BR0314377A - Composto, composição farmacêutica, tablete ou cápsula, método para tratar de distúrbios do snc em um ser humano, método para a profilaxia da enxaqueca em um ser humano, método para tratar psicoses em um ser humano, e, processo para preparar um composto - Google Patents

Composto, composição farmacêutica, tablete ou cápsula, método para tratar de distúrbios do snc em um ser humano, método para a profilaxia da enxaqueca em um ser humano, método para tratar psicoses em um ser humano, e, processo para preparar um composto

Info

Publication number
BR0314377A
BR0314377A BR0314377-5A BR0314377A BR0314377A BR 0314377 A BR0314377 A BR 0314377A BR 0314377 A BR0314377 A BR 0314377A BR 0314377 A BR0314377 A BR 0314377A
Authority
BR
Brazil
Prior art keywords
human
compound
treating
prophylaxis
capsule
Prior art date
Application number
BR0314377-5A
Other languages
English (en)
Other versions
BRPI0314377B1 (pt
BRPI0314377B8 (pt
Inventor
Thomas P Jerussi
Qun Kevin Fang
Mark Currie
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor Inc filed Critical Sepracor Inc
Publication of BR0314377A publication Critical patent/BR0314377A/pt
Publication of BRPI0314377B1 publication Critical patent/BRPI0314377B1/pt
Publication of BRPI0314377B8 publication Critical patent/BRPI0314377B8/pt

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/26All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/28Hydrogenated naphthalenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, TABLETE OU CáPSULA, MéTODO PARA TRATAR DE DISTúRBIOS DO SNC EM UM SER HUMANO, MéTODO PARA A PROFILAXIA DA ENXAQUECA EM UM SER HUMANO, MéTODO PARA TRATAR PSICOSES EM UM SER HUMANO, E, PROCESSO PARA PREPARAR UM COMPOSTO". O tratamento dos distúrbios do SNC (sistema nervoso central) com (1R,4S)-trans 4-(3,4-diclorofenil)-1,2,3,4-tetraidro-1-naftalenamina e (1S,4R)-trans 4-(3,4-diclorofenil)- 1,2,3,4-tetraidro-1-naftalenamina é apresentado. Um processo para preparar 4-(3,4-diclorofenil)-1,2,3,4-tetraidro1-naftalenamina também é apresentado. O processo inclui a preparação de todos os quatro isómeros de N-[4-(3,4-diclorofenil)-1,2,3,4-tetraidronaftalen1-il]formamida, os quais também são úteis.
BRPI0314377A 2002-09-16 2003-09-16 composto, composição farmacêutica, tablete ou cápsula, uso de uma quantidade terapeuticamente eficaz, e, processo para preparar um composto BRPI0314377B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41130402P 2002-09-16 2002-09-16
US41130502P 2002-09-16 2002-09-16
US60/411,304 2002-09-16
US60/411,305 2002-09-16
PCT/US2003/029110 WO2004024669A1 (en) 2002-09-16 2003-09-16 Treatment of cns disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine and its formamide

Publications (3)

Publication Number Publication Date
BR0314377A true BR0314377A (pt) 2005-07-19
BRPI0314377B1 BRPI0314377B1 (pt) 2020-11-24
BRPI0314377B8 BRPI0314377B8 (pt) 2021-05-25

Family

ID=31998027

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0314377A BRPI0314377B8 (pt) 2002-09-16 2003-09-16 composto, composição farmacêutica, tablete ou cápsula, uso de uma quantidade terapeuticamente eficaz, e, processo para preparar um composto

Country Status (16)

Country Link
US (6) US7087785B2 (pt)
EP (1) EP1542961B1 (pt)
JP (1) JP4610336B2 (pt)
KR (2) KR101067045B1 (pt)
CN (1) CN101712626B (pt)
AU (1) AU2003272460B2 (pt)
BR (1) BRPI0314377B8 (pt)
CA (1) CA2498152C (pt)
DK (1) DK1542961T3 (pt)
ES (1) ES2431519T3 (pt)
HK (1) HK1143559A1 (pt)
IL (1) IL167319A (pt)
MX (1) MXPA05002700A (pt)
NZ (1) NZ538741A (pt)
PT (1) PT1542961E (pt)
WO (1) WO2004024669A1 (pt)

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Also Published As

Publication number Publication date
ES2431519T3 (es) 2013-11-26
US7423179B2 (en) 2008-09-09
CN101712626A (zh) 2010-05-26
US20090292026A1 (en) 2009-11-26
US20040092605A1 (en) 2004-05-13
EP1542961B1 (en) 2013-09-11
AU2003272460A1 (en) 2004-04-30
JP2005539068A (ja) 2005-12-22
DK1542961T3 (da) 2013-11-04
US7105699B2 (en) 2006-09-12
US20080280993A1 (en) 2008-11-13
WO2004024669A1 (en) 2004-03-25
HK1143559A1 (en) 2011-01-07
CA2498152C (en) 2012-01-10
US20060216799A1 (en) 2006-09-28
KR20110091043A (ko) 2011-08-10
KR20050084552A (ko) 2005-08-26
US7790772B2 (en) 2010-09-07
PT1542961E (pt) 2013-11-05
MXPA05002700A (es) 2005-09-08
CA2498152A1 (en) 2004-03-25
US20060128993A1 (en) 2006-06-15
US7087785B2 (en) 2006-08-08
US7589237B2 (en) 2009-09-15
AU2003272460A2 (en) 2004-04-30
IL167319A (en) 2013-10-31
KR101067045B1 (ko) 2011-09-22
EP1542961A1 (en) 2005-06-22
AU2003272460B2 (en) 2009-12-17
BRPI0314377B1 (pt) 2020-11-24
JP4610336B2 (ja) 2011-01-12
NZ538741A (en) 2007-01-26
CN101712626B (zh) 2013-11-20
BRPI0314377B8 (pt) 2021-05-25
KR101165549B1 (ko) 2012-07-19
US20060014982A1 (en) 2006-01-19

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA:INT.CI. A61K 31/135, A61K 9/20, A61K 9/48, A61P 25/00, A61P 25/06, A61P 25/08, A61P 25/14, A61P 25/16, A61P 25/20, A61P 25/22, A61P 25/24, A61P 25/28, A61P 25/30, C07C 209/62, C07C 211/42

Ipc: A61K 31/135 (2011.01), A61K 9/20 (2011.01), A61K 9

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