-30
US8779123B2 (en) 2014-07-15
CN103848757B (zh) 2016-05-18
US20140163220A1 (en) 2014-06-12
MX349425B (es) 2017-07-28
UA117900C2 (uk) 2018-10-25
TWI519507B (zh) 2016-02-01
AU2013257530A1 (en) 2014-06-26
GEP20156413B (en) 2015-12-10
MA35806B1 (fr) 2014-12-01
TW201422570A (zh) 2014-06-16
FR2999178A1 (fr) 2014-06-13
EA023329B1 (ru) 2016-05-31
JP5863757B2 (ja) 2016-02-17
MY159691A (en) 2017-01-13
HK1199013A1 (zh) 2015-06-19
JO3320B1 (ar) 2019-03-13
EA201301235A1 (ru) 2014-06-30
FR2999178B1 (fr) 2014-11-28
KR20140073436A (ko) 2014-06-16

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Date Code Title Description
B03A Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
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