BR0208829A - Sal farmaceuticamente aceitável, composto, processos para a preparação de um sal, de um composto e de uma forma cristalina dos compostos, formulação farmacêutica, uso de um composto, e, método de profilaxia ou tratamento de uma arritmia - Google Patents
Sal farmaceuticamente aceitável, composto, processos para a preparação de um sal, de um composto e de uma forma cristalina dos compostos, formulação farmacêutica, uso de um composto, e, método de profilaxia ou tratamento de uma arritmiaInfo
- Publication number
- BR0208829A BR0208829A BR0208829-0A BR0208829A BR0208829A BR 0208829 A BR0208829 A BR 0208829A BR 0208829 A BR0208829 A BR 0208829A BR 0208829 A BR0208829 A BR 0208829A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- salt
- pharmaceutically acceptable
- treatment
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
"SAL FARMACEUTICAMENTE ACEITáVEL, COMPOSTO, PROCESSOS PARA A PREPARAçãO DE UM SAL, DE UM COMPOSTO E DE UMA FORMA CRISTALINA DOS COMPOSTOS, FORMULAçãO FARMACêUTICA USO DE UM COMPOSTO, E, MéTODO DE PROFILAXIA OU TRATAMENTO DE UMA ARRITMIA". São fornecidas formas substancialmente cristalinas de, 4-([3-{7-(3,3-dimetil-2-oxobutil)-9-oxa-3,7-diazabiciclo[3,3,1]non-3-il]- propil} amino)benzonitrila, 2-{7- [3-(4-cianoanilino)propil]-9-oxa-3,7diazabiciclo[3,3,1]non-3-il}etilcarb amato de terc-butila, 2-{7-[4-(4-cianofenil)butil]-9-oxa-3,7-diazabiciclo[3,3,1]non-3-il}etilcar bamato de tercbutila ou 2-{7-[(2S)-3-(4-cianofenóxi)-2-hidroxipropil]-9-oxa-3,7-diazabiciclo[3, 3,1]non-3-il}etilcarbamato de terc-butila e seus sais farmaceuticamente aceitáveis, cujos compostos são úteis no tratamento de arritmias cardíacas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0101327A SE0101327D0 (sv) | 2001-04-12 | 2001-04-12 | New crystalline forms |
| PCT/SE2002/000725 WO2002083688A1 (en) | 2001-04-12 | 2002-04-12 | 3,7-diazabicyclo [3.3.1] formulations as antiarhythmic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0208829A true BR0208829A (pt) | 2004-03-09 |
Family
ID=20283783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0208829-0A BR0208829A (pt) | 2001-04-12 | 2002-04-12 | Sal farmaceuticamente aceitável, composto, processos para a preparação de um sal, de um composto e de uma forma cristalina dos compostos, formulação farmacêutica, uso de um composto, e, método de profilaxia ou tratamento de uma arritmia |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US7217708B2 (pt) |
| EP (2) | EP1550663A1 (pt) |
| JP (1) | JP2004525970A (pt) |
| KR (1) | KR20030087078A (pt) |
| CN (1) | CN1269823C (pt) |
| AR (1) | AR035452A1 (pt) |
| AT (1) | ATE323095T1 (pt) |
| BR (1) | BR0208829A (pt) |
| CA (1) | CA2443470A1 (pt) |
| CZ (1) | CZ20032760A3 (pt) |
| DE (1) | DE60210598T2 (pt) |
| DK (1) | DK1389213T3 (pt) |
| EE (1) | EE200300504A (pt) |
| ES (1) | ES2261721T3 (pt) |
| HK (1) | HK1061026A1 (pt) |
| HU (1) | HUP0303487A3 (pt) |
| IL (1) | IL158250A0 (pt) |
| IS (1) | IS6980A (pt) |
| MX (1) | MXPA03009206A (pt) |
| NO (1) | NO20034527L (pt) |
| NZ (1) | NZ528560A (pt) |
| PL (1) | PL367179A1 (pt) |
| PT (1) | PT1389213E (pt) |
| RU (1) | RU2286993C2 (pt) |
| SE (1) | SE0101327D0 (pt) |
| SK (1) | SK12572003A3 (pt) |
| TW (1) | TWI237025B (pt) |
| UA (1) | UA74629C2 (pt) |
| WO (1) | WO2002083688A1 (pt) |
| ZA (1) | ZA200307759B (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI259836B (en) * | 2001-04-12 | 2006-08-11 | Astrazeneca Ab | Modified release formulation suitable for antiarrhythmic compounds |
| SE0401540D0 (sv) * | 2004-06-15 | 2004-06-15 | Astrazeneca Ab | New compounds |
| SE0401539D0 (sv) * | 2004-06-15 | 2004-06-15 | Astrazeneca Ab | New compounds |
| AR057064A1 (es) * | 2005-06-13 | 2007-11-14 | Astrazeneca Ab | Compuestos para el tratamiento de arritmias cardiacas, formulacion farmaceutica y preparacion del compuesto |
| EP1915380A4 (en) * | 2005-06-20 | 2010-03-17 | Astrazeneca Ab | PROCESS FOR THE SYNTHESIS OF N, N'-DISUBSTITUTED OXABISPIDINES |
| AR053901A1 (es) * | 2005-06-20 | 2007-05-23 | Astrazeneca Ab | Formas fisicas de oxabispidinas n,n'- disustituidas |
| TW200734342A (en) * | 2005-12-15 | 2007-09-16 | Astrazeneca Ab | New compounds for the treatment of cardiac arrhythmias |
| WO2007103970A2 (en) * | 2006-03-07 | 2007-09-13 | Endacea, Inc. | Compositions and methods for treating respiratory disorders |
| EP3026044B8 (en) | 2006-06-26 | 2018-12-19 | Akebia Therapeutics, Inc. | Prolyl hydroxylase inhibitors and methods of use |
| CA2837560C (en) | 2011-06-06 | 2017-02-14 | Akebia Therapeutics Inc. | Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer |
| NO2686520T3 (pt) | 2011-06-06 | 2018-03-17 | ||
| CN114404414A (zh) | 2013-06-13 | 2022-04-29 | 阿克比治疗有限公司 | 用于治疗贫血症的组合物和方法 |
| TWI665190B (zh) | 2013-11-15 | 2019-07-11 | 阿克比治療有限公司 | ｛［５－（３－氯苯基）－３－羥基吡啶－２－羰基］胺基｝乙酸之固體型式，其組合物及用途 |
| US10150734B2 (en) | 2015-01-23 | 2018-12-11 | Akebia Therapeutics, Inc. | Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof |
| BR112017021097B1 (pt) | 2015-04-01 | 2024-01-02 | Akebia Therapeutics, Inc | Formulação de dosagem oral e seu uso |
| TW202406895A (zh) | 2018-05-09 | 2024-02-16 | 美商阿克比治療有限公司 | 用於製備2-[[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基]乙酸之方法 |
| US11524939B2 (en) | 2019-11-13 | 2022-12-13 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3732094A1 (de) * | 1987-09-24 | 1989-04-06 | Basf Ag | Bispidinderivate als klasse iii-antiarrhythmika |
| US5110933A (en) * | 1989-11-13 | 1992-05-05 | Board Of Regents Of Oklahoma State University | Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof |
| SE9704709D0 (sv) * | 1997-12-17 | 1997-12-17 | Astra Ab | Pharmaceutically active compounds |
| SE9902268D0 (sv) | 1999-06-16 | 1999-06-16 | Astra Ab | Pharmaceutically active compounds |
| SE9903759D0 (sv) * | 1999-10-18 | 1999-10-18 | Astra Ab | Pharmaceutically active compounds |
-
2001
- 2001-04-12 SE SE0101327A patent/SE0101327D0/xx unknown
-
2002
- 2002-04-01 TW TW091106493A patent/TWI237025B/zh not_active IP Right Cessation
- 2002-04-02 AR ARP020101189A patent/AR035452A1/es not_active Application Discontinuation
- 2002-04-12 AT AT02761972T patent/ATE323095T1/de not_active IP Right Cessation
- 2002-04-12 HU HU0303487A patent/HUP0303487A3/hu unknown
- 2002-04-12 BR BR0208829-0A patent/BR0208829A/pt not_active IP Right Cessation
- 2002-04-12 WO PCT/SE2002/000725 patent/WO2002083688A1/en active IP Right Grant
- 2002-04-12 EP EP05007851A patent/EP1550663A1/en not_active Withdrawn
- 2002-04-12 RU RU2003129231/04A patent/RU2286993C2/ru not_active IP Right Cessation
- 2002-04-12 PT PT02761972T patent/PT1389213E/pt unknown
- 2002-04-12 EE EEP200300504A patent/EE200300504A/xx unknown
- 2002-04-12 PL PL02367179A patent/PL367179A1/xx unknown
- 2002-04-12 JP JP2002581443A patent/JP2004525970A/ja active Pending
- 2002-04-12 SK SK1257-2003A patent/SK12572003A3/sk not_active Application Discontinuation
- 2002-04-12 KR KR10-2003-7013320A patent/KR20030087078A/ko not_active Application Discontinuation
- 2002-04-12 CN CNB028116283A patent/CN1269823C/zh not_active Expired - Fee Related
- 2002-04-12 CA CA002443470A patent/CA2443470A1/en not_active Abandoned
- 2002-04-12 ES ES02761972T patent/ES2261721T3/es not_active Expired - Lifetime
- 2002-04-12 US US10/474,592 patent/US7217708B2/en not_active Expired - Fee Related
- 2002-04-12 NZ NZ528560A patent/NZ528560A/en unknown
- 2002-04-12 EP EP02761972A patent/EP1389213B1/en not_active Expired - Lifetime
- 2002-04-12 MX MXPA03009206A patent/MXPA03009206A/es active IP Right Grant
- 2002-04-12 DE DE60210598T patent/DE60210598T2/de not_active Expired - Fee Related
- 2002-04-12 DK DK02761972T patent/DK1389213T3/da active
- 2002-04-12 IL IL15825002A patent/IL158250A0/xx unknown
- 2002-04-12 CZ CZ20032760A patent/CZ20032760A3/cs unknown
- 2002-12-04 UA UA2003098709A patent/UA74629C2/uk unknown
-
2003
- 2003-10-03 ZA ZA200307759A patent/ZA200307759B/en unknown
- 2003-10-08 IS IS6980A patent/IS6980A/is unknown
- 2003-10-09 NO NO20034527A patent/NO20034527L/no not_active Application Discontinuation
-
2004
- 2004-06-08 HK HK04104077A patent/HK1061026A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A,7A E 8A ANUIDADES |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2055 DE 25/05/2010. |