BR0211491A - Geração de células dendrìticas totalmente madura e estáveis de produtos de leucafereses para aplicações clìnicas - Google Patents

Geração de células dendrìticas totalmente madura e estáveis de produtos de leucafereses para aplicações clìnicas

Info

Publication number
BR0211491A
BR0211491A BR0211491-7A BR0211491A BR0211491A BR 0211491 A BR0211491 A BR 0211491A BR 0211491 A BR0211491 A BR 0211491A BR 0211491 A BR0211491 A BR 0211491A
Authority
BR
Brazil
Prior art keywords
clinical applications
dendritic cell
fully mature
cell generation
stable
Prior art date
Application number
BR0211491-7A
Other languages
English (en)
Inventor
Gerold Schuler
Beatrice Thurner-Schuler
Thomas Berger
Original Assignee
Merix Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merix Bioscience Inc filed Critical Merix Bioscience Inc
Publication of BR0211491A publication Critical patent/BR0211491A/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • C12M3/04—Tissue, human, animal or plant cell, or virus culture apparatus with means providing thin layers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/08—Flask, bottle or test tube
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/34—Internal compartments or partitions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/02—Compounds of the arachidonic acid pathway, e.g. prostaglandins, leukotrienes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/25—Tumour necrosing factors [TNF]

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

"GERAçãO DE CéLULAS DENDRìTICAS TOTALMENTE MADURA E ESTáVEIS DE PRODUTOS DE LEUCAFERESES PARA APLICAçõES CLìNICAS". A presente invenção fornece um método para produzir células dendríticas imaturas ou células dendríticas maduras e estáveis que compreendem células progenitoras hematopoiéticas de cultivo em um mecanismo de cultivo estéril, um mecanismo adequado para o referido método e um método para preparar células mononucleares de sangue periférico, que são adequadas para cultivo de células dendríticas.
BR0211491-7A 2001-07-27 2002-07-26 Geração de células dendrìticas totalmente madura e estáveis de produtos de leucafereses para aplicações clìnicas BR0211491A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01118199A EP1279728A1 (en) 2001-07-27 2001-07-27 Generation of fully mature and stable dentritic cells from leukapheresis products for clinical applications
PCT/EP2002/008318 WO2003012081A1 (en) 2001-07-27 2002-07-26 Generation of fully mature and stable dendritic cells from leukaphereses products for clinical applications

Publications (1)

Publication Number Publication Date
BR0211491A true BR0211491A (pt) 2004-08-17

Family

ID=8178156

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0211491-7A BR0211491A (pt) 2001-07-27 2002-07-26 Geração de células dendrìticas totalmente madura e estáveis de produtos de leucafereses para aplicações clìnicas

Country Status (7)

Country Link
EP (2) EP1279728A1 (pt)
JP (1) JP2004535829A (pt)
KR (1) KR20040021664A (pt)
CN (1) CN1561388A (pt)
BR (1) BR0211491A (pt)
CA (1) CA2455327A1 (pt)
WO (1) WO2003012081A1 (pt)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7109031B2 (en) * 1999-04-20 2006-09-19 Yale University Methods for inducing the differentiation of monocytes into functional dendritic cells and immunotherapeutic compositions including such dendritic cells
JPWO2004025342A1 (ja) 2002-09-11 2006-01-12 富士通株式会社 デバイス製造方法
JP4668568B2 (ja) * 2003-08-26 2011-04-13 株式会社メディネット 培養容器、培養装置および細胞の培養方法
JP4371755B2 (ja) * 2003-09-26 2009-11-25 シスメックス株式会社 Ｂリンパ球の分類方法
JP4792566B2 (ja) * 2005-06-01 2011-10-12 財団法人ヒューマンサイエンス振興財団 樹状細胞を含む三次元培養ヒト皮膚モデル
US7745209B2 (en) * 2005-07-26 2010-06-29 Corning Incorporated Multilayered cell culture apparatus
AU2006297259A1 (en) 2005-09-30 2007-04-12 Oklahoma Medical Research Foundation Regulation of toll-like receptors on stem cells
EP1795589A1 (en) * 2005-12-07 2007-06-13 Gerold Prof. Dr. Schuler Method for the direct culture of dendritic cells without a preceding centrifugation step
EP1795587A1 (en) * 2005-12-07 2007-06-13 Schuler, Gerold, Prof. Dr. Method for the direct culture of dendritic cells without a preceding centrifugation step
US8778669B2 (en) * 2009-07-22 2014-07-15 Corning Incorporated Multilayer tissue culture vessel
BR112013008581A2 (pt) * 2010-10-12 2016-07-12 Nalge Nunc Int Corp dispositivo e bandejas de cultura de células e método para preparar pilha de bandejas para cultura de células
ES2435092B1 (es) 2012-06-14 2014-09-09 Aglaris Cell S.L. Método y sistema de cultivo celular
KR101477106B1 (ko) * 2014-07-14 2014-12-29 동아대학교 산학협력단 나노-마이크로 하이브리드 섬유 기반의 미성숙 수지상세포 배양방법 및 분석방법
KR102460969B1 (ko) 2014-10-29 2022-10-31 코닝 인코포레이티드 세포 배양 인서트
US11857970B2 (en) 2017-07-14 2024-01-02 Corning Incorporated Cell culture vessel
PL3652291T3 (pl) * 2017-07-14 2022-03-28 Corning Incorporated Naczynie do hodowli komórkowej
CN111051494B (zh) 2017-07-14 2024-03-29 康宁股份有限公司 用于手动或自动培养基交换的3d细胞培养容器
WO2019188044A1 (ja) * 2018-03-26 2019-10-03 日本ゼオン株式会社 多層細胞培養容器および細胞培養装置
PL3649226T3 (pl) 2018-07-13 2022-05-16 Corning Incorporated Płytki mikrodołkowe z boczną ścianką zawierającą powierzchnię dostarczającą płynną pożywkę
PL3649229T3 (pl) 2018-07-13 2021-12-06 Corning Incorporated Naczynia do hodowli komórkowych ze stabilizującymi urządzeniami
EP3649227A1 (en) 2018-07-13 2020-05-13 Corning Incorporated Fluidic devices including microplates with interconnected wells
WO2023245609A1 (en) * 2022-06-24 2023-12-28 Lihpao Life Science Corp. Method for producing mature dendritic cells

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FR2608169B1 (fr) * 1986-12-11 1989-03-03 Grenoble I Universite Scient M Module de culture de micro-organismes
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BE1004610A5 (fr) * 1990-11-29 1992-12-22 Spielmann Richard Bioreacteur rotatif a grande surface pour culture de cellules adherentes ou en suspension.
US5650325A (en) * 1990-11-29 1997-07-22 Spielmann; Richard Apparatus having a rotatable stack of parallel trays with culturing surfaces on opposite sides for liquid/gas exchange
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Also Published As

Publication number Publication date
EP1279728A1 (en) 2003-01-29
CA2455327A1 (en) 2003-02-13
WO2003012081A1 (en) 2003-02-13
CN1561388A (zh) 2005-01-05
JP2004535829A (ja) 2004-12-02
KR20040021664A (ko) 2004-03-10
EP1412483A1 (en) 2004-04-28

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: C12N 5/0784 (2010.01), C12M 1/24 (2006.01), C12M 1