BR0313083A - moléculas de adamts4 modificadas,polinucleotìdeo, vetor, processos para produção, composição farmacêutica, bem como uso das mesmas - Google Patents

moléculas de adamts4 modificadas,polinucleotìdeo, vetor, processos para produção, composição farmacêutica, bem como uso das mesmas

Info

Publication number
BR0313083A
BR0313083A BRPI0313083-5A BR0313083A BR0313083A BR 0313083 A BR0313083 A BR 0313083A BR 0313083 A BR0313083 A BR 0313083A BR 0313083 A BR0313083 A BR 0313083A
Authority
BR
Brazil
Prior art keywords
production
proteins
adamts4
polynucleotide
molecules
Prior art date
Application number
BRPI0313083-5A
Other languages
English (en)
Portuguese (pt)
Inventor
Christopher John
Carl R Flannery
Weilan Zeng
Lisa A Racie
Thomas Mcdonagh
Bethany A Freeman
Katy E Georgiadis
Edward R Lavallie
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BR0313083A publication Critical patent/BR0313083A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BRPI0313083-5A 2002-07-29 2003-07-29 moléculas de adamts4 modificadas,polinucleotìdeo, vetor, processos para produção, composição farmacêutica, bem como uso das mesmas BR0313083A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39872102P 2002-07-29 2002-07-29
PCT/US2003/023484 WO2004011637A2 (en) 2002-07-29 2003-07-29 Modified adamts4 molecules and method of use thereof

Publications (1)

Publication Number Publication Date
BR0313083A true BR0313083A (pt) 2007-07-17

Family

ID=31188463

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0313083-5A BR0313083A (pt) 2002-07-29 2003-07-29 moléculas de adamts4 modificadas,polinucleotìdeo, vetor, processos para produção, composição farmacêutica, bem como uso das mesmas

Country Status (10)

Country Link
US (2) US7118902B2 (enExample)
EP (1) EP1525307A2 (enExample)
JP (1) JP2005534308A (enExample)
CN (1) CN1681920A (enExample)
AU (1) AU2003261269A1 (enExample)
BR (1) BR0313083A (enExample)
CA (1) CA2492444A1 (enExample)
IL (1) IL166535A0 (enExample)
MX (1) MXPA05000959A (enExample)
WO (1) WO2004011637A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4252892B2 (ja) 2001-06-01 2009-04-08 三菱製紙株式会社 全熱交換素子用紙
JP2005516614A (ja) 2002-02-05 2005-06-09 ワイス 切断アグレカナーゼ分子
CN1681920A (zh) * 2002-07-29 2005-10-12 惠氏公司 修饰的admts4分子及其使用方法
US7696307B2 (en) * 2004-04-12 2010-04-13 The Trustees Of The University Of Pennsylvania Function and regulation of ADAMTS-1
JP2007535920A (ja) * 2004-04-16 2007-12-13 ワイス トランケート型ａｄａｍｔｓ分子
WO2007025248A2 (en) * 2005-08-25 2007-03-01 Wyeth Aggrecanase structure
US7625731B2 (en) 2005-08-25 2009-12-01 Wyeth Aggrecanase structure
GB0601976D0 (en) * 2006-02-01 2006-03-15 Merck Sharp & Dohme Proteins
US20100062431A1 (en) * 2006-05-18 2010-03-11 Sanofi-Aventis Use of adamts4 gene and protein polymorphisms
US8263072B2 (en) * 2007-06-22 2012-09-11 Genera Istrazivanja, d.o.o. ADAMTS4 as a blood biomarker and therapeutic target for chronic renal failure
JP5341756B2 (ja) * 2007-06-29 2013-11-13 国立大学法人名古屋大学 神経障害に基づく機能不全の改善剤およびＲｈｏキナーゼ活性化抑制剤
EP2420250A1 (en) 2010-08-13 2012-02-22 Universitätsklinikum Münster Anti-Syndecan-4 antibodies
CA2927525C (en) 2013-10-15 2023-01-31 Genefrontier Corporation Human antibody against aggrecanase-type adamts species for therapeutics of aggrecanase-related diseases

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3451575A (en) * 1967-09-15 1969-06-24 Geza Petro Jr Conveyor bucket with hydraulically-operated grille-like lid
US4419446A (en) * 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
US4554101A (en) * 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US4522811A (en) * 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4588684A (en) 1983-04-26 1986-05-13 Chiron Corporation a-Factor and its processing signals
ES8701226A1 (es) 1984-07-06 1986-11-16 Sandoz Ag Procedimiento de obtencion de una proteina de factor estimu-lante de colonias (csf) en primates
EP0177343B1 (en) 1984-10-05 1992-07-22 Genentech, Inc. Dna, cell cultures and methods for the secretion of heterologous proteins and periplasmic protein recovery
US6069229A (en) * 1997-03-07 2000-05-30 Schering Corporation Mammalian proteinases; oxidoreductases; related reagents
AU8513198A (en) * 1997-07-25 1999-02-16 Du Pont Pharmaceuticals Company Aggrecan degrading metallo proteases
US6842704B2 (en) * 1998-02-04 2005-01-11 Immunex Corporation Crystalline TNF-α-converting enzyme and uses thereof
WO2000053774A2 (en) * 1999-03-08 2000-09-14 Neurocrine Biosciences, Inc. Metalloproteinases and methods of use therefor
US6391610B1 (en) * 1999-08-06 2002-05-21 The Cleveland Clinic Foundation Nucleic acids encoding zinc metalloproteases
EP1136547A3 (en) * 2000-03-22 2002-09-25 Pfizer Products Inc. Adamts polypeptides, nucleic acids encoding them, and uses thereof
US6458552B1 (en) * 2000-06-06 2002-10-01 Ortho-Mcneil Pharmaceutical, Inc. Metalloprotease peptide substrates and methods
US20020151702A1 (en) * 2000-10-18 2002-10-17 Genetics Institute, Inc. Aggrecanase molecules
SE0102298D0 (sv) * 2001-06-27 2001-06-27 Astrazeneca Ab Crystal structure of enzyme and uses thereof
US20030148306A1 (en) * 2001-07-05 2003-08-07 Agostino Michael J. Aggrecanase molecules
WO2003016492A2 (en) * 2001-08-16 2003-02-27 The Regents Of The University Of Michigan Adamts13 genes and proteins and variants, and uses thereof
US20030105313A1 (en) * 2001-10-16 2003-06-05 American Home Products Corporation Aggrecanase molecules
JP2005515779A (ja) * 2002-01-31 2005-06-02 ワイス アグレカナーゼ分子
JP2005516614A (ja) * 2002-02-05 2005-06-09 ワイス 切断アグレカナーゼ分子
CN1681920A (zh) * 2002-07-29 2005-10-12 惠氏公司 修饰的admts4分子及其使用方法

Also Published As

Publication number Publication date
CN1681920A (zh) 2005-10-12
EP1525307A2 (en) 2005-04-27
US20060228354A1 (en) 2006-10-12
MXPA05000959A (es) 2005-05-16
US20040142863A1 (en) 2004-07-22
AU2003261269A1 (en) 2004-02-16
CA2492444A1 (en) 2004-02-05
WO2004011637A2 (en) 2004-02-05
WO2004011637A3 (en) 2004-04-08
JP2005534308A (ja) 2005-11-17
IL166535A0 (en) 2006-01-15
US7118902B2 (en) 2006-10-10

Similar Documents

Publication Publication Date Title
MX2007003906A (es) Metodos y composiciones para mejorar la produccion de proteinas recombinantes.
BRPI0814781A8 (pt) ''proteína, sequência de ácido nucleico, método para a produção de ácido itacônico, vetor, célula hospedeira, e, uso de um ácido cis-aconítico descarboxilase''
BR9915026A (pt) Móleculas de ácido nucléico codificando uma enzima ramificadora de bactérias do gênero neisseria bem como métodos para a produção de alfa-1,4 glicanos ramificados para alfa-1,6
PL1831386T3 (pl) Kwasowa proteaza grzybów w procesie fermentacji w nierozpuszczalnych substratach skrobi
BRPI0514680A (pt) produção de anticorpos anti-amilóide beta
BRPI0514703A (pt) produção de polipeptìdeos
BRPI0514694A (pt) produção de proteìna de fusão tnfr-ig
CY1112110T1 (el) Κυκλικο μοριο dna το οποιο διαθετει μια συμβατικη αφετηρια αντιγραφης, η διαδικασια παρασκευης του και η χρηση του στην γονιδιακη θεραπεια
BR0011499A (pt) Moléculas de ácido nucléico oriundas de plantas e células de,planta transgênicas de trigo e o seu uso para a produção de amido modificado
BR9815855A (pt) Genes e métodos para controle de nematóides em plantas
NO20074278L (no) Tigecyklinblandinger og fremgangsmater for fremstilling
IN2012DN00801A (enExample)
NO20072719L (no) Serumfritt cellekulturmedium for pattedyrceller
MX2019008914A (es) Purificacion de iduronato-2-sulfatasa.
MXPA05005323A (es) Policetido-sintasa productora de borrelidina y sus usos.
WO2004013312A3 (en) Tocopherol biosynthesis related genes and uses thereof
BRPI0009362B8 (pt) variante de uma alfa-amilase precursora, e, uso de uma variante de alfa-amilase
ECSP077240A (es) Variantes mejoradas de la aprotinina
NO20061470L (no) Fremgangsmate for fremstilling av gamma-karboksylerte proteiner
WO2004011637A3 (en) Modified adamts4 molecules and method of use thereof
ATE486128T1 (de) Zusammensetzungen und verfahren zur erhöhung der produktion rekombinanter gamma-carboxylierter proteine
ATE488591T1 (de) Neuer l-lysin-induzierbarer promotor
EA200700233A1 (ru) Новая последовательность для повышения экспрессии нуклеиновой кислоты
MX2007012954A (es) Sistemas de expresion en mamiferos.
SG160194A1 (en) Truncated aggrecanase molecules

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A E 8A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011.