BR0214425A - Compostos carbonilbenzoxazina para aperfeiçoamento de respostas sinápticas glutamatérgicas - Google Patents
Compostos carbonilbenzoxazina para aperfeiçoamento de respostas sinápticas glutamatérgicasInfo
- Publication number
- BR0214425A BR0214425A BR0214425-5A BR0214425A BR0214425A BR 0214425 A BR0214425 A BR 0214425A BR 0214425 A BR0214425 A BR 0214425A BR 0214425 A BR0214425 A BR 0214425A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- brain
- enhancement
- synaptic responses
- disorders
- Prior art date
Links
- FEFCQDINBPEMNU-UHFFFAOYSA-N 4h-1,2-benzoxazin-3-ylidenemethanone Chemical class C1=CC=C2ONC(=C=O)CC2=C1 FEFCQDINBPEMNU-UHFFFAOYSA-N 0.000 title 1
- 230000000848 glutamatergic effect Effects 0.000 title 1
- 230000009782 synaptic response Effects 0.000 title 1
- 210000004556 brain Anatomy 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 206010012289 Dementia Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 230000006399 behavior Effects 0.000 abstract 1
- 230000003930 cognitive ability Effects 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 206010027175 memory impairment Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001537 neural effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 210000000225 synapse Anatomy 0.000 abstract 1
- 230000000946 synaptic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
- C07D265/22—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"COMPOSTOS CARBONILBENZOXAZINA PARA APERFEIçOAMENTO DE RESPOSTAS SINáPTICAS GLUTAMATéRGICAS". A presente invenção refere-se à prevenção e tratamento de insuficiência cerebral, incluindo aperfeiçoamento de funcionamento receptor em sinapses em redes cerebrais responsáveis por comportamentos de ordem superior. Estas redes cerebrais estão envolvidas em habilidades cognitivas relacionadas a dano de memória, tal como é observado em uma variedade de demências, e em desequilíbrios em atividade neuronal entre diferentes regiões do cérebro, como é sugerido em distúrbios tais como mal de Parkinson, esquizofrenia e distúrbios afetivos. Em um aspecto particular, a presente invenção refere-se a compostos úteis para tratamento de tais condições, e processos de uso destes compostos para tal tratamento.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33333401P | 2001-11-26 | 2001-11-26 | |
| PCT/US2002/037646 WO2003045315A2 (en) | 2001-11-26 | 2002-11-25 | Carbonylbenzoxazine compounds for enhancing glutamatergic synaptic responses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0214425A true BR0214425A (pt) | 2004-11-03 |
Family
ID=23302344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0214425-5A BR0214425A (pt) | 2001-11-26 | 2002-11-25 | Compostos carbonilbenzoxazina para aperfeiçoamento de respostas sinápticas glutamatérgicas |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7799913B2 (pt) |
| EP (1) | EP1448537A4 (pt) |
| JP (1) | JP4620349B2 (pt) |
| KR (1) | KR100915176B1 (pt) |
| CN (1) | CN1620440A (pt) |
| AU (1) | AU2002352886B2 (pt) |
| BR (1) | BR0214425A (pt) |
| CA (1) | CA2463592A1 (pt) |
| CZ (1) | CZ2004632A3 (pt) |
| EA (1) | EA011034B1 (pt) |
| GE (1) | GEP20063859B (pt) |
| HR (1) | HRP20040424A2 (pt) |
| HU (1) | HUP0402279A3 (pt) |
| IL (1) | IL161452A0 (pt) |
| MA (1) | MA26233A1 (pt) |
| MX (1) | MXPA04004815A (pt) |
| NO (1) | NO20041590L (pt) |
| NZ (1) | NZ532368A (pt) |
| PL (1) | PL371722A1 (pt) |
| SK (1) | SK2292004A3 (pt) |
| UA (1) | UA79940C2 (pt) |
| WO (1) | WO2003045315A2 (pt) |
| ZA (1) | ZA200403729B (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100041647A1 (en) * | 2007-01-03 | 2010-02-18 | Cortex Pharmaceuticals, Inc. | 3-Substituted-[1,2,3]-Benzotriazinone compounds for enhancing glutamatergic synaptic responses |
| AU2007342365B2 (en) * | 2007-01-03 | 2012-11-15 | Les Laboratoires Servier | 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses |
| WO2011109398A2 (en) | 2010-03-02 | 2011-09-09 | President And Fellows Of Harvard College | Methods and compositions for treatment of angelman syndrome and autism spectrum disorders |
| US9260452B2 (en) | 2011-06-08 | 2016-02-16 | Sunovion Pharmaceuticals Inc. | Metabotrophic glutamate receptor 5 modulators and methods of use thereof |
| BR112015031249A2 (pt) | 2013-06-13 | 2017-07-25 | Veroscience Llc | método de tratamento, método para tratar um distúrbio metabólico ou um elemento chave do mesmo, método para normalizar um ritmo diário de liberação de dopamina no sumn, método para estimular a liberação de dopamina de neurônios dopaminérgicos no sumn de um indivíduo e composição farmacêutica |
| US10323027B2 (en) | 2015-06-26 | 2019-06-18 | Takeda Pharmaceutical Company Limited | 2,3-dihydro-4H-1,3-benzoxazin-4-one derivatives as modulators of cholinergic muscarinic M1 receptor |
| JP6787913B2 (ja) | 2015-10-20 | 2020-11-18 | 武田薬品工業株式会社 | 複素環化合物 |
| JP7365332B2 (ja) | 2017-08-07 | 2023-10-19 | ジョイント・ストック・カンパニー “バイオキャド” | Ｃｄｋ８／１９阻害薬としての新規ヘテロ環式化合物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2943087A (en) * | 1960-06-28 | n naoh | ||
| DE1122531B (de) * | 1957-09-13 | 1962-01-25 | Thomae Gmbh Dr K | Verfahren zur Herstellung von therapeutisch wertvollen 4-Oxo-2-(halogenalkyl)-2,3-dihydro-benzoxazinen-(1,3) |
| US4022139A (en) * | 1975-10-28 | 1977-05-10 | Blue Bell, Inc. | Tacker guide and method |
| EP0010348A1 (en) * | 1978-09-12 | 1980-04-30 | Imperial Chemical Industries Plc | Heterocyclic trichloromethyl derivatives, process for their preparation and their use |
| JPH0597824A (ja) * | 1990-09-25 | 1993-04-20 | Takeda Chem Ind Ltd | １，３−ベンゾオキサジン誘導体 |
| ATE253909T1 (de) | 1992-07-24 | 2003-11-15 | Univ California | Arzneimittel die den durch ampa rezeptoren vermittelten synaptischen response erhöhen |
| US5650409A (en) * | 1995-06-02 | 1997-07-22 | Cortex Pharmaceuticals, Inc. | Benzoyl piperidines/pyrrolidines for enhancing synaptic response |
| US5736543A (en) * | 1996-04-03 | 1998-04-07 | The Regents Of The University Of California | Benzoxazines for enhancing synaptic response |
| GB9716962D0 (en) * | 1997-08-12 | 1997-10-15 | Univ Birmingham | Liver function test |
| CN1280574A (zh) * | 1997-10-27 | 2001-01-17 | 雷迪研究基金会 | 新的杂环化合物及其在医药中的应用、它们的制备方法和含有它们的药物组合物 |
| ZA991301B (en) | 1998-02-18 | 1999-09-13 | Neurosearch As | Glutamate receptor modulators. |
| US6124278A (en) * | 1998-04-03 | 2000-09-26 | The Regents Of The University Of California | Acylbenzoxazines for enhancing synaptic response |
-
2002
- 2002-11-25 MX MXPA04004815A patent/MXPA04004815A/es active IP Right Grant
- 2002-11-25 GE GE5593A patent/GEP20063859B/en unknown
- 2002-11-25 JP JP2003546820A patent/JP4620349B2/ja not_active Expired - Fee Related
- 2002-11-25 US US10/495,049 patent/US7799913B2/en not_active Expired - Fee Related
- 2002-11-25 BR BR0214425-5A patent/BR0214425A/pt not_active Application Discontinuation
- 2002-11-25 EP EP02789846A patent/EP1448537A4/en not_active Withdrawn
- 2002-11-25 EA EA200400584A patent/EA011034B1/ru not_active IP Right Cessation
- 2002-11-25 CA CA002463592A patent/CA2463592A1/en not_active Abandoned
- 2002-11-25 AU AU2002352886A patent/AU2002352886B2/en not_active Ceased
- 2002-11-25 UA UA20040503965A patent/UA79940C2/uk unknown
- 2002-11-25 IL IL16145202A patent/IL161452A0/xx unknown
- 2002-11-25 CN CNA028234502A patent/CN1620440A/zh active Pending
- 2002-11-25 WO PCT/US2002/037646 patent/WO2003045315A2/en active Application Filing
- 2002-11-25 CZ CZ2004632A patent/CZ2004632A3/cs unknown
- 2002-11-25 NZ NZ532368A patent/NZ532368A/en not_active IP Right Cessation
- 2002-11-25 PL PL02371722A patent/PL371722A1/xx not_active Application Discontinuation
- 2002-11-25 SK SK229-2004A patent/SK2292004A3/sk not_active Application Discontinuation
- 2002-11-25 KR KR1020047007502A patent/KR100915176B1/ko not_active IP Right Cessation
- 2002-11-25 HU HU0402279A patent/HUP0402279A3/hu unknown
-
2004
- 2004-04-19 NO NO20041590A patent/NO20041590L/no not_active Application Discontinuation
- 2004-05-12 HR HR20040424A patent/HRP20040424A2/xx not_active Application Discontinuation
- 2004-05-14 ZA ZA200403729A patent/ZA200403729B/en unknown
- 2004-05-21 MA MA27691A patent/MA26233A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0402279A2 (hu) | 2005-02-28 |
| EA011034B1 (ru) | 2008-12-30 |
| JP4620349B2 (ja) | 2011-01-26 |
| WO2003045315A3 (en) | 2003-08-28 |
| GEP20063859B (en) | 2006-06-26 |
| WO2003045315A2 (en) | 2003-06-05 |
| EP1448537A4 (en) | 2005-05-04 |
| CN1620440A (zh) | 2005-05-25 |
| HUP0402279A3 (en) | 2008-09-29 |
| IL161452A0 (en) | 2004-09-27 |
| EA200400584A1 (ru) | 2005-02-24 |
| KR20040054777A (ko) | 2004-06-25 |
| AU2002352886A1 (en) | 2003-06-10 |
| SK2292004A3 (en) | 2004-09-08 |
| KR100915176B1 (ko) | 2009-09-03 |
| JP2005510532A (ja) | 2005-04-21 |
| NO20041590L (no) | 2004-07-12 |
| US20040259871A1 (en) | 2004-12-23 |
| MXPA04004815A (es) | 2005-02-17 |
| CA2463592A1 (en) | 2003-06-05 |
| CZ2004632A3 (cs) | 2004-08-18 |
| EP1448537A2 (en) | 2004-08-25 |
| HRP20040424A2 (en) | 2005-06-30 |
| US7799913B2 (en) | 2010-09-21 |
| AU2002352886B2 (en) | 2008-10-16 |
| ZA200403729B (en) | 2005-05-19 |
| PL371722A1 (en) | 2005-06-27 |
| UA79940C2 (en) | 2007-08-10 |
| NZ532368A (en) | 2006-10-27 |
| MA26233A1 (fr) | 2004-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |