AU2003261269A1 - Modified adamts4 molecules and method of use thereof - Google Patents

Modified adamts4 molecules and method of use thereof Download PDF

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Publication number
AU2003261269A1
AU2003261269A1 AU2003261269A AU2003261269A AU2003261269A1 AU 2003261269 A1 AU2003261269 A1 AU 2003261269A1 AU 2003261269 A AU2003261269 A AU 2003261269A AU 2003261269 A AU2003261269 A AU 2003261269A AU 2003261269 A1 AU2003261269 A1 AU 2003261269A1
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AU
Australia
Prior art keywords
protein
adamts4
modified
aggrecanase
adamts4 protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
AU2003261269A
Other languages
English (en)
Inventor
Christopher John Corcoran
Carl R. Flannery
Bethany A. Freeman
Katy E. Georgiadis
Edward R. Lavallie
Thomas Mcdonagh
Lisa A. Racie
Weilan Zeng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Publication of AU2003261269A1 publication Critical patent/AU2003261269A1/en
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2003261269A 2002-07-29 2003-07-29 Modified adamts4 molecules and method of use thereof Withdrawn AU2003261269A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39872102P 2002-07-29 2002-07-29
US60/398,721 2002-07-29
PCT/US2003/023484 WO2004011637A2 (en) 2002-07-29 2003-07-29 Modified adamts4 molecules and method of use thereof

Publications (1)

Publication Number Publication Date
AU2003261269A1 true AU2003261269A1 (en) 2004-02-16

Family

ID=31188463

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003261269A Withdrawn AU2003261269A1 (en) 2002-07-29 2003-07-29 Modified adamts4 molecules and method of use thereof

Country Status (10)

Country Link
US (2) US7118902B2 (enExample)
EP (1) EP1525307A2 (enExample)
JP (1) JP2005534308A (enExample)
CN (1) CN1681920A (enExample)
AU (1) AU2003261269A1 (enExample)
BR (1) BR0313083A (enExample)
CA (1) CA2492444A1 (enExample)
IL (1) IL166535A0 (enExample)
MX (1) MXPA05000959A (enExample)
WO (1) WO2004011637A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4252892B2 (ja) 2001-06-01 2009-04-08 三菱製紙株式会社 全熱交換素子用紙
JP2005516614A (ja) 2002-02-05 2005-06-09 ワイス 切断アグレカナーゼ分子
CN1681920A (zh) * 2002-07-29 2005-10-12 惠氏公司 修饰的admts4分子及其使用方法
US7696307B2 (en) * 2004-04-12 2010-04-13 The Trustees Of The University Of Pennsylvania Function and regulation of ADAMTS-1
JP2007535920A (ja) * 2004-04-16 2007-12-13 ワイス トランケート型ａｄａｍｔｓ分子
WO2007025248A2 (en) * 2005-08-25 2007-03-01 Wyeth Aggrecanase structure
US7625731B2 (en) 2005-08-25 2009-12-01 Wyeth Aggrecanase structure
GB0601976D0 (en) * 2006-02-01 2006-03-15 Merck Sharp & Dohme Proteins
US20100062431A1 (en) * 2006-05-18 2010-03-11 Sanofi-Aventis Use of adamts4 gene and protein polymorphisms
US8263072B2 (en) * 2007-06-22 2012-09-11 Genera Istrazivanja, d.o.o. ADAMTS4 as a blood biomarker and therapeutic target for chronic renal failure
JP5341756B2 (ja) * 2007-06-29 2013-11-13 国立大学法人名古屋大学 神経障害に基づく機能不全の改善剤およびＲｈｏキナーゼ活性化抑制剤
EP2420250A1 (en) 2010-08-13 2012-02-22 Universitätsklinikum Münster Anti-Syndecan-4 antibodies
CA2927525C (en) 2013-10-15 2023-01-31 Genefrontier Corporation Human antibody against aggrecanase-type adamts species for therapeutics of aggrecanase-related diseases

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3451575A (en) * 1967-09-15 1969-06-24 Geza Petro Jr Conveyor bucket with hydraulically-operated grille-like lid
US4419446A (en) * 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
US4554101A (en) * 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US4522811A (en) * 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4588684A (en) 1983-04-26 1986-05-13 Chiron Corporation a-Factor and its processing signals
ES8701226A1 (es) 1984-07-06 1986-11-16 Sandoz Ag Procedimiento de obtencion de una proteina de factor estimu-lante de colonias (csf) en primates
EP0177343B1 (en) 1984-10-05 1992-07-22 Genentech, Inc. Dna, cell cultures and methods for the secretion of heterologous proteins and periplasmic protein recovery
US6069229A (en) * 1997-03-07 2000-05-30 Schering Corporation Mammalian proteinases; oxidoreductases; related reagents
AU8513198A (en) * 1997-07-25 1999-02-16 Du Pont Pharmaceuticals Company Aggrecan degrading metallo proteases
US6842704B2 (en) * 1998-02-04 2005-01-11 Immunex Corporation Crystalline TNF-α-converting enzyme and uses thereof
WO2000053774A2 (en) * 1999-03-08 2000-09-14 Neurocrine Biosciences, Inc. Metalloproteinases and methods of use therefor
US6391610B1 (en) * 1999-08-06 2002-05-21 The Cleveland Clinic Foundation Nucleic acids encoding zinc metalloproteases
EP1136547A3 (en) * 2000-03-22 2002-09-25 Pfizer Products Inc. Adamts polypeptides, nucleic acids encoding them, and uses thereof
US6458552B1 (en) * 2000-06-06 2002-10-01 Ortho-Mcneil Pharmaceutical, Inc. Metalloprotease peptide substrates and methods
US20020151702A1 (en) * 2000-10-18 2002-10-17 Genetics Institute, Inc. Aggrecanase molecules
SE0102298D0 (sv) * 2001-06-27 2001-06-27 Astrazeneca Ab Crystal structure of enzyme and uses thereof
US20030148306A1 (en) * 2001-07-05 2003-08-07 Agostino Michael J. Aggrecanase molecules
WO2003016492A2 (en) * 2001-08-16 2003-02-27 The Regents Of The University Of Michigan Adamts13 genes and proteins and variants, and uses thereof
US20030105313A1 (en) * 2001-10-16 2003-06-05 American Home Products Corporation Aggrecanase molecules
JP2005515779A (ja) * 2002-01-31 2005-06-02 ワイス アグレカナーゼ分子
JP2005516614A (ja) * 2002-02-05 2005-06-09 ワイス 切断アグレカナーゼ分子
CN1681920A (zh) * 2002-07-29 2005-10-12 惠氏公司 修饰的admts4分子及其使用方法

Also Published As

Publication number Publication date
BR0313083A (pt) 2007-07-17
CN1681920A (zh) 2005-10-12
EP1525307A2 (en) 2005-04-27
US20060228354A1 (en) 2006-10-12
MXPA05000959A (es) 2005-05-16
US20040142863A1 (en) 2004-07-22
CA2492444A1 (en) 2004-02-05
WO2004011637A2 (en) 2004-02-05
WO2004011637A3 (en) 2004-04-08
JP2005534308A (ja) 2005-11-17
IL166535A0 (en) 2006-01-15
US7118902B2 (en) 2006-10-10

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Legal Events

Date Code Title Description
MK12 Application lapsed section 141(1)/reg 8.3(2) - applicant filed a written notice of withdrawal