BR0209727A - Microorganismo de tipo alimentar geneticamente modificado, processos para produzir folato de monoglutamila e para suprir folato biodisponìvel ao trato gastrointestinal de um mamìfero, e, produto alimentìcio - Google Patents

Microorganismo de tipo alimentar geneticamente modificado, processos para produzir folato de monoglutamila e para suprir folato biodisponìvel ao trato gastrointestinal de um mamìfero, e, produto alimentìcio

Info

Publication number
BR0209727A
BR0209727A BR0209727-3A BR0209727A BR0209727A BR 0209727 A BR0209727 A BR 0209727A BR 0209727 A BR0209727 A BR 0209727A BR 0209727 A BR0209727 A BR 0209727A
Authority
BR
Brazil
Prior art keywords
folate
food
producing
monoglutamyl
processes
Prior art date
Application number
BR0209727-3A
Other languages
English (en)
Inventor
Wilbert Feike Henricus Sybesma
Jeroen Hugenholtz
Igor Mierau
Maria Johanna Cath Starrenburg
Michiel Kleerebezem
Williem Meindert De Vos
Original Assignee
Campina Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Campina Bv filed Critical Campina Bv
Publication of BR0209727A publication Critical patent/BR0209727A/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/065—Microorganisms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1235—Diphosphotransferases (2.7.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C2220/00—Biochemical treatment
    • A23C2220/20—Treatment with microorganisms
    • A23C2220/202—Genetic engineering of microorganisms used in dairy technology
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"MICROORGANISMO DE TIPO ALIMENTAR GENETICAMENTE MODIFICADO, PROCESSOS PARA PRODUZIR FOLATO DE MONOGLUTAMILA E PARA SUPRIR FOLATO BIODISPONìVEL AO TRATO GASTROINTESTINAL DE UM MAMìFERO, E, PRODUTO ALIMENTìCIO". A invenção provê um processo para produzir folato biodisponível, isto é, ácido fólico tendo uma proporção aumentada de folato de monoglutamila e uma proporção diminuída de folato de poliglutamila, cultivando-se microorganismos de tipo alimentar, contendo uma atividade de poliglutamil hidrolase heteróloga ou homóloga ativa ou contendo aumentadas atividades de enzimas de biossíntese de folato. Os genes codificando a poliglutamil hidrolase e as enzimas de biossíntese de folato podem ser de várias origens, por exemplo, de roedores ou outros mamíferos, incluindo o homem. é também provido um alimento, especialmente um produto de laticínio, contendo tais microorganismos produzindo folato de monoglutamila.
BR0209727-3A 2001-05-28 2002-05-28 Microorganismo de tipo alimentar geneticamente modificado, processos para produzir folato de monoglutamila e para suprir folato biodisponìvel ao trato gastrointestinal de um mamìfero, e, produto alimentìcio BR0209727A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01202013A EP1262541A1 (en) 2001-05-28 2001-05-28 Production of bioavailable folic acid
PCT/NL2002/000340 WO2002097063A1 (en) 2001-05-28 2002-05-28 Production of bioavailable folic acid

Publications (1)

Publication Number Publication Date
BR0209727A true BR0209727A (pt) 2004-09-14

Family

ID=8180380

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0209727-3A BR0209727A (pt) 2001-05-28 2002-05-28 Microorganismo de tipo alimentar geneticamente modificado, processos para produzir folato de monoglutamila e para suprir folato biodisponìvel ao trato gastrointestinal de um mamìfero, e, produto alimentìcio

Country Status (12)

Country Link
US (2) US20040214261A1 (pt)
EP (2) EP1262541A1 (pt)
JP (1) JP2004527262A (pt)
CN (1) CN1513056A (pt)
BR (1) BR0209727A (pt)
CZ (1) CZ20033565A3 (pt)
HU (1) HUP0400435A3 (pt)
PL (1) PL368444A1 (pt)
RU (1) RU2342426C2 (pt)
SK (1) SK16332003A3 (pt)
WO (1) WO2002097063A1 (pt)
ZA (1) ZA200309155B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2227552E (pt) 2007-12-06 2012-02-08 Purac Biochem Bv Níveis de produção de folato aumentado por fermentação de sumo de melão com lactobacillus
CN101776665B (zh) * 2009-01-13 2013-09-11 上海医药工业研究院 一种乳酸链球菌素的hplc检测方法
CN105624182A (zh) * 2015-12-15 2016-06-01 重庆大学 生产四氢叶酸的重组质粒、基因工程菌株构建及应用
US20190365147A1 (en) * 2017-02-17 2019-12-05 Koninklijke Philips N.V. Temperature control device, food cooking device and method for controlling heating unit for cooking food
WO2021035421A1 (en) * 2019-08-23 2021-03-04 Chifeng Pharmaceutical Co., Ltd. Folate producing strain and the preparation and application thereof
WO2023180103A1 (en) * 2022-03-21 2023-09-28 Immundiagnostik Ag Kit of parts and microbiological method for assessment of the folate status in serum and red blood cells

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2135423T3 (es) * 1992-03-03 1999-11-01 Meiji Seika Kaisha Gamma-poliglutamato-hidrolasa y procedimiento de produccion de esta.
DE19929363A1 (de) * 1999-06-25 2000-12-28 Basf Lynx Bioscience Ag Gene aus Corynebacterium glutamicum für die Folsäurebiosynthese und ihr Einsatz zur mikrobiellen Herstellung von Folsäure

Also Published As

Publication number Publication date
JP2004527262A (ja) 2004-09-09
EP1392816A1 (en) 2004-03-03
ZA200309155B (en) 2004-11-25
SK16332003A3 (sk) 2004-07-07
US20040214261A1 (en) 2004-10-28
RU2003137558A (ru) 2005-05-20
CZ20033565A3 (cs) 2004-04-14
RU2342426C2 (ru) 2008-12-27
EP1262541A1 (en) 2002-12-04
CN1513056A (zh) 2004-07-14
HUP0400435A2 (hu) 2004-11-29
HUP0400435A3 (en) 2005-02-28
WO2002097063A1 (en) 2002-12-05
PL368444A1 (en) 2005-03-21
US20080248553A1 (en) 2008-10-09

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2108 DE 31/05/2011.

B15K Others concerning applications: alteration of classification

Ipc: A61K 38/45 (2006.01), A23L 29/00 (2016.01), A23L 3