BR0308576A - Compostos: composições farmacêuticas para administração em um mamìfero e métodos para inibir a enzima citocroma p450rai em um mamìfero - Google Patents
Compostos: composições farmacêuticas para administração em um mamìfero e métodos para inibir a enzima citocroma p450rai em um mamìferoInfo
- Publication number
- BR0308576A BR0308576A BR0308576-7A BR0308576A BR0308576A BR 0308576 A BR0308576 A BR 0308576A BR 0308576 A BR0308576 A BR 0308576A BR 0308576 A BR0308576 A BR 0308576A
- Authority
- BR
- Brazil
- Prior art keywords
- mammal
- compounds
- inhibiting
- administration
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"COMPOSTOS; COMPOSIçõES FARMACêUTICAS PARA ADMINISTRAçãO EM UM MAMìFERO E MéTODOS PARA INIBIR A ENZIMA CITOCROMA P450RAI EM UM MAMìFERO". Descreve-se compostos da fórmula (I) nos quais as variáveis estão definidas no relatório descritivo, que têm atividade inibitória de citocroma P450RAI-1 e P450RAI-2, e são apropriados para o tratamento de mamíferos portadores de condições tratáveis com retinóides, ou que são controladas por ou responsivas ao ácido retinóico nativo do organismo. As formulações que contêm os compostos da invenção podem ser administradas também com retinóides e/ou vitamina A, para intensificar ou prolongar os efeitos de medicações que contêm retinóides, vitamina A, ou o ácido retinóico nativo do organismo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/100,638 US6740676B2 (en) | 2002-03-19 | 2002-03-19 | 4-[(8-ethynyl, 8-vinyl or 8-ethynyl-methyl)-6-chromanoyl]-benzoic and 2-[4-[(8-ethynyl, 8-vinyl or 8-ethynyl-methyl)-6-chromanoyl]-phenyl]-acetic acid, their esters and salts having cytochrome p450rai inhibitory activity |
PCT/US2003/007612 WO2003080594A1 (en) | 2002-03-19 | 2003-03-11 | Substituted chroman derivatives having cytochrome p450rai inhibitory activity |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0308576A true BR0308576A (pt) | 2005-01-04 |
Family
ID=28452321
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0308576-7A BR0308576A (pt) | 2002-03-19 | 2003-03-11 | Compostos: composições farmacêuticas para administração em um mamìfero e métodos para inibir a enzima citocroma p450rai em um mamìfero |
Country Status (12)
Country | Link |
---|---|
US (2) | US6740676B2 (pt) |
EP (1) | EP1485368A1 (pt) |
JP (1) | JP2005525387A (pt) |
CN (1) | CN1656088A (pt) |
AR (1) | AR039027A1 (pt) |
AU (1) | AU2003213848B2 (pt) |
BR (1) | BR0308576A (pt) |
CA (1) | CA2478913A1 (pt) |
IL (1) | IL164103A0 (pt) |
MX (1) | MXPA04009046A (pt) |
TW (1) | TW200305399A (pt) |
WO (1) | WO2003080594A1 (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040077721A1 (en) * | 2002-03-19 | 2004-04-22 | Yang-Dar Yuan | Compositions and methods using compounds having cytochrome P450RAI inhibitory activity co-administered with vitamin A |
US6740676B2 (en) * | 2002-03-19 | 2004-05-25 | Allergan, Inc. | 4-[(8-ethynyl, 8-vinyl or 8-ethynyl-methyl)-6-chromanoyl]-benzoic and 2-[4-[(8-ethynyl, 8-vinyl or 8-ethynyl-methyl)-6-chromanoyl]-phenyl]-acetic acid, their esters and salts having cytochrome p450rai inhibitory activity |
JP4121537B2 (ja) | 2004-12-22 | 2008-07-23 | 日東電工株式会社 | 線維化抑制のための薬物担体および薬物担体キット |
US20120269886A1 (en) | 2004-12-22 | 2012-10-25 | Nitto Denko Corporation | Therapeutic agent for pulmonary fibrosis |
JP2009221164A (ja) * | 2008-03-17 | 2009-10-01 | Nitto Denko Corp | 肺線維症処置剤 |
US9572886B2 (en) | 2005-12-22 | 2017-02-21 | Nitto Denko Corporation | Agent for treating myelofibrosis |
KR100801029B1 (ko) | 2005-12-27 | 2008-02-04 | 제일모직주식회사 | 디아민 화합물 및 이를 이용한 액정 배향제 |
US20070185055A1 (en) * | 2006-02-06 | 2007-08-09 | Guang Liang Jiang | Method for treating cachexia with retinoid ligands |
TWI407971B (zh) | 2007-03-30 | 2013-09-11 | Nitto Denko Corp | Cancer cells and tumor-related fibroblasts |
AU2008329677B2 (en) * | 2007-11-28 | 2015-02-19 | Sequoia Pharmaceuticals, Inc. | Compositions and methods for inhibiting cytochrome P450 2D6 |
CN111233809B (zh) * | 2020-01-16 | 2021-12-03 | 广东省中医院(广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院) | 一种Millepachine-CA-4衍生物及其制备方法和应用 |
WO2023190164A1 (ja) * | 2022-03-28 | 2023-10-05 | 日油株式会社 | アリールエステルを含むカルボン酸の製造方法及びカチオン性脂質の製造方法 |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH651034A5 (de) | 1982-05-12 | 1985-08-30 | Hoffmann La Roche | Chroman-, thiochroman- oder 1,2,3,4-tetrahydrochinolinderivate und ihre verwendung als arzneimittel-wirkstoffe. |
EP0130795B1 (en) | 1983-07-05 | 1988-11-23 | Pfizer Inc. | Carboxylic acid derivatives useful for inhibiting the degradation of cartilage |
EP0155940A1 (en) | 1983-08-08 | 1985-10-02 | Sri International | Benzonorbornenyl, benzopyranyl and benzothiopyranyl retinoic acid analogues |
US4658065A (en) * | 1984-03-28 | 1987-04-14 | Asahi Kasei Kogyo Kabushiki Kaisha | Process for producing polyether polyol and a product |
US4826984A (en) | 1984-04-09 | 1989-05-02 | The Board Of Regents For The Oklahoma Agricultural And Mechanical College Acting For And On Behalf Of Oklahoma State University | Heteroarotinoid compounds as anticancer agents |
LU86351A1 (fr) | 1986-03-12 | 1987-11-11 | Oreal | Composes benzopyrannyl et benzothiopyrannyl benzoiques,leur procede de preparation et leur utilisation en cosmetique et en medecine humaine et veterinaire |
US5149705A (en) | 1987-03-13 | 1992-09-22 | Allergan, Inc. | Acetylenes disubstituted with a heteroaromatic group and a tetralin group and having retinoid like activity |
US5089509A (en) | 1988-09-15 | 1992-02-18 | Allergan, Inc. | Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity |
US5264578A (en) | 1987-03-20 | 1993-11-23 | Allergan, Inc. | Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity |
AU626881B2 (en) | 1988-07-14 | 1992-08-13 | F. Hoffmann-La Roche Ag | Benzofused heterocyclics used as pharmaceuticals |
US5045551A (en) | 1989-09-19 | 1991-09-03 | Allergan, Inc. | Acetylenes disubstituted with a heteroaromatic group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity |
US5399561A (en) | 1989-09-19 | 1995-03-21 | Allergan, Inc. | Acetylenes disubstituted with a phenyl or heteroaryl group and a 2-oxochromanyl, 2-oxothiochromanyl or 2-oxo-1,2,3,4-tetrahydro-quinolinyl group having retinoid-like biological activity |
US4980369A (en) | 1989-09-19 | 1990-12-25 | Allergan, Inc. | Acetylenes disubstituted with a phenyl group and a 2-substituted chromanyl or thiochromanyl group having retinoid-like activity |
US5023341A (en) | 1989-09-19 | 1991-06-11 | Allergan, Inc. | Compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity |
US5006550A (en) * | 1989-12-29 | 1991-04-09 | Allergan, Inc. | Chroman esters of phenols and benzoic acids having retinoid-like activity |
EP0553156A4 (en) * | 1990-10-09 | 1993-11-18 | Allergan, Inc. | Chromans and thiochromans with retinoid-like activity |
EP0571546B1 (en) | 1991-02-13 | 1996-10-16 | Allergan, Inc. | Chroman and thiochromans with phenylethynyl substituents at the 7-position having retinoid-like biological activity |
JP3157523B2 (ja) | 1991-03-26 | 2001-04-16 | アラーガン、インコーポレイテッド | レチノイド様生物学的活性を有する7位にヘテロアリールエチニル置換基を有するクロマンおよびチオクロマン |
US5134159A (en) | 1991-03-26 | 1992-07-28 | Allergan, Inc. | 7-chromanyl esters of phenols and benzoic acids having retinoid-like activity |
ES2066750T3 (es) | 1991-12-18 | 1998-07-01 | Salk Inst For Biological Studi | Metodo para la modulacion de procesos mediatizados por receptores de retinoides y compuestos de utilidad en dicho metodo. |
US5466861A (en) | 1992-11-25 | 1995-11-14 | Sri International | Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors |
ES2129115T3 (es) | 1993-01-11 | 1999-06-01 | Ligand Pharm Inc | Compuestos que tienen actividad selectiva para los receptores de retinoides x, y medios para la modulacion de procesos mediados por receptores de retinoides x. |
US5455265A (en) | 1993-02-11 | 1995-10-03 | Allergan, Inc. | Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors |
US5675024A (en) * | 1995-11-22 | 1997-10-07 | Allergan | Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity |
US5965606A (en) | 1995-12-29 | 1999-10-12 | Allergan Sales, Inc. | Methods of treatment with compounds having RAR.sub.α receptor specific or selective activity |
US6864367B2 (en) * | 2000-02-21 | 2005-03-08 | Takeda Chemical Industries, Ltd. | Process for producing cyclic compound |
CZ20024220A3 (cs) * | 2000-06-30 | 2003-06-18 | Unilever N. V. | Prostředek pro péči o pleť |
US6313107B1 (en) | 2000-08-29 | 2001-11-06 | Allergan Sales, Inc. | Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI |
WO2002018361A2 (en) * | 2000-08-29 | 2002-03-07 | Allergan, Inc. | Compounds having activity as inhibitors of cytochrome p450rai |
US6303785B1 (en) | 2000-08-29 | 2001-10-16 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
US6252090B1 (en) * | 2000-08-29 | 2001-06-26 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
US20040077721A1 (en) * | 2002-03-19 | 2004-04-22 | Yang-Dar Yuan | Compositions and methods using compounds having cytochrome P450RAI inhibitory activity co-administered with vitamin A |
US6740676B2 (en) * | 2002-03-19 | 2004-05-25 | Allergan, Inc. | 4-[(8-ethynyl, 8-vinyl or 8-ethynyl-methyl)-6-chromanoyl]-benzoic and 2-[4-[(8-ethynyl, 8-vinyl or 8-ethynyl-methyl)-6-chromanoyl]-phenyl]-acetic acid, their esters and salts having cytochrome p450rai inhibitory activity |
-
2002
- 2002-03-19 US US10/100,638 patent/US6740676B2/en not_active Expired - Fee Related
-
2003
- 2003-03-11 WO PCT/US2003/007612 patent/WO2003080594A1/en active Application Filing
- 2003-03-11 JP JP2003578348A patent/JP2005525387A/ja active Pending
- 2003-03-11 MX MXPA04009046A patent/MXPA04009046A/es active IP Right Grant
- 2003-03-11 EP EP03711542A patent/EP1485368A1/en not_active Withdrawn
- 2003-03-11 IL IL16410303A patent/IL164103A0/xx unknown
- 2003-03-11 CA CA002478913A patent/CA2478913A1/en not_active Abandoned
- 2003-03-11 BR BR0308576-7A patent/BR0308576A/pt not_active Application Discontinuation
- 2003-03-11 AU AU2003213848A patent/AU2003213848B2/en not_active Ceased
- 2003-03-11 CN CNA038114283A patent/CN1656088A/zh active Pending
- 2003-03-14 US US10/389,071 patent/US7351737B2/en not_active Expired - Fee Related
- 2003-03-19 AR ARP030100968A patent/AR039027A1/es unknown
- 2003-03-19 TW TW092106025A patent/TW200305399A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
TW200305399A (en) | 2003-11-01 |
US6740676B2 (en) | 2004-05-25 |
WO2003080594A1 (en) | 2003-10-02 |
CA2478913A1 (en) | 2003-10-02 |
AU2003213848B2 (en) | 2007-08-16 |
EP1485368A1 (en) | 2004-12-15 |
AR039027A1 (es) | 2005-02-02 |
US7351737B2 (en) | 2008-04-01 |
JP2005525387A (ja) | 2005-08-25 |
AU2003213848A1 (en) | 2003-10-08 |
US20030191181A1 (en) | 2003-10-09 |
US20030207937A1 (en) | 2003-11-06 |
MXPA04009046A (es) | 2005-06-08 |
CN1656088A (zh) | 2005-08-17 |
IL164103A0 (en) | 2005-12-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A,8A E 9A ANUIDADE(S). |
|
B08G | Application fees: restoration [chapter 8.7 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |