BR0210853A - ácidos nucléicos que codificam um antìgeno de 56 e 82 kda recombinantes de gametócitos de eimeria máxima e seus usos - Google Patents
ácidos nucléicos que codificam um antìgeno de 56 e 82 kda recombinantes de gametócitos de eimeria máxima e seus usosInfo
- Publication number
- BR0210853A BR0210853A BR0210853-4A BR0210853A BR0210853A BR 0210853 A BR0210853 A BR 0210853A BR 0210853 A BR0210853 A BR 0210853A BR 0210853 A BR0210853 A BR 0210853A
- Authority
- BR
- Brazil
- Prior art keywords
- eimeria
- kda
- recombinant
- provides
- present
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 7
- 102000036639 antigens Human genes 0.000 title abstract 6
- 108091007433 antigens Proteins 0.000 title abstract 6
- 241000223934 Eimeria maxima Species 0.000 title abstract 5
- 210000000973 gametocyte Anatomy 0.000 title abstract 4
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 3
- 208000003495 Coccidiosis Diseases 0.000 abstract 2
- 206010023076 Isosporiasis Diseases 0.000 abstract 2
- 241000223931 Eimeria acervulina Species 0.000 abstract 1
- 241000499566 Eimeria brunetti Species 0.000 abstract 1
- 241000179199 Eimeria mitis Species 0.000 abstract 1
- 241000499563 Eimeria necatrix Species 0.000 abstract 1
- 241000499544 Eimeria praecox Species 0.000 abstract 1
- 241000223932 Eimeria tenella Species 0.000 abstract 1
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 101710159910 Movement protein Proteins 0.000 abstract 1
- 101710164418 Movement protein TGB2 Proteins 0.000 abstract 1
- 102100021225 Serine hydroxymethyltransferase, cytosolic Human genes 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000010367 cloning Methods 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000012163 sequencing technique Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/455—Eimeria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"áCIDOS NUCLéICOS QUE CODIFICAM UM ANTìGENO DE 56 E 82 kDa RECOMBINANTES DE GAMETóCITOS DE EIMERIA MAXIMA E SEUS USOS". A presente invenção provê a clonagem recombinante e sequenciamento de dois dos principais antìgenos de gametócito de Eimeria maxima que têm pesos moleculares de 56 e 82 kDa e a expressão desses antígenos recombinantes em um sistema de expressão de E. coli utilizando o plasmídeo pTrcHis. A presente invenção também provê uma vacina contra coccidiose compreendendo o antígeno de 56 kDa ou 82 kDa recombinante. A presente invenção também provê duas proteínas de 30 kDa e três proteínas de 14 kDa de Gametócitos de Eimeria maxima que têm na extremidade terminal-N a seq³ência de aminoácidos descrita aqui. A presente invenção também provê uma vacina contra coccidiose compreendendo o antígeno de 56 kDa ou 82 kDa recombinante e qualquer uma das proteínas acima mencionadas. Adicionalmente, a presente invenção também provê um método de imunizar um indivíduo contra infecção por Eimeria tenella, Eimeria maxima, Eimeria acervulina, Eimeria necatrix, Eimeria praecox, Eimeria mitis ou Eimeria brunetti, ou um microorganismo que expressa um antígeno imunologicamente reativo cruzado, compreendendo a etapa de administrar ao indivíduo qualquer uma das vacinas acima mencionadas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30369901P | 2001-07-06 | 2001-07-06 | |
| PCT/US2002/021233 WO2003004683A2 (en) | 2001-07-06 | 2002-07-03 | Nucleic acids encoding recombinant 56 and 82 kda antigens from gametocytes of eimeria maxima and their uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0210853A true BR0210853A (pt) | 2005-08-30 |
Family
ID=23173289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0210853-4A BR0210853A (pt) | 2001-07-06 | 2002-07-03 | ácidos nucléicos que codificam um antìgeno de 56 e 82 kda recombinantes de gametócitos de eimeria máxima e seus usos |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7423137B2 (pt) |
| EP (1) | EP1432722B1 (pt) |
| JP (2) | JP2005501533A (pt) |
| CN (1) | CN1606565B (pt) |
| AT (1) | ATE454392T1 (pt) |
| AU (1) | AU2002316558B2 (pt) |
| BR (1) | BR0210853A (pt) |
| CA (1) | CA2467006A1 (pt) |
| DE (1) | DE60235021D1 (pt) |
| ES (1) | ES2339227T3 (pt) |
| HU (1) | HUP0600028A3 (pt) |
| IL (2) | IL159716A0 (pt) |
| MX (1) | MXPA04000127A (pt) |
| PL (1) | PL366540A1 (pt) |
| RU (1) | RU2004103469A (pt) |
| TR (1) | TR200400049T2 (pt) |
| WO (1) | WO2003004683A2 (pt) |
| ZA (1) | ZA200400479B (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0775746B1 (en) * | 1995-07-03 | 2005-11-23 | Akzo Nobel N.V. | Coccidiosis poultry vaccine |
| DE60235044D1 (de) | 2001-07-06 | 2010-02-25 | Abic Biolog Lab Ltd | REKOMBINANTES, 250 kDa GROSSES ANTIGEN AUS SPOROZOITEN/MEROZOITEN VON EIMERIA MAXIMA CODIERENDE NUKLEINSÄUREN UND IHRE VERWENDUNGEN |
| ZA200400479B (en) | 2001-07-06 | 2006-05-31 | Abic Biolog Lab Teva | Nucleic acids encoding recombinant 56 a 82 KDA antigens from gametocytes of Eimeria maxima and their use |
| ES2520026T3 (es) | 2006-09-18 | 2014-11-11 | The Board Of Trustees Of The University Of Arkansas | Composiciones y métodos para potenciar respuestas inmunitarias |
| ES2599905T3 (es) * | 2007-11-01 | 2017-02-06 | The Board Of Trustees Of The University Of Arkansas | Composiciones y métodos para aumentar las respuestas inmunitarias a Eimeria |
| US20100150958A1 (en) * | 2008-12-15 | 2010-06-17 | Vectogen Pty Ltd. | Methods and Compositions for Use of a Coccidiosis Vaccine |
| PL2956165T3 (pl) | 2013-02-14 | 2020-04-30 | The Board Of Trustees Of The University Of Arkansas | Kompozycje i sposoby wzmacniania odpowiedzi immunologicznych na Eimeria lub ograniczania infekcji Eimeria |
| CN106659787A (zh) * | 2014-05-23 | 2017-05-10 | 辉宝动物保健公司 | 组合、组合物及向动物施用所述组合或组合物的方法 |
| CN111471107B (zh) * | 2020-04-27 | 2023-04-18 | 中国农业大学 | 抗鸡球虫多价重组蛋白卵黄抗体及其制备方法和应用 |
| CN111840529B (zh) * | 2020-07-30 | 2023-08-25 | 广东省农业科学院动物卫生研究所 | 一种柔嫩艾美耳球虫重组多肽疫苗vkvq的制备及其在抗鸡球虫病中的应用方法 |
| CN113521264A (zh) * | 2021-07-14 | 2021-10-22 | 中国农业科学院北京畜牧兽医研究所 | 一种鸽球虫病活疫苗及其制备方法和应用 |
| CN114051971B (zh) * | 2021-08-26 | 2023-08-29 | 山东农巧农业科技有限公司 | 一种高效率乳鸽生态养殖方法 |
| CN114736308B (zh) * | 2022-03-15 | 2022-12-27 | 四川宜美康科技有限公司 | 球虫抗原肽/il5的融合蛋白基因工程菌的制备及用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0135712A3 (en) | 1983-08-19 | 1987-05-27 | American Cyanamid Company | Antigens and monoclonal antibodies reactive against sporozoites of eimeria spp. |
| CA1340520C (en) | 1984-06-05 | 1999-05-04 | Karel Z. Newman Jr. | Antigenic proteins and vaccines containing them and protective antibodies directed to them for prevention of coccidiosis caused by eimeria tenella and eimeria necatrix |
| US4639372A (en) | 1984-06-29 | 1987-01-27 | Merck & Co., Inc. | Coccidiosis vaccine |
| US5496550A (en) | 1986-08-14 | 1996-03-05 | Chilwalner | Method of reducing the output of Eimeria oocysts from a newborn chick |
| IL83523A (en) * | 1986-08-14 | 1994-10-21 | Chilwalner Partnership | Method of purification of eimeria gametocytes and coccidiosis vaccine containing them |
| ZA893740B (en) * | 1988-06-03 | 1990-02-28 | Hoffmann La Roche | Recombinant coccidiosis vaccines |
| JPH03505970A (ja) | 1988-07-05 | 1991-12-26 | ジェネックス・コーポレーション | 遺伝子工学によるコクシジウム症ワクチン |
| ZA200400479B (en) | 2001-07-06 | 2006-05-31 | Abic Biolog Lab Teva | Nucleic acids encoding recombinant 56 a 82 KDA antigens from gametocytes of Eimeria maxima and their use |
-
2001
- 2001-01-22 ZA ZA200400479A patent/ZA200400479B/xx unknown
-
2002
- 2002-07-03 ES ES02746870T patent/ES2339227T3/es not_active Expired - Lifetime
- 2002-07-03 JP JP2003510441A patent/JP2005501533A/ja active Pending
- 2002-07-03 WO PCT/US2002/021233 patent/WO2003004683A2/en active Application Filing
- 2002-07-03 TR TR2004/00049T patent/TR200400049T2/xx unknown
- 2002-07-03 IL IL15971602A patent/IL159716A0/xx unknown
- 2002-07-03 PL PL02366540A patent/PL366540A1/xx not_active Application Discontinuation
- 2002-07-03 DE DE60235021T patent/DE60235021D1/de not_active Expired - Lifetime
- 2002-07-03 HU HU0600028A patent/HUP0600028A3/hu not_active Application Discontinuation
- 2002-07-03 US US10/483,159 patent/US7423137B2/en not_active Expired - Fee Related
- 2002-07-03 EP EP02746870A patent/EP1432722B1/en not_active Expired - Lifetime
- 2002-07-03 BR BR0210853-4A patent/BR0210853A/pt not_active IP Right Cessation
- 2002-07-03 CA CA002467006A patent/CA2467006A1/en not_active Abandoned
- 2002-07-03 CN CN028174976A patent/CN1606565B/zh not_active Expired - Fee Related
- 2002-07-03 MX MXPA04000127A patent/MXPA04000127A/es not_active Application Discontinuation
- 2002-07-03 AT AT02746870T patent/ATE454392T1/de not_active IP Right Cessation
- 2002-07-03 RU RU2004103469/13A patent/RU2004103469A/ru not_active Application Discontinuation
- 2002-07-03 AU AU2002316558A patent/AU2002316558B2/en not_active Ceased
-
2004
- 2004-01-06 IL IL159716A patent/IL159716A/en not_active IP Right Cessation
-
2008
- 2008-05-30 US US12/156,206 patent/US7968695B2/en not_active Expired - Fee Related
- 2008-09-08 JP JP2008230091A patent/JP2009077713A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN1606565B (zh) | 2011-06-29 |
| ZA200400479B (en) | 2006-05-31 |
| US20050033042A1 (en) | 2005-02-10 |
| JP2005501533A (ja) | 2005-01-20 |
| AU2002316558B2 (en) | 2009-01-08 |
| JP2009077713A (ja) | 2009-04-16 |
| US7423137B2 (en) | 2008-09-09 |
| ATE454392T1 (de) | 2010-01-15 |
| ES2339227T3 (es) | 2010-05-18 |
| WO2003004683A3 (en) | 2004-04-29 |
| IL159716A (en) | 2010-06-16 |
| HUP0600028A2 (en) | 2006-04-28 |
| HUP0600028A3 (en) | 2010-01-28 |
| IL159716A0 (en) | 2004-06-20 |
| CA2467006A1 (en) | 2003-01-16 |
| RU2004103469A (ru) | 2005-04-10 |
| MXPA04000127A (es) | 2005-07-01 |
| EP1432722B1 (en) | 2010-01-06 |
| US7968695B2 (en) | 2011-06-28 |
| CN1606565A (zh) | 2005-04-13 |
| US20090196888A1 (en) | 2009-08-06 |
| EP1432722A2 (en) | 2004-06-30 |
| DE60235021D1 (de) | 2010-02-25 |
| EP1432722A4 (en) | 2005-08-10 |
| PL366540A1 (en) | 2005-02-07 |
| WO2003004683A2 (en) | 2003-01-16 |
| TR200400049T2 (tr) | 2009-01-21 |
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Legal Events
| Date | Code | Title | Description |
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| B06G | Technical and formal requirements: other requirements [chapter 6.7 patent gazette] |
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| B06G | Technical and formal requirements: other requirements [chapter 6.7 patent gazette] |
Free format text: EM ADITAMENTO A EXIGENCIA PUBLICADA NA RPI 1986 DE 27/01/2009, DEVE O DEPOSITANTE SOLICITAR A NOTIFICACAO DA FASE NACIONAL 1.03, DE ACORDO COM A PUBLICACAO INTERNACIONAL - WO -, PARA QUE A PETICAO NO020090022684 DE 09/03/2009, DE TRANSFERENCIA DE ALTERACAO DE NOME, SEJA ANALISADA PELO SECAO COMPETENTE. |
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| B12F | Other appeals [chapter 12.6 patent gazette] | ||
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Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
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| B15G | Petition not considered as such [chapter 15.7 patent gazette] |
Free format text: A PETICAO DE NO 20090022684, APRESENTADA EM 09/03/2009, EM VIRTUDE DO DISPOSTO NOS ARTS. 219, II, DA LPI (LEI 9279 / 96) DE 14/05/1996, E CONSIDERADA COMO PETICAO NAO CONHECIDA DEVIDO AO ARQUIVAMENTO DO PEDIDO PUBLICADO NA RPI NO 2360, DE 29/03/2016. |
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| B25E | Requested change of name of applicant rejected |
Owner name: BIOLOGICAL LABORATORIES TEVA LTD. (IL) |